Background: Truth-telling toward terminally ill patients is a challenging ethical issue in healthcare practice. However, there are no existing ethical guidelines or frameworks provided for Chinese nurses in relation to decision-making on truth-telling of terminal illness and the role of nurses thus is not explicit when encountering this issue. Objectives: The intention of this paper is to provide ethical guidelines or strategies with regards to decision-making on truth-telling of terminal illness for Chinese nurses. Methods: This paper initially present a case (...) scenario and then critically discuss the ethical issue in association with ethical principles and philosophical theories. Instead of focusing on attitudes toward truth disclosure, it aims to provide strategies regarding this issue for nurses. It highlights and discusses some of the relevant ethical assumptions around the perceived role of nurses in healthcare settings by focusing on nursing ethical virtues, nursing codes of ethics, and philosophical perspectives. And Confucian culture is discussed to explicate that deontology does not consider family-oriented care in China. Conclusion: Treating each family individually to explore the family’s beliefs and values on this issue is essential in healthcare practice and nurses should tailor their own approach to individual needs regarding truth-telling in different situations. Moreover, the Chinese Code of Ethics should be modified to be more specific and applicable. Finally, a narrative ethics approach should be applied and teamwork between nurses, physicians and families should be established to support cancer patients and to ensure their autonomy and hope. Ethical considerations: This paper was approved by the Ethics Committee of The Second Affiliated Hospital of Guangzhou Medical University. The authors have obtained consent to use the case study and it has been anonymised to preserve the patient's confidentiality. (shrink)

A Higher education system is closely related to a country’s development. Governments need to make appropriate adjustments to ensure the healthy and sustainable development of higher education. To measure and evaluate the development status of the national higher education system and propose a set of policies, the following work has been done in this paper: First, this paper establishes a comprehensive evaluation index system based on the AHP-FCE model. The healthy development of education in significant countries was compared horizontally and (...) vertically. The results of weighted scores were used to determine the Japanese higher education system as the research object. Secondly, this paper uses factor analysis and principal component analysis to evaluate the level of sustainable development of higher education, detecting development barriers that migrate from the current to the future. This paper proposes a healthy and sustainable development policy blueprint from four aspects. Finally, this article uses the ARMA time series model to predict the development trend of Japanese higher education in the next 30 years and formulates a timetable for corresponding implementation arrangements. In addition, this paper quantitatively evaluates the effectiveness of the policies we propose and their impact on reality and provides references for other countries in the world. (shrink)

Objective: Work stress is one of the urgent public health problems, which has aroused wide attention. In addition, work stress also has a negative impact on the development of enterprises. This study has three purposes: to understand the current status of working stress among couriers, to examine the association between work stress, job satisfaction and sleep quality of Chinese couriers, and to verify the mediating role of psychological capital.Methods: A cross-sectional survey was conducted among 3000 couriers in Beijing of China (...) from January to December 2019 using cluster stratified random sampling. Descriptive statistical analysis was used to describe demographic characteristics of respondents. Pearson correlation analysis was used to analyze the correlation among work stress, job satisfaction, sleep quality, and psychological capital. The mediating analysis was calculated role of psychological capital.Results: A total of 2831 participants were included in this study. The average score of work stress was 2.49 ± 0.76. Work stress was negatively correlated with job satisfaction, sleep quality, and psychological capital, respectively. The direct effect of work stress on job satisfaction is –0.223, and the total effect of work stress on job satisfaction is –0.267. The a*b*c’ is positive, indicating the mediating role psychological capital has in explaining the relationship between couriers’ work stress and job satisfaction. Moreover, psychological capital plays a mediating role between work stress and sleep quality among couriers.Conclusion: Couriers face certain work stress and should be paid attention to and psychological capital can effectively alleviate the work stress of couriers, so measures can be taken to improve it, promoting healthy development of employees and organizations. (shrink)

