We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

Presents a plethora of approaches to developing human potential in areas not conventionally addressed. Organized in two parts, this international collection of essays provides viable educational alternatives to those currently holding sway in an era of high-stakes accountability.

In 1956 Jacques Lacan proposed as interpretation of Edgar Allan Poe's "Purloined Letter" that at once challenged literary theorists and revealed a radically new conception of psychoanalysis. Lacan's far-reaching claims about language and truth provoked a vigorous critique by Jacques Derrida, whose essay in turn has spawned further responses from Barbara Johnson, Jane Gallop, Irene Harvey, Norman Holland, and others. The Purloined Poe brings Poe's story together with these readings to provide, in the words of the editors, "a structured (...) exercuse in the elaboration of textual interpretation. The Purloined Poe reprints the full text of Poe's story, followed by Lacan's "Seminar on 'The Purloined Letter,'" along with extensive commentary by the editors. Marie Bonaparte's and Shoshana Felman's discussions of traditional and contemporary approaches to "psychoanalysing" texts precede Alan Bass's new translation of Derrida's "Purveyor of Truth." The subsequent essays join the Lacan-Derrida debate and offer alternative readings by literary theorists, philosophers, psychologists, and psychoanalysts. The Purloined Poe convenes much of the most important current scholarship on "The Purloined Letter" and presents a rich sampling of poststructuralist discourse. (shrink)

Johns and Johnson analyze the invasion of Panama in order to explore the ways in which the War on Drugs has been used as an ideological justification for a projection of U.S. state power into Latin America. They characterize the Bush Administration's reasons for the invasion as cynical ideological rhetoric which covered up strategic interests the United States had in deposing Noriega and replacing him with a more cooperative regime. The authors particularly discuss the role of media coverage, including (...) the demonization of Noriega and the immediate adoption by the corporate media of the name Operation Just Cause, in legitimating the invasion and transforming it in popular ideology as a law enforcement operation. Finally, they examine the aftermath of the invasion in the United States--Bush's popularity ratings, the distortion of civilian casualty information, the macho celebration of the war--and in Panama--the destruction of the labor and independence movements, the puppet Endara government, and the increased drug trafficking through Panama. (shrink)

This is the first book to offer the best essays, articles, and speeches on ethics and intelligence that demonstrate the complex moral dilemmas in intelligence collection, analysis, and operations. Some are recently declassified and never before published, and all are written by authors whose backgrounds are as varied as their insights, including Robert M. Gates, former Director of the Central Intelligence Agency; John P. Langan, the Joseph Cardinal Bernardin Professor of Catholic Social Thought at the Kennedy Institute of Ethics, (...) Georgetown University; and Loch K. Johnson, Regents Professor of Political Science at the University of Georgia and recipient of the Owens Award for contributions to the understanding of U.S. intelligence activities. Creating the foundation for the study of ethics and intelligence by filling in the gap between warfare and philosophy, this is a valuable collection of literature for building an ethical code that is not dependent on any specific agency, department, or country. (shrink)

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Background While prenatal surgery historically was performed exclusively for lethal conditions, today intrauterine surgery is also performed to decrease postnatal disabilities for non-lethal conditions. We sought to describe physicians' attitudes about prenatal surgery for lethal and non-lethal conditions and to elucidate characteristics associated with these attitudes. Methods Survey of 1200 paediatric surgeons, neonatologists and maternal–fetal medicine specialists. Results Of 1176 eligible physicians, 670 responded. In the setting of a lethal condition for which prenatal surgery would likely result in the child (...) surviving with a severe disability, most respondents either disagreed or strongly disagreed that they would recommend the surgery. Male physicians were twice as likely to recommend surgery for the lethal condition, as were physicians who believe that abortion is morally wrong. Older physicians were less likely to recommend surgery. For non-lethal conditions, most respondents agreed that they would recommend prenatal surgery, even if the surgery increases the risk of prematurity or fetal death. Compared with MFMs, surgeons were less likely to recommend such surgery, as were physicians not affiliated with a fetal centre, and physicians who were religious. Conclusion Physician’s attitudes about prenatal surgery relate to physicians’ beliefs about disability as well as demographic, cultural and religious characteristics. Given the variety of views, parents are likely to receive different recommendations from their doctors about the preferable treatment choice. (shrink)

This book updates and adds to the classic Social Movements of the Sixties and Seventies, showing how social movement theory has grown and changed.

