Il sistema morale e l'agire umano secondo San Tommaso -- Il concetto di legge nella dottrina tomista -- La grazia e le virtù -- La conoscenza della giustizia -- Il pensiero politico di san Tommaso.

Alzheimer's disease (AD) is the most common cause of dementia, and there is currently no cure. The “β‐amyloid cascade hypothesis” of AD is the basis of current understanding of AD pathogenesis and drug discovery. However, no AD models have fully validated this hypothesis. We recently developed a human stem cell culture model of AD by cultivating genetically modified human neural stem cells in a three‐dimensional (3D) cell culture system. These cells were able to recapitulate key events of AD pathology including (...) β‐amyloid plaques and neurofibrillary tangles. In this review, we will discuss the progress and current limitations of AD mouse models and human stem cell models as well as explore the breakthroughs of 3D cell culture systems. We will also share our perspective on the potential of dish models of neurodegenerative diseases for studying pathogenic cascades and therapeutic drug discovery. (shrink)

This work provides an interesting, though sometimes rather sweeping, demonstration that the metaphysical problem of the same and the other is also the central problem of literature and literary criticism. The author defends the analogical imagination as the symbolic counterpart of participation in Platonic metaphysics.--D. C. B.

Using the principles and sometimes the conclusions of his teacher Adolf Stöhr, Cleve insists that he is giving a philosophical interpretation and not simply a philological reconstruction of these Pre-Socratics. The philosophers have been divided into 1) "Religious Reformers", 2) "Philosophers of Nature", 3) "Champions of Culture Politics"—"The Glossomorphics". There will certainly be disagreement on some of Cleve's interpretations but it must be said that Cleve carries through his philosophical reconstruction with admirable lucidity and consistency though, occasionally, some of his (...) criticisms of the "philologists" are rather waspish. Nevertheless, this is a splendid and important study which is a tribute to the author's erudition and insight.—D. J. B. (shrink)

This first article is intended as a brief introduction to the general philosophical assumptions of Newton: namely, his mathematicism, empiricism, positivism, reductionism, and dualism. These five "isms" provide an important background to the main articles that are also briefly described.

Marsh borrows Richard McKeon's methodological notion of the "problematic" approach to intellectual history. Concentrating on their dialectical character, English criticism from 1650-1800 is explored in the writings of the third Earl of Shaftesbury, Mark Akenside, David Hartley, and James Harris.—D. J. B.

Merleau-Ponty had projected a work of considerable dimensions, according to Lefort, which was to have borne the title now given to this posthumous volume. Though the chapters he had actually written out and the notes de travail selected by Lefort for this edition seem to be only introductory parts and suggestions of the larger work, they are already considerable in richness, depth and difficulty. Here we find Merleau-Ponty returning to the problems of his earlier works, showing why the problems posed (...) in the Phenomenology of Perception were "insoluble"; examining in ever greater depth the thought of Descartes, Leibniz, Kant, Hegel, Husserl, Heidegger and Sartre; uncovering the naiveté of scientific thinking and the false sophistication of reflective, dialectical and intuitionistic philosophies. He has moved well beyond phenomenology in the strict sense, toward his own interrogation ontologique and a theory of logic. Lefort has done an extraordinary and exemplary job of organizing, editing and annotating the manuscripts. —A. B. D. and C. D. (shrink)

Science naively presupposes the intelligibility of the universe, necessary laws, and a universal truth. The author reflects on these presuppositions to arrive at a demonstration of God's existence. In a vigorous and exclamatory style, he condemns the alternative views of idealism, phenomenology, and philosophies of science which cannot rationally justify their faith in a universal truth. The only rational basis for these presuppositions is a theistic God--the "Vérité mesurante" and "Pensée fondatrice" of scientific reason.--A. B. D.

A translation of selected parts from the first volume of the Polish phenomenologist's two volume work, The Controversy Over the Existence of the Real World. While its major theme is the relationship between consciousness and the real world, the specific aim of the chapters gathered here is to determine systematically what kind of existence belongs to the real world—if any. Ingarden undertakes an eidetic analysis of various concepts of existence and deals with such problems as causality and the differences between (...) processes, events and objects.—A. B. D. (shrink)

In addition to facing the known competitors in the formal economy, entrepreneurs must also be concerned with rivalry emanating from the informal economy. The informal economy is characterized by actions outside the normal scope of commerce, such as unsanctioned payments and gift-giving, as means of influencing competition. Scholars and policy makers alike have an interest in mitigating the impacts of such informal activity in that it might present an obstacle for legitimate commerce. Received theory suggests that country institutions can enable (...) and constrain productive activity, and, in doing so, influence competitive obstacles in a country. Leveraging 13,670 responses from entrepreneurs distributed across 59 countries, we provide evidence that two particular types of enabling institutions, countries’ property rights regulations and cooperative actions, are useful for lowering the obstacles presented by informal activity. We also find evidence that two constraining institutions, economic and financial regulations lead to more obstacles presented by informal activity. We describe implications for entrepreneurs, policy makers, and future researchers stemming from these findings. (shrink)

