Platforms for sharing genomic and phenotype data have been developed to promote genomic research, while maximizing the utility of existing datasets and minimizing the burden on participants. The value of genomic analysis of trios or family members has increased, especially in rare diseases and cancers. This article aims to argue the necessity of protection when sharing data from both patients and family members. Sharing patients’ and family members’ data collectively raises an ethical tension between the value of datasets and the (...) rights of participants, and increases the risk of re-identification. However, current data-sharing policies have no specific safeguards or provisions for familial data sharing. A quantitative survey conducted on 10,881 general adults in Japan indicated that they expected stronger protection mechanisms when their family members’ clinical and/or genomic data were shared together, as compared to when only their data were shared. A framework that respects decision-making and the right of withdrawal of participants, including family members, along with ensuring usefulness and security of data is needed. To enable this, we propose recommendations on ancillary safeguards for familial data sharing according to the stakeholders, namely, initial researchers, genomic researchers, data submitters, database operators, institutional review boards, and the public and participants. Families have played significant roles in genetic research, and its value is re-illuminated in the era of genomic medicine. It is important to make progress in data sharing while simultaneously protecting the privacy and interests of patients and families, and return its benefits to them. (shrink)

This paper has three tasks. First, I offer an interpretation of Jeremy Bentham’s theory of language which I hope can conciliate or integrate the three rival interpretations of its epistemological implication: reductionist realist, pragmatist, and fictionalist. It is accompanied by an interpretation of Bentham’s strategy for improving the state of language, which characterizes it as a “two-level” strategy. Second, by focusing on the linguistic thoughts of three philosophers, Locke, Condillac, and Tooke, I inquire into the sources of Bentham’s theory of (...) language, and then try to evaluate the originality of Bentham’s theory in the context of the empiricist tradition of linguistic thought of the age of the Enlightenment. The inquiry also enables us to understand how Bentham’s theory came to have such a complex structure as is revealed in the first part of this paper. Third, I ask the question as to why Bentham, after about a thirty-year hiatus, suddenly resumed writing on the problems of language and logic around 1811. Through exhibiting the outline of my answer to this question, I argue that his discovery of “delusion” led him to fight the “war of words” in various fields of society, and his awareness of the strong force of delusion for aggravating the state of language made him realize the urgent necessity to develop at length “an entirely new system of Logic, in which shall be comprehended a theory of language, considered in the most general point of view.”. (shrink)

Nanometre-sized ! '-martensites , a few nanometres in cross-sectional diameter, formed at intersections of deformation twins, have been found in a heavily deformed 316-type austenitic stainless steel and examined by high-resolution transmission electron microscopy . An orientation relationship was found to be close to the Kurdjumov-Sachs relationship, that is , . HRTEM observations were conducted with a beam direction parallel to . The observed nanometre-sized ! '-martensites exhibited a habit plane and the cross-section of the nanometre-sized ! '-martensites were elongated (...) along [545] % . It has been revealed that the nanometre-sized ! '-martensites of a few nanometres diameter formed at the intersections of deformation twins have a typical habit plane of , which is identical with that reported for a fully grown plate such as ! '-martensite. The origin of the observed habit plane is discussed on the basis of the d 112 ¢ {111} ! shear displacements assisting the % M ! ' transformation. (shrink)

In their comprehensive review article, De Bie et al., using some references, discreetly point out that pregnant women’s decision in Domain III to undergo fetal extraction via C-section should conti...

Improving public understanding and acceptance are critical for promoting coronavirus vaccination. However, how to promote COVID-19 vaccine programs remains controversial due to various ethical issues. This study, thus, aimed to survey the acceptance of COVID-19 vaccines among Japanese citizens and discuss relevant ethical issues. A cross-sectional survey was conducted via an online platform. An anonymous, quantitative, self-administered online questionnaire was sent to 6965 registered Japanese residents, which included questions regarding the respondent’s general knowledge, experience, and opinions of vaccines, vaccine development, (...) COVID-19, and COVID-19 vaccines. Of the 1569 respondents, 730 and 839 were categorized into the younger and older groups, respectively. Most of the respondents possessed general knowledge of COVID-19 vaccines and their features. Of the respondents, 57.8% definitely agreed or somewhat agreed to receive COVID-19 vaccines. The older group showed significantly greater willingness to receive vaccines and higher literacy regarding vaccines in general. Possible reasons for the older group’s greater willingness to receive COVID-19 vaccines are a high risk of severe COVID-19 infection and their past accumulated experience of receiving various vaccinations. Although active public intervention could increase vaccination rates, most of the respondents did not agree with mandatory vaccination. Furthermore, a gap between the participants in the COVID-19 vaccine trials and the prioritized population in real-world vaccination should be adjusted in future vaccine development. (shrink)