Johnson and Stricker published an opinion piece in the Journal of Medical Ethics presenting their perspective on the 2008 agreement between the Infectious Diseases Society of America (IDSA) and the Connecticut Attorney General with regard to the 2006 IDSA treatment guideline for Lyme disease. Their writings indicate that these authors hold unconventional views of a relatively common tick-transmitted bacterial infection caused by the spirochete Borrelia burgdorferi. Therefore, it should come as no surprise that their opinions would clash with the (...) IDSA's evidence-based guidelines for the diagnosis and treatment of Lyme disease. Their allegations of conflict of interest against the IDSA resemble those made against the National Institutes of Health, the Food and Drug Administration and the Centers for Disease Control and Prevention in 2000, which were found to be baseless. It is the responsibility of all physicians and medical scientists to stand up to antiscientific, baseless and unethical attacks on those who support an evidence-based approach to caring for patients. (shrink)

This article criticizes the standard way philosophers pose issues about the core practices of criminal justice institutions. Attempting to get at some of the presuppositions of posing these issues in terms of punishment, I construct a revised version of Rawls's ‘telishment’ case, a revision based on actual features of contemporary criminal justice practices in the USA. In addressing the implications of ‘racialment’, as I call it, some connections are made to current philosophical discussions about race. I conclude with brief remarks (...) about the importance of race to philosophical discussion as such. (shrink)

A student of Étienne Gilson and Joseph Owens, John P. Doyle taught medieval and Scholastic philosophy at Saint Louis University for forty years. Of continuing interest to Doyle has been the thought of Francisco Suárez, S.J. On this topic Doyle has published over a dozen articles and four English translations of portions of Suárez's key works. This volume celebrates the life and career of one of those rare kinds of scholars who has mastered an entire field of inquiry and (...) thought. (shrink)

Some recent discussions of A. N. Whitehead's treatment of the problem of value have stressed the point that his work in this field is open to serious objection. For example, Professor John Goheen claims that Whitehead's attempt to indicate distinguishing characteristics of experience of “the Good”, is too general to be adequate. He also suggests that this generality of approach makes it impossible for Whitehead to differentiate between different species of value. Further, according to Goheen, Whitehead involves himself in (...) confusion when he claims that satisfaction is achieved when experience is characterized by order ; and yet he also suggests that in some cases, the presence of disorder makes possible a higher type of satisfaction. Professor P. A. Schilpp agrees with Goheen in feeling that Whitehead's explanation of the good life in terms of “pattern” is too vague. In Schilpp's opinion, Whitehead does not answer the basic question: “What kind of pattern?” There is a further objection to Whitehead's “theory of the close connection between morality and beauty,” because at times it looks like an actual identification. Schilpp also objects to what appears to be Whitehead's identification of “good” with “interest”. Finally, it is claimed by Schilpp that Whitehead subordinates goodness to beauty. This interpretation is apparently supported by Prof. George Morgan who states: “Truth and moral values are instrumental except in so far as they enhance beauty.” Professor B. Morris objects to Whitehead's attempt to apply the mathematical method to aesthetic experience. He suggests that the method of symbolic logic is too abstract to deal adequately with concrete aesthetic data. Professor J. W. Blyth, as the result of his examination of Whitehead's theory of truth, reaches the conclusion that “the various elements involved in Whitehead's theory of truth cannot be brought together in one coherent and consistent system. (shrink)

This is a well-behaved concept in Newtonian physics. But a center of gravity is not an atom or a subatomic particle or any other physical item in the world. It has no mass; it has no color; it has no physical properties at all, except for spatio-temporal location. It is a fine example of what Hans Reichenbach would call an abstractum. It is a purely abstract object. It is, if you like , a theorist's fiction. It is not one of (...) the real things in the universe in addition to the atoms. But it is a fiction that has nicely defined, well delineated and well behaved role within physics. (shrink)

