Graphical AbstractThe loosening of chromatin structures gives rise to unrestricted access to DNA and thus transcription factors (TFs) can bind to their otherwise masked target sequences. Regions bound by the same set of TFs tend to be located in close proximity and this might increase the probability of activating illegitimate genomic rearrangements.

A manifesto for the humanities in the digital age, A New Republic of Letters argues that the history of texts, together with the methods by which they are preserved and made available for interpretation, are the overriding subjects of humanist study in the twenty-first century. Theory and philosophy, which have grounded the humanities for decades, no longer suffice as an intellectual framework. Jerome McGann proposes we look instead to philology--a discipline which has been out of fashion for many decades but (...) which models the concerns of digital humanities with surprising fidelity. For centuries, books have been the best way to preserve and transmit knowledge. But as libraries and museums digitize their archives and readers abandon paperbacks for tablet computers, digital media are replacing books as the repository of cultural memory. While both the mission of the humanities and its traditional modes of scholarship and critical study are the same, the digital environment is driving disciplines to work with new tools that require major, and often very difficult, institutional changes. Now more than ever, scholars need to recover the theory and method of philological investigation if the humanities are to meet their perennial commitments. Textual and editorial scholarship, often marginalized as a narrowly technical domain, should be made a priority of humanists' attention. (shrink)

Nietzsche se défend de séparer "l'un de l'autre l'amour et la raison". Mais, dans son oeuvre, l'amour dont il est question n'est pas l'amour de la vie, mais l'amor fati, lequel est acquiescement à l'impermanence des choses, à leur contingence et au monde comme volonté de puissance. Il s'ensuit que la raison en devient elle-même raison de la fatalité, antithèse irréductible des rationalités logicienne ou morale. Cette raison tragique, dont les autres noms sont "passion philosophique", "pensée libre" ou "sagesse sauvage", (...) constitue la raison de vivre du philosophe dionysiaque. Telle est la thèse du présent essai."--Page 4 of cover. (shrink)

Cet ouvrage est le premier d'une série de quatre études consacrées aux liens que Kant, Hegel, Nietzsche et Freud établissent entre éthique et esthétique.

Second, this collection of cognitive programs evolved in the Pleistocene to solve the adaptive problems regularly faced by our hunter-gatherer ancestors-...

Living in the Borderland addresses the evolution of Western consciousness and describes the emergence of the "Borderland," a spectrum of reality that is beyond the rational yet is palpable to an increasing number of individuals. Building on Jungian theory, Jerome Bernstein argues that a greater openness to transrational reality experienced by Borderland personalities allows new possibilities for understanding and healing confounding clinical and developmental enigmas." "Living in the Borderland challenges the standard clinical model, which views normality as an absence of (...) pathology and which equates normality with the rational. Jerome S. Bernstein describes how psychotherapy itself often contributes to the alienation of Borderland personalities by misperceiving the difference between the pathological and the sacred. The case studies included illustrate the potential this has for causing serious psychic and emotional damage to the patient." "This challenge to the orthodoxies and complacencies of western medicine's concept of pathology will interest Jungian Analysts, Psychotherapists, Psychiatrists and other physicians, as well as educators of children. (shrink)

"No soy de los que deploran la especialización; en todo caso, dudo que sea posible, aunque fuere deseable, frenar la persecución de un saber especializado, en complejas sociedades. Pero es que la filosofía del Derecho ha descansado tradicionalmente en una perspectiva muy amplia, y hay que lamentar de modo especial la pérdida de sus funciones unitivas debido a la extraordinaria necesidad presente de comprender y mejorar las instituciones jurídicas. La situación actual no clama por la desvalorización de la especialización, sino (...) que, por el contrario, desafía a los estudiosos a trascender las especializaciones de la filosofía del Derecho, y cualquiera fuere la utilidad que con ello pudiera lograrse, a construir una jusfilosofía que satisfaga más adecuadamente las presentes demandas". Jerome Hall. (shrink)

