In this book, Bradley Armour-Garb and James A. Woodbridge distinguish various species of fictionalism, locating and defending their own version of philosophical fictionalism. Addressing semantic and philosophical puzzles that arise from ordinary language, they consider such issues as the problem of non-being, plural identity claims, mental-attitude ascriptions, meaning attributions, and truth-talk. They consider 'deflationism about truth', explaining why deflationists should be fictionalists, and show how their philosophical fictionalist account of truth-talk underwrites a dissolution of the Liar Paradox and its (...) kin. They further explore the semantic notions of reference and predicate-satisfaction, showing how philosophical fictionalism can also resolve puzzles that these notions appear to present. Their critical examination of fictionalist approaches in philosophy, together with the development and application of their own brand of philosophical fictionalism, will be of great interest to scholars and upper-level students of philosophy of language, metaphysics, philosophical logic, philosophy of mind, epistemology, and linguistics. (shrink)

In the past few years, two new DNA topoisomerases have been discovered in bacteria, bringing the total number of DNA topoisomerases in E. coli to four. Two classes of topoisomerases, type 1 and type 2, are distinguishable by their amino acid homology and their apparent reaction mechanism. Of the four E. coli topoisomerases, there are two type 1 and two type 2 enzymes. In eukaryotes, the existence of multiple type 1 and type 2 enzymes has also become apparent. The existence (...) of these multiple enzymes provokes a question whose answer has both evolutionary and physiological implications: are these topoisomerases functionally redundant, or have they acquired sufficient specialization that they now perform unique biological reactions? In bacteria, there is evidence for both specialization and redundancy in the functions of topoisomerases. (shrink)

In a series of articles, Dan Lopez De Sa and Elia Zardini argue that several theorists have recently employed instances of paradoxical reasoning, while failing to see its problematic nature because it does not immediately (or obviously) yield inconsistency. In contrast, Lopez De Sa and Zardini claim that resultant inconsistency is not a necessary condition for paradoxicality. It is our contention that, even given their broader understanding of paradox, their arguments fail to undermine the instances of reasoning they attack, either (...) because they fail to see everything that is at work in that reasoning, or because they misunderstand what it is that the reasoning aims to show. (shrink)

Emotion plays a crucial role, both in general human experience and in psychiatric illnesses. Despite the importance of emotion, the relative lack of objective methodologies to scientifically studying emotional phenomena limits our current understanding and thereby calls for the development of novel methodologies, such us the study of illustrative animal models. Analysis of Drosophila and other insects has unlocked new opportunities to elucidate the behavioral phenotypes of fundamentally emotional phenomena. Here we propose an integrative model of basic emotions based on (...) observations of this animal model. The basic emotions are internal states that are modulated by neuromodulators, and these internal states are externally expressed as certain stereotypical behaviors, such as instinct, which is proposed as ancient mechanisms of survival. There are four kinds of basic emotions: happiness, sadness, fear, and anger, which are differentially associated with three core affects: reward (happiness), punishment (sadness), and stress (fear and anger). These core affects are analogous to the three primary colors (red, yellow, and blue) in that they are combined in various proportions to result in more complex “higher order” emotions, such as love and aesthetic emotion. We refer to our proposed model of emotions as called the “ Three Primary Color Model of Basic Emotions.”. (shrink)

Note: The paper attached here is a "pre-review" version, not the final version that has now been published online first at the link below. -/- In “Nothing is True,” Will Gamester defends a form of alethic nihilism that still grants truth-talk a kind of legitimacy: an expressive role that is implemented via a pretense. He argues that this view has all of the strengths of deflationism, while also providing an elegant resolution of the Liar Paradox and its kin. For the (...) alethic nihilist, Liar and related sentences are not true, and that is the end of the story. No contradiction arises because it does not thereby follow that any of these sentences are also true, since nothing is. Gamester concludes that the simplicity of this response to the semantic paradoxes makes alethic nihilism an attractive approach. We disagree. In addition to providing insurmountable obstacles for his form of alethic nihilism, we contend that a certain form of non-nihilist deflationism is better placed to deal with the paradoxes and to account for truth-talk more generally. (shrink)

The effort to revise the Declaration of Helsinki and the CIOMS Guidelines has sparked a sometimes vitriolic debate centering on the use of placebo controls.