Ben shu zhu yao cong san ge fang mian dui Zhou Dunyi li xue si xiang de mei xue te zhi jin xing jie du: yi shi gen ju qi "tai ji" guan fen xi "tai ji" zhi yuan rong mei, dong jing mei, he xie mei; er shi zai dui qi "jun zi guan" he "sheng ren guan" jin xing yan jiu de ji chu shang, zhan xian gang jian, zhong he, gao jie, sa luo, shang zhuo de (...) jun zi ren ge he yi "le" wei ben de sheng ren jing jie, shi dui chuan tong ren ge mei xue ji xian shi you chao yue de shuang chong te zheng de jin yi bu chan shi; san shi zai "xiang" yu "yi", "wen" yu "dao", "le" yun "li" de guan xi zhong fen xi "wen yi zai dao" de mei xue yi yun, cong ben ti de gao du fen xi wen dao guan xi, jiao wei jing zhun de chan shi le Zhou Dunyi "wen yi zai dao" de wen xue si xiang. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Philosophical Enactment and Bodily Cultivation in Early Daoism: In the Matrix of the Daodejing by Thomas MichaelJing Tan (bio) and Xiangfei Bao (bio)Philosophical Enactment and Bodily Cultivation in Early Daoism: In the Matrix of the Daodejing. By Thomas Michael. London: Bloomsbury Academic, 2022. Pp. x + 278. Hardcover $115.00, isbn 978-1-3502-3665-3. Thomas Michael's Philosophical Enactment and Bodily Cultivation in Early Daoism: In the Matrix of the Daodejing (hereafter (...) Philosophical Enactment) brings forward new perspectives and pathways to one of the most important topics concerning the reconstruction of early Daoist history. The author has contributed two other original and insightful monographs to the study of Daoism, including In the Shadows of the Dao: Laozi, the Sage, and the Daodejing (Albany, NY: State University of New York Press, 2015) and The Pristine Dao: Metaphysics in Early Daoist Discourse (Albany, NY: State University of New York Press, 2005). Together with his newly published research article "The Original Text of the Daodejing: Disentangling Versions and Recensions" (Religions 13, No. 4, (2022): 325), Michael has displayed his erudition and expertise in the study of early Chinese religion and philosophy in both a sinological and philosophical way. His Philosophical Enactment sheds new light on the history of early Daoism. Writing the history of early Daoism is not easy, as Daoism is not ready-made and has no clear boundaries. The difficulty lies not only in its entanglement with, for instance, Confucianism and Legalism, but also in when Daoism began and how it transformed. Narrating the origin and the vicissitude of Daoism requires a prescribed narrative logic or a choice of philosophical paradigm. Piling up materials is not history writing. A typical pattern in writing the history of early Daoism is distinguishing the Daoist school of philosophy (daojia 道家) from Daoist religion (daojiao 道教).1 Indeed, this distinction brings much convenience to the history writing of Daoism and has been adopted by many scholars. Though some do not explicitly state this distinction, the structure of their writings indicates it.2 The distinction between daojia and daojiao was recognized by scholars long before Fung Yu-Lan 馮友蘭 (1895-1900) published his A Brief History of Chinese Philosophy in 1948. [End Page 1] Xu Dishan 許地山 (1893-1941) believes that such a distinction can be traced back to the "Three Ranks" (sanpin shuo三品說) in Liu Xie's 劉勰 (ca. 465-532) "On Eliminating Doubts" (Miehuo lun滅惑論).3However, the received distinction between daojia and daojiao is a retrospective one. It is the product of modern discipline classification and is based on the modern understanding of philosophy and religion. Such a distinction must have been unknown to the people before and during the Han. This distinction may also cause difficulties, for instance, how to classify Ge Hong 葛洪 (283-343) and his works. Wang Ka 王卡 (1956-2017) categorized Ge Hong as a Daoist philosopher,4 while Tang Yijie 湯一介 (1927-2014) assigns Ge Hong to Daoist religion. Tang even asserts that Ge Hong established a theoretical system for Daoist religion. 5 The practice of distinguishing and dichotomizing the Daoist school of philosophy and Daoist religion has been opposed by many researchers. The French Sinologist Henri Maspéro (1883-1945) argues that daojia and daojiao are not so distinct as is often received; they both belong to the same ancient tradition. Maspéro's opposition to the dichotomy was also supported by Joseph Needham (1900-1995), Kristof Schipper (1934-2021), and others.6Although many scholars find it difficult to sharply separate the Daoist school of philosophy from Daoist religion,7 and also find it improper to dichotomize these two concepts, they still commonly accept the distinction and then trying to bridge the two. However, the dilemma faced by scholars compels us to wonder about the appropriateness of the philosophical paradigm dictating this distinction. In other words, do we have a more appropriate alternative? Thomas Michael's Philosophical Enactment provides us with a new perspective for reconsidering the problem of the relationship between the Daoist school of philosophy and Daoist religion, while also being an excellent example of the history writing of early Daoism. According to the general view, the Daodejing belongs to Daoist philosophy because it offers systematic... (shrink)

