The human spindle and kinetochore associated complex is required for proper mitotic progression. Extensive studies have demonstrated its important functions in both stable kinetochore-microtubule interactions and spindle checkpoint silencing. We suggest a model to explain how various Ska functions might be fulfilled by distinct pools of Ska at kinetochores. The Ndc80-loop pool of Ska is recruited by the Ndc80 loop, or together with some of its flanking sequences, and the recruitment is also dependent on Cdk1-mediated Ska3 phosphorylation. This pool seems (...) to play a more important role in silencing the spindle checkpoint than stabilizing kinetochore-microtubule interactions. In contrast, the Ndc80-N-terminus pool of Ska is recruited by the N-terminal domains of Ndc80 and appears to be more important for stabilizing kinetochore-microtubule interactions. Here, we review and discuss the evidence that supports this model and suggest further experiments to test the functioning mechanisms of the Ska complex. The human spindle and kinetochore associated complex plays essential functions in proper mitotic progression by promoting stable kinetochore-microtubule interactions and spindle checkpoint silencing. We propose that “distinct pools” of Ska—the Ndc80-loop and Ndc80-N-terminus pools—might fulfill these various functions. (shrink)
I sitt berömda bevis för tidens overklighet påstod McTaggart att det sätt händelser tycks skifta position i tiden från framtid till nutid och till förfluten tid, innebär en motsägelse. Vad McTaggart egentligen menade har varit föremål för en livlig debatt ända sedan beviset först publicerades 1908. Beviset består av två delar. I den första argumenterar McTaggart för att ingenting kan förändras förutom genom att övergå från framtid till förfluten tid. I den andra argumenterar han för att en sådan övergång innebär (...) en motsägelse och att det därför inte kan finnas någon förändring överhuvudtaget, vilket i sin tur innebär att det heller inte finns någon tid. De flesta filosofer är i dag eniga om att McTaggart har fel, men oeniga om på vilket sätt han har fel. Olika filosofer förkastar olika delar av beviset, beroende på om de har vad som kallas en A- eller B-uppfattning av tiden. De som har en A-uppfattning förnekar att tid förstådd som övergång från framtid till förfluten tid är motsägelsefull. De som har en B-uppfattning förnekar att en övergång från framtid till förfluten tid är nödvändig för förändring, men håller med om att sådan övergång är motsägelsefull. Det är min uppfattning att denna oenighet beror på att McTaggarts argument från första början blivit missuppfattat, av både A- och B-teoretiker. Av någon anledning har det alltid betraktats som ett självständigt argument, ett som är oberoende av det ontologiska system McTaggart förespråkade. Jag föreslår ett nytt sätt att förstå hur han menade att tiden är motsägelsefull. Ett sätt som tar hans ontologiska system som utgångspunkt. (shrink)
The body, the bodily condition of the human being, or embodiment as an essential aspect of the human situation in the lived world are important topics of phenomenological research and phenomenologically oriented anthropology. On the other hand, today also cognitive research and neurosciences are dealing with the topic of embodiment, mainly focusing on so-called embodied cognition. Modern neuroscience claims that both, thought and action can only be interpreted in the light of interactions between brain, body and environment. New trends in (...) phenomenology stress their familiarity with this position and focus on naturalizing phenomenology. In my view, this development disregards fundamental Husserlian claims concerning the naturalization of human subjectivity. In order to avoid such naturalizing effects, I focus on the transcendental-phenomenological interpretation of the lived body, and underline the intentional-genetic potential of Husserlian analyses. On this path, instead of relying on naturalizing embodiment, I develop a genetic understanding of the intentional embodiment of subjectivity and describe a peculiar form of intentionality as trans-bodily intentionality, thereby stressing its anthropological and socio-theoretical significance. (shrink)
