Although Next Generation Sequencing (NGS) has increased our ability to test and diagnose, its results are often not clear-cut and require a complex interpretation and negotiation process by both healthcare professionals and patients involved. In this paper, we explore how diagnoses identified through NGS are socially shaped under influence of the broader social context. Using an analytical framework stemming from the sociology of health and illness and science and technology studies, with a focus on the construction of diagnosis and the (...) role of uncertainty in medicine, we analyze the existing corpus of literature on NGS diagnostic practices. We show how in this early implementation phase of NGS, in which standardization efforts are not yet solidified, the boundary struggles around diagnoses obtained through NGS are particularly visible. We discuss the different steps in the diagnosis shaping process and what it subsequently entails to give and a receive a diagnosis using NGS. (shrink)

According to embodied theories of language (ETLs), word meaning relies on sensorimotor brain areas, generally dedicated to acting and perceiving in the real world. More specifically, words denoting actions are postulated to make use of neural motor areas, while words denoting visual properties draw on the resources of visual brain areas. Therefore, there is a direct correspondence between word meaning and the experience a listener has had with a word's referent on the brain level. Behavioral and neuroimaging studies have provided (...) evidence in favor of ETLs; however, recent studies have also shown that sensorimotor information is recruited in a flexible manner during language comprehension (e.g., Raposo et al. ; Van Dam et al., ), leaving open the question as to what level of language processing sensorimotor activations contribute. In this study, we investigated the time course of modality-specific contributions (i.e., the contribution of action information) as to word processing by manipulating both (a) the linguistic and (b) the action context in which target words were presented. Our results demonstrate that processes reflecting sensorimotor information play a role early in word processing (i.e., within 200 ms of word presentation), but that they are sensitive to the linguistic context in which a word is presented. In other words, when sensorimotor information is activated, it is activated quickly; however, specific words do not reliably activate a consistent sensorimotor pattern. (shrink)

Es besteht kein Zweifel, dass Hannah Arendt den klassischen republikanischen Tugenden des bürgerschaftlichen Engagements, der Partizipation und des politischen Handelns in ihrem Werk eine gewichtige Bedeutung verliehen hat. Ihr politisches Denken lebt von öffnenden Begriffen wie der Natalität, dem Anfang, der Pluralität, der Spontaneität oder der Freiheit des Menschen, etwas beginnen zu können. Und dennoch ist dieses Denken nur ein Teil von ihr und steht in einer konzeptionellen Beziehung zu einem dezidierten Ordnungsdenken, das in der Forschung bislang vernachlässigt wurde. Dieses (...) stärker in den Mittelpunkt der Auseinandersetzung zu rücken, ist das Anliegen dieses Bandes. ​​ ​. (shrink)

There is considerable evidence that language comprehenders derive lexical-semantic meaning by mentally simulating perceptual and motor attributes of described events. However, the nature of these simulations—including the level of detail that is incorporated and contexts under which simulations occur—is not well understood. Here, we examine the effects of first- versus third-person perspective on mental simulations during sentence comprehension. First-person sentences describing physical transfer towards or away from the body modulated response latencies when responses were made along a front-back axis, consistent (...) with the action-sentence compatibility effect. This effect was not observed for third-person sentences. The ACE was observed when making responses along a left-right axis for third-person, but not first-person sentences.sentences did not show an ACE along either axis. These results show that perspective is a detail that is simulated during action sentence comprehension, and that motoric activations are flexible and affected by the pronominal perspective used in the sentence. (shrink)

Das Buch ist eine philosophisch orientierte Einfuhrung in die Logik. Ihm liegt eine Konzeption zugrunde, die sich von mathematischen Einfuhrungen in die Logik unterscheidet, logische Regeln als universelle Sprachregeln versteht und sich bemuht, die Logik den Bedurfnissen der empirischen Wissenschaften besser anzupassen. Ausfuhrlich wird die klassische Aussagen- und Quantorenlogik behandelt. Philosophische Probleme der Logik, die Problematik der logischen Folgebeziehung, eine nichttraditionelle Pradikationstheorie, die intuitionistische Logik, die Konditionallogik, Grundlagen der Terminitheorie, modale Pradikate und ausgewahlte Probleme der Wissenschaftslogik gehen uber die ublichen (...) Einfuhrungen in die Logik hinaus. Das Buch setzt keine mathematischen Vorkenntnisse voraus, kann als Grundlage fur einen einjahrigen Logikkurs, aber auch zum Selbststudium genutzt werden. Der Autor des Buches ist seit 1976 Professor fur Logik am Institut fur Philosophie der Humboldt-Universitat zu Berlin. (shrink)

