It is estimated that one in ten U.S. adults suffers from chronic insomnia. If left untreated, chronic insomnia reduces quality of life and increases risk for psychiatric and medical disease, especially depression and anxiety. There are two forms of insomnia: secondary insomnia, in which it is comorbid with another condition such as psychiatric disorders, chronic pain conditions, or cardiopulmonary disorders, and primary insomnia, which does not coexist with any other disorder. This treatment program uses cognitive-behavioral therapy methods to correct poor (...) sleep habits. CBT has been proven in multiple studies to improve sleep hygiene by reducing time spent in bed before sleep onset, reducing time spent awake after first sleep onset, and increasing the quality and efficiency of sleep. Developed by the authors, this evidence based treatment can be used for both primary and secondary insomnia sufferers. Patients are first given information about healthy sleep and the reasons for improving sleep habits, then a behavioral program is developed to address that patient's specific sleep problems. Use of sleep logs, assessment forms, and other homework allows client and therapist to work together to develop an effective sleep regimen tailored specifically for each client. Finally, several sessions are dedicated to increasing compliance and problem-solving.TreatmentsThatWork represents the gold standard of behavioral healthcare interventions!BL All programs have been rigorously tested in clinical trials and are backed by years of researchBL A prestigious scientific advisory board, led by series Editor-In-Chief David H. Barlow, reviews and evaluates each intervention to ensure that it meets the highest standard of evidence so you can be confident that you are using the most effective treatment available to dateBL Our books are reliable and effective and make it easy for you to provide your clients with the best care availableBL Our corresponding workbooks contain psychoeducational information, forms and worksheets, and homework assignments to keep clients engaged and motivatedBL A companion website offers downloadable clinical tools and helpful resourcesBL Continuing Education Credits are now available on select titles in collaboration with PsychoEducational Resources, Inc. (shrink)

In a recent article in Philosophy Professor Knox makes a plea for a philosophic treatment of economic activity by way of contrast to either the specialized study of economic history or of economic science. The conclusion which was reached was embodied in the statement that “the historical and scientific methods of the study of economic activity leave incompletely satisfied the curiosity of students , and reach results which need special interpretation before they can be useful to politicians, let alone to (...) business men” . Each of these methods is said to involve unreal abstractions which detract from the usefulness of the study. A philosophic. (shrink)

Nussbaum misconstrues the difference between Plato and Aristotle over what is real for a debate over a conception of truth. She seems to mistake Aristotle's arguments against Plato' version of realism as an argument against realism per se, though the texts do not permit such a reading. She claims Aristotle is convinced that realism involves a fatal “failure of reference,” yet she produces not a single text where Aristotle is even remotely concerned about such a failure of reference given the (...) commitments of realism. And nowhere is the crucial question of the relationship between Aristotle's antirealism and his method of appearances explicitly addressed or resolved.Nussbaum offers us a fashionable Aristotle. I have argued that, far from being attractive and obviously right on a deep and recent metaphysuical debate, Nussbaum's Aristotle is confused and inconsistent and thus that it is a good thing the texts do not support such a characterization. (shrink)

Near the end of the long and often convoluted discussion of freedom in the chapter ‘Of Power’ in An Essay concerning Human Understanding, Locke states that in ‘The care of ourselves, that we mistake not imaginary for real happiness, is the necessary foundation of our liberty’. He goes on to explain that ‘we are by the necessity of preferring and pursuing true happiness as our greatest good, obliged to suspend the satisfaction of our desire in particular cases’. Locke then adds (...) that the ability to suspend our desires in particular cases is ‘the hinge on which turns the liberty of intellectual Beings’. Unfortunately, this hinge has proved a serious stumbling block for commentators. After three hundred years, serious scholarly disagreement remains about even the central orientation of Locke’s views on freedom. Locke was aware of the opacity surrounding portions of his discussion of liberty. In letters to several correspondents, he confesses to almost leaving it out of the first edition, fearing that ‘the novelty and subtlety of the matter itself... [would be taken] as the paradoxes of an innovator or the stumblings of an ill-advised wanderer’. As evidence that his worries were not far wrong, Locke adds that amongst his friends, ‘more have entered into discussion with... [me] about this one subject than about all the remaining chapters of the book’. My entry into this controversy will be by way of Leibniz, one of Locke’s earliest and most astute commentators. (shrink)

Understanding Everyday Life All of sociology necessarily begins with the understanding of everyday life, and all of sociology is directed either to ...

