BackgroundThe UN Convention on the Rights of Persons with Disabilities, and the reformed guardianship law in Germany, require that persons with a disability, including people with dementia in Alzheimer’s disease (PwAD), are supported in making self-determined decisions. This support is achieved through communication. While content-related communication is a deficit of PwAD, relational aspects of communication are a resource. Research in supported decision-making (SDM) has investigated the effectiveness of different content-related support strategies for PwAD but has only succeeded in improving understanding, (...) which, although one criterion of capacity to consent, is not sufficient to ensure overall capacity to consent. The aim of the ‘spatial intervention study’ of the DECIDE project is to examine an innovative resource-oriented SDM approach that focuses on relational aspects. We hypothesise that talking to PwAD in their familiar home setting (as opposed to a clinical setting) will reduce the complexity of the decision-making process and enhance overall capacity to consent. MethodsPeople with a suspected or confirmed diagnosis of dementia in Alzheimer’s disease will be recruited from two memory clinics (N = 80). We will use a randomised crossover design to investigate the intervention effect of the decision-making place on capacity to consent. Besides reasoning capacity, which is part of overall capacity to consent and will be the primary outcome, various secondary outcomes (e.g., other aspects of capacity to consent, subjective task complexity, decisional conflict) and suspected moderating or mediating variables (e.g., meaning of home, demographic characteristics) will be assessed.DiscussionThe results of the study will be used to develop a new SDM strategy that is based on relational resources for PwAD. If a change in location achieves the anticipated improvement in capacity to consent, future research should focus on implementing this SDM strategy in a cost-effective manner in clinical practice.Trial registration: DRKS00030799. (shrink)

BackgroundEverybody has the right to decide whether to receive specific medical treatment or not and to provide their free, prior and informed consent to do so. As dementia progresses, people with Alzheimer’s dementia (PwAD) can lose their capacity to provide informed consent to complex medical treatment. When the capacity to consent is lost, the autonomy of the affected person can only be guaranteed when an interpretable and valid advance directive exists. Advance directives are not yet common in Germany, and their (...) validity is often questionable. Once the dementia diagnosis has been made, it is assumed to be too late to write an advance directive. One approach used to support the completion of advance directives is ‘Respecting Choices’®—an internationally recognised, evidence-based model of Advance Care Planning (ACP), which, until now, has not been evaluated for the target group of PwAD. This study’s aims include (a) to investigate the proportion of valid advance directives in a memory clinic population of persons with suspected AD, (b) to determine the predictors of valid advance directives, and (c) to examine whether the offer of ACP can increase the proportion of valid advance directives in PwAD.MethodWe intend to recruit at leastN = 250 participants from two memory clinics in 50 consecutive weeks. Of these, the first 25 weeks constitute the baseline phase (no offer of ACP), the following 25 weeks constitute the intervention phase (offer of ACP). The existence and validity of an advance directive will be assessed twice (before and after the memory clinic appointment). Moreover, potential predictors of valid advance directives are assessed.DiscussionThe results of this study will enhance the development of consent procedures for advance directives of PwAD based on the ACP/Respecting Choices (R) approach. Therefore, this project contributes towards increasing the autonomy and inclusion of PwAD and the widespread acceptance of valid advance directives in PwAD.Trial RegistrationDRKS, DRKS00026691, registered 15th of October 2021,https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00026691. (shrink)

Alles dreht sich um Werte. Sie werden von Politikern herbeizitiert, gerne bekennt man sich zu ihnen? in der Konsumwelt, in der politischen Aktionskunst, beim Wohnen, beim Essen und im Fitnesskult. Wolfgang Ullrich nimmt die Karriere der Werte in verschiedenen Bereichen unter die Lupe. Seine These: Sich zu Werten zu bekennen ist so beliebt, weil es dem Selbstbewusstsein schmeichelt. Man darf sich dann moralisch gut und sogar kreativ fühlen. Ullrich untersucht, wie Werte im Einzelnen in Szene gesetzt werden. Aber (...) er fragt auch, wie sich gesellschaftspolitische Debatten unter diesen Vorzeichen entwickeln. (shrink)

