Gaston Franssen’s essay touches on important medical and literary topics: the experience of patients with unexplained somatic complaints, the importance of giving their symptoms a name or diagnosis, the verbal representation of what bothers them, or the uncertainty all parties have to live with when an underlying cause of the symptoms is missing. A diagnosis or name such as chronic fatigue syndrome can be a relief for its sufferers, as is expressed by one of the patients in the article: “I (...) wept with relief at having a name for it.” Yet CFS is but a name for something that, medically speaking, has no substance except for the patients” complaints. CFS shares this lack of objective physical signs with other... (shrink)

The need for a model -- Currently available models in psychiatry -- Introduction to enactivism -- Body and mind - and world -- The existential dimension and its role in psychiatry -- Enriched enactivism : existential sense-making, values, and socio-cultural worlds -- Enactive psychiatry : psychiatric disorders are disorders of sense-making -- An enactive approach to causes, diagnosis and treatment of psychiatric disorders.

This study examines an important aspect of energy history and policy: the intertwinement of energy technologies with ideals. Ideals play an important role in energy visions and innovation pathways. Aspirations to realize technical, social, and political ideals indicate a long-term commitment in the design of energy systems, distinguishable from commitment to other abstract goals, such as values. This study offers an analytical scheme that could help to conceptualize these differences and their impact on energy policy. In the proposed model, two (...) spheres of interaction are highlighted: a material sphere in which values and technologies co-evolve, and an imaginary sphere in which ideals interact with idealized technologies. Furthermore, the relation between these two spheres can be understood in different ways. This study examines three cases that are illustrative of the different roles of ideals in the development of energy technologies and visions: (1) the evolution of safety in nuclear reactor design; (2) visions of atomic power in France; (3) the political idealization of a tidal power scheme in the Severn Estuary. Finally, the developed model implies more general insights for the development of sociotechnical systems. Amongst others, it shows why certain projects and technologies remain a political, but not a techno–economic option. (shrink)

In this chapter we give an overview of current and historical conceptions of the nature of obsessions and compulsions. We discuss some open questions pertaining to the primacy of the affective, volitional or affective nature of obsessive-compulsive disorder (OCD). Furthermore, we add some phenomenological suggestions of our own. In particular, we point to the patients’ need for absolute certainty and the lack of trust underlying this need. Building on insights from Wittgenstein, we argue that the kind of certainty the patients (...) strive for is unattainable in principle via the acquisition of factual knowledge. Moreover, we suggest that the patients’ attempts to attain certainty are counter-productive as their excessive conscious control in fact undermines the trust they need. (shrink)

In the social world, multiple sensory channels are used concurrently to facilitate communication. Among human and nonhuman pri- mates, faces and voices are the primary means of transmitting social signals (Adolphs, 2003; Ghazanfar and Santos, 2004). Primates recognize the correspondence between species-specific facial and vocal expressions (Massaro, 1998; Ghazanfar and Logothetis, 2003; Izumi and Kojima, 2004), and these visual and auditory channels can be integrated into unified percepts to enhance detection and discrimination. Where and how such communication signals are integrated (...) at the neural level are poorly understood. In particular, it is unclear what role “unimodal” sensory areas, such as the auditory cortex, may play. We recorded local field potential activity, the signal that best correlates with human imaging and event-related potential signals, in both the core and lateral belt regions of the auditory cortex in awake behaving rhesus monkeys while they viewed vocalizing conspecifics. We demonstrate unequivocally that the primate auditory cortex integrates facial and vocal signals through enhancement and suppression of field potentials in both the core and lateral belt regions. The majority of these multisensory responses were specific to face/voice integration, and the lateral belt region shows a greater frequency of multisensory integration than the core region. These multisensory processes in the auditory cortex likely occur via recip- rocal interactions with the superior temporal sulcus. (shrink)

I. Tijdperk vam Cartesius tot Kant -- II. De strijd tussen idealisme en naturalisme in de negentiende eeuw.

Studies the social science of moral inquiry as an attempt to develop a psychology and sociology that would explain the complex in terms of the simple as the new physics was doing in the natural realm.