After reconstructing three arguments for Nietzsche’s descriptive analysis of the self as complex, this article clarifies some of greatness’s psychological conditions. It then offers three arguments for why we should not focus on these internal conditions when seeking to verify or to achieve greatness. First, Nietzsche’s descriptive analysis of the self renders introspection too coarse-grained and error-prone to verify the subtle type of unity required for greatness. Second, Nietzsche associates introspective appraisal of one’s psyche with a moral project that weakens (...) and represses the drives, such that inquiry into whether greatness’s internal conditions are satisfied typically speaks against their realization. Finally, the actions characteristic of Nietzsche’s great individuals prohibit introspective preoccupation with oneself. These arguments suggest that we should attend to outwardly directed accomplishments, rather than psychology, when appraising the greatness of others and seeking to become great ourselves. (shrink)

This paper examines the relative voluntariness of three types of virtue: 'epistemic' virtues like open-mindedness; 'motivational' virtues like courage, and more robustly 'moral' virtues like justice. A somewhat novel conception of the voluntariness of belief is offered in terms of the limited, but quite real, voluntariness of certain epistemic virtues.

In the seventeenth century, Newton published his famous experimentum crucis, in which he claimed that light is heterogeneous and is composed of rays with different refrangibilities. Experiments, especially the crucial experiment, were important for justifying Newton’s theory of light, and eventually his theory of color. A century later, Goethe conducted a series of experiments on the nature of color, especially in contradistinction to Newton, and he defended his research with a methodological principle formulated in “Der Versuch als Vermittler.” Goethe’s principle (...) included two elements: a series of experiments and resultant higher empirical evidence, which functioned as mediator between the objective and the subjective . Although the notion of experimentum crucis became popular among scientists for reconstructing experimental research and for justifying theories, especially for rhetorical purposes, Newton’s justification of his theory of light and color is best reconstructed in terms of Goethe’s methodological principle. Finally, Goethe’s principle has important consequences for the contemporary philosophical underdetermination thesis. (shrink)

Defending Kant against the charge that his ethics is formalistic has prompted some prominent interpreters to stress the “humanity” formulation of the categorical imperative. In this paper I argue that this more sophisticated account of Kantian ethics generates a deeper and more philosophically interesting Hegelian criticism (located primarily in the Phenomenology of Spirit). Hegel’s claim that the moral worldview is rife with dialectical conflict serves as a criticism both of Kant’s conception of the moral self and of his more basic (...) assumptions about the proper philosophical reply to the challenges posed by dogmatism and skepticism. As I will argue, the moral worldview unselfconsciously preserves elements of dogmatism and skepticism, even as it claims to be self-critical. Hegel’s strategy, then, is to accuse Kant of falling into a kind of practical antinomy that. (shrink)

Abstract:In conversation with Kiarina Kordela's Epistemontology, this essay considers how biopolitical capitalism relies upon the structural exclusion of experiences of dying and loss, while valorizing semblances of immortal transcendence. Following Kordela's argument that biopower attempts to "eternalize" the capitalist equation of being and value as coterminous with life through the production of experiences of false transcendence, this essay adds that the Hegelian critique of finitude clarifies the stakes of biopower's foreclosures of the death-event. With Lacan's account of foreclosure in mourning (...) in Seminar VI, the essay concludes with how the potentiality of loss can reinscribe the subject's (non)rapport with eternity. (shrink)

In this article, I introduce the notion of horizon for scientific practice (HSP), representing limits or boundaries within which scientists ply their trade, to facilitate analysis of scientific discovery and progress. The notion includes not only constraints that delimit scientific practice, e.g. of bringing experimentation to a temporary conclusion, but also possibilities that open up scientific practice to additional scientific discovery and to further scientific progress. Importantly, it represents scientific practice as a dynamic and developmental integration of activities to investigate (...) and analyze the natural world. I use the discovery of the clotting factor, thrombin, and the experiments conducted by the Johns Hopkins physiologist, William Howell, on the enzymatic nature of thrombin to illustrate the notion of HSP. In a concluding section, I compare the notion of HSP to other notions for scientific practice proposed in the history and philosophy of science literature. (shrink)

In The Structure of Scientific Revolutions, Kuhn claimed that theory choice is a conversion experience and depends upon the personality or psychology of the individual scientist making the choice. Critics charged Kuhn with an irrational and a relativistic position concerning theory choice, arguing he advocated a subjective instead of an objective approach to how scientists choose one theory over another and thereby undercut epistemic accounts for the generation of scientific knowledge. In response to critics Kuhn insisted that his approach, although (...) subjective, was still rational in that the criteria—composed of epistemic values—determining theory choice operate both objectively and subjectively. Recent work in cognitive neuropsychology, particularly in the dual-process theory of cognition, supports Kuhn’s notion of theory choice. In this paper, I initially discuss Kuhn’s approach to theory choice, along with criticism of it and his response to the criticism, followed by an examination of the dual-process theory of cognition. I then explore the application of dual-process theory to Kuhn’s notion of theory choice, especially in terms of a historical case study from the biomedical sciences. I finally discuss briefly the implications of the dual-process theory for contemporary philosophy of science. (shrink)