Summary In opposition to the traditional empiricist understanding of phantasy as a copy of perception and therefore as a weakened form of experience, this paper interprets phantasy as an independent and creative modus of consciousness that is responsible for the individuation of the subject. The article reconstructs Husserl’s approach to phantasy as a specific kind of intentional operation as well as its relationship with mood-intentionality, bodily-kinesthetic expressivity and with hyletic anticipation as a structure of sensibility. In this way, the bi-valence (...) of human experiential orders is claimed and the concept of bodily phantasy is pointed out. This leads the phenomenological analysis closer to the psychoanalytical approach to fantasy. The latter is investigated with reference to Freud’s concept of primary processual thinking and Gaddini’s understanding of bodily phantasy as a specific individuation factor within the personal history of bonding. (shrink)
There is no unproblematic way to study things as “African”, yet an epistemologically situated approach based on concrete technological projects situated in Africa and their social and political implications offers an important account of the intersection of the Fourth Industrial Revolution and African Studies. We explore this perspective through the notion of “indiscipline” using the Square Kilometre Array radio telescope project based in South Africa as a case study through which to observe “indiscipline” as a methodological approach to technoscience at (...) work. Indiscipline helps frame the socio-technical products of astrophysics and engineering, and we present the production of ventilators for COVID-19 patients as an example of how the design of mega-science projects can become entangled with the dynamic concerns of society. Our conclusion elaborates on the politics of large technological systems, opening up a conversation on the intersection of science and society in the context of the Fourth Industrial Revolution in African settings, using the template of experiences with the SKA and the National Ventilator Project in South Africa. (shrink)
Resenha: SKA, Jean-Louis. O Antigo Testamento explicado aos que conhecem pouco ou nada a respeito dele. São Paulo: Paulus, 2015. 163p. ISBN: 978-85-349-4182-2.
Metaetiken behandlar filosofiska frågor om hur moraliska påståenden, moraliska uppfattningar, moraliska fakta och moralisk kunskap är beskaffade – liksom frågan om sådana fakta och sådan kunskap överhuvudtaget finns. I centrum för denna introduktionsbok står frågan om moralen är objektiv – hur ska denna fråga förstås och hur kan olika svar på den försvaras? I relation till denna fråga diskuteras en rad besläktade ämnen, bland annat gällande moralisk oenighet, förhållandet mellan moral och vetenskap och frågan om moraliska övertygelser kan vara mer (...) eller mindre rationella. Grundbok i metaetik är avsedd att användas vid universitetskurser i metaetik och relaterade ämnen. Framställningen kräver dock inga särskilda filosofiska förkunskaper, och boken kan därmed läsas av alla som är intresserade av ämnet. (shrink)
Contents: PART 1. MODELS IN SCIENTIFIC PROCESSES. Joseph AGASSI: Why there is no theory of models. Ma??l??gorzata CZARNOCKA: Models and symbolic nature of knowledge. Adam GROBLER: The representational and the non-representational in models of scientific theories. Stephan HARTMANN: Models as a tool for the theory construction; some strategies of preliminary physics. William HERFEL: Nonlinear dynamical models as concrete construction. Elzbieta KA??L??USZY??N??SKA: Styles of thinking. Stathis PSILLOS: The cognitive interplay between theories and models: the case of 19th century optics. PART 2. (...) TOOLS OF SCIENCE. Nancy D. CARTWRIGHT, Towfic SHOMAR, Maricio SUAREZ: The tool-box of science. Javier ECHEVERRIA: The four contexts of scientific activity. Katline HAVAS: Continuity and change; kinds of negation in scientific