Der Band verbindet aktuelle Diskurse um nichtmenschliche oder mehr-als-menschliche Akteure in ästhetischen Prozessen mit der derzeit virulenten Debatte um "Care" bzw. Fürsorgeethik in der Kunst. Gefragt wird nach den Bedingungen, Modi und Konsequenzen einer nichtmenschlichen Ästhetik und danach, in welcher Form Tiere, Pflanzen, Pilze, Mikroben, Bakterien, Maschinen oder künstliche Intelligenzen im Rahmen von Kunstwerken handeln. Die Beiträge beleuchten, wie Künstler*innen mit nichtmenschlichen Entitäten im Rahmen von performativen oder installativen Kunstwerken interagieren und wie sie füreinander sorgen und füreinander verantwortlich sind.

Zusammenfassung Sportvereine reagieren auf einen Veränderungsdruck ihrer Umwelt selten einheitlich und keinesfalls immer so, wie es die damit verbundenen Forderungen nahe legen. Was steckt hinter diesem Phänomen? Weshalb ist es anscheinend so irrelevant für die Entwicklung der Sportvereine, wenn externe Experten die Notwendigkeit von Strukturveränderungen einfordern? Bedeutet dies, dass Sportvereine ausschließlich nach dem Gutdünken ihrer Funktionäre operieren, oder dass sie gar unfähig sind, sich von Ereignissen in ihrer Umwelt zu Lernprozessen anregen zu lassen? Der vorliegende Beitrag beschäftigt sich mit der (...) Lernfähigkeit von Sportorganisationen. Dabei zeigt sich der Sportverein als besonders lernfähig im Hinblick auf eine Abwehr von Irritationen. Die Notwendigkeit dieser Abwehr ergibt sich aus den sportvereinsspezifischen Organisationsstrukturen. (shrink)

Using an explicit task cuing paradigm, we tested whether masked cues can trigger task-set activation, which would suggest that unconsciously presented stimuli can impact cognitive control processes. Based on a critical assessment of previous findings on the priming of task-set activation, we present two experiments with a new method to approach this subject. Instead of using a prime, we varied the visibility of the cue. These cues either directly signaled particular tasks in Experiment 1, or certain task transitions in Experiment (...) 2. While both masked task and transition cues affected task choice, only task cues affected the speed of task performance. This observation suggests that task-specific stimulus–response rules can be activated only by masked cues that are uniquely associated with a particular task. Taken together, these results demonstrate that unconsciously presented stimuli have the power to activate corresponding task sets. (shrink)

This paper has two goals. The first is to develop a cross-linguistically valid model of modality and mood that captures the most important dimensions along which modal expressions vary. I posit a model with two such dimensions, one of volitivity, and one of event-orientation vs. speaker-orientation, mood being placed at the speaker-oriented end relative to modality proper. The second goal is to provide a new perspective on semantic change of modal expressions on the basis of the proposed model. I argue (...) that unidirectional change along the event-oriented / speaker-oriented dimension is the one overarching tendency of semantic change in modals. This stands in contrast to the widespread perception that change from deontic to epistemic is the dominant tendency. The directionality suggested in this new model is also more comprehensive than previously proposed tendencies of change, such as ‘‘from agent-oriented to epistemic’’, ‘‘from agent-oriented to speaker-oriented’’, and ‘‘from participant-internal to participant-external’’, as it better accounts for various kinds of change that have been previously neglected, including change from epistemic to deontic. (shrink)

The present study evaluates the cognitive representation of a kicking movement performed by a human and a humanoid robot, and how they are represented in experts and novices of soccer and robotics, respectively. To learn about the expertise-dependent development of memory structures, we compared the representation structures of soccer experts and robot experts concerning a human and humanoid robot kicking movement. We found different cognitive representation structures for both expertise groups under two different motor performance conditions . In general, the (...) expertise relies on the perceptual-motor knowledge of the human motor system. Thus, the soccer experts’ cognitive representation of the humanoid robot movement is dominated by their representation of the corresponding human movement. Additionally, our results suggest that robot experts, in contrast to soccer experts, access functional features of the technical system of the humanoid robot in addition to their perceptual-motor knowledge about the human motor system. Thus, their perceptual-motor and neuro-functional machine representation are integrated into a cognitive representation of the humanoid robot movement. (shrink)

chapter Introduction Poststructuralist perspectives on language, gender and sexual identity Since the inception of the field of language and gender in the, ...

