Perfect adaptation in a dynamical system is the phenomenon that one or more variables have an initial transient response to a persistent change in an external stimulus but revert to their original value as the system converges to equilibrium. With the help of the causal ordering algorithm, one can construct graphical representations of dynamical systems that represent the causal relations between the variables and the conditional independences in the equilibrium distribution. We apply these tools to formulate sufficient graphical conditions for (...) identifying perfect adaptation from a set of first-order differential equations. Furthermore, we give sufficient conditions to test for the presence of perfect adaptation in experimental equilibrium data. We apply this method to a simple model for a protein signalling pathway and test its predictions in both simulations and using real-world protein expression data. We demonstrate that perfect adaptation can lead to misleading orientation of edges in the output of causal discovery algorithms. (shrink)

This book deals with the history of the problem whether or not time can fully exist without the mind. This has been a vital issue in the philosophy of time, with intriguing arguments and solutions, from Aristotle to the present.

Anachronistic values A value becomes anachronistic when it no longer fits current historical conditions (institutions, technology, culture, etc.). From an ‘idealist’ perspective, this fact does not tell against the old value (accepted as true), but rather against the new conditions. However, from a ‘naturalist’ perspective which takes values to be the product of human interests and (therefore) as interconnected with a given historical context, such a conflict seems to make a value obsolete. But this is neither an empirical law nor (...) a normative rule. A defence of anachronistic values might still be perfectly reasonable. It is argued that such reasonableness depends mainly on three criteria: (un)certainty, scope and weight. (shrink)

Bundel filosofische essays over literatuurwetenschap.

This article discusses a number of metaphors about the nature of science, in connection with three types of metaphysical realism: minimal, moderate and essentialistic realism. From the beginning, Kuipers accepts the first and rejects the third type of realism, but it is only later on that he endorses the second type. It is argued that this makes his remarks on essentialistic realism somewhat misleading; and his moderate realism is compared with some realist positions taken by other philosophers. It is further (...) argued that the metaphors of the mirror, the net and the map correspond to essentialistic, minimal and moderate realism, respectively. This explains why the map metaphor is by far the most suitable one in the context of Kuipers' theory of science. This does not imply, however, that it is the (only) true one and that the others are false. (shrink)