According to the traditional Western concept of freedom, the ability to exercise free will depends on the availability of options and the possibility to consciously decide which one to choose. Since neuroscientific research increasingly shows the limits of what we in fact consciously control, it seems that our belief in free will and hence in personal autonomy is in trouble. -/- A closer look at the phenomenology of Obsessive-Compulsive Disorder (OCD) gives us reason to doubt the traditional concept of freedom (...) in terms of conscious control. Patients suffering from OCD experience themselves as unfree. The question is whether their lack of freedom is due to a lack of will power. Do they have too little conscious control over their thoughts and actions? Or could it be the opposite: are they exerting too much conscious control over their thoughts and actions? -/- In this chapter, we will argue that OCD patients testify to the general condition that exercising an increased conscious control over actions can in fact diminish the sense of agency rather than increase the experience of freedom. The experiences of these patients show that the traditional conception of freedom in terms of ‘free will’ has major shortcomings. There is an alternative, however, to be found in the work of Hannah Arendt. She advocates a conception of freedom as freedom in action. Combined with phenomenological insights on action, Arendt’s account of freedom helps us to get a more adequate understanding of the role of deliberation in the experience of freedom. We argue that the experience of freedom depends on the right balance between deliberate control and unreflective actions. (shrink)

We conducted an integrative data analysis to examine the hedonic character of nostalgia. We combined positive and negative affect measures from 41 experiments manipulating nostalgia. Overall, nostalgia inductions increased positive and ambivalent affect, but did not significantly alter negative affect. The magnitude of nostalgia’s effects varied markedly across different experimental inductions of the emotion. The hedonic character of nostalgia, then, depends on how the emotion is elicited and the benchmark to which it is compared. We discuss implications for theory and (...) research on nostalgia and emotions in general. (shrink)

Aurora, eller Morgenrøde er en enestående tekst fra højmiddelalderen, der knytter tanker og billeder fra Bibelen sammen med naturfilosofiske forestillinger om naturens ånd. Denne sammenstillingvar ny og udfordrende for datidens tænkemåde. Derfor blev teksten forbudt, gemt af vejen og først genfundet og udgivet i moderne tid. Det forhold, at Aurora, eller Morgenrøde skulle være skrevet af den berømte middelalderfilosof, Thomas Aquinas, som dennes sidstevidnesbyrd kort før han døde i 1274, er blevet afvist, ikke mindst af kirken. Ny forskning åbner imidlertid (...) spørgsmålet igen. I bogen her fortæller Aksel Haaning i tolv indledende kapitler den utrolige historie om glemte erfaringer af naturens liv fra europæisk filosofi og spiritualitet, herunder de ofte oversete bidrag fra arabisk kultur. De enkelte kapitler kan læses hver for sig, men udgør et samletbud på, hvordan fortid og nutid griber ind i hinanden. Når Haaning fortæller, står glemte tekster og tanker lyslevende for den moderne læser. Ifølge forfatteren, der har nærlæst de ældste kilder og håndskrifter, afspejler Aurora-teksten også et eksistentielt drama, der udspiller sig i vores eget forhold til natur"-- Back cover. (shrink)

The semantics of directional prepositions is investigated from the perspective of aspect. What distinguishes telic PPs (like to the house) from atelic PPs (like towards the house), taken as denoting sets of paths, is their algebraic structure: atelic PPs are cumulative, closed under the operation of concatenation, telic PPs are not. Not only does this allow for a natural and compositional account of how PPs contribute to the aspect of a sentence, but it also guides our understanding of the lexical (...) semantics of prepositions in important ways. Semantically, prepositions turn out to be quite similar to nouns and verbs. Nominal distinctions (like singular and plural, mass and count) and verbal classes (like semelfactives and degree achievements) have their prepositional counterparts. (shrink)

I am tasked with addressing philosophical hazards in the neuroscientific study of religion. As a philosopher concerned with the well-being of neuroscientists studying religion, I am inclined to begin with the philosophical hazards of philosophy. I am well aware of the extraordinary difficulties of both tasks, for the hazards are many and it is easy to miss the forest for the trees or the trees for the forest. Instead of focusing on one issue in great detail, I shall hang a (...) number of warning signs around a forest of issues that identify various philosophical hazards which deserve particular caution when it comes to neuroscience and religion. Since I am aiming for breadth over depth, my brief remarks on each issue shall be synoptic, non-exhaustive, contentious and suggestive for additional consideration and reflection. To redress such deficits, I have provided references for further reading. (shrink)

We approach the semantics of prepositions from the perspective of conceptual spaces. Focusing on purely spatial locative and directional prepositions, we analyze both types of prepositions in terms of polar coordinates instead of Cartesian coordinates. This makes it possible to demonstrate that the property of convexity holds quite generally in the domain of prepositions of location and direction, supporting the important role that this property plays in conceptual spaces.

