We propose the “microbiota‐inflammasome” hypothesis of major depressive disorder (MDD, a mental illness affecting the way a person feels and thinks, characterized by long‐lasting feelings of sadness). We hypothesize that pathological shifts in gut microbiota composition (dysbiosis) caused by stress and gut conditions result in the upregulation of pro‐inflammatory pathways mediated by the Nod‐like receptors family pyrin domain containing 3 (NLRP3) inflammasome (an intracellular platform involved in the activation of inflammatory processes). This upregulation exacerbates depressive symptomatology and further compounds gut (...) dysbiosis. In this review we describe MDD/chronic stress‐induced changes in: 1) NLRP3 inflammasome; 2) gut microbiota; and 3) metabolic pathways; and how inflammasome signaling may affect depressive‐like behavior and gut microbiota composition. The implication is that novel therapeutic strategies could emerge for MDD and co‐morbid conditions. A number of testable predictions surface from this microbiota‐gut‐inflammasome‐brain hypothesis of MDD, using approaches that modulate gut microbiota composition via inflammasome modulation, fecal microbiota transplantation, psychobiotics supplementation, or dietary change. (shrink)

Inauguration speech at chair number 18 of the Brasilian Academy of Philosophy.

This paper investigates some classical oppositional categories, like synthetic vs. analytic, posterior vs. prior, imagination vs. grammar, metaphor vs. hermeneutics, metaphysics vs. observation, innovation vs. routine, and image vs. sound, and the role they play in epistemology and philosophy of science. The epistemological framework of objective cognitive constructivism is of special interest in these investigations. Oppositional relations are formally represented using algebraic lattice structures like the cube and the hexagon of opposition, with applications in the contexts of modern color theory, (...) Kantian philosophy, Jungian psychology, and linguistics. (shrink)

Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

Conceptual congruency effects are biases induced by an irrelevant conceptual dimension of a task (e.g., location in vertical space) on the processing of another, relevant dimension (e.g., judging words’ emotional evaluation). Such effects are a central empirical pillar for recent views about how the mind/brain represents concepts. In the present paper, we show how attentional cueing (both exogenous and endogenous) to each conceptual dimension succeeds in modifying both the manifestation and the symmetry of the effect. The theoretical implications of this (...) finding are discussed. (shrink)

t. 1. Introducción a la filosofía del derecho.

This article has as its theme the democracy as fundamentalism, or the democratic fundamentalism. Its main objective is the recognition that the thinking about democracy can itself be fundamentalist, implying that not only religious fundamentalisms are a threat to contemporary democracy. Its method and object are the interpretation of texts by two contemporary philosophers who do not usually talk to each other, the Italian Gianni Vattimo and the French Jean-Luc Nancy. The essay's thesis is the affirmation of democratic thinking as (...) a form of fundamentalism, insofar as it fulfills certain conditions established by the two thinkers analyzed. These conditions are, in the language of the aforementioned philosophers, the framing of democracy under the so-called strong thought, or its subsumption to a metaphysical way of thought, so that it becomes incapable of self-criticism and its necessary reinvention. Thus, it is expected to contribute to the construction of a self-critical vision of democracy through dialogue with aspects of thought little known of important philosophers and also through the dialogue between philosophy and theology as emancipatory ways of knowing. (shrink)

This article provides a critical reading of the ‘Parecer CNE-CES 60, de 2014’, from the Ministry of education, Brazil, which defines the curriculum guidelines for courses of Baccalaureate in Theology. In its first section it discusses the theoretical background of the ‘Parecer’, questioning its illuminist orientation, as well as its pedagogical theory focused on contents and not on the students activities. It aims to show that are two opposed educational paradigms in the ‘Parecer’, the illuminist and the constructivist, although the (...) illuminist is the dominant one. It also question the view of the theologian present in the ‘Parecer’, marked by significant absences from the professional field of religious work. In the second section, the article presents a sample of particular interpretation of the ‘Parecer’, indicating the guidelines of a curriculum based on the constructivist paradigm. It dedicates special attention to the occult dimension of the curriculum and to an articulation of the student’s activities in relationship to the disciplines of the course. (shrink)

O Fisicalismo tem sido a posição filosófica monista mais aceita no mainstream do debate contemporâneo sobre a natureza do mental. Mas o que significa dizer que tudo o que existe é “físico”? O presente trabalho busca responder à pergunta: Como as teses fisicalistas contemporâneas têm definido o termo ‘físico’ em suas proposições? Para respondê-la foi realizada uma investigação teórico-filosófica baseada em revisão bibliográfica e análise lógica e conceitual. Quatro categorias gerais de definição do termo ‘físico’ foram identificadas numa revisão da (...) literatura. Existem igualmente fortes críticas às propostas de definição em toda a discussão filosófica. Não temos uma definição incontroversa do que seja uma propriedade física, tampouco consenso sobre qual deveria ser a formulação mais adequada da tese fisicalista. Assim, a questão que se coloca é: Por que estamos discutindo o valor de verdade de uma tese que nem mesmo tem conseguido ser formulada de forma adequada? (shrink)