Previous studies have explored children’s intergroup resource allocation in the context of preexisting intergroup resource inequality. However, resource inequality between social groups often originates from different factors. This study explored the role of the origins of resource inequality on children’s intergroup resource allocations. In experiment 1, when there was no explicit origin of the intergroup inequality, children of different ages mainly allocated resources in an equal way and 5- to 6-year-olds showed ingroup bias. In experiment 2, we examined the influence (...) of different origins of intergroup inequality and found that 5- to 6-year-olds perpetuated intergroup inequality when resource inequality was based on either a structural or an internal factor. However, 10- to 11-year-olds rectified inequality or allocated equally when intergroup inequality was based on regional disparity and perpetuated resource inequality when intergroup inequality was based on performance difference. The origins of inequality appear to play an important role in children’s intergroup resource allocations, and older children can distinguish different origins of intergroup inequality in resource allocation. (shrink)

Due to the excellent approximation ability, the neural networks based control method is used to achieve adaptive consensus of the fractional-order uncertain nonlinear multiagent systems with external disturbance. The unknown nonlinear term and the external disturbance term in the systems are compensated by using the radial basis function neural networks method, a corresponding fractional-order adaption law is designed to approach the ideal neural network weight matrix of the unknown nonlinear terms, and a control law is designed eventually. According to the (...) designed Lyapunov candidate function and the fractional theory, the systems stability is proved, and the adaptive consensus can be guaranteed by using the designed control law. Finally, two simulations are shown to illustrate the validity of the obtained results. (shrink)

The current WSN is vulnerable to a variety of malicious attacks, resulting in the decline of its comprehensive performance. Multihop routing involves a number of safety and privacy issues. Problems such as snooping, sinkhole, manipulation, cloning, wormhole, spoofing, and so on affect the integrity, availability, and confidentiality of the WSNs. Therefore, this paper mainly studies the mathematical modeling of WSN multiattack behavior discrimination based on the incidence matrix. The WSN node model is used to collect relevant data and mark and (...) map the disguised data, so as to determine the characteristics of multiattack behavior and establish the WSN multiattack behavior discrimination model based on the incidence matrix. The experimental results show that the designed multiattack behavior discrimination model can distinguish the attack type according to the characteristics, has high recognition ability, can spend a short time to effectively distinguish the attack behavior, has a low false positive rate, and can effectively improve the antiattack ability of the WSN. (shrink)

Closed-loop transcutaneous auricular vagal nerve stimulation was officially proposed in 2020. This work firstly reviewed two existing CL-taVNS forms: motor-activated auricular vagus nerve stimulation and respiratory-gated auricular vagal afferent nerve stimulation, and then proposed three future CL-taVNS systems: electroencephalography -gated CL-taVNS, electrocardiography -gated CL-taVNS, and subcutaneous humoral signals -gated CL-taVNS. We also highlighted the mechanisms, targets, technical issues, and patterns of CL-taVNS. By reviewing, proposing, and highlighting, this work might draw a preliminary blueprint for the development of CL-taVNS.

