In lieu of an abstract, here is a brief excerpt of the content:146 BOOK REVIEWS the years passed since Father Garrigou-Lagrange last published his De Revelatione would have allowed Thomistic scholars to retrieve and de· velop Aquinas's theological insights in their fullness. The danger of apologetics is that it can lead one to develop a teaching only along the lines set by those challenging the traditional teaching of the Church. In this particular instance, the Catholic apologists of the antimodernist period (...) were led to overstress the epistemological dimension of the theology of Revelation, leaving unstated that for Saint Thomas the primary term of analysis in this question is the knowledge of God. The need of Revelation for Saint Thomas stems from the call to man to share in the beatific vision. A paper on the relation of finality between faith and the beatific vision would have underlined the originality and true significance of the Thomistic tradition in theology. Saint John's Priory Laredo, Texas JOSEPH D'AMECOURT, F.J. The Eternity of the World in the Thought of Thomas Aquinas and his Contemporaries. Edited by J. B. M. WISSINK. Studien und Texte zur Geistesgeschichte des Mittelalters, edited by A. ZIMMERMAN, vol. 27. Leiden: E. J. Brill, 1990. Pp. viii+ 100. $28.75 (paper). This volume contains six short studies by five different scholars from the Netherlands on a topic accurately indicated by its title. These studies are a product of a symposium held by the Thomas Aquinas Workgroup, a scholarly association dedicated to investigating the thesis " that Aquinas first of all has to be understood as a theologian " and to " a rediscovery of the original Aquinas and his authentic thought" (p. vii). The topic chosen for these studies is a suitable one for the aims of the Workgroup, for it is one that requires a clear dis· tinction to be made between the realms of philosophy and theology, and it is one that has generated much interest and dispute-in the Middle Ages no less than today. This small collection of studies makes a con· tribution to scholarship, although there are weaknesses in some of the studies, as I shall note. F. J. A. de Grijs (pp. 1-8) argues that Thomas's purpose in writing the De aeternitate mundi was theological rather than philosophical in that Thomas provides a meditation on the meaning of eternity. This meditation, so de Grijs argues, is not only about the temporal eternity of the world but is even more about God's eternity. It shows us how BOOK REVIEWS 147 little we grasp of God's duration, or how we do not understand it rather than how we do understand it. J. A. Aertsen (pp. 9-19) ·responds to de Grijs by arguing that the work has a philosophical character. First, Aertsen explains, the fact that Thomas begins the De aeternitate mundi with the supposition on faith that the world had a temporal beginning in the past does not of itself (as de Grijs had thought) mean that the work is theological. Rather, it simply means that all believers agree that in fact the world had a temporal beginning, but the question at issue remains a philosophical one: could the world possibly have existed eternally in the past? Second, Aertsen points out that the reasoning in the De aeternitate mundi is much like that of Thomas's Disputed Question De potentia Dei, q. 3, a. 14, which has an explicitly philosophical character. Third, Thomas has already made it clear in his Commentary on the Sentences, bk. 2, d. 1, q. 1, a. 2, that the doctrine of creation, excluding the part of the doctrine that the world had a temporal beginning, is philosophically knowable in principle and known to philosophers in fact. Since the fact of creation is philosophically knowable and can he demonstrated without prejudice to the question of eternity, it cannot he said that an eternal past existence is incompatible with creation. Hence, the question of the compatibility of being eternal and being created-the very question for the De aeternitate mundi-is regarded by Thomas as philosophical rather than as theological. Aertsen's criticisms of de Grijs are sound, yet de Grijs's central point can he saved. De Grijs... (shrink)

It is generally believed that the uncertainty relation Δq Δp≥1/2ħ, where Δq and Δp are standard deviations, is the precise mathematical expression of the uncertainty principle for position and momentum in quantum mechanics. We show that actually it is not possible to derive from this relation two central claims of the uncertainty principle, namely, the impossibility of an arbitrarily sharp specification of both position and momentum (as in the single-slit diffraction experiment), and the impossibility of the determination of the path (...) of a particle in an interference experiment (such as the double-slit experiment). (shrink)