Is consolidation needed to account for retroactive interference in free recall? Interfering mental activity during the retention interval of a memory task impairs performance, in particular if the interference occurs in temporal proximity to the encoding of the to-be-remembered information. There are at least two rival theoretical accounts of this temporal gradient of retroactive interference. The cognitive neuroscience literature has suggested neural consolidation is a pivotal factor determining item recall. According to this account, interfering activity interrupts consolidation processes that would (...) otherwise stabilize the memory representations of TBR items post-encoding. Temporal distinctiveness theory, by contrast, proposes that the retrievability of items depends on their isolation in psychological time. According to this theory, information processed after the encoding of TBR material will reduce the temporal distinctiveness of the TBR information. To test between these accounts, implementations of consolidation were added to the SIMPLE model of memory and learning. We report data from two experiments utilizing a two-list free recall paradigm. Modeling results imply that SIMPLE was able to model the data and did not benefit from the addition of consolidation. It is concluded that the temporal gradient of retroactive interference cannot be taken as evidence for memory consolidation. (shrink)

Immanuel Kant is, famously, not only the major philosopher of European enlightenment, but also one of the first philosophers to develop a philosophical theory of “human races”. How do these two sides of Kant relate to each other? What is the significance of race in Kant’s philosophy? In this article, we aim to discuss these questions by taking a close look into the conceptual and philosophical presuppositions underlying Kant’s understanding of race; relating them to the concept of teleology as developed (...) by Kant in the Critique of Judgement and to the idea of natural history that can be derived from there. In the last two chapters, we intertwine both perspectives in such a way that, on the one hand, we can determine the philosophical significance of race for Kant, and, on the other hand, show how a race-sensible perspective gives new and critical insight into Kant’s concept of reason. (shrink)

Menschen schreiben sich ein Selbst zu. Die Wissenschaften haben Mühe zu sagen, was das ist und wie es zustande kommt. Sie sind sich aber sicher, dass wir es haben und brauchen. Für Forscher ist es jedoch kaum greifbar und deshalb ein verflixtes Problem. Daran wird die Entwicklung einer starken KI scheitern, Menschen bleiben etwas anderes. Der Inhalt Die Stunde Null; Vorteile der Sterblichkeit Die Erfindung des Selbst; ohne Selbsttäuschung geht es nicht Nagelprobe Moral; warum der Liberalismus einen Neustart braucht Über (...) den Autor Dr. Heiko Reisch ist Philosoph und arbeitet als Kommunikationsberater und Journalist. Er ist Autor der,,Kleinen Geschichte der Philosophie" bei Springer VS. (shrink)

This study presents a contrastive corpus linguistic analysis of language use before and after Stonewall. It uses theoretical insights on normativity from the field of language and sexuality to investigate how the shifting normativities associated with the Stonewall Riots – widely considered the central event of gay liberation in the Western world – have shaped our conceptualization of sexuality as it surfaces in language use. Drawing on two corpora of gay men’s pre-Stonewall narratives dating from two time periods, the analysis (...) combines quantitative and qualitative corpus linguistic methods to examine discursive shifts as evident from narrators’ language use. The study identifies the terms homosexual and normal as central contrastive labels in PRE, and gay and straight as corresponding terms in POST. Other discursive shifts detected are from sexual desire/practices to identity, from an individualistic to a community-based conceptualization of sexuality, and from unquestioned heteronormativity and gender binarism to a weakening of such dominant discourses. The findings are discussed in relation to the desire-identity shift, which is traditionally assumed to have taken place at the end of the 19th century, and shed new light on Stonewall as a central event for the development of an identity-based conceptualization of sexuality as we know it today. (shrink)

Implicit and explicit filling-in phenomena should be distinguished. Blind spot phenomena and mechanisms of boundary completion can be accounted for by implicit filling-in. Surface regions are “painted” with perceptual quantities, such as brightness, by explicit filling-in. “Filling-in” and “finding-out” relate to different computational tasks. Mechanisms of purposive computation (e.g., for navigation) evaluate local measurements, thus “finding out”; whereas mechanisms for grasping might require passive reconstruction, thus “filling in.”.

