Apathy and depression are frequently observed as behavioral and psychological symptoms of dementia, respectively, and are important for ensuring adequate care. This study aims to explore effective non-pharmacological interventions for apathy and depression with mild cognitive impairment and dementia. Five search engines including PubMed, Scopus, CINAHL, PsycInfo, and Web of Science were used to extract relevant studies. Inclusion criteria were studies that involved participants who were diagnosed with MCI or dementia, included quantitative assessments of each symptom, and employed randomized controlled (...) trials. Twenty studies were extracted, with interventions have been conducted in care facilities, the community, and hospitals. Participants in many studies had MCI or mild-to-moderate dementia but were not diagnosed with the subtypes of dementia. Few studies had set apathy and depression as the primary outcomes of non-pharmacological interventions. The findings suggested that emotional and stimulation-oriented approaches to apathy and depression would be useful for people with MCI or mild-to-moderate dementia. It would be helpful for therapists to assess the clinical features of the target symptoms for selecting suitable interventions. Additionally, increasing the number of randomized controlled trials focusing on apathy or depression as primary outcomes would offer a more definite conclusion for future systematic reviews. (shrink)

Something should be done for a better global environment as soon as possible. This paper investigates the direction of management of the global environment and proposes new, concrete ideas for it.

Aworkshop was held August 26–28, 2015, by the Earth- Life Science Institute (ELSI) Origins Network (EON, see Appendix I) at the Tokyo Institute of Technology. This meeting gathered a diverse group of around 40 scholars researching the origins of life (OoL) from various perspectives with the intent to find common ground, identify key questions and investigations for progress, and guide EON by suggesting a roadmap of activities. Specific challenges that the attendees were encouraged to address included the following: What key (...) questions, ideas, and investigations should the OoL research community address in the near and long term? How can this community better organize itself and prioritize its efforts? What roles can particular subfields play, and what can ELSI and EON do to facilitate research progress? (See also Appendix II.) The present document is a product of that workshop; a white paper that serves as a record of the discussion that took place and a guide and stimulus to the solution of the most urgent and important issues in the study of the OoL. This paper is not intended to be comprehensive or a balanced representation of the opinions of the entire OoL research community. It is intended to present a number of important position statements that contain many aspirational goals and suggestions as to how progress can be made in understanding the OoL. The key role played in the field by current societies and recurring meetings over the past many decades is fully acknowledged, including the International Society for the Study of the Origin of Life (ISSOL) and its official journal Origins of Life and Evolution of Biospheres, as well as the International Society for Artificial Life (ISAL). (shrink)

During brain development, neural precursor cells (NPCs) in different brain regions produce different types of neurons, and each of these regions plays a different role in the adult brain. Therefore, precise regionalization is essential in the early stages of brain development, and irregular regionalization has been proposed as the cause of neurodevelopmental disorders. The mechanisms underlying brain regionalization have been well studied in terms of morphogen‐induced expression of critical transcription factors for regionalization. NPC potential in different brain regions is defined (...) by chromatin structures that regulate the plasticity of gene expression. Herein, we present recent findings on the importance of chromatin structure in brain regionalization, particularly with respect to its regulation by Polycomb‐group proteins and chromatin accessibility. (shrink)

西田幾多郎の中心概念「永遠の今」を外部の多様な言説に向けて開放することで、西田哲学の新たな可能性を切り開く。プラトン、アウグスティヌス、ハイデッガー、九鬼周造、デリダ、アガンベン、木村敏といった西洋哲 学、宗教学、現代思想、精神病理学の代表者たちの議論と西田の言説を突き合わせ、その緻密な解釈と検証を通して、これまで時間論で見逃されてきたカイロスの系譜とその意義を照らし出す。既成の西田研究に問題を投げ かける著者十年の集大成。岩波現代文庫オリジナル版。.