In addition, this volume can be used in courses specifically dealing with ethnomethodology, in graduate seminars dealing with these issues, and in academic work ...

This collection of ten original essays was first published in 1977. It engages the 'crisis in sociology' at the most fundamental level of thought and experience. Existential sociology is defined as the study and understanding of all forms of human existence. Without seeking to erect a pristine philosophical sanctuary of its own, Existential Sociology examines and criticizes the underlying philosophical assumptions of previous theories of social science, while elaborating its own approach to human understanding. The contributors are concerned with constructing (...) practical as well as theoretical truths about social life - how we feel, think and act. In contrast to most other sociologies, the emphasis is on the independence and dominance of human feelings over the evaluative and cognitive features of social actions. Students and teachers of sociology and people in related fields interested in the connection between social science and their own subjects will find Existential Sociology useful and absorbing. (shrink)

Leibniz devoted immense energy and thought to questions concerning moral responsibility and human freedom. This paper examines Leibniz’s views on freedom and sin in two important early texts - “Von der Allmacht Allmacht und Allwissenheit Gottes und der Freiheit des Menschen” and “Confessio Philosophi” - as a propaedeutic to a detailed examination of the development of Leibniz’s views on freedom and sin. In particular, my aim is to see if Leibniz’s early thinking on freedom and sin in these early writings (...) was among those metaphysical topics about which he changed his mind. My focus is on human, not divine, freedom, and the young Leibniz’s metaphysical psychology, rather than his early efforts in theodicy. I conclude that Leibniz’s views on freedom and sin are in place as early as 1672/3, and remain relatively stable thereafter. (shrink)

Commentators have long been fascinated by the problem of freedom in Leibniz's system. Many of the recent studies begin with Leibniz's views on modality, truth, and so-called superessentialism, and then investigate whether these doctrines are compatible with freedom and contingency. There is, however, another dimension to Leibniz's thinking about freedom that has been largely overlooked in the recent literature. ;Leibniz inherited a medieval debate about God's foreknowledge of and providence over human free actions, and unlike the other great philosophers of (...) the early modern period, set out to solve it. This means the problem of human freedom for Leibniz was nested in the larger problem of God's creation, preservation, and governance of the entire created order. ;In this dissertation I set out the late medieval debate and Leibniz's adjudication of it. I argue that Leibniz offers a strong notion of providence that is a via media between the two competing paradigms of the late seventeenth century, Molinism and Banezianism. In light of these theological commitments, I offer a new assessment of Leibniz's views of divine and human freedom. (shrink)

The present study investigated the influence of emotional stimuli in the flanker task. In six experiments, separate influences of anticipating and reacting to valence-laden stimuli (affective pictures or facial expressions) on the flanker effect and its sequential modulation (also known as conflict adaptation) were examined. The results showed that there was little evidence that emotional stimuli influenced cognitive control when positive and negative stimuli appeared randomly during the flanker task. When positive and negative stimuli were separated between different participant groups (...) in order to exclude a possible contamination from the effect of one valence to that of another, the sequential modulation was reduced when valence-laden stimuli were anticipated or had been presented on a preceding trial, regardless of the valence of the stimuli. A similar pattern was also obtained with facial expressions but only for response accuracy and only after valence-laden stimuli were presented on a preceding trial. The influences of anticipating and reacting to emotional stimuli were only partially replicated in the final two experiments where the arousal and valence of affective pictures were manipulated orthogonally. The lack of consistent influences of emotional stimuli on the flanker effect challenges the existing theories that implicate affective contributions to cognitive control. (shrink)

RNA localization is a powerful strategy used by cells to localize proteins to subcellular domains and to control protein synthesis regionally. In germ cells, RNA targeting has profound implications for development, setting up polarities in genetic information that drive cell fate during embryogenesis. The frog oocyte offers a useful system for studying the mechanism of RNA localization. Here, we discuss critically the process of RNA localization during frog oogenesis. Three major pathways have been identified that are temporally and spatially separated (...) in oogenesis. Each pathway uses a different mechanism to effect RNA localization. In some cases, localization elements within the 3' untranslated region have been identified and have provided unique insights into the localization process. This important field is still in its infancy, however, and much remains to be learned. BioEssays 21:546–557, 1999. © 1999 John Wiley & Sons, Inc. (shrink)

This chapter contains sections titled: Moral Argument Science and Health Argument Social Policy Argument.