Brand rumors can harm brands’ image and bring significant impacts on customers’ decision-making and sharing behavior. Finding practical strategies for preventing the spread of brand rumors continues to be a challenge. Building on the social contagion theory, the current research enriches the discussion on understanding why people spread rumors and how to deal with the spreading of rumors. Sharing brand rumors is motivated by a variety of complex psychological reasons, but prior research didn’t adequately analyze the problem from a complexity (...) perspective. Therefore, using a sample of 416 interviewers within eight types of brand rumors, this study employs fuzzy-set qualitative comparative analysis to investigate the combination of rumor psychological communication motivations in brand activities and solutions to prevent the spread of brand rumors. The current study discoveries three and two first-level configurational solutions, respectively, that can promote positive and negative rumor spreading. To summarize, emotional stimulation is a key component in the spread of rumors; altruism and relationship management motivation can coexist at times; and untrusted rumors are disseminated through other motivation factors. Solutions to prevent rumors from spreading are also provided. Furthermore, the findings help to understand the psychology of configurational motivation and how it can help brands reduce the spread of brand rumors. Finally, these discoveries’ theoretical contributions and practical implications are presented. (shrink)

This study used priming paradigm with lexical decision task to examine the effects of different levels of semantic relatedness on the identification of Chinese phonetic–semantic compound characters. Unlike previous studies that simply classify Chinese compound characters as semantically transparent or opaque, we categorize the semantic relatedness between semantic radicals and the target characters containing them into five levels: highly related, moderately related, minimally related, unrelated but sharing the semantic radical, and unrelated without sharing the semantic radical. Moreover, three stimulus-onset asynchrony (...) s were used in this study to dissociate the radical- and character-level semantic priming effects. Results revealed a graded priming effect of the semantic radical on character recognition in Chinese readers for all SOAs. More specifically, the facilitative effect of the semantic radical on character processing was most evident for the high condition, followed by the minimal, form-only, and control conditions. This suggests a graded priming effect of the semantic radical on character identification. (shrink)

Although research in the feedback-seeking behavior literature has primarily focused on feedback-seeking from supervisors, some emerging works have begun to explore the benefits of coworker feedback-seeking behavior. Based on the social exchange theory, we investigated how and when seeking feedback from coworkers will benefit the seekers. Using a sample of 327 teachers from China, we find that seeking feedback from coworkers is positively associated with task performance and workplace well-being. Seeking feedback from coworkers is also positively associated with coworker relationship. (...) Moreover, the coworker relationship mediates the effects of seeking feedback from coworkers and task performance and workplace well-being, and moderates the strength of the relationship between seeking feedback from coworkers on task performance and workplace well-being. Theoretical and practical implications of our findings are discussed. (shrink)