This article identifies the structural and conceptual aspects of a visual construction often used in advertisements to establish a metaphoric or associative relation, that is, symmetric object alignment (SOA). It offers an account of the formal ingredients of SOA, which fall into two groups: object-constitutive factors (like size, shape, and color) and object-depictment factors (like perspective, orientation, and distance from viewing point). Both factors allow us to treat SOA as a visual rhetorical scheme. We also discuss how SOA relates to (...) conceptual structure, metaphoric or otherwise. Four types of relations are distinguished, based on the way in which perceptual and conceptual characteristics interact. Finally, we discuss the way in which these characteristics relate to the processing of such visual messages. One depictment factor will be focused on in particular: one-to-one versus one-to-many alignments. An attempt is made to connect these 2 patterns to the much-discussed topic in verbal metaphor theory, object comparison versus categorization. (shrink)

In this article we describe two core ontologies of law that specify knowledge that is common to all domains of law. The first one, FOLaw describes and explains dependencies between types of knowledge in legal reasoning; the second one, LRI-Core ontology, captures the main concepts in legal information processing. Although FOLaw has shown to be of high practical value in various applied European ICT projects, its reuse is rather limited as it is rather concerned with the structure of legal reasoning (...) than with legal knowledge itself: as many other “legal core ontologies”, FOLaw is therefore rather an epistemological framework than an ontology. Therefore, we also developed LRI-Core. As we argue here that legal knowledge is based to a large extend on common-sense knowledge, LRI-Core is particularly inspired by research on abstract common-sense concepts. The main categories of LRI-Core are: physical, mental and abstract concepts. Roles cover in particular social worlds. Another special category are occurrences; terms that denote events and situations. We illustrate the use of LRI-Core with an ontology for Dutch criminal law, developed in the e-Court European project. (shrink)

An important and supposedly impactful form of clinical ethics support is moral case deliberation. Empirical evidence, however, is limited with regard to its actual impact. With this literature review, we aim to investigate the empirical evidence of MCD, thereby a) informing the practice, and b) providing a focus for further research on and development of MCD in healthcare settings. A systematic literature search was conducted in the electronic databases PubMed, CINAHL and Web of Science. Both the data collection and the (...) qualitative data analysis followed a stepwise approach, including continuous peer review and careful documentation of our decisions. The qualitative analysis was supported by ATLAS.ti. Based on a qualitative analysis of 25 empirical papers, we identified four clusters of themes: 1) facilitators and barriers in the preparation and context of MCD, i.e., a safe and open atmosphere created by a facilitator, a concrete case, commitment of participants, a focus on the moral dimension, and a supportive organization; 2) changes that are brought about on a personal and inter-professional level, with regard to professional’s feelings of relief, relatedness and confidence; understanding of the perspectives of colleagues, one’s own perspective and the moral issue at stake; and awareness of the moral dimension of one’s work and awareness of the importance of reflection; 3) changes that are brought about in caring for patients and families; and 4) changes that are brought about on an organizational level. This review shows that MCD brings about changes in practice, mostly for the professional in inter-professional interactions. Most reported changes are considered positive, although challenges, frustrations and absence of change were also reported. Empirical evidence of a concrete impact on the quality of patient care is limited and is mostly based on self-reports. With patient-focused and methodologically sound qualitative research, the practice and the value of MCD in healthcare settings can be better understood, thus making a stronger case for this kind of ethics support. (shrink)

This article examines the structure and processing of editorial cartoons appropriating Joe Rosenthal's famous Iwo Jima photograph in view of the theory of conceptual blending (Fauconnier & Turner, 2002 Fauconnier, G. and Turner, M. 2002. The way we think: Conceptual blending and the mind's hidden complexities, New York,, NY: Basic Books. [Google Scholar]). The main claim argued is that Blending theory accounts for complex processes of meaning constructing provoked by editorial cartoons that invoke several conceptual domains to define and evaluate (...) their topic, Iwo Jima cartoons being cases in point. The second section introduces the relevant aspects of Blending theory: mental spaces and types of blending networks. The third section addresses the Iwo Jima image as one particular input space; a moral criterion to which the selected sociopolitical topic of the cartoon is compared and judged. The fourth section isolates four types of graphic operations blending the Iwo Jima image with topical entities. The fifth section demonstrates how various kinds of blends give rise to either positive or negative evaluations. The final section argues that the study's scope of application extends to any kind of multi-domain cartoon, not just those addressed in this article. (shrink)