Truth-talk exhibits certain features that render it philosophically suspect and motivate a deflationary account. I offer a new formulation of deflationism that explains truth-talk in terms of semantic pretense. This amounts to a fictionalist account of truth-talk but avoids an error-theoretic interpretation and its resulting incoherence. The pretense analysis fits especially well with deflationism’s central commitment, and it handles truth-talk’s unusual features effectively. In particular, this approach suggests an interesting strategy for dealing with the Liar paradox. This version of deflationism (...) has advantages over the formulations currently available in the literature, mainly because it offers a more satisfying account of the generalizing role deflationary views take as truth-talk’s central function. Explaining the notion of truth in terms of pretense generates some special concerns, but none we cannot address through careful consideration of how pretense operates in truth-talk and of the attitudes instances of pretending involve. (shrink)

This paper raises the question of how a history of the philosophy of eighteenth-century Britain should be written. First, it describes the usual answer to this question, which divides the period into what happened before Hume, then Hume, then responses to Hume. It notes that this answer does not correspond well with how the period saw itself. It then considers how ‘philosophy’ is defined in Britain in the eighteenth century, taking into account dictionary definitions, book titles, and university syllabi. Obvious (...) differences between eighteenth-century and twenty-first-century philosophy are explored, including the idea that ‘natural philosophy’ is as much part of philosophy as moral philosophy, metaphysics, and logic, and the difficulty of making a distinction between philosophy and what we now call psychology. In the final section of the paper some difficulties are raised regarding the hypothesis that ‘enlightenment’ might provide an organizing concept for a more historically sensitive account of eighteenth-century British philosophy. (shrink)

In this work, McGilvray explains Noam Chomsky's rationalist view of human nature.

The complex-systems approach to cognitive science seeks to move beyond the formalism of information exchange and to situate cognition within the broader formalism of energy flow. Changes in cognitive performance exhibit a fractal (i.e., power-law) relationship between size and time scale. These fractal fluctuations reflect the flow of energy at all scales governing cognition. Information transfer, as traditionally understood in the cognitive sciences, may be a subset of this multiscale energy flow. The cognitive system exhibits not just a single power-law (...) relationship between fluctuation size and time scale but actually exhibits many power-law relationships, whether over time or space. This change in fractal scaling, that is, multifractality, provides new insights into changes in energy flow through the cognitive system. We survey recent findings demonstrating the role of multifractality in (a) understanding atypical developmental outcomes, and (b) predicting cognitive change. We propose that multifractality provides insights into energy flows driving the emergence of cognitive structure. (shrink)

It is shown that belief in providence and a future state are key components of Hutcheson’s account of moral virtue. Though Hutcheson holds that human beings are naturally virtuous, religion is necessary to give virtuous dispositions support and stability. The aspects of Hutcheson’s moral psychology which lead him to this conclusion are spelled out in detail. It is argued that religion and virtue are connected in this way in both the Dublin writings (the Inquiry and the Essay ) and the (...) later pedagogical texts, and that, therefore, there are reasons to question claims made by James Moore to the effect that Hutcheson had two distinct philosophical “systems.”. (shrink)

A definitive and authoritative guide to a vibrant and growing discipline in current philosophy, The Bloomsbury Companion to Contemporary Philosophy of Medicine presents an overview of the issues facing contemporary philosophy of medicine, the research methods required to understand them and a trajectory for the discipline's future. -/- Written by world leaders in the discipline, this companion addresses the ontological, epistemic, and methodological challenges facing philosophers of medicine today, from the debate between evidence-based and person-centered medicine, medical humanism, and gender (...) medicine, to traditional issues such as disease, health, and clinical reasoning and decision-making. Practical and forward-looking, it also includes a detailed guide to research sources, a glossary of key terms, and an annotated bibliography, as well as an introductory survey of research methods and discussion of new research directions emerging in response to the rapid changes in modern medicine. -/- “Philosophy needs medicine', Hillel Braude argues, 'to become more relevant'. By showing how modern medicine provides philosophers with a rich source of material for investigating issues facing contemporary society, The Bloomsbury Companion to Contemporary Philosophy of Medicine introduces the opportunities medicine offers philosophers together with the resources and skills required to contribute to contemporary debates and discussions. (shrink)

The Self We Live By confronts the serious challenges facing the self in postmodern times. Taking issue with contemporary trivializations of the self, the book traces a course of development from the early pragmatists who formulated what they called the 'empirical self', to contemporary constructionist views of the storied self. Presenting an institutional context for the increasing complexity and ubiquity of narrative identity, the authors illustrate the 'everyday technology of self construction' and idscuss the resulting moral climate. The book is (...) suitable for advanced undergraduates and graduate students in courses such as Individual in Society, Contemporary American Society, Social Psychology, Social Interaction and Culture & Personality. (shrink)