ObjectiveType 2 diabetes mellitus (T2DM) is a high risk of cognitive decline and dementia, but the underlying mechanisms are not yet clearly understood. This study aimed to explore the functional connectivity (FC) and topological properties among whole brain networks and correlations with impaired cognition and distinguish T2DM from healthy controls (HC) to identify potential biomarkers for cognition abnormalities.MethodsA total of 80 T2DM and 55 well-matched HC were recruited in this study. Subjects’ clinical data, neuropsychological tests and resting-state functional magnetic resonance (...) imaging data were acquired. Whole-brain network FC were mapped, the topological characteristics were analyzed using a graph-theoretic approach, the FC and topological characteristics of the network were compared between T2DM and HC using a general linear model, and correlations between networks and clinical and cognitive characteristics were identified. The support vector machine (SVM) model was used to identify differences between T2DM and HC.ResultsIn patients with T2DM, FC was higher in two core regions [precuneus/posterior cingulated cortex (PCC)_1 and later prefrontal cortex_1] in the default mode network and lower in bilateral superior parietal lobes (within dorsal attention network), and decreased between the right medial frontal cortex and left auditory cortex. The FC of the right frontal medial-left auditory cortex was positively correlated with the Montreal Cognitive Assessment scales and negatively correlated with the blood glucose levels. Long-range connectivity between bilateral auditory cortex was missing in the T2DM. The nodal degree centrality and efficiency of PCC were higher in T2DM than in HC (P < 0.005). The nodal degree centrality in the PCC in the SVM model was 97.56% accurate in distinguishing T2DM patients from HC, demonstrating the reliability of the prediction model.ConclusionFunctional abnormalities in the auditory cortex in T2DM may be related to cognitive impairment, such as memory and attention, and nodal degree centrality in the PCC might serve as a potential neuroimaging biomarker to predict and identify T2DM. (shrink)

The connotation of the “Luddite Imagination” refers to the concepts of the “Luddite Movement” and the “Luddites”, those events and individuals who are seen as conservatives behind the times. The negative connotation of the “Luddite Imagination” changed from the political connotation to cultural connotation. Neo-Luddism identifys the rational advocacy in defense of the old Luddite Movement; There are deep-seated issues involved behind the rehabilitation of thenegative connotation of the “Luddite Imagination”; It has comparative implications on China’s modernization process.

This paper proposes the modified generalization of the HSS to solve a large and sparse continuous Sylvester equation, improving the efficiency and robustness. The analysis shows that the MGHSS converges to the unique solution of AX + XB = C unconditionally. We also propose an inexact variant of the MGHSS and prove its convergence under certain conditions. Numerical experiments verify the efficiency of the proposed methods.

The quality and quantity of training data are crucial to the performance of a deep-learning-based brain-computer interface system. However, it is not practical to record EEG data over several long calibration sessions. A promising time- and cost-efficient solution is artificial data generation or data augmentation. Here, we proposed a DA method for the motor imagery EEG signal called brain-area-recombination. For the BAR, each sample was first separated into two ones by left/right brain channels, and the artificial samples were generated by (...) recombining the half-samples. We then designed two schemas corresponding to the single- and multi-subject scenarios. Extensive experiments using the classifier of EEGnet were conducted on two public datasets under various training set sizes. In both schemas, the BAR method can make the EEGnet have a better performance of classification. To make a comparative investigation, we selected two common DA methods, and the BAR method beat them. Further, using the proposed BAR for augmentation, EEGnet achieved up to 8.3% improvement than a typical decoding algorithm CSP-SVM, note that both the models were trained on the augmented dataset. This study shows that BAR usage can significantly improve the classification ability of deep learning to MI-EEG signals. To a certain extent, it may promote the development of deep learning technology in the field of BCI. (shrink)

Protein redox reactions are one of the most basic and important biochemical actions. As amino acids are weak redox mediators, most protein redox functions are undertaken by protein cofactors, which include organic ligands and transition metal ions. Since both kinds of redox cofactors were available in the pre‐protein RNA world, it is challenging to explore which one was more involved in redox processes of primitive proteins? In this paper, using an examination of the redox cofactor usage of putative ancient proteins, (...) we infer that organic ligands participated more frequently than transition metals in redox reactions of primitive proteins, at least as protein cofactors. This is further supported by the relative abundance of amino acids in the primordial world. Supplementary material for this article can be found on the BioEssays website. BioEssays 30:766–771, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

