Genomic research—including whole genome sequencing and whole exome sequencing—has a growing presence in contemporary biomedical investigation. The capacity of sequencing techniques to generate results that go beyond the primary aims of the research—historically referred to as “incidental findings”—has generated considerable discussion as to how this information should be handled—that is, whether incidental results should be returned, and if so, which ones.Federal regulations governing most human subjects research in the United States require the disclosure of “the procedures to be followed” in (...) the research as part of the informed consent process. It seems reasonable to assume—and indeed, many commentators have concluded—that genomic investigators will be expected to inform participants about, among other procedures, the prospect that incidental findings will become available and the mechanisms for dealing with them. Investigators, most of whom will not have dealt with these issues before, will face considerable challenges in framing meaningful disclosures for research participants.To help in this task, we undertook to identify the elements that should be included in the informed consent process related to incidental findings. We did this by surveying a large number of genomic researchers (n = 241) and by conducting in‐depth interviews with a smaller number of researchers (n = 28) and genomic research participants (n = 20). Based on these findings, it seems clear to us that routine approaches to informed consent are not likely to be effective in genomic research in which the prospect of incidental findings exists. Ensuring that participants’ decisions are informed and meaningful will require innovative approaches to dealing with the consent issue. We have identified four prototypical models of a consent process for return of incidental findings. (shrink)

Reply to a commentary by Felicitas Holzer and Ignacio Mastroleoon “Models of Consent to Return of Incidental Findings in Genomic Research.”.

An important objection to signaling approaches to representation is that, if signaling behavior is driven by the maximization of usefulness, then signals will typically carry much more information about agent-dependent usefulness than about objective features of the world. This sort of considerations are sometimes taken to provide support for an anti-realist stance on representation itself. The author examines the game-theoretic version of this skeptical line of argument developed by Donald Hoffman and his colleagues. It is shown that their argument only (...) works under an extremely impoverished picture of the informational connections that hold between agent and world. In particular, it only works for cue-driven agents, in Kim Sterelny’s sense. In cases in which the agents’ understanding of what is useful results from combining pieces of information that reach them in different ways, and that complement one another, maximizing usefulness involves construing first a picture of agent-independent, objective matters of fact. (shrink)

Perhaps the most widely touted of GPT-4’s at-launch, zero-shot capabilities has been its reported 90th-percentile performance on the Uniform Bar Exam. This paper begins by investigating the methodological challenges in documenting and verifying the 90th-percentile claim, presenting four sets of findings that indicate that OpenAI’s estimates of GPT-4’s UBE percentile are overinflated. First, although GPT-4’s UBE score nears the 90th percentile when examining approximate conversions from February administrations of the Illinois Bar Exam, these estimates are heavily skewed towards repeat test-takers (...) who failed the July administration and score significantly lower than the general test-taking population. Second, data from a recent July administration of the same exam suggests GPT-4’s overall UBE percentile was below the 69th percentile, and $$\sim$$ ∼ 48th percentile on essays. Third, examining official NCBE data and using several conservative statistical assumptions, GPT-4’s performance against first-time test takers is estimated to be $$\sim$$ ∼ 62nd percentile, including $$\sim$$ ∼ 42nd percentile on essays. Fourth, when examining only those who passed the exam (i.e. licensed or license-pending attorneys), GPT-4’s performance is estimated to drop to $$\sim$$ ∼ 48th percentile overall, and $$\sim$$ ∼ 15th percentile on essays. In addition to investigating the validity of the percentile claim, the paper also investigates the validity of GPT-4’s reported scaled UBE score of 298. The paper successfully replicates the MBE score, but highlights several methodological issues in the grading of the MPT + MEE components of the exam, which call into question the validity of the reported essay score. Finally, the paper investigates the effect of different hyperparameter combinations on GPT-4’s MBE performance, finding no significant effect of adjusting temperature settings, and a significant effect of few-shot chain-of-thought prompting over basic zero-shot prompting. Taken together, these findings carry timely insights for the desirability and feasibility of outsourcing legally relevant tasks to AI models, as well as for the importance for AI developers to implement rigorous and transparent capabilities evaluations to help secure safe and trustworthy AI. (shrink)