This is a compact, comparative analysis of Western and Chinese thought according to distinctive styles of thought and attitudes toward the world and what can be known of it. The model of Western Philosophy is presented as an abstract whole beyond experience—the Kantian ideal; the model of Chinese thought is a concrete whole found in experience. Chinese thought, as amply represented by passages from Confucius, Mencius and others, always has a feeling for the concrete, for a particular fact intuitively suggesting (...) a universal law; and it always has a predilection for paradox. The author thinks that abstract Western thought is still under the sway of Kant's concepts and forms of judgment, even in its current tendency toward the concrete.—A. B. D. (shrink)

Aristotle's rejection of the Platonic ideas robbed him of Plato's unity of Being and Value as well. By an extensive, clear interpretation and analysis of the whole Aristotelian corpus, Oates shows that Aristotle lacks a coherent theory of value. While considerations of value unavoidably occur in the Metaphysics, just as ontological ones do in the Ethics, nowhere in Aristotle is there a unification of axiology and ontology. For this reason, Oates argues, the Nicomachean Ethics fails to be a theory of (...) moral good. The book is a temperate, perhaps non-controversial critique of Aristotle, and its polished, easy style makes it a pleasure to read.—A. B. D. (shrink)

A bi-lingual edition of poems and a "free philosophical treatise" by a poet-logician who is now imprisoned somewhere in Russia. In this choppy and compressed treatise, written hours before he was arrested, the writer discusses some pseudo-problems of philosophy, argues against the principle of excluded middle, and states the real problem of philosophy as being the relationship between the subconscious and consciousness.--A. B. D.

This brief work valuably shows how a distinguished historian ascertains the causes of his historical facts. Koht, a Norwegian European historian, eschews any philosophy of history, claiming only that the nature of man is permanent through historical change. Drawing from his own historical research he discusses the significance of the different forces of history. These are religion, economics, class consciousness, the power of the state, war, revolt, science, and internationalism. No one force or cause is primary.—A. B. D.

A far less exhaustive work than Richardson's scholarly tome, but more focused than Vycinas' ventriloquial interpretation, Guilead's book concentrates on the theme of freedom in Sein und Zeit and in Heidegger's later works. The author is in full control of Heidegger's terminology and he succinctly reports how Heidegger uncovers and destroys the subjectivism of modern philosophy, as represented by Descartes, Leibniz, Kant, Nietzsche, and Marx. Guilead contends that the germ of the "Kehre" was already present in Sein und Seit [[sic]]. (...) Heidegger's later thought shows that man is a cosmic being, a relation to Being, and his freedom can not be rooted in subjectivity but in the realization of his authentic cosmic being, in his "habitation," "dwelling," and "building." The author finds two problems in Heidegger's philosophy: a lack of real otherness in beings, and a danger of humanizing Being. But are they not one problem?—A. B. D. (shrink)

Based on the Mahlon Powell lectures given at Indiana University, this slim, well translated book is surprisingly rich and visionary in its pursuit of a metaphysics of language. Dufrenne, a phenomenologist, argues that positivistic and syntactical linguistics wrongly ignore the phenomenon of living speech, while formal logic, seeking to rid itself of its natural and intuitive origins, is necessarily rooted in them. What is needed is a phenomenology of human speech which would lead to a metaphysics of man's spoken intercourse (...) with the world. In the end, poetry has the last word.--A. B. D. (shrink)

The important features of Hartmann's realist ontology are first described as presuppositions of his regional ontology of spirit. Then Breton sympathetically investigates the categories of "l'être spirituel" and focuses on Hartmann's notion of objective spirit, contrasting it with Hegel's. Despite Hartmann's rejection of systems, Breton concludes that his ontology of the levels of being is "architecturally" systematic.—A. B. D.

Edith Stein was Husserl's student and private secretary. This study of empathy was originally her doctoral dissertation. After a reduction to pure consciousness, she describes the essence of empathy as a kind of perception sui generis, both like and unlike other acts of consciousness. Different theories of experiencing the other are briefly evaluated. The second part of the book is devoted to the role of empathy in the constitution of the psycho-physical individual and, ultimately, of the person. Written in short, (...) numbered paragraphs, the analysis tends to be jerky and without direction. But there is a sustained description of the living body, antedating Merleau-Ponty's corps vécu by thirty years. The translation seems too literal, and typographical errors abound.—A. B. D. (shrink)

A reprint of the book published in 1942, with the addition of an appendix and a new preface. Beginning with the concrete and conceptual aspects of the person and showing how the principles of logic are embodied in human experience, the author describes the ontological and logical connections between the world, man and God.--A. B. D.