This paper provides a systematic literature review, analysis and discussion of methods that are proposed to practise ethics in research and innovation. Ethical considerations concerning the impacts of R&I are increasingly important, due to the quickening pace of technological innovation and the ubiquitous use of the outcomes of R&I processes in society. For this reason, several methods for practising ethics have been developed in different fields of R&I. The paper first of all presents a systematic search of academic sources that (...) present and discuss such methods. Secondly, it provides a categorisation of these methods according to three main kinds: ex ante methods, dealing with emerging technologies, intra methods, dealing with technology design, and ex post methods, dealing with ethical analysis of existing technologies. Thirdly, it discusses the methods by considering problems in the way they deal with the uncertainty of technological change, ethical technology design, the identification, analysis and resolving of ethical impacts of technologies and stakeholder participation. The results and discussion of our literature review are valuable for gaining an overview of the state of the art and serve as an outline of a future research agenda of methods for practising ethics in R&I. (shrink)

Religion is undergoing a transformation in current Western society. In addition to organized religions, there is a notable movement towards spirituality that is not associated with any institutions but in which experiences and notions of transcendence are still important. Transcendence can be described as God, the absolute, Mystery, the Other, the other as alterity, depending on one's worldview. In this book, these shifts in the views of transcendence in various areas of culture such as philosophy, theology, art, and politics are (...) explored on the basis of a fourfold heuristic model (proposed by Wessel Stoker)"--Back cover. (shrink)

The spectrum of religious experience and spirituality in contemporary postmodern, postsecular and religiously pluralized Western culture is extremely broad. Is it possible to trace the development, the shifts, breaches and patterns of religious and spiritual transcendence in this deeply diversified context? In this volume, a heuristic model of four types of transcendence is proposed and discussed. The four types are immanent transcendence, radical transcendence, radical immanence and transcendence as alterity. Of each type two examples from contemporary cultural discourses, ranging from (...) theology and philosophy to popular culture are presented and the viability of the model as such is critically assessed. The pairs of examples show how different kinds of content are given to the same type. By illuminating this dialectic between formal categories of notions of transcendence and their specific content in various areas of culture, the book can aid further exploration of the preconditions, possibilities, difficulties and limitations of relating to and expressing (a) sense(s) of transcendence within a postmodern world. (shrink)

Wie kam der Mensch zu der Vorstellung, dass es Götter gibt? Enthält die Sprache des Mythos Hinweise auf Ursprung und Entwicklung des religiösen Denkens? In einer wissenschaftshistorischen Studie wird hier die Theorie des Klassischen Philologen Hermann Usener (1834-1905) vom Ursprung der Religion (1896) und deren Rezeption in den Werken von Albrecht Dieterich, Ludwig Radermacher, Aby Warburg und Walter F. Otto untersucht. Mit seiner strukturanalytisch entwickelten Lehre von der religiösen Begriffsbildung hat Usener die seit der Romantik geführte Ursprungsdebatte neu aufgerollt und (...) dazu inspiriert, sein Projekt aufzugreifen und kritisch fortzuschreiben. (shrink)

PurposeThe purpose of this paper is to develop a critique of value sensitive design (VSD) and to propose an alternative approach that does not depart from a heuristic of value(s), but from virtue ethics, called virtuous practice design (VPD).Design/methodology/approachThis paper develops a philosophical argument, draws from a philosophical method (i.e. virtue ethics) and applies this method to a particular case study that draws from a narrative interview.FindingsIn this paper, authors show how an approach that takes virtue instead of value as (...) the central notion for aiming at a design that is sensitive to ethical concerns can be fruitful both in theory and in practice.Originality/valueThis paper presents the first attempt to ground an approach aimed at ethical technology design on the tradition of virtue ethics. As such, it presents VPD as a potentially fruitful alternative to VSD. (shrink)

