Introduction With an ageing population, end-of-life care is increasing in importance. The present work investigated characteristics and time trends of older peoples' attitudes towards euthanasia and an end-of-life pill. Methods Three samples aged 64 years or older from the Longitudinal Ageing Study Amsterdam (N=1284 (2001), N=1303 (2005) and N=1245 (2008)) were studied. Respondents were asked whether they could imagine requesting their physician to end their life (euthanasia), or imagine asking for a pill to end their life if they became tired (...) of living in the absence of a severe disease (end-of-life pill). Using logistic multivariable techniques, changes of attitudes over time and their association with demographic and health characteristics were assessed. Results The proportion of respondents with a positive attitude somewhat increased over time, but significantly only among the 64–74 age group. For euthanasia, these percentages were 58% (2001), 64% (2005) and 70% (2008) (OR of most recent versus earliest period (95% CI): 1.30 (1.17 to 1.44)). For an end-of-life pill, these percentages were 31% (2001), 33% (2005) and 45% (2008) (OR (95% CI): 1.37 (1.23 to 1.52)). For the end-of-life pill, interaction between the most recent time period and age group was significant. Conclusions An increasing proportion of older people reported that they could imagine desiring euthanasia or an end-of-life pill. This may imply an increased interest in deciding about your own life and stresses the importance to take older peoples' wishes seriously. (shrink)

ZusammenfassungDie rechtliche Regelung der Fortpflanzungsmedizin ist dringend reformbedürftig. Das Embryonenschutzgesetz von 1990 erfasst die neuesten technischen Entwicklungen nicht, ist in manchen Bereichen unstimmig und lückenhaft, setzt die betroffenen Frauen, Paare und Kinder unnötigen gesundheitlichen Risiken aus, erschwert paradoxerweise die Durchsetzung von Kinderrechten und erzeugt Gerechtigkeitsprobleme und Rechtsunsicherheit für die betroffenen Paare und die behandelnden Ärztinnen und Ärzte.Das Embryonenschutzgesetz enthält zudem nur strafrechtliche Verbote. Diese erlauben keine angemessene Reaktion auf die medizinische Entwicklung und den gesellschaftlichen Wandel und werden der Komplexität der (...) Materie nicht gerecht.Diese Probleme müssen gelöst werden. Der Bundesgesetzgeber verfügt seit mehr als 20 Jahren über die Kompetenz zur Regelung der Fortpflanzungsmedizin. Er sollte in der kommenden Legislaturperiode ein umfassendes Fortpflanzungsmedizingesetz schaffen. (shrink)

The DAP (Death Associated Protein) kinase family is a novel subfamily of pro-apoptotic serine/threonine kinases. All five DAP kinase family members identified to date are ubiquitously expressed in various tissues and are capable of inducing apoptosis. The sequence homology of the five kinases is largely restricted to the N-terminal kinase domain. In contrast, the adjacent C-terminal regions are very diverse and link individual family members to specific signal transduction pathways. There is increasing evidence that DAP kinase family members are involved (...) in both extrinsic and intrinsic pathways of apoptosis and may play a role in tumor progression. This review will focus on structural composition and subcellular localization of DAP kinase family members and on signal transduction pathways leading to their activation. Potential mechanisms of DAP kinase family-mediated apoptosis will be discussed. BioEssays 23:352–358, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Competitive athletes act within cultures of risk in sports and often decide to return to sport despite having acute health problems. The outcomes of such risky return-to-play decisions can not only negatively affect their future health, but also limit their sports performance or even upset their career paths. Following risk-management-decision theory with its focus on active risk defusing, we developed a model for understanding the process of return-to-play decision making from an athlete’s perspective. Based on the method of active information (...) search, a quasi-naturalistic return-to-play decision scenario was created in order to assess amateur team sport athletes’ decision making strategies. The main goals were to identify different information acquisition patterns and to analyze the influence of social pressure to play hurt on decision making. A total of 72 competitive team sport athletes (36 females, 36 males, m= 25.7 years of age, 3rd to 6th league level) out of three disciplines (volleyball, basketball, and handball) participated in the experimental study. Facing the same medical scenario (a partial tear of the supraspinatus tendon), athletes show different approaches to return-to-play decision making. The main focus is on potential sporting consequences of withdrawal from competition due to injury, while only few players favoring well-informed decisions based on thorough risk analysis. The athletes who chose the medically risky alternative to play hurt mostly employed strategies of active risk defusing, which got activated when severe sporting consequences were perceived. Those who chose to withdraw from competition primarily referred to maximin heuristic, particularly when social pressure to play was reduced. The findings can be used to improve rehabilitation. (shrink)

The development of modern programmable pacemaker-systems has led to a series of questions which until now have apparently not existed in the treatment of cardiac rhythm disturbances. These questions touch especially on the problem of whether the relation which usually exists between a diagnostic step and its therapeutic consequence, namely its therapeutic relevance, is abolished or at least changed.