Il y a chez Platon, Montaigne, Spinoza et Freud une réflexion sur la vie et la mort qui présente une similitude : chez aucun d'eux, la vie n'est le bien le plus précieux que l'homme puisse connaître, car, chez tous, le seul bien réel est la liberté de penser le vrai. Dans cet ouvrage est mis au jour le fait que, pour un idéaliste et pour un fataliste, la mort délivre du faux avec, pour conséquence, qu'elle en devient désirable. Dans (...) un second ouvrage, La liberté, l'existence et la mort chez Spinoza et Freud, est analysée la transformation du rapport entre la philosophie et la mort, consécutive au rationalisme déterministe qui met fin à l'illusion que la philosophie et la pensée demeurent inconditionnées : il s'ensuit que le détachement spirituel de Platon et de Montaigne semble impraticable face à la vie et à la mort telles que la raison les conçoit. (shrink)

Dans un précédent ouvrage, La liberté, la pensée et la mort chez Platon et Montaigne, il a été montré que, chez Platon comme chez Montaigne, la mort, loin d'être le plus terrible des maux, est en fait une libération, car elle rend possible un détachement d'avec la vie qui leur est apparue soit contaminée par des fictions, soit cruellement angoissante. Les mêmes thèmes sont repris dans cet ouvrage avec Spinoza et Freud, mais dans un contexte déterministe qui les empêche de (...) croire encore à la possibilité d'une pensée humaine inconditionnée. La philosophie ne suffit plus à apprendre à mourir. Sans une analyse des causes qui déterminent l'activité mentale, à savoir le désir et les pulsions animiques, la pensée demeure asservie à des finalités imaginaires. Il s'ensuit que, pour philosopher, il faut d'abord renoncer au fantasme du sujet libre ou du moi maître de lui-même. Ce sont ces personnages qui doivent mourir pour penser et exister librement. En ce sens, la mort apparaît, ici aussi, comme une délivrance qui devient, de ce fait, désirable. (shrink)

Nietzsche a mené une double lutte, d'une part, contre la "sagesse insigne" subjuguée par le pouvoir de la logique et, d'autre part, mais en vertu de la même passion philosophique, contre la peur. Ce combat donne le jour à une liberté et à une rébellion surhumaines et solitaires contre le "ressentiment" et contre ce qu'il engendre : la cruauté de la culture. C'est à la description de cette insurrection tragique que cet ouvrage est consacré.

Proceedings of a conference held in Sept. 2009 in London, England.

Implemented gradually since 2002 and following in the footsteps of the “Bologna Process” initiated in the late 1990s, successive reforms of university education in France have profoundly changed the landscape of higher professional degrees. The Diplômes d’Enseignement Supérieur Spécialisé (DESS) (Specialized Higher Education Diplomas), which have become professional Masters, offer a paradigmatic example of the tensions between the former aims of professionalization in universities and the teaching to, by, or for research present in these diplomas. The case of the professional (...) Master’s degree in “Strategy and Engineering in Adult Training” (SIFA) at Rennes 2 University illustrates this problem. (shrink)

A theory that treats language not as an abstract symbol system but as a function of our brains and experience, integrating recent findings from biology, ...

Three experiments explored the effects of word problem cueing on debiasing versions of the bat-and-ball problem. In the experimental condition order, participants solved a simpler isomorphic version of the problem prior to solving a standard version that, critically, had the same item-and-dollar amounts. Conversely, in the control condition order, participants solved the standard version prior to solving the isomorph. Across the first 2 experiments, participants cued with the isomorph were more likely to correctly solve the standard version of the problem. (...) In the third experiment, this cueing effect was not replicated, but importantly cued participants were more likely to correctly solve the standard version of the problem with other item-and-dollar amounts, indicating near transfer. Far transfer was evident in faster response times to other problems in the Cognitive Reflection Test following practice. Along with providing converging evidence for the cueing account, these results are consistent with recent attentional debiasing findings. (shrink)