Digital phenotyping is the term given to the capturing and use of user log data from health and wellbeing technologies used in apps and cloud-based services. This paper explores ethical issues in making use of digital phenotype data in the arena of digital health interventions. Products and services based on digital wellbeing technologies typically include mobile device apps as well as browser-based apps to a lesser extent, and can include telephony-based services, text-based chatbots, and voice-activated chatbots. Many of these digital (...) products and services are simultaneously available across many channels in order to maximize availability for users. Digital wellbeing technologies offer useful methods for real-time data capture of the interactions of users with the products and services. It is possible to design what data are recorded, how and where it may be stored, and, crucially, how it can be analyzed to reveal individual or collective usage patterns. The paper also examines digital phenotyping workflows, before enumerating the ethical concerns pertaining to different types of digital phenotype data, highlighting ethical considerations for collection, storage, and use of the data. A case study of a digital health app is used to illustrate the ethical issues. The case study explores the issues from a perspective of data prospecting and subsequent machine learning. The ethical use of machine learning and artificial intelligence on digital phenotype data and the broader issues in democratizing machine learning and artificial intelligence for digital phenotype data are then explored in detail. (shrink)

Based on brain imaging findings, we present a model according to which addiction emerges as an imbalance in the information processing and integration among various brain circuits and functions. The dysfunctions reflect (a) decreased sensitivity of reward circuits, (b) enhanced sensitivity of memory circuits to conditioned expectations to drugs and drug cues, stress reactivity, and (c) negative mood, and a weakened control circuit. Although initial experimentation with a drug of abuse is largely a voluntary behavior, continued drug use can eventually (...) impair neuronal circuits in the brain that are involved in free will, turning drug use into an automatic compulsive behavior. The ability of addictive drugs to co‐opt neurotransmitter signals between neurons (including dopamine, glutamate, and GABA) modifies the function of different neuronal circuits, which begin to falter at different stages of an addiction trajectory. Upon exposure to the drug, drug cues or stress this results in unrestrained hyperactivation of the motivation/drive circuit that results in the compulsive drug intake that characterizes addiction. (shrink)

The foremost Italian philosopher of the first half of the 20th century, Croce's influence extended to every aspect of Italian intellectual life. This collection explores the depth, originality, and significance of his thought.

Sophie de Grouchy, marquise de Condorcet, réinterprète la doctrine de la sympathie propre à la tradition moraliste écossaise dans le sens d’une réévaluation de ses origines physiologiques, ce qui affecte profondément ses dimensions morales et sociales. Dans le cadre d’un rousseauisme compassionnel, elle transforme Adam Smith en un républicain sentimentaliste modéré, précurseur des Idéologues. Elle s’emploie pour cela à montrer que la déférence envers le pouvoir établi, surtout la royauté, érigée par Adam Smith en servilité quasi fétichiste envers les puissants (...) et les rois, doit être réexaminée dans le cadre d’une économie affective post-révolutionnaire. Malgré le risque d’un mimétisme affectif enflammé par une rhétorique démagogique, Sophie de Grouchy mise sur la moralisation de l’identification avec la souffrance humaine, et sur sa régulation par des lois et institutions réformées pour tenir compte d’une nature humaine profondément sympathique. L’institutionnalisation de la sympathie morale est censée porter remède aux tragédies dues à la ségrégation sociale. En revanche, Adam Smith souligne à la fois la corruption morale due à l’adulation des puissants, et l’illusion socialement utile d’un imaginaire collectif cultivé par la tragédie classique et peuplé d’idéalisations du statut social. Adam Smith explore en outre d’une façon originale une dimension quasi psychanalytique de l’idéal social du moi qui anticipe la problématisation du culte du chef, là où la marquise se contente de critiquer le meneur de foule. (shrink)

Biology lacks a central organism concept that unambiguously marks the distinction between organism and non-organism because the most important questions about organisms do not depend on this concept. I argue that the two main ways to discover useful biological generalizations about multicellular organization—the study of homology within multicellular lineages and of convergent evolution across lineages in which multicellularity has been independently established—do not require what would have to be a stipulative sharpening of an organism concept.