In this paper, we engage in a philosophical investigation of how blockchain technologies such as cryptocurrencies can mediate our social world. Emerging blockchain-based decentralised applications have the potential to transform our financial system, our bureaucracies and models of governance. We construct an ontological framework of “narrative technologies” that allows us to show how these technologies, like texts, can configure our social reality. Drawing from the work of Ricoeur and responding to the works of Searle, in postphenomenology and STS, we show (...) how blockchain technologies bring about a process of emplotment: an organisation of characters and events. First, we show how blockchain technologies actively configure plots such as financial transactions by rendering them increasingly rigid. Secondly, we show how they configure abstractions from the world of action, by replacing human interactions with automated code. Third, we investigate the role of people’s interpretative distances towards blockchain technologies: discussing the importance of greater public involvement with their application in different realms of social life. (shrink)

In this paper, we engage in a philosophical investigation of how blockchain technologies such as cryptocurrencies can mediate our social world. Emerging blockchain-based decentralised applications have the potential to transform our financial system, our bureaucracies and models of governance. We construct an ontological framework of “narrative technologies” that allows us to show how these technologies, like texts, can configure our social reality. Drawing from the work of Ricoeur and responding to the works of Searle, in postphenomenology and STS, we show (...) how blockchain technologies bring about a process of emplotment: an organisation of characters and events. First, we show how blockchain technologies actively configure plots such as financial transactions by rendering them increasingly rigid. Secondly, we show how they configure abstractions from the world of action, by replacing human interactions with automated code. Third, we investigate the role of people’s interpretative distances towards blockchain technologies: discussing the importance of greater public involvement with their application in different realms of social life. (shrink)

Today, a major technological trend is the increasing focus on the person: technical systems personalize, customize, and tailor to the person in both beneficial and troubling ways. This trend has moved beyond the realm of commerce and has become a matter of public governance, where systems for citizen risk scoring, predictive policing, and social credit scores proliferate. What these systems have in common is that they may target the person and her ethical and political dispositions, her virtues. Virtue ethics is (...) the most appropriate approach for evaluating the impacts of these new systems, which has translated in a revival of talk about virtue in technology ethics. Yet, the focus on individual dispositions has rightly been criticized for lacking a concern with the political collective and institutional structures. This paper advocates a new direction of research into civic virtue, which is situated in between personal dispositions and structures of governance. First, it surveys the discourse on virtue ethics of technology, emphasizing its neglect of the political dimension of impacts of emerging technologies. Second, it presents a pluralist conception of civic virtue that enables us to scrutinize the impact of technology on civic virtue on three different levels of reciprocal reputation building, the cultivation of internal goods, and excellence in the public sphere. Third, it illustrates the benefits of this conceptions by discussing some paradigmatic examples of emerging technologies that aim to cultivate civic virtue. (shrink)

The legitimacy of the dominant intensive meat production system with respect to the issue of animal welfare is increasingly being questioned by stakeholders across the meat supply chain. The current meat supply is highly undifferentiated, catering only for the extremes of morality concerns (i.e., conventional vs. organic meat products). However, a latent need for compromise products has been identified. That is, consumer differences exist regarding the trade-offs they make between different aspects associated with meat consumption. The heterogeneity in consumer demand (...) could function as a starting point for market segmentation, targeting and positioning regarding animal welfare concepts that are differentiated in terms of animal welfare and price levels. Despite this, stakeholders in the meat supply chain seem to be trapped in the dominant business model focused on low cost prices. This paper aims to identify conflicting interests that stakeholders in the meat supply chain experience in order to increase understanding of why heterogeneous consumer preferences are not met by a more differentiated supply of meat products produced at different levels of animal welfare standards. In addition, characteristics of the supply chain that contribute to the existence of high exit barriers and difficulty to shift to more animal-friendly production systems are identified. Following the analysis of conflicting interests among stakeholders and factors that contribute to difficulty to transform the existing dominant regime, different routes are discussed that may help and motivate stakeholders to overcome these barriers and stimulate the creation of new markets. (shrink)