This paper presents a general computational treatment of how mammals are able to deal with visual objects and environments. The model tries to cover the entire range from behavior and phenomenological experience to detailed neural encodings in crude but computationally plausible reductive steps. The problems addressed include perceptual constancies, eye movements and the stable visual world, object descriptions, perceptual generalizations, and the representation of extrapersonal space.The entire development is based on an action-oriented notion of perception. The observer is assumed to (...) be continuously sampling the ambient light for information of current value. The central problem of vision is taken to be categorizing and locating objects in the environment. The critical step in this process is the linking of visual information to symbolic object descriptions; this is calledindexing, from the analogy of identifying a book from index terms. The system must also identifysituationsand use this knowledge to guide movement and other actions in the environment. The treatment focuses on the different representations of information used in the visual system.The four representational frames capture information in the following forms: retinotopic, head-based, symbolic, and allocentric. The functional roles of the four frames, the communication among them, and their suggested neurophysiological realization constitute the core of the paper. The model is perforce crude, but appears to be consistent with all relevant findings. (shrink)

In examining the puzzle of experience, and its possible solutions, Valberg discusses relevant views of Hume, Kant, Heidegger, Wittgenstein, and Strawson, as well as ideas from the recent philosophy of perception. Finally, he describes and analyzes a manifestation of the puzzle outside philosophy, in everyday experience.

First published in 1977, Emotion, Thought and Therapy is a study of Hume and Spinoza and the relationship of philosophical theories of the emotions to psychological theories of therapy. Jerome Neu argues that the Spinozists are closer to the truth; that is, that thoughts are of greater importance than feelings in the classification and discrimination of emotional states. He then contends that if the Spinozists are closer to the truth, we have the beginning of an argument to show that Freudian (...) or analytic therapies make philosophic sense. Throughout the book, careful attention is paid to modern discussions in philosophy of mind and psychology, and materials from anthropology and other relevant disciplines are considered. At the centre of the discussion is the notion of ‘thought-dependence’. Therapies for psychological disorders are placed along a spectrum in accordance with the role they assign to thoughts. The Spinozist view of the emotions can be seen as at the extreme thought end of a corresponding spectrum of theories of the emotions. The book suggests that this stream may help explain the spectrum of therapeutic theories and the possibilities that exist for psychological development and change. This book will be of interest to students of philosophy, psychology and counselling. (shrink)

This remarkable book is the most comprehensive study ever written of the history of moral philosophy in the seventeenth and eighteenth centuries. Its aim is to set Kant's still influential ethics in its historical context by showing in detail what the central questions in moral philosophy were for him and how he arrived at his own distinctive ethical views. The book is organised into four main sections, each exploring moral philosophy by discussing the work of many influential philosophers of the (...) seventeenth and eighteenth centuries. In an epilogue the author discusses Kant's view of his own historicity, and of the aims of moral philosophy. In its range, in its analyses of many philosophers not discussed elsewhere, and in revealing the subtle interweaving of religious and political thought with moral philosophy, this is an unprecedented account of the evolution of Kant's ethics. (shrink)

Here in more than a hundred photographs is portrayed Liebling's Minnesota. During two decades marked by social, political and cultural change, Liebling travelled the state and found his largest subject -- the depiction and interpretation of commonplace human experience. The images range from the grain elevators and skid row of Minneapolis to the slaughterhouses in South St. Paul and the poor, working-class streets of St. Paul's West Side; from the Iron Range and the Red Lake Indian reservation in the north (...) to the farming towns in the south. The vision of Minnesota that emerges from the extraordinary photographs is uniquely that of the artist, yet it leads viewers effortlessly to an enhanced understanding of the places, the times, and, always, the people. (shrink)

Christopher Boorse’s biostatistical theory of medical disorder claims that biological part-dysfunction (i.e., failure of an internal mechanism to perform its biological function), a factual criterion, is both necessary and sufficient for disorder. Jerome Wakefield’s harmful dysfunction analysis of medical disorder agrees that part-dysfunction is necessary but rejects the sufficiency claim, maintaining that disorder also requires that the part-dysfunction causes harm to the individual, a value criterion. In this paper, I present two considerations against the sufficiency claim. First, I analyze Boorse’s (...) central argument for the sufficiency claim, the “pathologist argument,” which takes pathologists’ intuitions about pathology as determinative of medical disorder and conclude that it begs the question and fails to support the sufficiency claim. Second, I present four counterexamples from the medical literature in which salient part-dysfunctions are considered nondisorders, including healthy disease carriers, HIV-positive status, benign mutations, and situs inversus totalis, thus falsifying the sufficiency claim and supporting the harm criterion. (shrink)