Cellular identity and its response to external or internal signalling variations are encoded in a cell's genome as regulatory information. The genomic regions that specify this type of information are highly variable and degenerated in their sequence determinants, as it is becoming increasingly evident through the application of genome‐scale methods to study gene expression. Here, we speculate that the same scenario applies to the regulatory regions controlling where DNA replication starts in the metazoan genome. We propose that replication origins cannot (...) be defined as unique genomic features, but rather that DNA synthesis initiates opportunistically from accessible DNA sites, making cells highly robust and adaptable to environmental or developmental changes. (shrink)

The present study aimed to explore and map the views of Portuguese laypersons regarding the acceptability of downsizing and restructuring measures during a recession. Two hundred and seven participants with various levels of training in economics were presented with a number of realistic scenarios depicting various measures, and were asked to indicate the extent to which they considered them to be acceptable. The scenarios were created by varying three factors likely to have an impact on people’s views: the magnitude of (...) a company’s reduction in net sales, the magnitude of planned downsizing, and the way in which downsizing would be implemented, either through layoffs, job alliances or both. Six qualitatively different personal positions were found. Four of these following positions were expected: never acceptable, mainly depends on the magnitude of downsizing, mainly acceptable and job alliance. Two unexpected positions were also observed: drastic measures and undetermined. (shrink)

The present study aimed to explore and map the views of Portuguese laypersons regarding the legitimacy of bonuses for senior executives. Two hundred eight participants, with various levels of training in economics, were presented with a number of concrete scenarios depicting the circumstances in which senior executives have received bonuses of variable amounts, and they were asked to indicate the extent to which such bonuses may be considered as legitimate. The scenarios were created by varying four factors likely to have (...) an impact on people’s views: the extent to which the objectives fixed by the company have been met or not, the global economic context in which the company has performed, the availability of experienced senior executives in the sector under consideration, and the amount of money that has been awarded, in terms of both the euros and multiples of the average worker’s pay. Five qualitatively different personal positions were found. The most common positions were that executive bonuses were either never legitimate or not very legitimate. People without any background in economics were more likely to hold these views than people with a background in economics. The remaining 45 % of the participants supported the awarding of bonus, but their support was conditional, and the main condition was the extent to which the company’s objectives were met. Thus for most participants, the practice of awarding extra pay to senior executives was either never legitimate, or legitimate only when the company’s objectives have been attained, or legitimate only when, even in a time of economic crisis, the company’s objectives have been surpassed. (shrink)

O ato de amamentar apresenta diversos benefícios tanto à mãe quanto ao bebê. No entanto, amamentar um bebê com cardiopatia requer inúmeros desafios. Este estudo tem o propósito de compreender a vivência do aleitamento materno de bebês com cardiopatia congênita e as propostas dos serviços de saúde à paciente com essas condições. Estudo descritivo, qualitativo, realizado por meio de entrevista semiestruturada com mães de bebês internados em hospital de referência em cardiopediatria. Utilizou-se a técnica de análise de conteúdo de Minayo, (...) com referencial teórico específico para embasamento da discussão. Os resultados encontrados apontam para a dura realidade dessas mães que se deparam com inúmeras dificuldades diante do enfrentamento da doença e das repercussões emocionais e físicas advindas dela. O impacto emocional e inviabilização dos cuidados com a amamentação exige uma equipe de saúde especializada para oferecer suporte afetivo, fortalecer vínculo mãe-bebê e minimizar prejuízos que a doença pode ocasionar. (shrink)

This book is dedicated to clarify ambiguous concepts from the world of creativity and innovation. One of the initial triggers for the development of the book was the perceived ambiguity of the binomials Design vs. Design Thinking and Innovation vs. Invention. Frequently, designers and innovation consultants are questioned by their clients about the relationships between these kind of concepts. Has the second emerged through the first, or vice-verse? Is one part of the other? Where are the similarities and which are (...) the differences? This conceptual incomprehension makes itself noticeable between many ambiguous concepts in the world of innovation and creativity. What is the difference between Radical and Disruptive Innovation? Or is Social Innovation the same as Social Intervention? And regarding Creativity, are Creativity and Creative Thinking the same? In this book the reader will find answers to these kinds of questions and doubts. 28 authors from 10 different countries and cultural backgrounds are questioning current definitions and perceptions, by comparing different sources and ideas, or simply by giving their personal opinions. Some of the authors have an academic background, others a practical one, being either entrepreneurs, working with innovation in companies, or being innovation/design consultants. (shrink)