progress. Matthias KAISER: The independence of scientific phenomena. W??l??adys??l??aw KRAJEWSKI: Scientific meta-philosophy. Ilkka NIINILUOTO: The emergence if scientific specialities: six models. Leszek NOWAK: Antirealism, realism and idealization. Rinat M. NUGAYEV: Classic, modern and postmodern scientific unification. Veikko RANTALA: Translation and scientific change. Gerhard SCHURZ: Theories and their applications - a case of nonmonotonic reasoning. Witold STRAWI??N??SKI: The unity of science today. Vardan TOROSIAN: Are the ethic and logic of science compatible. PART 3. UNSHARP APPROACHES IN SCIENCE. Ernest W. ADAMS: Problems and prospects in a theory of inexact first-order theories. Wolfgang BALZER and Gerhard ZOUBEK: On the comparison of approximative empirical claims. Gianpierro CATTANEO, Maria Luisa DALLA CHIARA, Roberto GIUNTINI: The unsharp approaches to quantum theory. Theo A.F. KUIPERS: Falsification versus efficient truth approximation. Bernhard LAUTH: Limiting decidability and probability. Jaros??l??aw PYKACZ: Many-valued logics in foundations of quantum mechanics. Roman R. ZAPATRIN: Logico-algebraic approach to spacetime quantization. (shrink)
We describe our explicit Lorentz-invariant solution of the Einstein and null geodesic equations for the deflection experiment of 2002 September 8 when a massive moving body, Jupiter, passed within 3.7’ of a line-of-sight to a distant quasar. We develop a general relativistic framework which shows that our measurement of the retarded position of a moving light-ray deflecting body (Jupiter) by making use of the gravitational time delay of quasar’s radio wave is equivalent to comparison of the relativistic laws of the (...) Lorentz transformation for gravity and light. Because, according to Einstein, the Lorentz transformation of gravity field variables must depend on a fundamental speed c, its measurement through the retarded position of Jupiter in the gravitational time delay allows us to study the causal nature of gravity and to set an upper limit on the speed of propagation of gravity in the near zone of the solar system as contrasted to the speed of the radio waves. In particular, the v/c term beyond of the standard Einstein’s deflection, which we measured to 20% accuracy, is associated with the aberration of the null direction of the gravity force (“aberration of gravity”) caused by the Lorentz transformation of the Christoffel symbols from the static frame of Jupiter to the moving frame of observer. General relativistic formulation of the experiment identifies the aberration of gravity with the retardation of gravity because the speed of gravitational waves in Einstein’s theory is equal to the speed of propagation of the gravity force. We discuss the misconceptions which have inhibited the acceptance of this interpretation of the experiment. We also comment on other interpretations of this experiment by Asada, Will, Samuel, Pascual–Sánchez, and Carlip and show that their “speed of light” interpretations confuse the Lorentz transformation for gravity with that for light, and the fundamental speed of gravity with the physical speed of light from the quasar. For this reason, the “speed of light” interpretations are not entirely consistent with a retarded Liénard–Wiechert solution of the Einstein equations, and do not properly incorporate how the phase of the radio waves from the quasar is perturbed by the retarded gravitational field of Jupiter. Although all of the formulations predict the same deflection to the order of v/c, our formulation shows that the underlying cause of this deflection term is associated with the aberration of gravity and not of light, and that the interpretations predict different deflections at higher orders of v/c beyond the Shapiro delay, thus, making their measurement highly desirable for deeper testing of general relativity in future astrometric experiments like Gaia, SIM, and SKA. (shrink)