By utilizing new information from both clinical and experimental (lesion, electrophysiological, and gene-activation) studies with animals, the anatomy underlying anterograde amnesia has been reformulated. The distinction between temporal lobe and diencephalic amnesia is of limited value in that a common feature of anterograde amnesia is damage to part of an comprising the hippocampus, the fornix, the mamillary bodies, and the anterior thalamic nuclei. This view, which can be traced back to Delay and Brion (1969), differs from other recent models in (...) placing critical importance on the efferents from the hippocampus via the fornix to the diencephalon. These are necessary for the encoding and, hence, the effective subsequent recall of episodic memory. An additional feature of this hippocampalanterior thalamic and the perirhinal–medial dorsal thalamic systems are compromised, leading to severe deficits in both recall and recognition. (shrink)

Sixteen Muslim, Jewish, and Christian scholars sought to answer one question: 'Do our three scriptures unite or divide us?' Each essay examines scriptural sources as read in the classical and medieval traditions, addressing issues including how each tradition addresses the 'other' within its tradition and without, and the challenges of modernity.

The last thirty years has witnessed an explosion of scholarly books and articles on Locke which, claims Harpham, has "recast our most basic understanding of Locke as a historical actor and political theorist, the Two Treatises as a document, and liberalism as a coherent tradition of political discourse". The seven articles in this volume attempt to assess this "new scholarship," which is described as revisionist and historicist. This volume is now probably the best introduction to the "new scholarship." The introduction (...) by Edward Harpham, "Locke's Two Treatises in Perspective," and the bibliography provide a nice summary of key ideas, books, and articles. The essence of the new perspective is best stated by Richard Ascraft [[sic]] in "The Politics of Locke's Two Treatises of Government": "Locke's thought is thus both philosophically more conservative and politically more radical than we have hitherto supposed. In short, Locke is at once closer to Aristotle and Hooker and to the levelers and Sidney than the prevailing interpretations of his political thought maintain". Ashcraft attempts to separate Locke from the philosophy of Hobbes on such issues as resistance, toleration, justice and natural law, obligation; he directs his argument against Macpherson and Strauss, whose presences haunt the borders of the new scholarship. Eldon Eisenach, in his "Religion and Locke's Two Treatises of Government," interprets Locke's philosophy as marked by a deep skepticism regarding the reach of natural reason and informed by a "deep faith in the efficacy of biblical revelation" as the source of our moral and political duties. Eisenach comes close to dissenting from the new scholarship by wondering whether "Dunn and Ashcraft" are whistling in the dark concerning the coherence of Locke's "worldview"; but he closes ranks with the assertion that the Essay lays out a path to salvation. Eisenach concludes that Locke is not antireligious and secular, but a defender of biblical Christianity. The new scholarship must emphasize all the more a "spiritualist and assertively evangelical Locke". David Resnick, in "Rationality and the Two Treatises," attempts to recover the portrait of Locke as an antitraditionalist, committed to a critical rationalism. Resnick uses Weber's theory of rationality to render a consistent account of Locke's social analysis. Yet Resnick also insists that Locke's political philosophy is not self-interested and atomistic but is rooted in a fully Christian worldview: "Locke's deeply held theological convictions about the existence, benevolence and rationality of God ground his reasoning in a metaphysically stable framework". This religious assumption provides a basis for Locke's "rationality." But a new inconsistency is opened up by this resolution--a rationalism rooted in religious faith, by a philosopher who continually urged their distinction. Karen Iversen Vaughn, in "The Economic Background to Locke's Two Treatises of Government," attempts to correct the new scholarship's neglect of the economic premises of Locke's political philosophy; this neglect is part of an overreaction to Macpherson, but Vaughn offers a moderate economic interpretation of Locke. Vaughn shows the importance of rational self-interest in economic behavior, the necessity of political society to set conditions for economic pursuit: limit on sovereign power is an example of self-interest and evidence that "economic aspects of man's behavior permeated all aspects of life". Further, "civil society requires enforceable rules to contain the self-seeking actions of all men, so that life, liberty and property can be protected". Vaughn's essay opens the back door to the "self-interested" Locke of the "old scholarship." Ronald Hamowy, in "Cato's Letters, John Locke, and the Republican Paradigm," also seeks to redress the imbalance of the new scholarship, arguing that Locke's philosophy was not displaced by the civic humanist tradition and republican virtue. He offers a detailed analysis of Cato's Letters by John Tenchard and Thomas Gordon. Like Locke, "Cato" defines political authority in terms of inalienable rights. His analysis of liberty is strikingly Lockean, and not republican. Pocock's assessment of Locke's irrelevance to Whiggism and the American founding must be rejected. In the final essay, "Locke's Two Treatises and Contemporary Thought: Freedom, Community and the Liberal Tradition," Stephen L. Newman compares contemporary American libertarian and communitarian alternatives to the liberal welfare state. Newman offers a very trenchant criticism of libertarianism as decidedly non-Lockean by dint of its utter depoliticization of all behavior and its tendency to restore the execution of natural law to the private citizen and private groups. On the other hand, communitarianism fails to provide a sufficiently specific and robust notion of the common good, and more consistent writers like Walzer and Barber fall back not upon a teleological community, but autonomy mixed with participation. Locke's distinction of politics from economics, family, and social groups still provides the most workable and realistic account of politics available in the modern world; hence Newman concludes that libertarianism and communitarianism offer "impoverished" political theories. (shrink)