This article focuses on the power of technological mediation from the point of view of autonomist Marxism. The first part of the article discusses the theories developed on technological mediation in postphenomenology and critical theory of technology with regard to their respective power perspectives and ways of coping with relations of power embedded in technical artifacts and systems. Rather than focusing on the clashes between the hermeneutic postphenomenological approach and the dialectics of critical theory, it is argued that in both (...) the category of resistance amidst power-relations is at least similar in one regard: resistance to the power of technology is conceptualized as a reactive force. The second part of the article reads technological mediation through the lens of the antagonistic power-perspective on class struggle developed in autonomist Marxism. The outline of a provisional autonomist philosophy of technology is developed using Foucauldian dispositifs of biopower in contrast to the hermeneutic and dialectical approach. It is thus argued that resistance should here be understood in terms of practice that subverts the technically mediated circuit of production itself. (shrink)

In contrast to the well-developed analysis of British feminism's implication in the late 19th-and early 20th-century reconstruction of the British national and imperial project, research into comparable areas of Dutch history are only just emerging. Taking as its starting point several conclusions drawn from postcolonial writing in the eld of British imperialism, this article investigates an important moment in the history of Dutch feminism, the Nationale Tentoonstelling van Vrouwenarbeid, to examine Dutch feminism's complicity in the Dutch imperial project. Simultaneously, it (...) examines the appropriation by colonial reformists of a `maternalist politics' to redene that project. In so doing, the article aims to focus attention on the interaction between metropolitan and colonial discourse and the place of maternalist politics in each. Further, the article briey reects on the signicance for Indonesian women of the operation of such discourses in the colonial context. (shrink)

Being more than mere passive objects used at human will, technologies co-determine the values and structures that shape the EU agricultural system. Technologies actively shape human interpretation, human action and co-shape our moral standards and routines. It is therefore important to account for the moral significance of agricultural technologies when characterising the structures in place within EU agriculture as well as when trying to understand why a particular agricultural technology is favoured or strongly opposed. From this perspective on technology, an (...) interesting question to pose, is how, within their current use context, genetically modified crops mediate human interpretation and human practice? This technology is of particular interest, because after more than 30 years, the debate on GM crops is still profound and highly polarised within EU society. Yet, too often, this debate is devalued as being irrational or irrelevant, while we show in this article, based on a technological mediation analysis, how ethical concerns about agricultural practices have co-evolved with the technological development of GM crops. This qualifies public debate on GM crops in the EU as both legitimate and relevant, as, from this perspective on technology, it can be seen as an important way to both characterise and discuss how EU agriculture is and should be organised. Analysing technology in terms of the myriad ways in which it mediates the relationship between humans and their world, further allows us to make some suggestions about how to broaden the ongoing EU discussion beyond the current dichotomous Yes/no framing. (shrink)

I argue that culpable ignorance can be irreducibly collective. In some cases, it is not fair to expect any individual to have avoided her ignorance of some fact, but it is fair to expect the agents together to have avoided their ignorance of that fact. Hence, no agent is individually culpable for her ignorance, but they are culpable for their ignorance together. This provides us with good reason to think that any group that is culpably ignorant in this irreducibly collective (...) sense is non-distributively collectively responsible for subsequent unwitting acts and consequences. (shrink)

Although a large number of studies have explored the main causes of gender inequality in academia, less attention has been given to the processes underlying the failure of gender equality initiatives to enhance gender representation, especially at the professorial level. We offer a critical discourse analysis of recently promulgated gender policy documents of the five Flemish universities, and demonstrate that defensive institutional work is a fundamental process underlying resistance to gender equality in the academic profession. That is, powerful organizational actors (...) resist gender change by intentionally deploying a combination of discursive strategies that legitimate what we describe as non–time-bound gender equality initiatives: The expected outcomes are undetermined in time, and they delegitimate concrete, time-bound measures that define specific outcomes against well-defined deadlines. By explicitly bringing a temporal dimension into our analysis, we argue that defensive institutional work deflects questions regarding what ought to be achieved when, and contributes to the slow pace of gender change in academia. (shrink)