The COVID-19 pandemic challenged countries, regions, schools, and individuals. School closures due to lockdowns forced changes in the teaching practices and the learning support provided to children at home. This study aimed to provide insights on the changes between the first and the second lockdowns in Portugal, concerning remote teaching practices and family support to children's education. A self-report questionnaire was filled by 144 parents of third grade students. The results show that, between the two lockdowns, there was a significant (...) decrease in the amount of support provided at home to school assignments and activities, as well as in the amount of time spent by students in TV broadcasted lessons and in reading training supported by the family. Inversely, families reported a significant increase in the amount of time spent by students in independent reading activities and in the time spent in training reading guided by teachers. The number of synchronous lessons with a teacher and the number of times students trained reading during a synchronous lesson also increased in the second lockdown. Additionally, in the second lockdown, parents perceived synchronous lessons to be more effective at improving their child's reading skills and perceived themselves as more capable of supporting their child in reading acquisition. These findings are used to discuss school responses and remote teaching and learning practices during the COVID-19 pandemic. (shrink)

The purpose of this study was to identify the relative contribution of individual and contextual predictors to students’ attitudes toward the acceptability of cheating and plagiarism. A group of 324 students from a tertiary institution in New Zealand completed an online survey. The findings indicate that gender, justice sensitivity, and understanding of university policies regarding academic dishonesty were the key predictors of the students’ attitudes toward the acceptability of cheating and plagiarism, both as agents of dishonest conduct and as witnesses (...) of misconduct among their peers. The implications of these findings for the development of policies and initiatives in tertiary institutions are discussed. (shrink)

Microbiome research shows that human health is foundationally intertwined with the ecology of microbial communities living on and in our bodies. This challenges the categorical separation of organisms from environments that has been central to biomedicine, and questions the boundaries between them. Biomedicine is left with an empirical problem: how to understand causal pathways between host health, microbiota and environment? We propose a conceptual tool – environmentality – to think through this problem. Environmentality is the state or quality of being (...) an environment for something else in a particular context: a fully perspectival proposition. Its power lies partly in what Isabelle Stengers has called the efficacy of the word itself, contrasting the dominant sense of the word environment as something both external and fixed. Through three case studies, we argue that environmentality can help think about the causality of microbiota vis-a-vis host health in a processual, relational and situated manner, across scales and temporalities. We situate this intervention within historical trajectories of thought in biomedicine, focusing on the challenge microbiome research poses to an aperspectival body. We argue that addressing entanglements between microbial and human lives requires that the environment is brought into the clinic, thus shortening the conceptual gap between medicine and public health. (shrink)

As neuroscience methods begin to dominate emotion research it is critical for researchers to remember that peripheral embodiments are critical to understanding emotional experience and emotion—behavior links. Much of modern emotion research assumes reliable mind—body connections that suggest that changes in emotional states influence bodily responses and, vice versa, that somatovisceral information shapes emotional experiences. However, there may be important qualifications to the link between the mind and the (peripheral) body. For example, the ability to sense internal and external bodily (...) states declines in older age as does activation of physiological systems, all of which may contribute to an impairment in emotional experiences and how emotions influence behavior. I describe this phenomenon as maturational dualism and suggest implications of this for emotion in older adults. (shrink)

This study investigates whether employees attribute different motives to their organization's corporate social responsibility efforts and if these motives influence employee performance. Specifically, we investigate whether employees could distinguish between intrinsic and extrinsic CSR motives by surveying 229 employee–supervisor dyads from various industries , and the impact of these perceptions on in-role and extra-role performance of subordinates. We found that employee task performance increases when employees attribute both intrinsic and extrinsic motives for CSR. Moreover, when employees perceive that their organization (...) invests in a CSR practice that is both intrinsic and extrinsic, they also tend to exert extra effort in their work. Theoretical and practical implications are also discussed alongside future research directions. (shrink)