Experimental balance is usually understood as the control for the value of the conditions, other than the one under study, which are liable to affect the result of a test. We discuss three different approaches to balance. ‘Millean balance’ requires identifying and equalizing ex ante the value of these conditions in order to conduct solid causal inferences. ‘Fisherian balance’ measures ex post the influence of uncontrolled conditions through the analysis of variance. In ‘efficiency balance’ the value of the antecedent conditions (...) is decided ex ante according to the efficiency they yield in the estimation of the treatment outcome. Against some old arguments by Worrall, we show that in both Fisherian and efficiency balance there are good reasons to randomize the allocation of treatments, in particular when there is no agreement among experimenters as to the antecedent conditions to be controlled for. (shrink)

Tomando como pretexto el concepto de libertad como no-dominación acuñado por Philip Pettit en su celebre Republicanismo, este breve artículo discurre mostrando el proyecto walzeriano de una sociedad libre de dominación, en la cual hombres y mujeres no se sientan subyugados bajo ningún poder y en ..

This article discusses the meaning of the notion of virtuality in modern physics. To this end, it develops considerations on the introduction and establishment in nuclear physics of two independent concepts at the turn of the 1920s and 1930s: that of the virtual state, used in the context of neutron scattering studies, and that of the virtual transition, useful for the theoretical understanding of strong nuclear forces, which forms the basis of what are now called virtual particles. Their comparative analysis (...) highlights the theoretical nature of virtual entities and processes in modern physics. It also shows how the virtual has been associated with various purely physical attributes, leading to a form of polysemy of the term, from the beginning of the application of these concepts. (shrink)

A partir de los postulados de una concepción semántica de norma y su clasificación en reglas y principios, Robert Alexy ha enunciado una tesis fuerte de la separación, al concebir que entre ambos tipos de normas no solo existe una diferencia gradual, sino también cualitativa. En este contexto, los principios son descritos como mandatos de optimización, caracterizados por un cumplimiento gradual en atención a las posibilidades reales y jurídicas, y a través de la denominada técnica de la ponderación. A pesar (...) de las objeciones recibidas, la vigencia de esta tesis resulta incuestionable, sirviendo todavía de inspiración a las nuevas generaciones de juristas interesados en la Teoría del Derecho. En el presente capítulo se pretende exponer de manera sucinta pero precisa los postulados del principialismo alexyano, las críticas más recurrentes y sus posibles respuestas, para terminar con algunas notas interpretativas que persiguen contribuir a la continuación del camino trazado por el insigne profesor alemán. (shrink)

This paper proposes a five-part empirical typology of interconnections of race and class. We describe the mechanisms whereby (1) race is a form of class relation; (2) race relations and class relations reciprocally affect each other; (3) race acts as a sorting mechanism into class locations; (4) race acts as a mediating linkage to class locations; and (5) race interacts with class in determining other outcomes. Rather than insisting on one or another mechanism as the overarching framework for conceptualising the (...) interconnections between race and class, we propose a theoretical integration of all five within a functionalist model. The model reconciles the empirical effects of race variables with a class-functionalist explanation of race. Our typology of interconnections is useful for situating concrete empirical phenomena, and our theoretical integration of those interconnections offers a coherent explanatory system that captures the recursive causality of race and class. (shrink)

El Menón es un buen ejemplo del uso de la ironía socrática como forma de refutación. Específicamente, la forma lógica de reducción al absurdo constituye un dispositivo muy relacionado con la ironía socrática. En este artículo, se examinan analíticamente los cuatro elementos de la ironía que se presentan en el diálogo: 1. el conocimiento falso como una posición inicial asumida por los interlocutores de Sócrates; 2. la igno­ rancia socrática; 3. la reducción al absurdo del falso saber inicial; y 4. (...) el reconocimiento del error y la ignorancia. (shrink)

Naturalistic accounts of culture share the assumption that culture is nothing more than information in people minds/brains and the environment. They do not provide, however, neither a definition nor a theory of information. I address this lacuna adopting a theory of information called “Situation Theory” (Barwise and Perry, 1983). I argue that the notions of constraint and attunement allow to account for cultural information, and, furthermore, that culture is, at a fundamental level, constituted by a set of constraints. Constraints are (...) necessary for information to flow, and attunement to constraints is necessary for an organism to exploit such cultural information. Keywords: Situations, situation theory, naturalistic theories of culture, cultural groups, constraints, conventions. (shrink)

O ensaio propõe a leitura de duas estórias de Guimarães Rosa, “A terceira margemdo rio”, de Primeiras estórias, e “Desenredo”, de Tutameia, as quais, em algum momento, serãocotejadas com Bartleby, o escrivão, de Melville. Partindo dos títulos rosianos, deduzir-se-ãoduas potências, uma neutralizadora que abdica de tudo, a outra, também neutralizadora, quequer tudo, propondo, por fim, uma ideia de leitura que se encerra nas estórias.