Publication in the biomedical literature is important because it is the major pathway by which new concepts and discoveries are disseminated amongst scientists. In the last 30 years there has been a dramatic increase, not only in the volume of publications but in the number of authors per article as well. This paper summarizes the current literature on authorship and its proliferation in medicine. From the literature it becomes clear that for biomedical articles, the mean number of authors increased from (...) 1.7 in 1960 to 3.1 in 1990, and there are indications that this trend is even greater in clinical medicine such that single authorship almost has disappeared. Formal guidelines of who should be considered an author have been set by the International Committee of Medical Journal Editors. There are studies suggesting that not all authors on multiauthor papers fulfill these criteria. Inappropriate multiple authorship leads to dilution of authorship responsibility and unjustified citation in curriculum vitae. Recommendations regarding the prevention of inappropriate authorship are given in this paper. (shrink)

As a member of the British Oxford Group, psychologist Richard Ryder marked the beginning of the modern animal rights and animal welfare movement in the seventies. By introducing the concept “speciesism.” Ryder contributed importantly to the expansion of this movement. Surprisingly little attention has been paid to Ryder’s moral theory, “painism”, that aims to resolve the conflict between the two predominant rival theories in animal ethics, the deontological of Tom Regan and the utilitarian of Peter Singer. First, this paper examines (...) the kernel and historical sources of Ryder’s painist theory, linking it to the work of John Rawls and Jean-Jacques Rousseau. Second, it examines Ryder’s critique of utilitarianism. It is argued that his critique of Singer’s use of the word “sentience” is unconvincing and that his critique of utilitarian aggregation as not taking a full account of the metaphysical separateness of persons, has already been countered and dealt with. Finally this paper looks at some of the counterintuitive implications of Ryder’s theory and argues that utilitarianism might have more resources for dealing with its own alleged counterintuitive implications than Ryder acknowledges. (shrink)

Turing progressions have been often used to measure the proof-theoretic strength of mathematical theories: iterate adding consistency of some weak base theory until you “hit” the target theory. Turing progressions based on n-consistency give rise to a \ proof-theoretic ordinal \ also denoted \. As such, to each theory U we can assign the sequence of corresponding \ ordinals \. We call this sequence a Turing-Taylor expansion or spectrum of a theory. In this paper, we relate Turing-Taylor expansions of sub-theories (...) of Peano Arithmetic to Ignatiev’s universal model for the closed fragment of the polymodal provability logic \. In particular, we observe that each point in the Ignatiev model can be seen as Turing-Taylor expansions of formal mathematical theories. Moreover, each sub-theory of Peano Arithmetic that allows for a Turing-Taylor expansion will define a unique point in Ignatiev’s model. (shrink)

This paper is a presentation of astatus quæstionis, to wit of the problemof the interpretability logic of all reasonablearithmetical theories.We present both the arithmetical side and themodal side of the question.Dedicated to Dick de Jongh on the occasion of his 60th birthday.

Small tandem DNA duplications in the range of 15 to 300 base‐pairs play an important role in the aetiology of human disease and contribute to genome diversity. Here, we discuss different proposed mechanisms for their occurrence and argue that this type of structural variation mainly results from mutagenic repair of chromosomal breaks. This hypothesis is supported by both bioinformatical analysis of insertions occurring in the genome of different species and disease alleles, as well as by CRISPR/Cas9‐based experimental data from different (...) model systems. Recent work points to fill‐in synthesis at double‐stranded DNA breaks with complementary sequences, regulated by end‐joining mechanisms, to account for small tandem duplications. We will review the prevalence of small tandem duplications in the population, and we will speculate on the potential sources of DNA damage that could give rise to this mutational signature. With the development of novel algorithms to analyse sequencing data, small tandem duplications are now more frequently detected in the human genome and identified as oncogenic gain‐of‐function mutations. Understanding their origin could lead to optimized treatment regimens to prevent therapy‐induced activation of oncogenes and might expose novel vulnerabilities in cancer. (shrink)

Summary John Frederic Daniell (1790–1845) invented the constant battery in 1836. He meant it to be a philosophical instrument to be utilized in both lecture demonstrations and electrochemical laboratory research. But the constant battery was taken up in electrometallurgy, not primarily as a source of electric current but more as an electrodeposition device. As such it became an essential tool in the development of galvanoplastics (electroforming). This article traces the tortuous transformation of this lecture demonstration apparatus into an electrometallurgical tool, (...) and includes some aspects of British and French patent laws, and the electrogilding industry. (shrink)