-/- Irony is an intriguing topic, central to the study of meaning in language. This book provides an introduction to the pragmatics of irony. It surveys key work carried out on irony in a range of disciplines such as semantics, pragmatics, philosophy and literary studies, and from a variety of theoretical perspectives including Grice's approach, Sperber and Wilson's echoic account, and Clark and Gerrig's pretense theory. It looks at a number of uses of irony and explores how irony can be (...) misunderstood cross-culturally, before delving into the key debates on the pragmatics of irony: is irony always negative? Why do speakers communicate via irony, and which strategies do they usually employ? How are irony and sarcasm different? Is irony always funny? To answer these questions, basic pragmatic notions are introduced and explained. It includes multiple examples and activities to enable the reader to apply the theoretical frameworks to actual everyday instances of irony. (shrink)

The cognitive reserve is widely accepted as the active ability to cope with brain damage, using preexisting cognitive and compensatory processes. The common CR proxies used are the number of formal years of education, intelligence quotient or premorbid functioning, occupation attainment, and participation in leisure activities. More recently, it has employed the level of literacy and engagement in high-level cognitive demand of professional activities. This study aims to identify and summarize published methodologies to assess the CR quantitatively. We searched for (...) published studies on PubMed, ScienceDirect, and Web of Science between September 2018 and September 2021. We only included those studies that characterized the CR assessment methodology. The search strategy identified 1,285 publications, of which 25 were included. Most of the instruments targeted proxies individually. The lack of a gold standard tool that incorporates all proxies and cognitive tests highlights the need to develop a more holistic battery for the quantitative assessment of CR. Further studies should focus on a quantitative methodology that includes all these proxies supported by normative data to improve the use of CR as a valid measure in clinical contexts. (shrink)

Neste artigo, pretendo analisar alguns pontos centrais que culminam no amadurecimento da reflexão de Arendt em relação ao pensamento de Marx e ao marxismo. Para tanto, será analisado a leitura de Arendt a partir dos excertos presentes em Karl Marx and the Tradition of Western Political Thought, escrito no início da década de 1950, texto que é uma espécie de complementação do The Origins of Totalitarianism (1951) e fazia parte de um projeto pensado por Arendt de escrever um livro sobre (...) os “elementos totalitários do marxismo”. Visto que esse escrito nunca foi finalizado e o esse projeto foi abandonado, considero que a análise desse texto além de esclarecer muitos pontos importantes da crítica de Arendt a Marx e ao marxismo, pode nos servir também de ponte para o seu Magnum Opus The Human Condition (1958). A minha hipótese é de que, na visão de Arendt, a ruptura presente no pensamento de Marx em relação a tradição da filosofia política acontece com base em um tipo de linguagem que é resultado da própria tradição. Portanto, os resultados práticos do pensamento marxiano e dos marxismos seriam consequência da tradição do pensamento político ocidental quando convertido numa práxis radical. (shrink)

_The first major biography in English in over thirty years of the seminal modern Jewish thinker Martin Buber_ An authority on the twentieth‑century philosopher Martin Buber, Paul Mendes-Flohr offers the first major biography in English in thirty years of this seminal modern Jewish thinker. The book is organized around several key moments, such as his sudden abandonment by his mother when he was a child of three, a foundational trauma that, Mendes-Flohr shows, left an enduring mark on Buber’s (...) inner life, attuning him to the fragility of human relations and the need to nurture them with what he would call a “dialogical attentiveness.” Buber’s philosophical and theological writings, most famously _I and Thou,_ made significant contributions to religious and Jewish thought, philosophical anthropology, biblical studies, political theory, and Zionism. In this accessible new biography, Mendes-Flohr situates Buber’s life and legacy in the intellectual and cultural life of German Jewry as well as in the broader European intellectual life of the first half of the twentieth century. (shrink)

