Shape and locomotion of tissue cells depend on the interaction of elements of the cytoskeleton, adhesion to the substrate and an intracellular hydrostatic pressure. The existence of this pressure becomes obvious from increase in cell volume on cessation of contractile forces and from observations with ultrasound acoustic microscopy. Wherever such an internal pressure is established, it is involved in generation of shape and driving force of cell locomotion. Therefore each hypothesis on cell shape and locomotion must consider this property of (...) a living cell. Apparently different types of locomotion depend on differences in substrate adhesion and/or cytoskeleton organisation. (shrink)

Karl Hahn, Jahrgang 1937, war bis zu seiner Emeritierung im Jahr 2003 Professor für Politische Theorie und Ideengeschichte an der Westfälischen Wilhelms-Universität Münster. Hierbei hat er die Klassiker der abendländischen Geistesgeschichte nicht in einem kanonisch-schematischen Profil gelehrt, sondern die jeweiligen Themen und Theoreme mit lebensfüllender Leidenschaft vermittelt. Seine Vorlesungen und Seminare an der Universität zeugen, wie auch seine Vorträge und Tagungsbeiträge, von einem streitbaren Geist, der stets auch um die aktualisierende Bezugnahme bemüht war. Stets hat er pointiert Stellung bezogen, (...) auch gegen den Mainstream des Faches, das er kritisch hinterfragt hat. Ob Platon, Fichte oder auch Simone Weil: Bei Karl Hahn stehen philosophische Überlegungen für eine Suche nach der Vollendung des Daseins in seinen unendlich vielen und offenen Aussagemöglichkeiten. Hahns großes Lebensthema war und ist hierbei das tragische Element des menschlichen Wesens, dessen Kleinheit und Begrenztheit angesichts der großen Fragen der menschlichen Existenz. Das hat er seinen Studierenden mit auf den Weg gegeben. Und auch den Kolleginnen und Kollegen, die bereit waren, zuzuhören. Mit dem vorliegenden Band wird der Wissenschaftler zum Anlass seines 80. Geburtstages geehrt, der seine Verdienste nicht in der flüchtigen Wertschätzung des Feuilletons, sondern grundsätzlich im Diskurs der Seminarräume und Kongressveranstaltungen erworben hat. (shrink)

Wir brauchen eine gerechtere Globalisierung – diese Einsicht ist ebenso alternativlos, wie sie utopisch anmutet. Um dennoch die realistische Hoffnung auf eine kosmopolitische Weltordnung in Aussicht zu stellen, konstruiert die Schrift einen Menschenrechtsansatz globaler Gerechtigkeit. Teil I beschäftigt sich mit der Frage der Praktikabilität. Das Problem wird zunächst an Kants kosmopolitischen Schriften herausgearbeitet, um es dann methodisch anhand von Rawls’ politischem Konstruktivismus und Honneths normativem Rekonstruktivismus zu lösen. Anschließend an Max Weber, Hans Jonas und Hannah Arendt wird dann in Teil (...) II eine Theorie politischer Verantwortung entwickelt, die sich auf globale politische Verantwortungsverhältnisse übertragen lässt. Teil III legt schließlich einen Menschenrechtsansatz globaler Gerechtigkeit vor. Diese realistische Utopie ist pragmatisch darin begründet, dass das globale Menschenrechtsregime bereits politische Verantwortungsverhältnisse für die wichtigsten menschlichen Interessen etabliert hat. Aus der politischen Menschenrechtspraxis und ihrer Idee einer universellen Menschenwürde, so die Grundthese der Schrift, lässt sich eine globale politische Gerechtigkeitskonzeption rekonstruieren. (shrink)

Philosophical discussions on causal inference in medicine are stuck in dyadic camps, each defending one kind of evidence or method rather than another as best support for causal hypotheses. Whereas Evidence Based Medicine advocates the use of Randomised Controlled Trials and systematic reviews of RCTs as gold standard, philosophers of science emphasise the importance of mechanisms and their distinctive informational contribution to causal inference and assessment. Some have suggested the adoption of a pluralistic approach to causal inference, and an inductive (...) rather than hypothetico-deductive inferential paradigm. However, these proposals deliver no clear guidelines about how such plurality of evidence sources should jointly justify hypotheses of causal associations. We here develop such guidelines by first giving a philosophical analysis of the underpinnings of Hill’s viewpoints on causality. We then put forward an evidence-amalgamation framework adopting a Bayesian net approach to model causal inference in pharmacology for the assessment of harms. Our framework accommodates a number of intuitions already expressed in the literature concerning the EBM vs. pluralist debate on causal inference, evidence hierarchies, causal holism, relevance, and reliability. (shrink)

This article sketches an idealized strategy for the identification of neural correlates of consciousness. The proposed strategy is based on a state space approach originating from the analysis of dynamical systems. The article then focuses on one constituent of consciousness, phenomenal awareness. Several rudimentary requirements for the identification of neural correlates of phenomenal awareness are suggested. These requirements are related to empirical data on selective attention, on completely intrinsic selection and on globally unconscious states. As an example, neuroscientific findings on (...) synchronized γ activity are categorized according to these requirements. (shrink)

Metaphysics, geometry, and the problems with diagrams -- The Pythagorean theorem: Euclid I.47 and VI.31 -- Thales and geometry: Egypt, Miletus, and beyond -- Pythagoras and the famous theorems -- From the Pythagorean theorem to the construction of the cosmos out of right triangles.