In this article we assess the general claim that Durkheimian sociology has reactionary, fascist, or totalitarian affinities, and the specific claim that Marcel Déat’s Durkheimian background was a significant factor in his becoming a Nazi sympathizer. We do so by comparing the different trajectories of the interwar generation of young Durkheimians and find that only one, i.e. Déat, can be said to have become fascist. Indeed, what characterizes this generation of Durkheimians is the variety of the ways in which they (...) responded to the crises of the interwar years, both politically and scientifically. Nonetheless, most remained on the political left, and during the war many younger members of the Durkheimian group either fled the country or were involved in the French Resistance. As the only personal link between the Durkheimian group and fascism, Déat’s career is of particular interest. Instead of Déat’s being an orthodox Durkheimian, his successive engagements embody the intellectual fragmentation and heterodoxy characteristic of the interwar generation. We outline Déat’s career by foregrounding the conjunctural and dispositional factors that we believe point toward a more plausible explanation of Déat’s transformation than does an internalist history-of-ideas approach according to which his political evolution can be explained by reference to an underlying intellectual continuity. Déat’s fascism is better explained by the repeated frustration of his political and intellectual ambitions that ultimately led to a fateful accommodation with Nazi power than by any tendency inherent to Durkheimian sociology. (shrink)

The recent declaration of the largest municipal bankruptcy in US history has propelled Detroit’s plight into the international spotlight. Though a victim of the general decline of US manufacturing, drawing on Thomas Sugrue’s pioneering work I argue that Detroit’s crisis is better understood as a specifically urban crisis. The city’s concentrated poverty and desolation and its fiscal straits are not reducible to broader economic trends, nor are they exclusively the product of political mismanagement. Rather, they are the outcome of a (...) long history of economic decentralization and racial segregation, made worse by a politico-administrative arrangement that distributes wealth and services unequally across the metropolitan area. By imposing municipal austerity, Detroit’s bankruptcy is unlikely to do much to address these fundamental inequalities. Any plan to revitalize the city must move beyond boosterism and tackle head on the problems of racial and economic segregation that continue to affect Detroit’s 700,000 residents. (shrink)

Genetic Algorithms(GAs) are effective approximation algorithms which focus on “hopeful area” in the searching process. However, in harder problems, it is often very difficult to maintain a favorable trade-off between exploitation and exploration. All individuals leave the big-valley including the global optimum, and concentrate on another big-valley including a local optimum often. In this paper, we define such a situation on conventional GAs as the “UV-phenomenon”, and suggest UV-structures as hard landscape structures that will cause the UV-phenomenon. We introduce a (...) test function which has explicit UV-structures, and show UV-phenomenon caused by them. Next we analyze Fletcher and Powell function to confirm our hypothesis. Finally we propose a novel framework of GAs which can cope with UV-structures. (shrink)

本研究は、史料的裏付けにもとづく、東アジア三地域における気の思想・文化の歴史や内容、特徴を明らかにし、東アジアにおける気の総合的・体系的研究の基礎を構築している。.

Sex chromosomes in plants have been known for a century, but only recently have we begun to understand the mechanisms behind sex determination in dioecious plants. Here, we discuss evolution of sex determination, focusing on Silene latifolia, where evolution of separate sexes is consistent with the classic “two mutations” model—a loss of function male sterility mutation and a gain of function gynoecium suppression mutation, which turned an ancestral hermaphroditic population into separate males and females. Interestingly, the gynoecium suppression function in (...) S. latifolia evolved via loss of function in at least two sex‐linked genes and works via gene dosage balance between sex‐linked, and autosomal genes. This system resembles X/A‐ratio‐based sex determination systems in Drosophila and Rumex, and could represent a steppingstone in the evolution of X/A‐ratio‐based sex determination from an active Y system. (shrink)

Graphical AbstractYeast mitochondria frequently mutate, and some dysfunctional mitochondria out-compete wild-type versions. The retrograde response enables yeast to tolerate dysfunction, but also produces ribosomal DNA circles (ERCs). We propose that ERC accumulation increases expression of the rDNA antisense gene, TAR1, which counteracts spread of respiration-deficient mitochondria in matings with wild-type yeast.