Irony is acknowledged to be usually critical: the ironic speaker tends to exhibit an apparent positive attitude in order to communicate a negative valuation. The reverse is considered to be also possible though: the ironic speaker can praise by apparent blaming, although it seldom happens. This unbalance between the two sorts of ironic examples is the so-called asymmetry issue of irony. Here I shall deny the possibility of being ironic without criticizing — hence the asymmetry issue is an illusion. By (...) claiming that irony is always critical I suggest an even stronger claim: criticism is what distinguishes irony from the similar phenomenon of metaphor. (shrink)

Spatial planning policies are fundamental blocks for the implementation of sustainable development goals. Still, despite the growing adoption of environmental proxies, as it is nature-based solutions, the study of their institutionalization in policy and spatial planning is in the early stages. Simultaneously, the use of discursive and interpretative methods to unfold the social structures related to environmental issues is growing, nonetheless, their application is more common to supranational narratives. This article proposes a conceptual and methodological approach to using critical discourse (...) analysis for studying the institutionalization and conceptualization of nature-related issues in policy and spatial planning at national and local levels. This is done by discussing the ontological relations between the discursive institutionalist theory and critical discourse analysis as a methodology. It contains four main stages: clarifying the analytical focus; mapping policy and planning documents; analyzing macro discourse, which includes critical textual analysis, text-type analysis, and intertextuality analysis, and, at last, the fourth phase, interpretation within the institutional context. It provides a tool for researchers less familiar with linguistics but interested in performing discourse analysis to understand the integration of environmental narratives within policy and spatial planning. (shrink)

In the context of the free will debate, both compatibilists and event-causal libertarians consider that the agent’s mental states and events are what directly causes her decision to act. However, according to the ‘disappearing agent’ objection, if the agent is nothing over and above her physical and mental components, which ultimately bring about her decision, and that decision remains undetermined up to the moment when it is made, then it is a chancy and uncontrolled event. According to agent-causalism, this sort (...) of problem can be overcome if one realizes that the agent herself, as an irreducible substance, is the true originator of her actions. I’ll present arguments that favor this view. Event-causalists have countered that if the agent identifies with some of the inner states that play the self-determining causal role in bringing about the action, then it is as though the action was directly caused by herself. I’ll object that this is not a distinctive aspect of free agency. Agent-causalism has been criticized from most naturalistically inclined fronts, and it must address risks of implausibility, contradiction and unintelligibility. Even though I’ll acknowledge these challenges, I’ll still argue that libertarian free will cannot be defended by any reductionist alternative, and that agent-causalism does not conflict with contemporary science but only with some of its unproven assumptions. (shrink)

Early embryogenesis is marked by a frail Spindle Assembly Checkpoint (SAC). The time of SAC acquisition varies depending on the species, cell size or a yet to be uncovered developmental timer. This means that for a specific number of divisions, biorientation of sister chromatids occurs unsupervised. When error‐prone segregation is an issue, an aneuploidy‐selective apoptosis system can come into play to eliminate chromosomally unbalanced cells resulting in healthy newborns. However, aneuploidy content can be too great to overcome, endangering viability.SAC generates (...) a diffusible signal to lengthen time spent in mitosis if needed, ensuring correct chromosome segregation, a fundamental factor in the generation of euploid cells. Thus, it remains puzzling what benefit could come from delaying SAC acquisition till later in the development. In this review, we describe what is known on SAC acquisition in distinct species and highlight pending research as well as potential applications for such knowledge. (shrink)

This volume of essays takes as its point of departure Martin Buber's principle of dialogue, which he applied as a comprehensive hermeneutic method for the study of various cultural phenomena. The volume critically evaluates the methodological purchase to be gained by the introduction of Buber's conception of dialogue in political theory, psychology and psychiatry, and religious studies.