According to the objective Bayesian approach to inductive logic, premisses inductively entail a conclusion just when every probability function with maximal entropy, from all those that satisfy the premisses, satisfies the conclusion. When premisses and conclusion are constraints on probabilities of sentences of a first-order predicate language, however, it is by no means obvious how to determine these maximal entropy functions. This paper makes progress on the problem in the following ways. Firstly, we introduce the concept of a limit in (...) entropy and show that, if the set of probability functions satisfying the premisses contains a limit in entropy, then this limit point is unique and is the maximal entropy probability function. Next, we turn to the special case in which the premisses are categorical sentences of the logical language. We show that if the uniform probability function gives the premisses positive probability, then the maximal entropy function can be found by simply conditionalising this uniform prior on the premisses. We generalise our results to demonstrate agreement between the maximal entropy approach and Jeffrey conditionalisation in the case in which there is a single premiss that specifies the probability of a sentence of the language. We show that, after learning such a premiss, certain inferences are preserved, namely inferences to inductive tautologies. Finally, we consider potential pathologies of the approach: we explore the extent to which the maximal entropy approach is invariant under permutations of the constants of the language, and we discuss some cases in which there is no maximal entropy probability function. (shrink)

Yoga teacher, podcaster, and blogger Kori Hahn presents a new-age guide for harnessing the principles of yoga to manifest a better life. The book teaches readers how to develop simple, personalized rituals using techniques such as affirmations, breath work, meditation, journaling, and visualization.

This collection of essays discusses the work of Jurgen Habermas - the philosopher and exponent of the tradition known as Critical Theory. His works defend the Enlightenment ideas of rationality, humanism, and the possibilities of discourse.

Narrative allegory is distinguished from mythology as reality from symbol; it is, in short, the proper intermedium between person and personification. Where it is too strongly individualized, it ceases to be allegory […]. In the community of scholars of intermedia research, the above quoted citation is commonly regarded as Coleridge’s coining of the term “intermedium” or “intermediality”. However, a short glance at the discursive strategy of his argument emphasizes that his notion of “intermedium” must be closely linked to the poetics (...) and aesthetics of 19th-century romanticism. For the romantic poet, the term of “intermedium” does not point to media relations or intermedia processes but to.. (shrink)

We study questionnaire responses to situations in which sacrificing one life may save many other lives. We demonstrate gender differences in moral judgments: males are more supportive of the sacrifice than females. We investigate a source of the endorsement of the sacrifice: antisocial preferences. First, we measure individual proneness to spiteful behavior, using an experimental game with monetary stakes. We demonstrate that spitefulness can be sizable—a fifth of our participants behave spitefully—but it is not associated with gender. Second, we find (...) that gender is consistently associated with responses even when we account for individual differences in the propensity to spitefulness. (shrink)

As digital media becomes more central to the lives of adolescents, it also becomes increasingly relevant for their sexual communication. Sexting as an important image-based digital medium provides opportunities for self-determined digital communication, but also carries specific risks for boundary violations. Accordingly, sexting is understood either as an everyday, or as risky and deviant behavior among adolescents. In the affectedness of boundary violations gender plays an important role. However, it is still unclear to what extent digital sexual communication restores stereotypical (...) gender roles and restrictive sexuality norms or, alternatively, enables new spaces of possibility. In this sense, current research points to a desideratum regarding adolescents’ orientations toward sexting as a practice between spaces of possibility and boundary violations. This paper discusses the possibilities, but also the risks, of intimate digital communication among adolescents. The main question is, how adolescents themselves perceive sexting practices and how they position themselves between both spaces for possibility and for the exchange of unwanted sexual content. For this purpose, orientations toward normalities and gender of students are reconstructed. To answer these questions, twelve single-sex, group discussions were carried out with students aged 16 and 17 at five different secondary schools in northern Germany. A total of 20 boys and 22 girls took part. The group discussions were structured by a narrative generating guideline. The analysis draws its methodology from the Documentary Method, regarding implicit and explicit forms of knowledge and discourse. It results in a typology of three types with different orientations. The study shows, that most of the students consider sexting to be a risky practice; only one type shows normality in the use of sexting. At the same time, some of the young people are interested in experimenting with image-based intimate digital communication. Further, gender differences in use and affectedness are also documented. In this way, orientations toward gender stereotypes “favor” both the attribution of responsibility to girls, and overlook the responsibility of students who perpetrated the boundary violation. The orientations of adolescents should be taken more into account in research as well as in educational programs for the prevention of sexual violence. (shrink)

