Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

Stories and legends in which animals teach ethical behavior from a Jewish perspective.

Summary Using the neurological syndrome kuru as a frame, Warwick Anderson examines the social dynamics and material culture of its medical investigation among the Fore people conducted by D. Carleton Gajdusek beginning at midcentury. The Collectors of Lost Souls: Turning Kuru Scientists into White Men uses a postcolonial framework to complicate dominant/subordinate binaries and diffusionist accounts of indigenous contacts with medical science. Anderson proposes that colonies are specific sites of production of medical knowledge. He draws a distinction between traditional and (...) advanced economies in regard to individual rights to make an argument in support of context-specific ethical regulation for medical research and suggests a role for historians of science in interrogating the process of globalisation. (shrink)

Since the middle of the 20th century, suicidology, as a group of disciplines working to understand and prevent suicide, has reinforced the long-held view that suicide is caused first and foremost b...

Summary Watters questions the universality of mental illness and warns of the harms that accompany the exportation of Western typologies to non-Western cultures. He is particularly concerned that these effects will be exacerbated by the upcoming revisions of the Diagnostic and Statistical Manual of Mental Disorders (DSM-V). Building on his examination of non-Western practices, Watters exposes the historical instability of mental health classifications in North America to question the validity of current DSM categories. Although Watters' warnings about the dangers of (...) the globalisation of the DSM are persuasive, they may be overreaching as our examination of the successful incorporation of Western created autism services, information, and interventions in the developing world suggests. (shrink)

James I. The Political Works of James I. Reprinted from the Edition of 1616. With an Introduction by Charles Howard McIlwain. Cambridge: Harvard University Press, 1918. cxi, 354 pp. Reprinted 2002 by The Lawbook Exchange, Ltd.

The New Zealand philosopher, Robert Nola (1940-2022), has died. He was a kind man, a good friend, and a fine philosopher. Here is how I remember him.

In El Salvador from 1978 to 1988, contraceptive use among married women 15–44 years of age increased from 34% to 47%, and the total fertility rate declined from 6·3 to 4·6 children per woman. Most of this change took place from 1978 to 1985. Sterilization is the most prevalent method used, but nearly one-half of the women who are sterilized did not use any contraception before their operation. Few young couples use reversible methods of contraception to space births or delay (...) the start of childbearing. On average, women wait 8 years after marriage and have nearly three children before they use contraception. (shrink)

Can we ever be fully practically justified in acting contrary to moral demands? My contention is that the answer is 'no'. I argue that by adopting a 'buck-passing' account of wrongness we can provide a philosophically satisfying answer to the familiar 'why should I be moral?'. In working my way toward the buck-passing account of wrongness, I outline the metaethical and 'metanormative' assumptions on which my theory stands. I also consider and reject the 'internalist' answer to 'why should I be (...) moral?'. The account I end up with is decidedly non-consequentialist and it is consistent with common-sense morality. It also provides a way of showing why moral considerations are overridingly normative in a way that is consistent with our best current understanding of what practical reason requires of us. (shrink)

Although sensorimotor contingencies may explain visual perception, it is difficult to extend this concept to speech perception. However, the basic concept of perception as active hypothesis testing using attention does extend well to speech perception. We propose that the concept of sensorimotor contingencies can be broadened to sensory-attentional contingencies, thereby accounting for speech perception as well as vision.

On doxastic theories of propositional faith,necessarily,S has faith that p only if S believes that p. On nondoxastic theories of propositional faith, it’s false that,necessarily,S has faith that p only if S believes that p. In this article, I defend three arguments for nondoxastic theories of faith and I respond to published criticisms of them.

In I 7 Aristotle lays down criteria for what is to count as human happiness. Happiness for man is self-sufficient , complete without qualification , peculiar to humans , excellent , and best and most complete . Many interpreters agree that in X 6–8 Aristotle uses these along with other criteria to disqualify the life of amusement and rank one happy life above another.

In I 7 Aristotle lays down criteria for what is to count as human happiness. Happiness for man is self-sufficient, complete without qualification, peculiar to humans, excellent, and best and most complete. Many interpreters agree that in X 6–8 Aristotle uses these along with other criteria to disqualify the life of amusement and rank one happy life above another.