Evangelization in the present contemporary context, transmission of faith, and the new architecture of communication are this article’s central axes. Just as interconnected cogwheels, they need to function together to hand on faith appropriately in today’s world. Our society, marked by unprecedented experiences in the field of digital culture, gave rise to a “new person”, who lives and relates within a new architecture of communication altogether. In the communicative process of digital culture, the modality of communication has changed from a (...) unilinear mode of transmission to networked, interactive, collaborative forms of interaction. Based on the teachings of the Second Vatican Council, and in an effort to rethink the present modalities of faith transmission, this study concerns both the convergence and continuity of the Magisterium of the Church on evangelization and the urgency for her to engage in a dialogue between faith and culture. This requires an attitude of courage to consider more deeply the relation between faith, Church life, and the current transformations as experienced today. For in the digital culture, a new perception and understanding of faith has grown and developed. New languages have challenged conventional paradigms and prompted us into a change of mentality and pastoral practice. (shrink)

Cada concepción de la persona responde a un modelo antropológico determinado. Sin embargo, todas confluyen como mínimo, en dos aspectos: todas las personas son receptoras de su vida y todas comparten un anhelo último de felicidad. Pero, ¿qué implicaciones tiene esto en la búsqueda del éxito del hombre? ¿Es compatible con la vinculación al otro? ¿Qué implica ser altruista y qué rol desempeña esta conducta en la consecución del éxito? ¿Es el ser humano altruista de forma innata? De este modo, (...) se pretende analizar el fenómeno del altruismo, su origen y su sentido en la persecución del éxito de la persona desde las dimensiones biológica, psicológica y antropológica que conforman a la persona. (shrink)

Neste trabalho, apresenta-se a análise das matrículas e da implementação da Lei Federal n. 12.711/2012, conhecida como Lei de Cotas e Ações Afirmativas, para ingresso nos Cursos Técnicos de Agropecuária e Informática na forma Integrada ao Ensino Médio, no Instituto Federal do Tocantins (IFTO) – Campus Dianópolis, no período de 2014 a 2018. A partir do estudo dessa Lei, do Decreto n. 7.824/2012, da Portaria Normativa do Ministério da Educação (MEC) n. 18/2012 e dos editais publicados pelo Instituto, foi realizado (...) um levantamento do número de estudantes beneficiados pela Lei nos processos seletivos para ingresso nesses cursos, por meio dos dados do Sistema Integrado de Gestão Acadêmica (Siga/IFTO). Ao analisar os editais e as matrículas, concluiu-se que, apesar da oferta de vagas prevista na Lei n. 12.711/2012, apenas nos anos de 2014 e 2015 houve alunos aprovados. Nos demais anos analisados, os estudantes não alcançaram a nota mínima para aprovação no vestibular. Assim, os alunos ingressantes pelo sistema de cotas, em 2014, compuseram a maioria dos que concluíram os cursos. (shrink)

Does the interaction between climactic demands, monetary resources, and freedom suggest a more general relationship between the environmental challenges that human societies face and their resources to meet those challenges? Using data on press freedom (Van de Vliert 2011a), we found no evidence of a similar interaction with natural resources (as measured by oil exports) or risk for natural disasters.

What happens when we unexpectedly see an attractive potential partner? Previous studies in laboratory settings suggest that the visualization of attractive and unattractive photographs influences the perception of time. The major aim of this research is to study time perception and attraction in a realistic social scenario, by investigating if changes in subjective time measured during a speed dating are associated with attraction. The duration of the dates was variable and participants had to estimate the time that passed. Among other (...) measures, participants also rated the potential partners in terms of their physical attractiveness before and after the dates and reported if they would like to exchange contact with them. Results showed that, in a real speed dating situation, when there is a perception of the partner as being physically more attractive, women tend to overestimate the duration of that meeting, whereas men tend to underestimate its duration. Such changes may reflect evolutionary adaptations which make the human cognitive system more responsive in situations related to reproductive fitness. (shrink)

A public health emergency, as the COVID-19 pandemic, may lead to shortages of potentially life-saving treatments. In this situation, it is necessary, justifiable and proportionate to have decision tools in place to enable healthcare professionals to triage and prioritise access to those resources. An ethically sound framework should consider the principles of beneficence and fair allocation. Scientific Societies across Europe were concerned with this problem early in the pandemic and published guidelines to support their professionals and institutions. This article aims (...) to compare triage policies from medical bodies across Europe, to characterise the process of triage and the ethical values, principles and theories that were proposed in different countries during the first outbreak of COVID-19. (shrink)