Auf der Suche nach objektiver Wahrheit wurde in den Wissenschaften das Prinzip der Relationalitat popular: Gegenstandsbereiche gleich welcher Art werden als reine Beziehungsgeflechte beschrieben, nach dem Vorbild der Mathematik (diese Notwendigkeit entstand nicht zuletzt durch die Relativitatstheorie). Um Reales theoretisch zu erfassen, etwa um Dinge zahlen zu konnen, braucht man ein Identitatsprinzip fur Gegenstande. Das formal beste und einzig universelle ist die Identitat der Ununterscheidbaren. In Verbindung mit dem modernen Strukturalismus fuhrt dies aber zum geisterhaften Verschwinden realer Dinge in der (...) Beschreibung, wenn beziehungsmassig Symmetrie vorliegt. Objektive Beschreibungen erfassen also nur asymmetrische Strukturen korrekt. Manches Reale wird somit nicht objektiv erfasst.". (shrink)

Augmented Reality (AR) is commonly defined as a digital layer of information viewed on top of the physical world through a smartphone, tablet or eyewear. Increasingly, this understanding of AR is shifting to a dynamic framework of ‘smart things’, including wearable technology, sensors and artificial intelligence (AI), with the ability to intercede in key moments and to deliver contextual and meaningful experiences. The things that come into context are the logical next steps in an evolutionary development towards computers that are (...) better able to show empathy in relation to people: even more human-oriented, anticipative and ubiquitous. Thus, this outsourcing of meaning to empathic technologies points to one of the fundamental questions concerning the relation of human and technology – the nature of the trust that users place in technology. (shrink)

Epistemic scoring rules are the en vogue tool for justifications of the probability norm and further norms of rational belief formation. They are different in kind and application from statistical scoring rules from which they arose. In the first part of the paper I argue that statistical scoring rules, properly understood, are in principle better suited to justify the probability norm than their epistemic brethren. Furthermore, I give a justification of the probability norm applying statistical scoring rules. In the second (...) part of the paper I give a variety of justifications of norms for rational belief formation employing statistical scoring rules. Furthermore, general properties of statistical scoring rules are investigated. Epistemic scoring rules feature as a useful technical tool for constructing statistical scoring rules. (shrink)

This paper presents the contributions of Alcindo Flores Cabral, professor of Chemistry at the Faculdade de Agronomia Eliseu Maciel, nowadays part of the Universidade Federal de Pelotas, to chemistry teaching. It is a contribution almost unknown to the Brazilian chemical community, although recognized as valuable by several renowned chemists abroad, like W. Hückel, G. Charlot, F. Strong, E. Fessenden and others. Cabral’s innovative helical representation is presented in connection not only with contemporary representations, but also an incursion is made into (...) the first helical systems proposed, those of Hinrichs and of Baumhauer. Some comments are made not only on Cabral’s Classificação Natural dos Elementos, published in 1946, but also about other texts he wrote for an efficient chemistry teaching. (shrink)

Este artigo apresenta a contribuição de Alcindo Flores Cabral (1907-1982) - professor de química da Faculdade de Agronomia Eliseu Maciel, hoje incorporada à Universidade Federal de Pelotas - ao ensino de química, uma contribuição quase desconhecida pela própria comunidade química brasileira, embora reconhecida como relevante por diversos químicos estrangeiros importantes, como W. Hückel, G. Charlot, F. Strong, E. Fessenden e outros. A inovadora representação helicoidal de Cabral é apresentada não só em conexão com representações contemporâneas, mas também inclui-se uma incursão (...) pelos primeiros sistemas helicoidais propostos, os de Hinrichs e de Baumhauer. Apresentam-se alguns comentários não somente sobre a Classificação natural dos elementos, publicada em 1946, mas também sobre outros textos escritos para tornar mais eficaz o ensino de química. (shrink)

O presente trabalho examina os aspectos históricos da extração do óleo de canela-sassafrás (Ocotea pretiosa Mez), rico em safrol, no Alto e Médio Vale do Itajaí, a partir de 1940, por iniciativa de Otto Grimm, no município de Rio do Sul. Apresenta-se o tema no contexto da memória química em Santa Catarina, e discutem-se os procedimentos utilizados, e principalmente os motivos que levaram tal indústria incipiente a não se converter em uma indústria de química fina. Para tanto, são apresentados alguns (...) dados pertinentes à química do safrol, indicando que tal indústria poderia ter evoluído, bem como os aspectos econômicos e sociais que, ao lado da proibição do corte da canela-sassafrás, levaram em 1990 à extinção definitiva dessa "química fina que poderia ter sido". (shrink)