Mercier and Sperber (M&S) argue that reasoning has evolved primarily as an adjunct to persuasive communication rather than as a basis for consequential choice. Recent research on decision-related regret suggests that regret aversion and concomitant needs for justification may underpin a complementary mechanism that can, if appropriately deployed, convert M&S's facile arguer into an effective decision maker, with obvious evolutionary advantages.

Examines ontological presuppositions that inform traditional and Bayesian positions on the uncertainties of belief in economic theory. D. Knight and J.M. Keynes’ views on the risks and uncertainties in economics; Reasons for the popularity of the Bayesian view in modern economic theory.

Acceptable programming systems have many nice properties like s-m-n-Theorem, Composition and Kleene Recursion Theorem. Those properties are sometimes called control structures, to emphasize that they yield tools to implement programs in programming systems. It has been studied, among others by Riccardi and Royer, how these control structures influence or even characterize the notion of acceptable programming system. The following is an investigation, how these control structures behave in the more general setting of complete numberings as defined by Mal'cev and Eršov.

Acceptable programming systems have many nice properties like s-m-n-Theorem, Composition and Kleene Recursion Theorem. Those properties are sometimes called control structures, to emphasize that they yield tools to implement programs in programming systems. It has been studied, among others by Riccardi and Royer, how these control structures influence or even characterize the notion of acceptable programming system. The following is an investigation, how these control structures behave in the more general setting of complete numberings as defined by Mal'cev and Eršov.

Objectives:Social isolation is increasing in aging societies and several studies have shown a relation with worse cognition in old age. However, less is known about the association in the oldest-old (85+); the group that is at highest risk for both social isolation and dementia. Methods:Analyses were based on follow-up 5 to 9 of the longitudinal German study on aging, cognition, and dementia in primary care patients (AgeCoDe) and the study on needs, health service use, costs, and health-related quality of life (...) in a large sample of oldest-old primary care patients (AgeQualiDe), a multi-center population-based prospective cohort study. Measurements included the Lubben Social Network Scale (LSNS-6), with a score below 12 indicating social isolation, as well as the Mini-Mental Status Examination (MMSE) as an indicator of cognitive function. Results:Dementia-free study participants (n = 942) were M = 86.4 (SD = 3.0) years old at observation onset, 68.2% were women. One third (32.3%) of them were socially isolated. Adjusted linear hybrid mixed effects models revealed significantly lower cognitive function in individuals with smaller social networks (β = 0.5, 95% CI = 0.3-0.7, p <.001). Moreover, changes in an individual's social network size were significantly associated with cognitive changes over time (β = 0.2, 95% CI = 0.1-0.4, p =.003), indicating worse cognitive function with shrinking social networks. Conclusion:Social isolation is highly prevalent among oldest-old individuals, being a risk factor for decreases in cognitive function. Consequently, it is important to maintain a socially active lifestyle into very old age. Likewise, this calls for effective ways to prevent social isolation. (shrink)

Interest in John Maynard Keynes has increased significantly over the past decade with the publication of his collected writings, increased access to his unpublished papers, and the resulting explosion of secondary literature. Responding to this renewed attention, this collection brings together economists and historians of economics with scholars from philosophy and other related fields to reconsider Keynes’s work and its legacy. Several of these essays look at Keynes not simply as an economist, but more broadly as a philosopher. Special attention (...) is directed to his views on aesthetics and moral philosophy, as well as his contributions as a probability theorist. The development of the Keynesian heritage is also considered: How did Keynesian ideas become assimilated and domesticated into the mainstream of economic thought—to the point of becoming dominant as the orthodoxy of the economics profession? What was the relationship between postwar British conservatives, Keynes’s work, and Britain’s relative economic decline? The archivist in charge of Keynes’s papers provides an additional vantage point on Keynes’s working methods and the broad range of scholars interested in his writings. Finally, all of the essays are followed by a responder’s comments, thus providing an exchange of viewpoints. _Contributors. _A. W. Coats, Allin F. Cottrell, Jacqueline Cox, William Darity, John Davis, Robert Dimand, Peter Groenewegen, Kevin Hoover, Henry E. Kyburg Jr., David Laidler, Michael S. Lawlor, Greg Lilly, D. E. Moggridge, R. M. O’Donnell, Kerry Pearce, Jochen Runde, Teddy Seidenfeld, J. D. Tomlinson. (shrink)

