1-2. Sōkō -- 3. Katō Hiroyuki kōen zenshū ; Shizen to rinri ; Kokka no tōchiken ; Sekininron ; Jinsei no shizen to waga kuni no zento.

Establishment of cell lineage identity from multipotent progenitors is controlled by cooperative actions of lineage‐specific and stably expressed transcription factors, combined with input from environmental signals. Lineage‐specific master transcription factors activate and repress gene expression by recruiting consistently expressed transcription factors and chromatin modifiers to their target loci. Recent technical advances in genome‐wide and multi‐omics analysis have shed light on unexpected mechanisms that underlie more complicated actions of transcription factors in cell fate decisions. In this review, we discuss functional dynamics (...) of stably expressed and continuously required factors, Notch and Runx family members, throughout developmental stages of early T cell development in the thymus. Pre‐ and post‐commitment stage‐specific transcription factors induce dynamic redeployment of Notch and Runx binding genomic regions. Thus, together with stage‐specific transcription factors, shared transcription factors across distinct developmental stages regulate acquisition of T lineage identity. (shrink)

This collection of classic works from the mid-nineteenth through mid-twentieth centuries was originally published under the auspices of the Royal Asiastic Society. Spanning over 100 years in oriental scholarship, primary texts include work by Frederic Rosen, W.F. Thompson, C. Edward Sachau, R.A. Nicholson, W.H.T. Gairdner, W.M. Miller, James Robson, and many others.

We study the dynamics of a vortex in superfluid He4. This is carried out by deriving the effective Lagrangian for the center of the vortex by starting with the time-dependent Ginzburg-Landau formalism. From the resultant equation of motion for a vortex, we arrive at a novel aspect for the Magnus force which has long been known in fluid dynamics. This force has a geometric origin and is expected to occur in other form of condensates such as vortex excitations for quantum (...) Hall fluids or ferromagnets. We also consider the force of non geometric origin, the pinning force coming from the impurity. (shrink)

エンジニアの「知」は21世紀を拓けるか。モノを「つくる」とは、どういうことか。技術者の心に由来する「知」のありように迫る。技術における「知」の現代性を確認する。.

In this paper, we would present an overview of the recent studies on the role of diagram in mathematics. Traditionally, mathematicians and philosophers had thought that diagram should not be used in mathematical proofs, because relying on diagram would cause to various types of fallacies. But recently, some logicians and philosophers try to show that diagram has a legitimate place in proving mathematical theorems. We would review such trends of studies and provide some perspective from viewpoint of philosophy of mathematics.

日本朱子学、日本陽明学、徂徠学、幕末思想など、代表的な思想家たちの歴史観/政治観を軸に近世を俯瞰する著者の代表研究。.

Previous research found that application of eyeshadow on the upper eyelids induces overestimation of eye size. The present study examined whether this eyeshadow illusion is dependent on or independent of viewpoint. We created a three-dimensional model of a female face and manipulated the presence/absence of eyeshadow and face orientation around the axis of yaw (Experiment 1) or pitch (Experiment 2) rotation. Using the staircase method, we measured perceived eye size for each face stimulus. Results showed that the eyeshadow illusion occurred (...) regardless of face orientation around axes of both yaw and pitch rotations. Crucially, the illusion’s magnitude did not vary across face orientations; lack of interaction between the illusion’s magnitude and face orientation was confirmed by small values of Bayes factors. These findings ruled out the hypothesis that eyeshadow serves as a depth cue and leads to overestimation of eye size due to size-distance scaling. Alternatively, the present findings suggest that the eyeshadow illusion can be well explained by the assimilation between the eyes and eyeshadow, which also facilitates assimilation between the eyes and eyebrows. Practical implications and the present findings’ generalizability are also discussed. (shrink)

This article constructs a static model of information acquisition when the agent does not know exactly what pieces of information he is missing. A representation of preferences over information channels and menus of lotteries is shown by adapting the model of unforeseen contingencies by Dekel et al. (Econometrica 69:891–934, 2001; Econometrica 75:591–600, 2007), which is an extension of Kreps (Econometrica 47:565–576, 1979; Economic analysis of markets and games: essays in honor of Frank Hahn, 1992). Also, characterisation of informativeness of an (...) information channel analogous to the one by Blackwell (Ann Math Stud 24:265–272, 1953) is examined in conjunction with the preference for flexibility by applying the structure of Shapley value. (shrink)

This paper studies a fundamental mechanism by which conflicts between arguments are drawn from sentiments regarding acceptability of the arguments. Given sets of arguments, an inverse abstract argumentation problem seeks attack relations between arguments such that acceptability semantics interprets each argument in the sets of arguments as being acceptable in each of the attack relations. It is an inverse problem of the traditional problem we refer to as the forward abstract argumentation problem. Given an attack relation, the forward abstract argumentation (...) problem seeks sets of arguments such that acceptability semantics interprets each argument in the sets of arguments as being acceptable in the attack relation. We give a probabilistic model of argumentation-theoretic inference. It is a generative model formalising the process by which acceptability semantics interprets acceptability of arguments in a given attack relation. We show that it gives a broad view of solutions to the forward and inverse abstract argumentation problems. Specifically, solutions to the inverse and forward abstract argumentation problems are shown to be equivalent to a maximum likelihood estimate and maximum likelihood prediction, respectively, which are both available with the generative model. In addition, they are shown to be special cases of the posterior distribution and the evidence, respectively, which are both obtained by probabilistic inference on the generative model. We report an experiment result and application example of the generative model in the inverse problems. (shrink)

Volume 6, Issue 3, September 2015, Page 292-309.

Volume 6, Issue 3, September 2015, Page 292-309.

簡潔性、実用性に卓越したQuineの『方法』を詳説、それに基づきG ̈odelやChurchの定理を含む、標準的な論理学を厳密に展開する。また、認識論理学の「自然演繹法」化の、1つの可能性を提案する。更に、「超実数」の必要性を強調し、それにより種々のアポリア(パラドッ クス等)の解明を試みる。.

Actomyosin (actin‐myosin II complex)‐mediated contractile forces are central to the generation of multifaceted uni‐ and multi‐cellular material properties and dynamics such as cell division, migration, and tissue morphogenesis. In the present article, we summarize our recent researches addressing molecular mechanisms that ensure actomyosin‐mediated directional cell–cell junction remodeling, either shortening or extension, driving cell rearrangement for epithelial morphogenesis. Genetic perturbation clarified two points concerning cell–cell junction remodeling: an inhibitory mechanism against negative feedback in which actomyosin contractile forces, which are well known (...) to induce cell–cell junction shortening, can concomitantly alter actin dynamics, oppositely leading to perturbation of the shortening; and tricellular junctions as a point that organizes extension of new cell–cell junctions after shortening. These findings highlight the notion that cells develop underpinning mechanisms to transform the multi‐tasking property of actomyosin contractile forces into specific and proper cellular dynamics in space and time. (shrink)