Paul Ricœur has been one of the most influential and intellectually challenging philosophers of the last century, and his work has contributed to a vast array of fields: studies of language, of history, of ethics and politics. However, he has up until recently only had a minor impact on the philosophy of technology. Interpreting Technology aims to put Ricœur’s work at the centre of contemporary philosophical thinking concerning technology. It investigates his project of critical hermeneutics for rethinking established theories of (...) technology, the growing ethical and political impacts of technologies on the modern lifeworld, and ways of analysing global sociotechnical systems such as the Internet. Ricœur’s philosophy allows us to approach questions such as: how could narrative theory enhance our understanding of technological mediation? How can our technical practices be informed by the ethical aim of living the good life, with and for others, in just institutions? And how does the emerging global media landscape shape our sense of self, and our understanding of history? These questions are more timely than ever, considering the enormous impact technologies have on daily life in the 21st century: on how we shape ourselves with health apps, how we engage with one-another through social media, and how we act politically through digital platforms. (shrink)

The quickening pace of technological development on a global scale and its increasing impact on the relation between human beings and their lifeworld has led to a surge in philosophical discussions concerning technology. Philosophy of technology after the “empirical turn” has been dominated by three approaches: actor-network theory, critical theory of technology and postphenomenology. Recently, scholars have started to question the philosophical roots of these approaches. This paper critically questions Ihde’s early adoption of Heidegger’s philosophy of technology in postphenomenology. First, (...) the paper clarifies the central contributions of Heidegger’s philosophy of technology to postphenomenology. It then uses Heidegger’s early work on Aristotle to argue that Ihde’s notion of “use context” is based on a distorted account of Heidegger’s notion of the “totality of relevance”. Correspondingly, it contends that this has led to a misinterpretation of Heidegger’s technology critique. Second, an alternative reading of Heidegger’s ideas concerning technology is offered. This reading traces Heidegger’s use of the concept of telos in the totality of relevance to his discussion of Aristotelian virtue. It is subsequently shown how the question of the temporality of the mode of being of virtue is related to the notion of authenticity, which lies at the heart of Heidegger’s philosophy. Finally, the paper argues that postphenomenology could gain from philosophers who targeted Heidegger’s central notion of authenticity, notably Arendt and Ricoeur. (shrink)

ISBN 3110150077 (paperback) DEM 58.00 A collection of invited papers on the role of preferences and desires in practical reasoning: including rational decision making, the concept of welfare, and ethics. With a substantial introduction and a bibliographical survey. culture-specific and universal factors.

_Encountering Bigotry_ examines the occurrence of emotionally fraught and socially provocative expressions, such as racism, sexism, homophobia, anti-Semitism, classism, and other forms of hatred of outgroups or others, in everyday experience. The editors categorize such remarks as projections, particular forms of perceiving oneself and others in the world. This projection allows the person to perceive emotional intensity without owning the feeling or experiencing anxiety-producing emotions. Such projections are not pathological, they observe, but rather "faulty" and not beyond repair. Utilizing experiences (...) gathered from various people and settings, and deriving theory from common psychoanalytic and Gestalt therapy, the observations and conclusions found in _Encountering Bigotry_ are as applicable in any social context as they are in the therapeutic relationship. (shrink)

Originally published in Norwegian in 1941, this is the magnum opus of one of Norway's most celebrated philosophers, now made available in English for the first time. It examines the concept of the tragic and attempts to construct a more precise and useful definition, on the basis of a "biosophical" look at the situation of organisms in their environment and their attempt to realize interests on multiple fronts through abilities they possess in a variety of degrees. This is a theory (...) of genius, and of the dangers that frequently accompany it, and a sober account of the perils of consciousness for the human species. The robust and thorough treatment includes in-depth analysis of the relationship between real-world tragedies and those portrayed in theater and literature. This widely anticipated translation will be of interest to academics as well as to all readers who are interested in philosophical pessimism and tragedy. (shrink)