Both W9 and OP3‐4 were known to bind the receptor activator of NF‐κB ligand (RANKL), inhibiting osteoclastogenesis. Recently, both peptides were shown to stimulate osteoblast differentiation; however, the mechanism underlying the activity of these peptides remains to be clarified. A primary osteoblast culture showed that rapamycin, an mTORC1 inhibitor, which was recently demonstrated to be an important serine/threonine kinase for bone formation, inhibited the peptide‐induced alkaline phosphatase activity. Furthermore, both peptides promoted the phosphorylation of Akt and S6K1, an upstream molecule (...) of mTORC1 and the effector molecule of mTORC1, respectively. In the in vivo calvarial defect model, W9 and OP3‐4 accelerated BMP‐2‐induced bone formation to a similar extent, which was confirmed by histomorphometric analyses using fluorescence images of undecalcified sections. Our data suggest that these RANKL‐binding peptides could stimulate the mTORC1 activity, which might play a role in the acceleration of BMP‐2‐induced bone regeneration by the RANKL‐binding peptides. (shrink)

One of this century's leading works on Zen, this book is a valuable source for those wishing to understand its concepts in the context of Japanese life and art.

ウィトゲンシュタインの言語ゲームと龍樹の空思想を軸に、無明=実在論を反実在論に転ずれば、仏教思想は相貌を一変し、和辻哲郎の説く「縁起‐内‐存在」の倫理の哲学史的意義も鮮明になる。本書の透徹した言葉を熟 読玩味するときひらかれる新しい世界像にあなたは驚くに違いない。.

Wabi Sabi is the Japanese Zen philosophy that all things are imperfect, unfinished and impermanent. It is a fresh way of seeing and moving through the world when our lives, literally and figuratively, feel cluttered. This book shows us how to apply this concept in the context of daily life and offers ideas on how to see it, embrace it and incorporate it into everyday thoughts, objects and situations."--Publisher description.

『日本唯物論史』などで知られるわが国の唯物論哲学の開拓者・永田廣志の生涯をまとめ、その理論活動の意義を解明。哲学研究者と在野の郷土史家との共同研究が生み出した成果。本邦初公開の貴重な資料や秘蔵写真も多 数紹介。.

dai 1-kan. Ningen, kyōiku ga umarekawaru tame -- dai 2-kan. Ningen to no deai, kyōiku to no deai -- dai 3 kan. Ningenrashiku naru tedate -- dai 4-kan. Jinrui no kibō, osanago -- dai 5-kan. Shishū, ushinawareta kisetsu o motomete -- dai 6-kan. Aru mazushiki shōgai no kiroku -- [7] Kyōiku to kyōikugaku.

A proof is given for the theorem that at least one bound state exists in a one-dimensional attractive potential however weak it may be. The proof is constructive in that it provides a method to explicitly solve the eigenvalue problem for the eigenvalues as well as the eigenfunctions. The method is well suited to precise numerical calculations.

敗戦、そして戸坂獄死から70年。1930年代、反戦運動が特高警察に根こそぎ弾圧されていくなかで、6年間にわたってしたたかに抵抗を続けた、世界に例のない文化組織「唯物論研究会」。戸坂潤をはじめ、この唯研 に集う若き知識人たちは、ファシズムが吹き荒れる下でも、人生を楽しみ、仲間と交わり、好戦イデオロギーに抗い続け、のちに戦後の民主主義運動の芽となっていった。.

思想家・後藤新平は、「儒服をつけた英雄」蕃山から何を学んだのか? 百年先を読んだ政治家、後藤新平(1857-1929)の思想はどのようにして培われてきたのか。後藤新平が終生の愛読書としていた熊沢蕃山(1619-91)の『集義和書』を手がかりに、思想家・後藤新平の知ら れざる中枢に切り込む。.

新しい社会科学の構築へ。来たるべき社会の基礎となる社会科学的方法論の課題を、第一線で活躍する十二名が「思想学」の観点から論じる。自由思想、啓蒙思想から神学、経済学まで多彩な視座より先哲の歩みを分析し、 思想研究の未来を探る充実の書。.

現代を生き抜くための武器としての哲学を、西野カナ、ミスチル、いきものがかり等Jポップの歌詞を題材に、気鋭の哲学者が説く。.

We investigate how weak square principles are denied by Chang’s Conjecture and its generalizations. Among other things we prove that Chang’s Conjecture does not imply the failure of \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\square_{\omega_1, 2}}$$\end{document}, i.e. Chang’s Conjecture is consistent with \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\square_{\omega_1, 2}}$$\end{document}.

The primary objective of this anthology is to make intergenerational justice an issue for intercultural philosophy, and, conversely, to allow the latter to enrich the former. In times of large-scale environmental destabilization, fair- ness between generations is an urgent issue of justice across time, but it is also a global issue of justice across geographical and nation-state borders. This means that the future generations envisioned by the currently living also cross these borders. Thus, different philosophical cultures and traditions of thought (...) should converse to re ect on what is fair to future people. In the remainder of this introduction, we will detail these claims and give an overview of the volume’s chapters. (shrink)

Minami–Sakai :883–898, 2016) investigated the cofinal types of the Katětov and the Katětov–Blass orders on the family of all \ ideals. In this paper we discuss these orders on analytic P-ideals and Borel ideals. We prove the following:The family of all analytic P-ideals has the largest element with respect to the Katětov and the Katětov–Blass orders.The family of all Borel ideals is countably upward directed with respect to the Katětov and the Katětov–Blass orders. In the course of the proof of (...) the latter result, we also prove that for any analytic ideal \ there is a Borel ideal \ with \. (shrink)

To become more broadly applicable, positions on AI ethics require perspectives from non-Western regions and cultures such as China and Japan. In this paper, we propose that the addition of the concept of harmony to the discussion on ethical AI would be highly beneficial due to its centrality in East Asian cultures and its applicability to the challenge of designing AI for social good. We first present a synopsis of different definitions of harmony in multiple contexts, such as music and (...) society, which reveals that the concept is, at its core, about well-balanced relationships and appropriate actions which give rise to order, balance, and aesthetically pleasing phenomena. The mediator for these well-balanced relationships isTaktwhich is an ability to act thoughtfully and sensibly according to the specific situation and to put things into proportion and order. We propose that the central challenge of building harmonizing AI is to make intelligent systems tactful and also to design and use them tactfully. For an AI system to become tactful, it needs to be able to have an advanced sensitivity to the specific contexts which it is in and their social and ethical implications and have the capability of approximately inferring the emotional and cognitive states of people with whom it is interacting. (shrink)

哲学者・古在由重がひとりの同時代人として、戦争に突き進み拡大する戦中、そして平和と民主主義を希求する戦後のなかで、何を学び、考え、仲間たちとどう交遊・談話し、どう生き、闘ったか。膨大な「古在由重文庫」 (藤沢市湘南大庭市民図書館所蔵)―古在の蔵書・著作はもちろん、原稿メモ、講義テープ、日記・手帳、書簡、新聞スクラップなど―ならびに関係者の著作・文章を渉猟し、さらに多数の人々の聞き取りなど六年をかけて 取材・執筆し、時代に正面から立ち向かった哲学者の実像に迫る力作。.