Context. The identification of the sources that reionized the Universe and their specific contribution to this process are key missing pieces of our knowledge of the early Universe. Faint star-forming galaxies may be the main contributors to the ionizing photon budget during the epoch of reionization, but their escaping photons cannot be detected directly due to inter-galactic medium opacity. Hence, it is essential to characterize the properties of faint galaxies with significant Lyman continuum photon leakage up to z 4 to (...) define indirect indicators allowing analogues to be found at the highest redshift. Aims. Long gamma-ray bursts explode typically in star-forming regions of faint, star-forming galaxies. Through LGRB afterglow spectroscopy it is possible to detect directly LyC photons. Our aim is to use LGRBs as tools to study LyC leakage from faint, star-forming galaxies at high redshift. Methods. Here we present the observations of LyC emission in the afterglow spectra of GRB 191004B at z = 3:5055, together with those of the other two previously known LyC-emitting LGRB, to determine their LyC escape fraction and compare their properties. Results. From the afterglow spectrum of GRB 191004B we determine a neutral hydrogen column density at the LGRB redshift of og =17:2 0:15, and negligible extinction. The only metal absorption lines detected are C iv and Si iv. In contrast to GRB 050908 and GRB 060607A, the host galaxy of GRB 191004B displays significant Ly emission. From its Ly emission and the non-detection of Balmer emission lines we constrain its star-formation rate to 1 SFR 4:7 M yr. 1. We fit the Ly emission with a shell model and find parameters values consistent with the observed ones. The absolute LyC escape fractions we find for GRB 191004B, GRB 050908 and GRB 060607A are of 0:35+0:10.0:11, 0:08+0:05.0:04 and :20+0:05.0:05, respectively. We compare the LyC escape fraction of LGRBs to the values of other LyC emitters found from the literature, showing that LGRB afterglows can be powerful tools to study LyC escape for faint high-redshift star-forming galaxies. Indeed we could push LyC leakage studies to much higher absolute magnitudes. The host galaxies of the three LGRB presented here have all M1600 >.19:5 mag, with the GRB 060607A host at M1600 >.16 mag. LGRB hosts may therefore be particularly suitable for exploring the ionizing escape fraction in galaxies that are too faint or distant for conventional techniques. Furthermore the time investment is very small compared to galaxy studies. (shrink)

The rapid rise of international collaborative science has enabled access to genomic data. In this article, it is argued that to move beyond mapping genomic variation to understanding its role in complex disease aetiology and treatment will require extending data sharing for the purposes of clinical research translation and implementation.

Here we discuss the challenge posed by self-organization to the Darwinian conception of evolution. As we point out, natural selection can only be the major creative agency in evolution if all or most of the adaptive complexity manifest in living organisms is built up over many generations by the cumulative selection of naturally occurring small, random mutations or variants, i.e., additive, incremental steps over an extended period of time. Biological self-organization—witnessed classically in the folding of a protein, or in the (...) formation of the cell membrane—is a fundamentally different means of generating complexity. We agree that self-organizing systems may be fine-tuned by selection and that self-organization may be therefore considered a complementary mechanism to natural selection as a causal agency in the evolution of life. But we argue that if self-organization proves to be a common mechanism for the generation of adaptive order from the molecular to the organismic level, then this will greatly undermine the Darwinian claim that natural selection is the major creative agency in evolution. We also point out that although complex self-organizing systems are easy to create in the electronic realm of cellular automata, to date translating in silico simulations into real material structures that self-organize into complex forms from local interactions between their constituents has not proved easy. This suggests that self-organizing systems analogous to those utilized by biological systems are at least rare and may indeed represent, as pre-Darwinists believed, a unique ascending hierarchy of natural forms. Such a unique adaptive hierarchy would pose another major challenge to the current Darwinian view of evolution, as it would mean the basic forms of life are necessary features of the order of nature and that the major pathways of evolution are determined by physical law, or more specifically by the self-organizing properties of biomatter, rather than natural selection. (shrink)