This note proposes to emend the problematic preserved reading ad cuius mensae sacra (Val. Max. 4.2.3) to ad Iouis mensae sacra.

Kritik: Formbildung und Formbegriff. Das Formdenken der Moderne, hrsg. von Ralph Ubl. Malika Maskarinec, Rahel Villinger und Markus Klammer, Paderborn: Fink 2019.

In jüngerer Zeit findet wieder eine vermehrte Auseinandersetzung mit den Kategorien der Freiheit in der Kritik der praktischen Vernunft statt. Die vorliegende Arbeit bereichert diese neu erwachte Diskussion, indem sie anhand einer entwicklungsgeschichtlich orientierten Betrachtung die vernunftarchitektonische Stellung praktischer Kategorien bei Kant umfassend analysiert: Die Untersuchung nimmt ihren Ausgang bei einer frühen Reflexion, in der Kant die "Categorien der Moralität" als Funktionen der Freiheit bestimmt, und verfolgt das Thema einer praktischen Kategorienlehre über dessen eigentliche Entfaltung in der zweiten Kritik hinaus (...) bis in die Metaphysik der Sitten, in der sich in Kant bei der Entfaltung von Rechts- und Tugendlehre eines kategorialen Leitfadens bedient. (shrink)

This conceptual paper analyses the arguments which have been made in favour of a transition towards humanistic management. In order to reconcile economic as well as moral arguments an integrative model of humanistic management is presented. This model outlines prospective lines of empirical research especially in the area where business conduct is profitable but not humanistic.

Cancer is a complex disease, necessitating research on many different levels; at the subcellular level to identify genes, proteins and signaling pathways associated with the disease; at the cellular level to identify, for example, cell-cell adhesion and communication mechanisms; at the tissue level to investigate disruption of homeostasis and interaction with the tissue of origin or settlement of metastasis; and finally at the systems level to explore its global impact, e.g. through the mechanism of cachexia. Mathematical models have been proposed (...) to identify key mechanisms that underlie dynamics and events at every scale of interest, and increasing effort is now being paid to multi-scale models that bridge the different scales. With more biological data becoming available and with increased interdisciplinary efforts, theoretical models are rendering suitable tools to predict the origin and course of the disease. The ultimate aims of cancer models, however, are to enlighten our concept of the carcinogenesis process and to assist in the designing of treatment protocols that can reduce mortality and improve patient quality of life. Conventional treatment of cancer is surgery combined with radiotherapy or chemotherapy for localized tumors or systemic treatment of advanced cancers, respectively. Although radiation is widely used as treatment, most scheduling is based on empirical knowledge and less on the predictions of sophisticated growth dynamical models of treatment response. Part of the failure to translate modeling research to the clinic may stem from language barriers, exacerbated by often esoteric model renderings with inaccessible parameterization. Here we discuss some ideas for combining tractable dynamical tumor growth models with radiation response models using biologically accessible parameters to provide a more intuitive and exploitable framework for understanding the complexity of radiotherapy treatment and failure. (shrink)

ABSTRACT This paper reports on an empirical performance analysis of four modal theorem provers on benchmark suites of randomly generated formulae. The theorem provers tested are the Davis-Putnam-based procedure KSAT, the tableaux-based system KRZIS, the sequent-based Logics Workbench, and a translation approach combined with the first-order theorem prover SPASS. Our benchmark suites are sets of multi-modal formulae in a certain normal form randomly generated according to the scheme of Giunchiglia and Sebastiani [GS 96a, GS 96b]. We investigate the quality of (...) the random modal formulae and show that the scheme has some shortcomings, which may lead to mistaken conclusions. We propose improvements to the evaluation method and show that the translation approach provides a viable alternative to the other approaches. (shrink)

Following the publication of the Contributions to Philosophy, Mindfulness and the History of Being, the question of the significance of Heidegger’s later work has been widely discussed. However, th...