BackgroundHIV cure research involving cell and gene therapy has intensified in recent years. There is a growing need to identify ethical standards and safeguards to ensure cell and gene therapy (CGT) HIV cure research remains valued and acceptable to as many stakeholders as possible as it advances on a global scale.MethodsTo elicit preliminary ethical and practical considerations to guide CGT HIV cure research, we implemented a qualitative, in-depth interview study with three key stakeholder groups in the United States: (1) biomedical (...) HIV cure researchers, (2) bioethicists, and (3) community stakeholders. Interviews permitted evaluation of informants’ perspectives on how CGT HIV cure research should ethically occur, and were transcribed verbatim. We applied conventional content analysis focused on inductive reasoning to analyze the rich qualitative data and derive key ethical and practical considerations related to CGT towards an HIV cure.ResultsWe interviewed 13 biomedical researchers, 5 community members, and 1 bioethicist. Informants generated considerations related to: perceived benefits of CGT towards an HIV cure, perceived risks, considerations necessary to ensure an acceptable benefit/risk balance, CGT strategies considered unacceptable, additional ethical considerations, and considerations for first-in-human CGT HIV cure trials. Informants also proposed important safeguards to developing CGT approaches towards an HIV cure, such as the importance of mitigating off-target effects, mitigating risks associated with long-term duration of CGT interventions, and mitigating risks of immune overreactions.ConclusionOur study identified preliminary considerations for CGT-based HIV cure across three key stakeholder groups. Respondents identified an ideal cure strategy as one which would durably control HIV infection, protect the individual from re-acquisition, and eliminate transmission to others. Known and unknown risks should be anticipated and perceived as learning opportunities to preserve and honor the altruism of participants. Preclinical studies should support these considerations and be transparently reviewed by regulatory experts and peers prior to first-in-human studies. To protect the public trust in CGT HIV cure research, ethical and practical considerations should be periodically revisited and updated as the science continues to evolve. Additional ethics studies are required to expand stakeholder participation to include traditionally marginalized groups and clinical care providers. (shrink)

The paper focuses on the current conditions of the Shoah’s memory transmission. The purpose is to point out the frames where a contemporary theory and praxis of the collective memory can be formulated. The first section, reffering to most recent studies, shows both components caracterizing today’s process of memorizing the Shoah: the passagge from memory to post-memory (Hirsh) and the whirling increase of the chance to record and reproduce the past (Derrida, Ferraris). In the second secion, referring to this theoretical (...) frame, I analyse the radical trasformations of the monument as the traditional media of the european public memory. The reference to the empirical case of the Denkmal für die ermordeten Juden Europas, the Shoah’s Memorial designed by Peter Eisenman, underlines the shift from monument to counter-monument (Young, J. E.) by materializing both the troubles and an inventive strategy to exit the saturation of the current memorial speech. (shrink)

L’objectif de cet article est d’évaluer le sens et la portée de la locution autourgous tês philosophias, qui apparaît dans le Banquet I, 5. J’espère montrer que cette locution en dit plus qu’elle n’en a l’air prima facie. Je soutiendrai que l’ensemble du passage dépasse la simple opposition entre la ( philo ) sophia gratuite de Socrate et la sophia non gratuite des sophistes, d’une part, et la richesse de Callias et la pauvreté des socratiques, d’autre part. Mon point de (...) départ sera le prologue du Banquet, suivi d’une analyse des Mémorables I, 6, texte où l’on trouve une conception de philosophia en tant que diaita ; j’analyserai ensuite les textes du corpus xénophontien où figure le mot autourgos, lui aussi associé à la notion de diaita. Ce parcours analytique montrera qu’il y a deux visions de la philosophie en jeu dans le Banquet I, 5 : celle de Callias, qui croit que Socrate et les siens ont les âmes purifiées, mais qui, en même temps, ne comprend pas tout à fait leur pratique philosophique, et celle de Socrate qui, dans sa réplique à la provocation de Callias, lui présente de manière condensée sa vision de la philosophie. (shrink)