Unrecognized presuppositions about patient appearance have become increasingly important in medicine, medical ethics and medical law. Symptoms of these historically conditioned assumptions include common ageism, aesthetic surgery, and litigation about ‘wrongful life’. These phenomena suggest a societal intolerance for what is considered an ‘abnormal’ appearance. Among others, eighteenth-century artists and anatomists helped to set these twentieth-century precedents, actually measuring deviations of external traits to analogous deformations of the soul, and drawing moral conclusions from physiognomic measurements. Other eighteenth-century artists countered with (...) pathognomy, recognizing that uneven physical features may indicate humanity, instead of character flaws. We suggest that there is an important and as yet unrecognized role played by visual and perceptual preferences in our judgments concerning normalcy and anomaly. We further suggest a shift away from our current fashion-magazine, youth-oriented aesthetic, and towards an aesthetic of imperfection. Physicians and medical students can be made aware of their historically conditioned reactions to ‘abnormal’ appearing patients by studying the understandings and methods with which artists have portrayed those who are considered deformed in appearance. (shrink)

The 1995 Encyclopedia of Bioethics is an almost complete reworking of the original 1978 edition, due to the expanding nature of the field. The following article focuses on how the second edition of the Encyclopedia deals with the topic of “clinical ethics” and three related topics: “nursing ethics”, “trust”, and “conflict of interest”. We assess their relevance to the current developments in these fields and the Encyclopedia's usefulness as a resource to ethics consultants, researchers and clinicians. We emphasize the heterogeneity (...) of clinical ethics as a still new and evolving field. (shrink)

We consider the desirability, or otherwise, of various forms of induction in the light of certain principles and inductive methods within predicate uncertain reasoning. Our general conclusion is that there remain conflicts within the area whose resolution will require a deeper understanding of the fundamental relationship between individuals and properties.

The legal framework governing claims of medical negligence is extensively documented within South African (SA) jurisprudence, with a predominant focus on the liability of medical practitioners. In contrast, the liability of pharmacists has received comparatively scant attention. This issue was recently highlighted by a case in which a woman from the Western Cape initiated legal action against Clicks, a leading health, beauty and wellness retailer and SA’s largest retail pharmacy chain, alleging that the provision of incorrect medication nearly cost her (...) life. At the time of writing, the case has yet to advance to trial. This article explores the legal and ethical dimensions of medical negligence attributed to pharmacists within the context of their professional duties. Additionally, it investigates how similar cases are adjudicated in foreign jurisdictions, with a specific focus on the US. (shrink)

Postnatally, heart muscle cells almost completely lose their ability to divide, which makes their loss after trauma irreversible. Potential repair by cell grafting or mobilizing endogenous cells is of particular interest for possible treatments for heart disease, where the poor capacity for cardiomyocyte proliferation probably contributes to the irreversibility of heart failure. Knowledge of the molecular mechanisms that underly formation of heart muscle cells might provide opportunities to repair the diseased heart by induction of (trans) differentiation of endogenous or exogenous (...) cells into heart muscle cells. We briefly review the molecular mechanisms involved in early development of the linear heart tube by differentiation of mesodermal cells into heart muscle cells. Because the initial heart tube does not comprise all the cardiac compartments present in the adult heart, heart muscle cells are added to the distal borders of the tube and within the tube. At both distal borders, mesodermal cell are recruited into the cardiac lineage and, within the heart tube, muscular septa are formed. In this review, the relative late additions of heart muscle cells to the linear heart tube are described and the potential underlying molecular mechanisms are discussed. BioEssays 26:248–261, 2004. Wiley Periodicals, Inc. (shrink)

The construction of complex simulation models and the application of new computer hardware to ecological problems has resulted in the need for many ecologists to rely on computer programmers to develop their modelling software. However, this can lead to a lack of flexibility and understanding in model implementation and in resource problems for researchers. This paper presents a new programming language, Viola, based on a simple organisational concept which can be used by most researchers to develop complex simulations much more (...) easily than could be achieved with standard programming languages such as C++. The language is object oriented and implemented through a visual interface. It is specifically designed to cope with complicated individual based behavioural simulations and comes with embedded concurrency handling abilities. (shrink)