While we are commonly told that the distinctive method of mathematics is rigorous proof, and that the special topic of mathematics is abstract structure, there has been no agreement among mathematicians, logicians, or philosophers as to just what either of these assertions means. John P. Burgess clarifies the nature of mathematical rigor and of mathematical structure, and above all of the relation between the two, taking into account some of the latest developments in mathematics, including the rise of experimental (...) mathematics on the one hand and computerized formal proofs on the other hand. Along the way, a great many historical developments in mathematics, philosophy, and logic are surveyed. Yet very little in the way of background knowledge on the part of the reader is presupposed. (shrink)

What kind of persons could engage in political torture? Not only the morally impaired who lack empathy or compassion, or even the merely obedient, but also the righteous who struggle with conscience, and the realists who set morality aside.

The most important distinctively American contribution to philosophy is the pragmatist tradition. In this short, lucid, and completely convincing exposition, Professor John P. Murphy begins by exploring the roots of this tradition as found in the work of Peirce, James, and Dewey, demonstrating its power and originality. Historians of philosophy will appreciate the insight Murphy brings to these figures, but the special value of this book lies in his discussion of how the pragmatist spirit has flowered in contemporary philosophy (...) in the work of Quine, Rorty, and Davidson.Throughout, Murphy emphasizes the logic and structure of the views held by these six philosophers and what it is they have in common that makes their work especially “pragmatist.” There is no better introduction to this historical tradition and perhaps no better way into the philosophies of the contemporaries whom Murphy discusses.Interest in pragmatist ideas is undergoing a revival at present, and this book shows us why. It will be of interest to both historians of philosophy and students of contemporary philosophy. (shrink)

Introduction A brief look at the competing present-day interpretations of Hume's philosophy will leave the uninitiated reader completely baffled. On the one hand , Hume is seen as a philosopher who attempted to analyse concepts with ...

David Hume's A Treatise of Human Nature presents the most important account of skepticism in the history of modern philosophy. In this lucid and thorough introduction to the work, John P. Wright examines the development of Hume's ideas in the Treatise, their relation to eighteenth-century theories of the imagination and passions, and the reception they received when Hume published the Treatise. He explains Hume's arguments concerning the inability of reason to establish the basic beliefs which underlie science and morals, (...) as well as his arguments showing why we are nevertheless psychologically compelled to accept such beliefs. The book will be a valuable guide for those seeking to understand the nature of modern skepticism and its connection with the founding of the human sciences during the Enlightenment. (shrink)