The chapter of Kant’s Critique of Practical Reason entitled “Table of the categories of liberty, in relation to the concepts of good and evil”, to which this year the Bonn conference “Kant und die ‘Kategorien der Freiheit’” was devoted, today still arouses many questions: is the table of the categories of liberty sufficient to cover the whole practical domain, including that of the empirically conditioned? And if this is the case, what is the meaning of the genitive “of liberty”, and (...) to which Kantian concept of liberty do the categories owe their name? Are they concepts of autonomous volition, referable exclusively to good and evil as Gut and Böse or also to Wohl and Weh? And since “practical concepts a priori … soon become knowledge” (KpV A 116), in what does practical knowledge consist, and what is its relationship with the practical conscience of the subject, with Gewissen? In the present panorama of German research on Kant, Heiner F. Klemme, Jochen Bojanowski, Dieter Sturma, José M. Torralba, Christian Krijnen, Stephen Zimmermann and Hans F. Fulda endeavour to give an answer to such issues and make an important contribution to present-day research on Kantian problems of practical judgment and the meanings of liberty and of the logical functions of the categories. (shrink)

Die Welt ist alles, was wir in unseren naturwissenschaftlichen Theorien beschreiben können – so eine weit verbreitete Überzeugung, die seit den Tagen des Positivismus unser Weltbild bestimmt. Aber reicht das tatsächlich schon aus? Wer sich am Ideal der wissenschaftlichen Erkenntnis orientiert, neigt dazu, viele nicht-begriffliche Erfahrungsformen zu unterschlagen, die uns aus dem Alltag vertraut sind: Symbolsysteme wie Musik, Literatur oder Bilder, Instanzen der unmittelbaren Erfahrung wie Anschauung, Wahrnehmung oder Gefühl und den Bereich des praktischen Könnens. In der Regel sind wir (...) nicht in der Lage, den Gehalt dieser Phänomene vollständig begrifflich wiederzugeben. Dennoch ist das weite Feld des Nichtbegrifflichen eine unverzichtbare Voraussetzung unserer Sätze und Gedanken: Ohne Kunst, Wahrnehmung und Handeln gibt es kein Denken, keine Wissenschaft, keine Philosophie. Der Band geht der Vielfalt des Nicht-Begrifflichen in ästhetischen, symboltheoretischen und semantischen Untersuchungen nach. Aus ihnen ergibt sich ein umfassender systematischer Überblick über eines der spannendsten und offensten Problemfelder der aktuellen philosophischen Debatte. Mit Beiträgen von: Andreas Bartels, Uwe Baumann, Volker Beeh, Gottfried Boehm, Olaf Breidbach, Joachim Bromand, Gottfried Gabriel, Markus Gabriel, Ernest Wolf Gazo, Annemarie Gethmann-Siefert, Jürgen Goldstein, Jens Halfwassen, Thomas Sören Hoffmann, Wolfgang Harms, Jochen Hörisch, Peter Janich, Guilherme F. R. Kisteumacher, Jakub Kloc-Konkolowicz, Imi Knoebel, Theo Kobusch, Klaus-M. Kodalle, Sibylle Krämer, Guido Kreis, Wolfgang Kubin, Sönke Lorenz, Antonio Cota Marçal, Aliasghar Mosleh, Theodoros Penolidis, Dominik Perler, Hans-Joachim Pieper, Andrzej Przylebski, Birgit Sandkaulen, Matthias Schmoeckel, Oswald Schwemmer, Josef Simon, Pirmin Stekeler-Weithofer, Dieter Teichert, Kai Vogeley, Gottfried Willems und Gereon Wolters. (shrink)

On Avicenna, 980-1037, a Muslim philosopher.