The lack of concrete guidance provided by managerial moral standards and the ambiguity of the expectations they create are discussed in terms of the moral stress experienced by many managers. It is argued that requisite clarity and feelings of obligation with respect to moral standards derive ultimately from public discussion of moral issues within organizations and from shared public agreement about appropriate behavior. Suggestions are made about ways in which the moral dimension of an organization's culture can be more effectively (...) managed. This is the third in a research series of three papers. (shrink)

As an alternative to using the concepts of emotion, fear, anger, and the like as scientific tools, this article advocates an approach based on the concepts of core affect and psychological construction, expanding the domain of inquiry beyond “emotion”. Core affect is a neurophysiological state that underlies simply feeling good or bad, drowsy or energised. Psychological construction is not one process but an umbrella term for the various processes that produce: (a) a particular emotional episode's “components” (such as facial movement, (...) vocal tone, peripheral nervous system change, appraisal, attribution, behaviour, subjective experience, and emotion regulation); (b) associations among the components; and (c) the categorisation of the pattern of components as a specific emotion. (shrink)

En este texto, se explora la historia temprana del republicanismo en América Latina por el medio de los escritos de Francisco Bilbao, uno de los intelectuales radicales chilenos más importantes del siglo XIX. El pensamiento de Bilbao sobre la cuestión del cambio revolucionario fue fuertemente influenciado por su comprensión de la tradición revolucionaria republicana francesa. Examinamos las relaciones transatlánticas que dieron forma al pensamiento de Bilbao, el desarrollo del republicanismo chileno en las secuelas de la independencia política, y las Revoluciones (...) Francesas de 1789 y 1848. Sostenemos que la “regeneración” de la república chilena se convirtió en una especie de misión histórica para Bilbao y su generación de estudiantes universitarios y jóvenes profesionales. Para llevar a cabo esta misión histórica, ellos se hicieron intermediarios entre la vanguardia del pensamiento político en el mundo Atlántico y las realidades sociales obstinadas de un Chile postcolonial. Además, mostramos cómo el radicalismo de Bilbao inspiraba un contraataque feroz por las autoridades eclesiásticas conservadores, indicando cómo la Iglesia Católica respondería a los desafíos futuros * Traducido del inglés por: José A. Bravo de Rueda, Profesor de Español Facultad de Estudios Liberales, Universidad Agrícola y Técnica del Estado de Carolina del Norte, EEUU. El presente artículo es una traducción, con cambios menores en el texto, de James A. Wood, «The republic regenerated: French and Chilean revolutions in the imagination of Francisco Bilbao, 1842-1851». En Atlantic Studies Volume 3, Issue 1, April 2006. pp. 7-23. (shrink)

The combination in the “succession narrative” of completely plausible candor about the human and confidence in the sovereign involvement of the Lord, poses the question of providence in the most profound way possible.

Today, modern Western medicine is facing a quality-of-care crisis that is undermining the patient–physician relationship. In this paper, a notion of the epistemically virtuous clinician is proposed in terms of both the reliabilist and responsibilist versions of virtue epistemology, in order to help address this crisis. To that end, a clinical case study from the literature is first reconstructed. The reliabilist intellectual virtues, including the perceptual and conceptual virtues, are then discussed and applied to the case study. Next, a similar (...) method is employed to examine the responsibilist intellectual virtues, including curiosity, courage, honesty, and humility, and to apply them to the case study. To round out the discussion, the love of knowledge and both theoretical and practical wisdom are explored and applied to the case study. The paper concludes with a brief discussion of how the notion of an epistemically virtuous clinician addresses the quality-of-care crisis, in terms of the connection between ethical and intellectual virtues, and of the notion’s implications for medical education. (shrink)

This is the first book to provide a comprehensive overview of the entire career of one of Britain's greatest men of letters. It sets in biographical and historical context all of Hume's works, from A Treatise of Human Nature to The History of England, bringing to light the major influences on the course of Hume's intellectual development, and paying careful attention to the differences between the wide variety of literary genres with which Hume experimented. The major events in Hume's life (...) are fully described, but the main focus is on Hume's intentions as a philosophical analyst of human nature, politics, commerce, English history, and religion. Careful attention is paid to Hume's intellectual relations with his contemporaries. The goal is to reveal Hume as a man intensely concerned with the realization of an ideal of open-minded, objective, rigorous, dispassionate dialogue about all the principal questions faced by his age. (shrink)

The essays contained in this volume illustrate the work of Fr. James A. Weisheipl, whose writing and teaching have resulted in important additions to our understanding of nature and motion.