. The uniform prior distribution is often seen as a mathematical description of noninformativeness. This paper uses the well-known Three Prisoners Paradox to examine the impossibility of maintaining noninformativeness throughout hierarchization. The Paradox has been solved by Bayesian conditioning over the choice made by the Warder when asked to name a prisoner who will be shot. We generalize the paradox to situations of N prisoners, k executions and m announcements made by the Warder. We then extend the consequences of hierarchically (...) placing uniform and symmetrical priors for the probability p of the Warder naming Prisoner B, say. We prove that breaks of indifference and neutrality caused by assignment of uniform and symmetrical priors in lieu of degenerate indifference probabilities hold in general. Speaking of unknown probabilities or of probability of a probability must be forbidden as meaningless. Bruno de Finetti, 1977 I regard the use of hierarchical chains as a technique helping you to sharpen your subjective probabilities. I. J. Good, 1981. (shrink)

Although recent empirical research suggests that there is a gender gap in Anglophone philosophy, no research has been done on the representation of women in non‐Anglophone philosophy. The present study constitutes a first step toward filling this void in the literature by providing empirical evidence on the representation of female students and female faculty members in Greek universities' departments of philosophy. Our findings indicate that the underrepresentation of female students in philosophy is not a universal phenomenon, since female students constitute (...) the majority of philosophy students in Greece at both the undergraduate and the graduate levels. However, our findings also suggest that the low number of women in philosophy at the faculty level is not a problem unique to Anglophone philosophy, since female faculty members comprise, on average, only 29% of philosophy faculty members in Greece. In order to explain these findings, we argue, first, that the teaching of philosophy at the secondary level may motivate female students in Greece to enter and persist in philosophy, and, second, that since the gender gap at the faculty level in Greece cannot be attributed to the low number of female students in the philosophy pipeline, the causes of women's poor participation in philosophy at the faculty level should be looked for elsewhere. (shrink)

A presente proposta tem como objetivo dialogar sobre o papel social da religião e sua relação com o desrespeito à alteridade no espaço escolar. Partindo do conceito de Lévinas sobre alteridade, buscar-se-á analisar a relação conflituosa existente entre alunos adeptos de religiões de matriz africana e alunos que professam outra religião, buscando assim refletir para sobre o papel do professor nesses casos. Discussões como estas se fazem necessárias, pois buscam meios para amenizar esses conflitos; para isso, fundamenta-se em pensadores que (...) abordam a importância da não banalização do outro e da valorização das religiões de matriz africana, compreendendo que as mesmas fazem parte da realidade dos alunos e que, por muito tempo, foram inviabilizadas, demonizadas e hoje ainda passam por um processo de não aceitação por parte da sociedade, neste caso no meio escolar. Parte deste artigo foi apresentado durante o I Colóquio Internacional Bullying Submerso: Religião e Etnicidade na Escola, promovido pelo Programa de pós Graduação em Ciências da Religião da Pontifícia Universidade Católica de Goiás, em outubro de 2015, e é fruto de pesquisas realizadas[1] no doutorado e de vivências enquanto professora de 1° e 2° fase da rede estadual da mesma cidade, e como umbandista Omó Ifá e abiã de orisá. [1] Essa pesquisa não recebeu financiamento, porém, parte dela foi realizada durante os estudos de doutorado. (shrink)

Background:Moral distress is considered to be the negative feelings that arise when one knows the morally correct response to a situation but cannot act because of institutional or hierarchal constraints.Objectives:To analyze moral distress and its relation with sociodemographic and academic variables in undergraduate students from different universities in Brazil.Method:Quantitative study with a cross-sectional design. Data were collected through the Moral Distress Scale for Nursing Students, with 499 nursing students from three universities in the extreme south of Brazil answering the scale. (...) The data were analyzed in the statistical software SPSS version 22.0, through descriptive statistical analysis, association tests (t-test and analysis of variance), and linear regression models.Ethical considerations:Approval for the study was obtained from the Research Ethics Committee at Universidade Federal do Rio Grande.Findings:The mean intensity of moral distress in the constructs ranged from 1.60 to 2.55. As to the occurrence of situations leading to moral distress in the constructs, the frequencies ranged from 1.21 to 2.43. The intensity level of moral distress showed higher averages in the more advanced grades of the undergraduate nursing course, when compared to the early grades of this course (between 5 and 10 grade, average = 2.60–3.14, p = 0.000).Conclusion:The demographic and academic characteristics of the undergraduate nursing students who referred higher levels of moral distress were being enrolled in the final course semesters, were at a federal university, and had no prior degree as an auxiliary nurse/nursing technician. (shrink)

