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John Appleby
King's College London
  1.  52
    Mitochondrial Replacement: Ethics and Identity.Anthony Wrigley, Stephen Wilkinson & John B. Appleby - 2015 - Bioethics 29 (9):631-638.
    Mitochondrial replacement techniques have the potential to allow prospective parents who are at risk of passing on debilitating or even life-threatening mitochondrial disorders to have healthy children to whom they are genetically related. Ethical concerns have however been raised about these techniques. This article focuses on one aspect of the ethical debate, the question of whether there is any moral difference between the two types of MRT proposed: Pronuclear Transfer and Maternal Spindle Transfer. It examines how questions of identity impact (...)
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  2. The ethical challenges of the clinical introduction of mitochondrial replacement techniques.John B. Appleby - 2015 - Medicine, Health Care and Philosophy 18 (4):501-514.
    Mitochondrial DNA (mtDNA) diseases are a group of neuromuscular diseases that often cause suffering and premature death. New mitochondrial replacement techniques (MRTs) may offer women with mtDNA diseases the opportunity to have healthy offspring to whom they are genetically related. MRTs will likely be ready to license for clinical use in the near future and a discussion of the ethics of the clinical introduction ofMRTs is needed. This paper begins by evaluating three concerns about the safety of MRTs for clinical (...)
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    Should Mitochondrial Donation Be Anonymous?John B. Appleby - 2018 - Journal of Medicine and Philosophy 43 (2):261-280.
    Currently in the United Kingdom, anyone donating gametes has the status of an open-identity donor. This means that, at the age of 18, persons conceived with gametes donated since April 1, 2005 have a right to access certain pieces of identifying information about their donor. However, in early 2015, the UK Parliament approved new regulations that make mitochondrial donors anonymous. Both mitochondrial donation and gamete donation are similar in the basic sense that they involve the contribution of gamete materials to (...)
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    The Ethics of Mitochondrial Replacement.John B. Appleby, Rosamund Scott & Stephen Wilkinson - 2016 - Bioethics 31 (1):2-6.
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    The ‘haves’ and ‘have-nots’ of personal protective equipment during the COVID-19 pandemic: the ethics of emerging inequalities amongst healthcare workers.Clifford Shelton, Kariem El-Boghdadly & John B. Appleby - 2022 - Journal of Medical Ethics 48 (10):653-657.
    The COVID-19 pandemic has exacerbated inequalities, including among the healthcare workforce. Based on recent literature and drawing on our experiences of working in operating theatres and critical care in the UK’s National Health Service during the pandemic, we review the role of personal protective equipment and consider the ethical implications of its design, availability and provision at a time of unprecedented demand. Several important inequalities have emerged, driven by factors such as individuals purchasing their own personal protective equipment, inconsistencies between (...)
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