Las 15 piezas que ahora lo conforman abrevan en la Historia, en confeciones personales y entrevistas, y mezclan la literatura y el periodismo de manera audaz y perfecta. Los protagonistas son hombres excepcionales y el momento que se ha elegido para contar son las visperas de sus muertes -tal vez el momento de mayor soledad y de mayor intimidad de un hombre. A traves de la magistral escritura de Tomas Eloy Martinez tenemos el privilegio de asistir a los ultimos (...) minutos de sus vidas, el momento previo a perderlo todo y cuando, resistiendo a la indiferencia del mundo, se suena con alguna inmortalidad. (shrink)

Mark Rowlands develops a novel account of remembering in which episodic memories survive in a mutated form after their content has been long forgotten. He dubs this account “Rilkean memories.” I draw from this account to argue that episodic memories of past epistemic harms resulting from Miranda Fricker’s account of testimonial injustice, can persist as embodied behavioral or bodily dispositions that have negative epistemic and practical consequences long after these episodic memories have been forgotten. The way that others judge us (...) as epistemic agents—as people with the capacity to know or the ability to contribute to the pool of knowledge—and following this judgment, treat or fail to treat us as epistemic agents can cause us to adopt attitudes or behaviors with consequences to our epistemic agency. When embodied as Rilkean memories, these attitudes or behaviors raise new difficulties and become quite difficult to eradicate. (shrink)

We aim to map out the points of confluence between phronesis and emotion, as well as the nature of this confluence. We do so based on philosophical and psychological explanations of emotions and phronesis. Making sound decisions, which requires phronesis, is an important matter, but its relationship with emotions has only just begun to be studied. We propose that the interplay between phronesis and emotion is possible (rather than inevitable) because both have a cognitive-behavioural structure and because emotions are hierarchical. (...) In the case of emotion, there are no gaps between the cognitive and behavioural dimensions, while phronetic acts can only manifest if cognitive and behavioural aspects are activated simultaneously. The confluence we identify is bidirectional and involves mutual enrichment in this dual dimension. On the one hand, phronesis enriches emotion because it involves extra subjective knowledge and allows emotion to be directed towards higher goals. On the other hand, emotions enrich phronesis because phronesis makes decisions based on sensitive preferences and because emotions confirm correctness in the context of moral decision making. Methodologically, this study is theoretical and interdisciplinary, as our approach is both philosophical and psychological. Philosophy helps us to improve the conceptual foundation of the construct, while psychology provides an analysis of the emotional process, allowing philosophy to understand how emotional evaluation-assessment and motivation lead to decision making. (shrink)

In recent years, the most widespread doctrine about the conflicts between fundamental (usually constitutional) legal rights could be summarized in the following three main theses: (1) The elements in conflict are legal principles, as opposed to legal rules; (2) Those conflicts are not consequences of the existence of inconsistencies or antinomies between the norms involved, but rather depend on the empirical circumstances of the case. In other words, the norms are logically consistent and the conflicts are not determinable a priori (...) or in abstracto , but only in concreto ; and (3) The classical criteria for solving conflicts between norms, such as lex superior , lex posterior and lex specialis , are not suitable to solve conflicts among fundamental legal rights. Indeed, they require a specific method known as ‘weighing and balancing’. Although all three theses could be (and indeed have been) regarded as problematic, in this paper I address mainly the second one. I try to show that there is room for a tertium genus between antinomies (deontic inconsistencies) and conflicts caused by strict empirical circumstances that I call ‘contextual antinomies’. There are situations in which the norms involved are not inconsistent but the conflict arises for logical reasons. My thesis is that many conflicts between fundamental legal rights fall in this category. I offer, in an appendix, a proposal of formalization of this kind of conflict and the elements involved in it. (shrink)

Part One: The lottery of birth: 1. Luck 2. Punishment 3. Reward -- Part Two: The illusion of consent: 4. Control 5. Elections 6. Markets 7. Media -- Part Three: The fight for our freedom: 8. Creativity 9. Knowledge 10. Power 11. Survival 12. Empathy.