Metaphysical realism about mental disorder is the thesis that mental disorder exists mind-independently. There are two ways to challenge metaphysical realism about mental disorder. The first is by denying that mental disorder exists. The second is by denying that mental disorder exists mind-independently. Or, differently put, by arguing that mental disorder is mind-dependent. The aim of this paper is three-fold: (a) to examine three ways in which mental disorder can be said to be mind-dependent (namely, by being causally dependent on (...) the human mind, by being weakly dependent on human attitudes, and by being strongly dependent on human attitudes), (b) to clarify their differences, and (c) to discuss their implications regarding metaphysical realism about mental disorder. I argue that mental disorder being mind-dependent in the first two senses is compatible with metaphysical realism about mental disorder, whereas mental disorder being mind-dependent in the third sense is not. (shrink)

Philosophy courses help students develop logical reasoning and argument skills or so it is widely assumed. To test if this is actually the case, we examined university students’ familiarity with the basic tools for argument. Our findings, based on a sample of 651 students enrolled in philosophy courses at six Greek universities, indicate that students who have prior experience with philosophy are more familiar with the basic tools for argument, and that students who have taken philosophy courses at the university (...) have stronger argument-recognition and argument-evaluation skills compared to university students with no prior experience with philosophy. Moreover, our findings suggest that students get more familiar with the basic tools for argument as their level of engagement with philosophy increases, and that they get significantly better at evaluating arguments when they become graduate students in philosophy. However, our findings also suggest that the majority of students in philosophy classrooms haven’t developed fluency in basic argument-related concepts and skills. To remedy this, we argue that philosophy instructors need to re-think the place that the teaching of argument has in philosophy courses, and the way that they teach students about argument. (shrink)

Although there is a growing acknowledgement of the potential of a more nuanced healthcare paradigm and practice, the discourses of health promotion—and with that nursing and other healthcare professionals’ practice—still tend to focus on the medical diagnosis, disease and the rationale of biomedicine. There is a need for shifting to a human practice that draws on a broader perspective related to illness. This requires a transformation of practices which can be constructed within a narrative understanding. A narrative approach appreciates the (...) importance of emotion and intersubjective relation in the telling and listening that occur in the clinical encounter. The essence of nursing lies in the creative imagination, the sensitive spirit and the intelligent understanding of the individuals’ possibilities of becoming empowered in his or her own life. This entails that the focus of the use of patients’ narratives is, ultimately, not the story itself, but the nurses’ and other healthcare professionals’ ability to support the patients in finding useful meaning in their stories. Herein, it is of particular importance to let the patients narrate about what is sparkling moments or events in the lived life. Stories with such focus can open up for patients’ hopes and dreams, which gives inspiration for finding meaningful ways to cope in life empowering personal recovery. It is, therefore, crucial to transform clinical settings into places that acknowledge the need for imagination and creativity, aiming at creating the opportunity for sensibility and vision essential to encouraging a narrative approach and thereby the ability to reflect upon and promote a healing process. (shrink)

Proceeding on a limited number of general, widely accepted equity criteria, we develop a proposal for distributing common resources. In particular, the proposed fair division mechanism is individually rational, envy-free, Pareto-efficient and satisfies the stand alone test, which follows as a minimum requirement from the resource and population monotonicity criteria. Applied to international climate policy, the thrust of this proposal is that the South should initially be fully compensated for the greenhouse gas abatement measures it is to undertake as a (...) result of efficiency considerations. (shrink)

Consequence is at the heart of logic, and an account of consequence offers a vital tool in the evaluation of arguments. This text presents what the authors term as 'logical pluralism' arguing that the notion of logical consequence doesn't pin down one deductive consequence relation; it allows for many of them.

