Time processing is a multifaceted skill crucial for managing different aspects of life. In the current work, we explored the relationship between interoception and time processing by examining research on clinical models. We investigated whether time processing deficits are associated with dysfunction of the interoceptive system and/or insular cortex activity, which is crucial in decoding internal body signaling. Furthermore, we explored whether insular activation predicts the subjective experience of time (that is, the subjective duration of a target stimulus to be (...) timed). Overall, our work suggests that alteration of the interoceptive system could be a common psychophysiological hallmark of mental disorders affected by time processing deficits. (shrink)

Neurophysiological studies in monkeys and neuroimaging studies in humans support a model of empathy according to which there exists a shared code between perception and production of emotion. The neural circuitry critical to this mechanism is composed of frontal and parietal areas matching the observation and execution of action, and interacting heavily with the superior temporal cortex. Further, this cortical system is linked to the limbic system by means of an anterior sector of the human insular lobe.

Transcutaneous auricular vagus nerve stimulation, a non-invasive alternative to vagus nerve stimulation with implantable devices, has shown promise in treating disorders such as depression, migraine, and insomnia. Studies of these disorders with resting-state functional magnetic resonance imaging have found sustained changes in resting-state functional connectivity in patients treated with low frequency taVNS. A recent study has reported reductions in pain scores in patients with rheumatoid arthritis after a 12-week treatment of high-frequency sub-threshold taVNS. However, no studies to date have examined (...) the effects of high-frequency sub-threshold taVNS on rsFC. The objective of this study was to determine whether high-frequency sub-threshold taVNS induces changes in rsFC using seed regions from the cingulate cortex and insula, brain regions that play a key role in interoception and processing of pain. With a single-blind placebo-controlled repeated measures experimental design, rsfMRI scans were acquired before and after 15 min of either sub-threshold taVNS treatment or a sham control. Significant taVNS-related changes in functional connections to the cingulate cortex were detected between the anterior cingulate cortex and right superior temporal gyrus and between the midcingulate cortex and right inferior parietal lobule. In addition, significant changes in functional connections to the insula were detected between the posterior insula and right precuneus and between the anterior insula and right cuneus gyrus. These results suggest that high-frequency sub-threshold taVNS can lead to sustained effects on the rsFC of brain regions involved in interoception and processing of pain in a cohort of healthy subjects. This study lays the foundation for future rsfMRI studies of high-frequency sub-threshold taVNS in clinical populations. (shrink)

The neural correlates of software programming skills have been the target of an increasing number of studies in the past few years. Those studies focused on error-monitoring during software code inspection. Others have studied task-related cognitive load as measured by distinct neurophysiological measures. Most studies addressed only syntax errors. However, a recent functional MRI study suggested a pivotal role of the insula during error-monitoring when challenging deep-level analysis of code inspection was required. This raised the hypothesis that the (...) class='Hi'>insula is causally involved in deep error-monitoring. To confirm this hypothesis, we carried out a new fMRI study where participants performed a deep source-code comprehension task that included error-monitoring to detect bugs in the code. The generality of our paradigm was enhanced by comparison with a variety of tasks related to text reading and bugless source-code understanding. Healthy adult programmers participated in this 3T fMRI experiment. The activation maps evoked by error-related events confirmed significant activations in the insula [p < 0.05]. Importantly, a posterior-to-anterior causality shift was observed concerning the role of the insula: in the absence of error, causal directions were mainly bottom-up, whereas, in their presence, the strong causal top-down effects from frontal regions, in particular, the anterior cingulate cortex was observed. (shrink)

Les fouilles de Délos effectuées au début du XXe siècle ont mis au jour une trentaine de blocs provenant de pressoirs. Certains d'entre eux appartenaient à des installations produisant des huiles alimentaire et lampante (cf. BCH 121 [1997], p. 573-615), d'autres sont probablement à relier à la fabrication des parfums mentionnée par Pline. Deux maies de pressoir ont été découvertes dans la Maison IB du Quartier du stade, fouillée en 1912 par A. Plassart et interprétée comme un restaurant à cause (...) de la découverte de quatre fourneaux. De nouvelles recherches conduites en 1997 ont montré la complexité de l'histoire de cette demeure qui, vers le début du Ier siècle av. J.-C, comporta une importante fabrique de parfums. Une salle fut alors équipée de deux presses à coins servant à extraire des huiles à parfum et de fourneaux où l'on faisait chauffer l'huile et les aromates. Au cours d'une phase ultérieure, la parfumerie fut démantelée et la demeure probablement convertie en établissement de bains. Les acquis de cette fouille et de celle de l'huilerie IIΙΟ du Quartier du théâtre permettent d'interpréter les blocs anciennement retrouvés et de mesurer la place respective de la production du vin, de l'huile alimentaire et des parfums dans l'île de Délos à l'époque hellénistique et durant l'Empire romain. (shrink)

We describe a neural monitor of environmental and physiological resources that informs effort expenditure. Depending on resources and environmental stability, serotonergic and dopaminergic neuromodulations favor different behavioral controls that are organized in corticostriatal loops. This broader perspective produces some suggestions and questions that may not be covered by the foraging approach to vigor of Shadmehr and Ahmed (2020).