Vem har rätt att delta i vilka beslut? Det torde vara uppenbart att svaret på denna fråga är en viktig del av en teori om demokrati; ty är det något som alla uppfattningar om demokrati har gemensamt så är det en referens till en mängd individer, ett samhälle eller ett »folk» som är, i någon mening, självstyrande. Därför är det överraskande att inte mycket har skrivits om detta problem i de klassiska verken om demokrati. Som Robert Dahl uttrycker det, »hur (...) man ska avgöra vilka som legitimt utgör »folket» … och i kraft av detta har rätt att styra sig själva … är ett problem som nästan totalt har försummats av alla de stora politiska filosoferna som skrivit om demokrati.» (Dahl, 1970, s. 60). (shrink)
Contents: PART I. PHILOSOPHICAL EXPLANATIONS OF CREATIVITY AND CONSCIOUSNESS. Krystyna ZAMIARA: The psychological approach to creativity. A critical appraisal. Rick L. FRANKLIN: Creativity and depth in understanding. Zdzis??l??awa PIATEK: Creativity of life and F.W. Nietzsche's idea of Superman. Jaromír JANOUSEK: Dialogue and joint activity: A psychological approach. Krystyna ZAMIARA: Some remarks on Piaget's notion of "consciousness" and its importance for the studies of culture. Anna GA??L??DOWA, and Aleksander NELICKI: Attitudes towards values as a factor determining creativity. PART II. THE ROLE (...) OF CREATIVITY IN THE THEORY-BUILDING. Leszek NOWAK: On creativity in theory-building. Izabella NOWAK: Discovery and correspondence. A contribution to the idealizational approach to science. Jerzy BRZEZI??N??SKI: Research process in psychology in the context of the researcher's methodological consciousness. Andrzej FALKOWSKI: Cognitive similarity in scientific discovery: An ecological approach. PART III: CONSCIOUSNESS IN HISTORICAL PERSPECTIVE. Kathleen V. WILKES: Inside insight. Franco DI MARIA, and Gioacchino LAVANCO: History and epistemology of the unconscious. Franco DI MARIA, and Gioacchino LAVANCO: Conscious/unconscious and group-analysis. Banjamin WALLACE, Andrzej KOKOSZKA, and Deanna D. TUROSKY: Historical and contemporary thoughts on consciousness and its altered states. PART IV. BETWEEN EXPRESSION AND PROJECTION. Micha??l?? STASIAKIEWICZ: Creativity and projection: Paradigm opposition and implicit correspondence. Anna BRZEZI??N??SKA: Creative expression versus projection. PART V. THE ROLE OF PSYCHOPHYSIOLOGICAL COMPONENTS IN EXPLANATION OF PHENOMENA OF CONSCIOUSNESS AND CREATIVITY. Mario BUNGE: Explaining creativity. Piotr WOLSKI: Hemispheric asymmetry and consciousness. Is there any relationship? Andrzej KOKOSZKA: A rationale for psychology of consciousness. PSYCHOLOGICAL EXPLANATIONS OF CREATIVITY AND CONSCIOUSNESS. Santo DI NUOVO: Consciousness and attention. Tomasz MARUSZEWSKI: Two looks on consciousness. Is there any interface between philosophy of science and psychology? Marek KOWALCZYK: On the question of the functions of consciousness. Dean Keith SIMONTON: From childhood giftedness to creative genius. Magdalena FAFROWICZ, Tadeusz MAREK, and Czes??l??aw NOWOROL: Effectiveness of innovation as a function of creative style of behavior and type of leadership. Mark A. RUNCO, and Joni RADIO GAYNOR: Creativity and optimal development. (shrink)
I denna artikel skall jag mycket kortfattat och översiktligt presentera ett antal olika uppfattningar, inom samtida analytisk filosofi, om språklig mening. Jag ska försöka framhäva de mest grundläggande idéerna och de viktigaste skillnaderna i synsätt. Framställningen är organiserad kring en rad fundamentala distinktioner och meningsmotsättningar. Utrymmet tillåter inte någon mer detaljerad framställning av enskilda teorier.
Den här rapporten analyserar kortfattat Joseph H. Carens senaste bok, The Ethics of immigration. Den inledande delen av dokumentet berör de grundläggande principerna från boken och hur Carens härleder sin utvärdering av olika immigrations och integrations principer från Ius Soli inom ett liberalt demokratiskt ramverk. Den andra delen behandlar bokens huvudsakliga metodologiska område, detta är den dualistiska strukturen Carens använder och hur den ska bli förstådd med hans givande bidrag. Slutligen kommer dokumentet undersöka den milda anti-cosmopolitan attityden Carens håller och (...) dess implikationer. (shrink)