Im Beitrag wird ausgeführt, wie Krisensituationen wie die Coronapandemie Zirkel der Entgrenzung von Misstrauen, Projektionen und Spaltungen in Gang bringen können. Im Zuge dessen werden dann auch individuelle Pathologie und psychische Desintegration, wie sie sich zum Beispiel in Verfolgungsängsten zum Ausdruck bringen, kollektiv neu gerahmt und damit normalisiert. Anhand von Befunden einer Pilotstudie werden entsprechende Dynamiken nachgezeichnet, und es wird aufgezeigt, welche psychosozialen Funktionen der Triumph des Misstrauens erlangen kann.

No final do prólogo do Fédon, há uma tensão entre desejo de morte e proibição do suicídio entendida por Cebes como um contrassenso manifesto. Contudo, o que se mostra um disparate é na realidade o recurso platônico para introduzir grandes temas que serão trabalhados ao longo do diálogo. Delinear-se-á, numa curiosa trama de mythos e lógos, um ponto crucial que reverbera no restante do diálogo e que possui, com efeito, grande envergadura para o pensamento filosófico e religioso posterior: trata-se do (...) passo 62b, no qual se diz que “nós homens estamos numa certa de phrourá”. Como entender essa afirmação, cuja obscuridade é reconhecida pelo próprio Sócrates? Parece-nos que a compreensão desse passo depende da interpretação e, por conseguinte, da tradução que se dá para o termo phrourá. Afinal, trata-se de prisão, cárcere, custódia, posto, ou serviço de guarda? Devido às muitas controvérsias que esse vocábulo tem causado desde a Antiguidade, e na confiança de que essa discussão ainda está longe de encontrar seu termo, este artigo tem como objetivo não só analisar a semântica desse vocábulo grego, mas também articulá-la com o passo no qual está inserida. E o pano de fundo: uma visão religiosa particular que afirma o divino ser o que cuida dos homens. Em suma, espera-se que esse debate proporcione recursos para novas pesquisas e reflexões férteis sobre a filosofia platônica. (shrink)

In order to highlight the intimate relationship between imagining, drawing and making worlds, this essay questions the educational meaning of children to initiate in the action of drawing in face of the growing cultural tendency of the body being less and less required to produce senses. The incarnated action of drawing, as an aesthetic action of touching and being touched by the world when transposing the visible limits and entering into the intimacy of worldly invisibility, constitutes an experience that is (...) as recurrent and trivialized in school daily life as it is existentially complex due to its poetic power to enter the invisible and inaugurate worldviews. The historical disqualification of the image and imagination in Western thought, supported by the separation between subjectivity of the body and objectivity of the world, does not allow educational thought to consider the phenomenon of poetic imagination as an existential experience of language insertion in the world from the gesture of drawing. Gesture that finds its specificity in the instant the hand traces and inscribes lines on the surface of the supports as infinitely creative writing. The aesthetic gesture of drawing, temporalized by the rhythm of the body in the emergence of the fabulation that accompanies the repetition of the marks, implies a poetic experience of language that involves the fusion of two senses: that of the gesture in materiality and that of the mark configured in it, marked and cicatrized in the surface of the support by the body’s action that performed it. The approximation between education, arts and childhood allows us to highlight the philosophical and pedagogical tensions that involve the question of poetic imagination and to take another look at the action of drawing in the context of children's education. What emerges, from the dialogue between Gaston Bachelard, Maurice Merleau-Ponty and Jean-Luc Nancy, is the relevance of the educational intention of caring for the vital function of language as an aesthetic and poetic experience that is constituted in the processuality of the body to make something appear that produces and contains presence, that which promotes and expands the existential density of the real. (shrink)

What happens when someone acts? A familiar answer goes like this. There is something that the agent wants, and there is an action that he believes conducive to its attainment. His desire for the end, and his belief in the action as a means, justify taking the action, and they jointly cause an intention to take it, which in turn causes the corresponding movements of the agent's body. I think that the standard story is flawed in several respects. The flaw (...) that will concern me in this paper is that the story fails to include an agent-or, more precisely, fails to cast the agent in his proper role. (shrink)

Providing an original and systematic treatment of foundational issues in philosophy of religion, J. L. Schellenberg's new book addresses the structure of..