Dans cet article est discutée l'hypothèse récente selon laquelle un type de maison attesté jusqu'ici à partir de l'époque hellénistique à Délos pourrait remonter à l'époque classique (Ve s. av. J.-C.) : maison simple, allongée, organisée autour d'une cour sur laquelle s'ouvre, à l'arrière, un ensemble caractéristique de deux ou trois pièces (oecus maior et annexe[s]) et souvent dotée, en façade, d'un vestibule et de pièces de service. On propose un réexamen de la maison Ο dans l'îlot III du Quartier (...) du théâtre, qui sert de preuve à cette hypothèse. À la base des murs visibles, quatre phases sont distinguées : ce n'est que dans la deuxième phase que la maison examinée ici a été construite, intégrant des murs préexistants de l'époque classique (première phase) ; elle fait partie du premier « programme urbanis- tique » attesté dans ce quartier et ne peut remonter avant la construction du théâtre au IIIe siècle av. J.-C. Après une transformation avec embellissement (troisième phase), au cours de laquelle ont été ajoutées des latrines, des pièces additionnelles et une colonnade, une huilerie a été installée dans la maison au début du Ier siècle av. J.-C. (quatrième phase). (shrink)

We propose that synesthetic cross‐activation between the primary auditory cortex and the anatomically adjacent insula may help explain two puzzling conditions—autonomous sensory meridian response (ASMR) and misophonia—in which quotidian sounds involuntarily trigger strong emotional responses. In ASMR the sounds engender relaxation, while in misophonia they trigger an aversive response. The insula both plays an important role in autonomic nervous system control and integrates multiple interoceptive maps representing the physiological state of the body to substantiate a dynamic representation of (...) emotional wellbeing. We propose that in ASMR cross‐activation of the map for affective (sensual) touch leads to an increase in subjective wellbeing and parasympathetic activity. Conversely, in misophonia the effect of the cross‐activation is to decrease emotional wellbeing and increase sympathetic activity. Our hypothesis also illuminates the connection between hearing and wellbeing more broadly and helps explain why so many people experience decreased wellbeing from modern urban soundscapes. (shrink)

A recent strand in the philosophical literature on addiction emphasizes problems with diachronic self-control. Hanna Pickard, for example, argues that an important aspect of addiction consists in inability to identify with a non-addicted future self. This literature sits alongside another that treats addiction as the product of neural changes that “hijack” mechanisms of reward prediction, habit formation decision making and cognitive control. This hijacking literature originates in accounts that treat the neural changes characteristic of addiction as a brain disease. This (...) paper provides a framework based on predictive processing accounts of self-awareness that integrates the hijacking and diachronic accounts. I discuss a hijacking account proposed to explain disruption of addiction following lesion to the anterior insula cortex. I show how insula activity contributes to the type of identification implicated in diachronic accounts and how deactivation of the anterior insula can disrupt addiction by alienating the subject from her addictive tendencies. This is consistent with neural evidence but also incorporates the personal level features of addiction that are opaque to neural level explanation. (shrink)

Movement perception and its role in aesthetic experience have been often studied, within empirical aesthetics, in relation to the human body. No such specificity has been defined in neuroimaging studies with respect to contents lacking a human form. The aim of this work was to explore, through functional magnetic imaging (fMRI), how perceived movement is processed during the aesthetic judgment of paintings using two types of content: human subjects and scenes of nature. Participants, untutored in the arts, were shown the (...) stimuli and asked to make aesthetic judgments. Additionally, they were instructed to observe the paintings and to rate their perceived movement in separate blocks. Observation highlighted spontaneous processes associated with aesthetic experience, whereas movement judgment outlined activations specifically related to movement processing. The ratings recorded during aesthetic judgment revealed that nature scenes received higher scored than human content paintings. The imaging data showed similar activation, relative to baseline, for all stimuli in the three tasks, including activation of occipito-temporal areas, posterior parietal and premotor cortices. Contrast analyses within aesthetic judgment task showed that human content activated, relative to nature, precuneus, fusiform gyrus and posterior temporal areas, whose activation was prominent for dynamic human paintings. In contrast, nature scenes activated, relative to human stimuli, occipital and posterior parietal cortex/precuneus, involved in visuospatial exploration and pragmatic coding of movement, as well as central insula. Static nature paintings further activated, relative to dynamic nature stimuli, central and posterior insula. Besides insular activation, which was specific for aesthetic judgment, we found a large overlap in the activation pattern characterizing each stimulus dimension (content and dynamism) across observation, aesthetic judgment and movement judgment tasks. These findings support the idea that the aesthetic evaluation of artworks depicting both human subjects and nature scenes involves a motor component, and that the associated neural processes occur quite spontaneously in the viewer. Furthermore, considering the functional roles of posterior and central insula, we suggest that nature paintings may evoke aesthetic processes requiring an additional proprioceptive and sensori-motor component implemented by “motor accessibility” to the represented scenario, which is needed to judge the aesthetic value of the observed painting. (shrink)