Among the many teaching methods, inquiry-based teaching is considered to be an effective way for students to learn and solve problems on their own. However, most of the research related to inquiry-based teaching and learning has concentrated mainly on K-12 education, while few to no studies have focused on the application of inquiry-based teaching and learning in project design courses at university level. Therefore, in order to expand the understanding of the application effect of inquiry-based teaching at university level, this (...) study adopted the quasi-experimental design method, and through the purposive sampling method, 20 students from the Department of Fashion Design at a University of Science and Technology were invited to participate in this study. During the 9-month period, teaching experiments were carried out using two inquiry models, QC/ADEAC and QD/ODEAC. First, when participants were thinking of a creative topic, they followed the process: Question, Collection/Analysis, Discussion, Explanation, Amendment, and Confirmation in the course. During the production process, the participants were allowed to improve on their work through the process of Question, Doing/Observation, Discussion, Explanation, Amendment, and Confirmation. The teacher became a true guide, so that the participants could explore and work out how to improve their designs through independent inquiry and practice. In this study, questionnaires were administered to participants at five important stages of the design project: “theme development,” “color development,” “first Work,” “second Work,” and “third Work.” The results of the five surveys showed that the participants’ curriculum interest, curriculum value perception, and curriculum confidence in the inquiry program all increased. (shrink)

To investigate the phenomenon of patient–physician mistrust in China, a qualitative study involving 107 physicians, nurses and health officials in Guangdong Province, southern China, was conducted through semi-structured interviews and focus groups. In this paper we report the key findings of the empirical study and argue for the essential role of medical professionalism in rebuilding patient-physician trust. Health professionals are trapped in a vicious circle of mistrust. Mistrust leads to increased levels of fear and self-protection by doctors which exacerbate difficulties (...) in communication; in turn, this increases physician workloads, adding to a strong sense of injustice and victimization. These factors produce poorer healthcare outcomes and increasingly discontented and angry patients, escalate conflicts and disputes, and result in negative media coverage, all these ultimately contributing to even greater levels of mistrust. The vicious circle indicates not only the crisis of patient-physician relationship but the crisis of medicine as a profession and institution. Underlying the circle is the inherent conflict of interest in the healthcare system by which health professionals and hospitals have become profit-driven. This institutional conflict of interest seriously compromises the fundamental principle of medical professionalism—the primacy of patient welfare—as well as the traditional Chinese ideal of “medicine as the art of humanity”. Patient trust can be restored through rectifying this institutional conflict of interest and promoting medical professionalism via a series of recommended practical measures. (shrink)

Gender differences in science and engineering have been studied in various countries. Most of these studies find that women are underrepresented in the S&E workforce and publish less than their male peers. The factors that contribute to gender differences in experience and performance in S&E careers can vary from one country to another, yet they remain underexplored. This paper is among the first to systematically compare gender differences in the publication productivity of academic scientists and engineers with doctoral degrees in (...) the U.S. and China. Findings from negative binomial regressions show that women publish less than their male counterparts in science but not in engineering in the U.S. In China, women do not differ from men in publication productivity in science but publish more than their male counterparts in engineering. In addition, we find that some background variables affect men’s and women’s publication productivity differently. The findings are analyzed in the context of the different cultures of the two fields and of the two countries. Limitations and policy implications are also discussed. (shrink)

What is the significance of bodily awareness for bodily action? The orthodox philosophical account from O'Shaughnessy claims that bodily awareness is necessary for bodily action. Whilst O'Shaughnessy's account appears to be consonant with the phenomenology of ordinary agency, it falls afoul to empirical counterexamples. The failure of O'Shaughnessy's account and its cousins might suggest that bodily action does not depend on bodily awareness. On the contrary, I argue that the contrast between the character of afferented and deafferented agency shows that (...) bodily awareness is crucial to explaining the distinctive character of bodily action in neurologically normal agents. In particular, the capacity to feel one's body ‘from the inside’ appears to be a condition on the capacity to act with one's body in a way that is not like remote control. This dependency of capacities is at once empirically adequate and in tune with the phenomenology of ordinary agency. (shrink)