Abstract I argue that meaning in life is importantly influenced by bioloical ties. More specifically, I maintain that knowing one's relatives and especially one's parents provides a kind of self-knowledge that is of irreplaceable value in the life-task of identity formation. These claims lead me to the conclusion that it is immoral to create children with the intention that they be alienated from their bioloical relatives?for example, by donor conception.

Retributive theories of punishment argue that punishing a criminal for a crime she committed is sufficient reason for a justified and morally permissible punishment. But what about when the state gets lucky in its decision to punish? I argue that retributive theories of punishment are subject to “Gettier” style cases from epistemology. Such cases demonstrate that the state needs more than to just get lucky, and as these retributive theories of punishment stand, there is no anti-luck condition. I’ll argue that (...) Gettier-style cases demonstrate an impermissible instance of punishment, even though they meet the conditions of retributive theories of punishment. Retributive theories are, therefore, too weak. The safety condition from epistemology provides the anti-luck condition needed for permissible punishment. I argue that two forms of retributivism, rights-forfeiture and what I call standard retributivism, are both subject to Gettier-style cases. Unlike the literature on standards of proof, this paper argues that safety is a condition on punishment itself, i.e., in all nearby possible worlds, the accuser must correctly accuse the convicted for the crime they actually committed. (shrink)

Supervaluationism is often described as the most popular semantic treatment of indeterminacy. There’s little consensus, however, about how to fill out the bare-bones idea to include a characterization of logical consequence. The paper explores one methodology for choosing between the logics: pick a logic thatnorms beliefas classical consequence is standardly thought to do. The main focus of the paper considers a variant of standard supervaluational, on which we can characterizedegrees of determinacy. It applies the methodology above to focus ondegree logic. (...) This is developed first in a basic, single-premise case; and then extended to the multipremise case, and to allowdegreesof consequence. The metatheoretic properties of degree logic are set out. On the positive side, the logic is supraclassical—all classical valid sequents are degree logic valid. Strikingly, metarules such as cut and conjunction introduction fail. (shrink)

J.L. Schellenberg offers a path to a new kind of religious outlook. Reflection on our early stage in the evolutionary process leads to skepticism about religion, but also offers a new answer to the problem of faith and reason, and the possibility of a new, evolutionary form of religion.

v. 1. Nicomachean ethics. Politics. The Athenian Constitution. Rhetoric. On Poetics.--v. 2. Logic.--v. 3. Physics. Metaphysics. On the soul. Short physical treaties.--v. 4. On the heavens. On generation and corruption. Meteorology. Biological treatises.

This paper focuses on the question of whether divine passibility is metaphysically possible using the work of Hartshorne, Creel, Shields, Taliaferro and Sarot. Passibilism is seen to be difficult to assert because of the problem of radical particularity, which is the problem of how God might feel in exactitude the experience of many diverse creatures which are radically particular while also feeling different experiences of other equally radically particular beings. I conclude that the question of passibility is an unresolved problem (...) and should be addressed from the perspective of specific attributes of God such as omniscience and omnipresence. (shrink)

This paper offers an alternate explanation of cases from the doxastic wronging literature. These cases violate what I call the degree of inquiry right—a novel account of zetetic obligations to inquire when interests are at stake. The degree of inquiry right is a moral right against other epistemic agents to inquire to a certain threshold when a belief undermines one’s interests. Thus, the agents are sometimes obligated to leave inquiry open. I argue that we have relevant interests in reputation, relationships, (...) and the well-being of our social groups. These interests generate obligations against others to “do their homework” before closing inquiry. This alternate account makes better sense of puzzles that accounts of doxastic wronging fall prey to. (shrink)

The aim of this paper is to elaborate on the phenomenological approach to expertise as proposed by Dreyfus and Dreyfus and to give an account of the extent to which their approach may contribute to a better understanding of how athletes may use their cognitive capacities during high-level skill execution. Dreyfus and Dreyfus's non-representational view of experience-based expertise implies that, given enough relevant experience, the skill learner, when expert, will respond intuitively to immediate situations with no recourse to deliberate actions (...) or mental representations. The paper will subsequently outline some implications and consequences of such an approach and will also examine to what extent Dreyfus and Dreyfus's skill model is capable to resist different attacks that have been made against their view, and in particular regarding the practical application of their approach to the skill domain of competitive sport. (shrink)