: We offer a response to three themes arising from the commentators’ inquiries and critiques: The epistemological compatibility of enactivism and conceptual metaphor theory; the ….

Context: How can an enactive approach to the teaching and learning of mathematics be implemented, which fosters mathematical thinking, making intensive use of metaphorizing and taking into account ….

We review and discuss A. H. Louie’s book “More than Life Itself: A Reflexion on Formal Systems and Biology” from an interdisciplinary viewpoint, involving both biology and mathematics, taking into account new developments and related theories.