Major events such as the COVID-19 pandemic, Olympic Games, and G20 Summit bring about supplier disruption risks and challenges to supply chain management. To help deal with these risks, a virtual dual-sourcing production-inventory system can be deployed. In this paper, we study such a system which consists of a raw material supplier, a manufacturer, and a virtual dual-sourcing contingency supplier. The manufacturer needs to determine the production, procurement, and inventory plan of raw materials. When its supplier is interrupted, the manufacturer (...) may need to adjust the production and inventory plan and work with the contingency supplier. We develop a system dynamics method to simulate the operations in this production-inventory system to identify the approximately optimal order-up-to-level inventory policies. We find that the virtual dual production-inventory strategy can be the optimal contingency policy to deal with supplier dynamic disruption risks. Furthermore, for disruption risk with low frequency and long duration, the manufacturer should increase the safety inventory level before the disruption. Otherwise, it should increase the safety inventory level in every cycle. (shrink)

Ben shu yi Ming ru Li Cai de jiang xue huo dong yu xue pai jian gou wei zhong xin, tan tao cong shi liu shi ji chu dao shi qi shi ji mo li xue qun ti zhong xin xing xue shuo he xue pai de chan sheng, chuan bo, kuo zhan yu chuan cheng de mo shi, bing zhuo zhong cong si xiang shi de jiao du jie shi zhe zhong mo shi chan sheng he yun xing de (...) si xiang gen yuan yu nei zai dong li. Quan shu zheng wen gong qi zhang, zhu yao nei rong fen wei shang xia liang bian, shang bian yi hong guan zong lun de fang shi, cong li xue jing dian "Da xue" de wen ben bian dong he quan shi jing zheng qie ru, tan tao zhong wan Ming li xue xue shuo he xue pai jian gou de li lun gen ju; xia bian yi Li Cai de "zhi xiu" xue shuo ji qi jiang xue huo dong zuo wei ge an yan jiu, tan tao li xue xue shuo he xue pai de chuan bo ji chuan cheng de she hui hua tu jing. (shrink)

Emergence is a notorious philosophical term of art. A variety of theorists have appropriated it for their purposes ever since George Henry Lewes gave it a philosophical sense in his 1875 Problems of Life and Mind. We might roughly characterize the shared meaning thus: emergent entities (properties or substances) ‘arise’ out of more fundamental entities and yet are ‘novel’ or ‘irreducible’ with respect to them. (For example, it is sometimes said that consciousness is an emergent property of the brain.) Each (...) of the quoted terms is slippery in its own right, and their specifications yield the varied notions of emergence that we discuss below. There has been renewed interest in emergence within discussions of the behavior of complex systems and debates over the reconcilability of mental causation, intentionality, or consciousness with physicalism. (shrink)

To explore whether the generation of new protein folds could be linked to metallic cofactor recruitment, we identified the oldest examples of folds for manganese, iron, zinc, and copper proteins by analyzing their fold‐domain mapping patterns. We discovered that the generation of these folds was tightly coupled to corresponding metals. We found that the emerging order for these folds, i.e., manganese and iron protein folds appeared earlier than zinc and copper counterparts, coincides with the putative bioavailability of the corresponding metals (...) in the ancient anoxic ocean. Therefore, we conclude that metallic cofactors, like organic cofactors, play an evolutionary role in the formation of new protein folds. This link could be explained by the emergence of protein structures with novel folds that could fulfill the new protein functions introduced by the metallic cofactors. These findings not only have important implications for understanding the evolutionary mechanisms of protein architectures, but also provide a further interpretation for the evolutionary story of superoxide dismutases. (shrink)