In this article we address torture in military and police organizations as a public health and human rights challenge that needs to be addressed through multiple levels of intervention. While most mental health approaches focus on treating the harmful effects of such violence on individuals and communities, the goal of the project described here was to develop a primary prevention strategy at the institutional level to prevent torture from occurring in the first place. Such an approach requires understanding and altering (...) the conditions that cause and sustain “atrocity producing situations”. Given the persistence of torture across the world and its profound health consequences, this is an increasingly important issue in global health and human rights. (shrink)

Based on A. P. D. Mourelatos's "Events, Processes, and States", an overview of the literature on „verb types‟ is provided in this paper;the basic conceptual, logical and grammatical tests for the identification of different verb types are also briefly reviewed.Such tests, it is argued, reveal variations in a verb’s grammatical and/or lexical aspect; accordingly, verb types should be viewed as regularities governing aspectual variation within and across sentences. Verb types are not associated with particular verbs, predicates or sentences; rather, a (...) verb type is the sum of ways in which a verb‟s aspect may vary. In other words, verb types describe the possibilities for a verb to appear in one or another of a series of interrelated constructions. Verb types are verbal possibilities or, to use B. L. Whorf‟s apt term, fashions of speaking which cut across typical grammatical classifications. It is further argued that verb types, as “mere” fashions of speaking, cannot provide a firm basis for any metaphysics of „situation types‟; i.e., the metaphysics of verb types cannot be founded on their linguistics. (shrink)

In spite of advances in medicine and public health, malaria and other mosquito‐borne diseases are on the rise worldwide. Although vaccines, genetically modified mosquitoes and safer insecticides are under development, herein we examine a promising new approach to malaria control through better repellents. Current repellents, usually based on DEET, inhibit host finding by impeding insect olfaction, but have significant drawbacks. We discuss how comparative genomics, using data from the Anopheles genome project, allows the rapid identification of members of three protein (...) classes critical to insect olfaction: odorant‐binding proteins, G‐protein‐coupled receptors, and odorant‐degrading enzymes. A rational design approach similar to that used by the pharmaceutical industry for drug development can then be applied to the development of products that interfere with mosquito olfaction. Such products have the potential to provide more complete, safer and longer lasting protection than conventional repellents, preventing disease transmission by interrupting the parasite life cycle. BioEssays 25:1011–1020, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

Abstract: In this paper we argue that Robert Kane’s theory of free will cannot accommodate the possibility of a sinless individual who faces morally significant choices because a sinless agent cannot voluntarily accord value to an immoral desire, and we argue that Kane’s theory requires this. Since the Jesus of the historic Christian tradition is held to be sinless, we think Christians should reject Kane’s theory because it seems irreconcilable with historic Christian Christology. We consider two objections to our argument (...) and argue that both fail. (shrink)

The conventional paradigm for developing new treatments for disease mainly involves either the discovery of new drug targets, or finding new, improved drugs for old targets. However, an ion channel found only in invertebrates offers the potential of a completely new paradigm in which an established drug target can be re‐engineered to serve as a new candidate therapeutic agent. The L‐glutamate‐gated chloride channels (GluCls) of invertebrates are absent from vertebrate genomes, offering the opportunity to introduce this exogenous, inhibitory, L‐glutamate receptor (...) into vertebrate neuronal circuits either as a tool with which to study neural networks, or a candidate therapy. Epileptic seizures can involve L‐glutamate‐induced hyper‐excitation and toxicity. Variant GluCls, with their inhibitory responses to L‐glutamate, when engineered into human neurons, might counter the excitotoxic effects of excess L‐glutamate. In reviewing recent studies on model organisms, it appears that this approach might offer a new paradigm for the development of candidate therapeutics for epilepsy. (shrink)