A partir de la “mitodología” y la fenomenología de las religiones, analizo el cuento “Blancanieves y los siete enanos” e identifico ele- mentos que sugieren un origen lunar e iniciático de él; además, encuentro semejanzas entre Blancanieves y algunas otras sacerdotisas de la luna.

I address the problem of the distinction between semantic and conceptual representations from general considerations about how to distinguish a representational kind. I consider three different ways of telling representational kinds apart – in terms of structure, processing and content – and I examine if semantic representations may constitute a distinct kind with respect to each of them. I argue that the best options for semantic representation to be regarded as a distinct representational kind with respect to each of the (...) three criteria conflict with each other, since it appears respectively as an atomic representation, as a sort of procedural rule or as a structured complex. (shrink)

I address the problem of the distinction between semantic and conceptual representations from general considerations about how to distinguish a representational kind. I consider three different ways of telling representational kinds apart – in terms of structure, processing and content – and I examine if semantic representations may constitute a distinct kind with respect to each of them. I argue that the best options for semantic representation to be regarded as a distinct representational kind with respect to each of the (...) three criteria conflict with each other, since it appears respectively as an atomic representation, as a sort of procedural rule or as a structured complex. (shrink)

Political solutions to problems like global warming and social justice are often stymied by an inability to productively communicate in everyday conversations. Motivated by these communication problems, the paper considers the role of the virtuous listener in conversations. Rather than the scripted exchanges of information between individuals, we focus on lively, intra-active conversations that are mediating events. In such conversations, the listener plays a participatory role by contributing to the content and form of the conversation. Unlike Miranda Fricker’s negative virtue (...) of testimonial justice, which neutralizes the listener’s identity-prejudices in their credibility judgments of the speaker’s testimony, we consider the positive virtues of a good listener. These positive virtues enable listeners to productively contribute to the conversation by helping create the fertile epistemic space of a non-adversarial, caring relationship that facilitates critical and creative thinking. (shrink)

En El sentido de la filosofía, Antonio Zirión se propone analizar, entre otras cosas, el papel y la función que cumple la fenomenología en la obra y el pensamiento de José Gaos. En mi comentario abordo, en primer lugar, el contraste entre los conceptos de fenomenología y método fenomenológico de Husserl y Gaos. En segundo lugar, recupero la discusión acerca de los límites entre fenomenología y metafísica al interior del pensamiento de Gaos, lo que desemboca en un concepto más amplio (...) de fenomenología, vinculado a la idea de una filosofía científica. En tercer lugar, propongo otro acercamiento posible a los motivos fenomenológicos en Gaos. (shrink)

Life in the text and the text in life: here we would place an “ethos of reading”. To sustain this, the categories of “subject” and “object” are rethought; the process of ethic liberation of sensibility and pleasure encouraged by Kant are described; the independence of taste with respect to knowle..

Neuropsychologist Mario Martinez is a pioneer in the science of the mindbody--his term for that essential oneness of cognition and biology--and a passionate advocate for its power to reshape our lives, if we work with it consciously. In The MindBody Self, he builds on the foundation he laid in... MindBody Code to explore the cultural conditions that coauthor our reality and shape every aspect of our lives, from health and longevity to relationships and self-esteem. Then he offers practical tools (...) we can use to shed outworn patterns and create sustainable change. You'll read about: How our cultural beliefs affect the diagnosis, prognosis, and treatment of disease; The difference between growing older (which we all do) and "aging" by our culture's standards (which we can learn not to do); What happens when we move "beyond the pale" of our tribe's expectations; How to navigate adversity using uncertainty as a guide; Biocognitive tools for a healthy life. (shrink)

Educational Social Responsibility (EduSR) is the voluntary provision of the educational institution that, as a natural space of social possibilities, favors the deployment of its members towards others, showing it with transparency based on observable indicators. The intention of this book is: a) to try to analyze what is essential that we all share in our respective experiences of EduSR, b) to illuminate so that everyone can make their interpretation in the most accurate way possible and their evaluations in the (...) most reasonable way, c) offer illustrative and convincing arguments, d) invite people to inhabit education with EduSR from their own originality. It is about being sensitive to the danger of corseting and also to the danger of not demanding, for fear of corseting. (shrink)