BackgroundPost-stroke depression is one of the most common neuropsychiatric diseases in patients with stroke, and it can increase the disability rate, mortality, and recurrence rate of stroke. Currently, many clinical studies have indicated that traditional Chinese medicine, such as acupuncture and herbs, Western medicine, rehabilitation, repeated transcranial magnetic stimulation, and other treatment methods, are effective in treating PSD. However, no study has formulated a comprehensive treatment plan that integrates TCM, Western medicine, and rehabilitation for PSD. Thus, this trial aims to (...) assess the efficacy and safety of integrative medicine for treating PSD.MethodsThis multicenter, prospective, randomized, controlled study aims to form a set of effective clinical treatment schemes that integrate TCM, Western medicine, and rehabilitation for PSD. A total of 202 participants recruited from four centers will be randomized into either the integrative medicine or standard care group. Standard care—basic treatment, general nursing care, and exercise therapy—will be provided to all participants. The integrative medicine group will also receive acupuncture, Chinese herbs, and repeated transcranial magnetic stimulation. Participants will receive acupuncture and rTMS treatments five times per week for 4 weeks and will be administered Chinese herbs, basic treatment, general nursing care, and exercise therapy for 4 weeks. The primary outcomes include the Hamilton Depression Scale, Self-Rating Depression Scale, and Activity of Daily Living Scale. And the secondary outcomes include the Montreal Cognitive Assessment Scale, the Fugl-Meyer Assessment Scale, and the Pittsburgh Sleep Quality Index. All outcome measures will be evaluated at baseline, week 4, and week 8. Safety assessments will be performed throughout the study.DiscussionThis study is expected to verify the efficacy and safety of integrative medicine for treating PSD, providing an evidence-based clinical reference for the future development of a standardized scheme.Clinical trial registrationClinicalTrials.gov, identifier: NCT05187975. (shrink)

The following framework of theses, roughly hewn, shapes contemporary discussion of the problem of mental causation: (1) Non-Identity of the Mental and the Physical Mental properties and states cannot be identified with specific physical properties and states. (2) Causal Closure (Completeness) of the Physical The objective probability of every physical event is fixed by prior physical events and laws alone. (This thesis is sometimes expressed in terms of explanation: In tracing the causal history of any physical event, one need not (...) advert to any non-physical events or laws. To the extent that there is any explanation available for a physical event, there is a complete explanation available couched entirely in physical vocabulary. We prefer the probability formulation, as it should be acceptable to any physicalist, though some reject the explanation formulation.) (3) Causal Exclusion There is at most one complete and wholly independent explanation for any given event or sequence of events. (shrink)

Emotional creativity refers to a set of cognitive abilities and personality traits related to the originality of emotional experience and expression. Previous studies have found that emotional creativity can positively predict posttraumatic growth and mental health. The outbreak of coronavirus disease 2019 (COVID-19) has posed great challenges to people’s daily lives and their mental health status. Therefore, this study aims to address the following two questions: whether emotional creativity can improve posttraumatic growth and mental health during the COVID-19 pandemic and (...) how it works. To do this, a multiple mediation model has been proposed, which supposes that emotional creativity is associated with posttraumatic growth and mental health through perceived social support and regulatory emotional self-efficacy. The study involved 423 participants from multiple regions with different COVID-19 involvement levels. Participants were asked to complete a questionnaire with six parts, which included Emotional Creativity Inventory (ECI), Regulatory Emotional Self-Efficacy Scale (RES), Stress-Related Growth Scale-Short Form (SRGS-SF), Multidimensional Scale of Perceived Social Support scale (MSPSS), Brief Symptom Inventory-18 scale (BSI-18), and COVID-19-related life events questionnaire. Path analysis used to examine the mediation model indicated that under the control of COVID-19-related life events and age, perceived social support mediated a positive association between emotional creativity and posttraumatic growth as well as a negative association between emotional creativity and all mental health problems, including somatization, depression, and anxiety. Regulatory emotional self-efficacy mediates the association between emotional creativity and posttraumatic growth, emotional creativity and anxiety, and emotional creativity and depression. The results suggest that emotional creativity plays an important role in coping with stressful events related to COVID-19. Furthermore, these results might provide a better understanding of the possible paths through which emotional creativity is related to psychological outcomes, such as mental health and posttraumatic growth. (shrink)