Multidrug-resistant Acinetobacter baumannii is recognized to be among the most difficult antimicrobial-resistant gram negative bacilli to control and treat. One of the major challenges that the pathogenic bacteria face in their host is the scarcity of freely available iron. To survive under such conditions, bacteria express new proteins on their outer membrane and also secrete iron chelators called siderophores. Antibodies directed against these proteins associated with iron uptake exert a bacteriostatic or bactericidal effect against A. baumanii in vitro, by blocking (...) siderophore mediated iron uptake pathways. Attempts should be made to discover peptides that could mimic protein epitopes and possess the same immunogenicity as the whole protein. Subsequently, theoretical methods for epitope prediction have been developed leading to synthesis of such peptides that are important for development of immunodiagnostic tests and vaccines. The present study was designed to in silico resolving the major obstacles in the control or in prevention of the diseases caused by A. baumannii. We exploited bioinformatic tools to better understand and characterize the Baumannii acinetobactin utilization structure of A. baumannii and select appropriate regions as effective B cell epitopes. In conclusion, amino acids 26–191 of cork domain and 321–635 of part of the barrel domain including L4–L9, were selected as vaccine candidates. These two regions contain functional exposed amino acids with higher score of B cell epitopes properties. Majority of amino acids are hydrophilic, flexible, accessible, and favorable for B cells from secondary structure point of view. (shrink)

Bilinguals have been shown to perform worse than monolinguals in a variety of verbal tasks. This study investigated this bilingual verbal cost in a large-scale picture-naming study conducted in Spanish. We explored how individual characteristics of the participants and the linguistic properties of the words being spoken influence this performance cost. In particular, we focused on the contributions of lexical frequency and phonological similarity across translations. The naming performance of Spanish-Catalan bilinguals speaking in their dominant and non-dominant language was compared (...) to that of Spanish monolinguals. Single trial naming latencies were analyzed by means of linear mixed models accounting for individual effects at the participant and item level. While decreasing lexical frequency was shown to increase naming latencies in all groups, this variable by itself did not account for the bilingual cost. In turn, our results showed that the bilingual cost disappeared when naming words with high phonological similarity across translations. In short, our results show that frequency of use can play a role in the emergence of the bilingual cost, but that phonological similarity across translations should be regarded as one of the most important variables that determine the bilingual cost in speech production. Low phonological similarity across translations yields worse performance in bilinguals and promotes the bilingual cost in naming performance. The implications of our results for the effect of phonological similarity across translations within the bilingual speech production system are discussed. (shrink)

Publication date: 30 November 2016 Source: Author: Akram Sadat Hosseini, Esmaeil Zohdi Racism is a worldwide matter that is based on the physical characteristics of people's division into different categories on which some people become superior and some inferior. Racism and ethnicity are usually considered as the same concepts while in fact ethnicity is a sub-class of racism. In every nation, there are some ethnic groups with the same origin and similar customs that may or may not be judged equally (...) by the power-handler ethnic groups. An example of such country is Afghanistan which is severely an ethnic country. This study explores the social, cultural, and scientific investigations done on the people's races and ethnical characteristics by using Afghan types as examples. Racism is not the result of scientific observation, but it is due to the human differences that happened between 16th and 19th century when people began differentiating among themselves. This aspect of racism is well expressed by the American sociologist "Feagin". In his view, the natural superiority of some people over others is rejected. The novel The Kite Runner depicts the two major Afghan ethnical populations, Pashtun and Hazara, and their social, cultural, and religious conflicts. Accordingly, this article will try to examine the root of ethnic prejudices and oppression among the Afghan people in the novel and the reasons for their ethnic conducts are explained and analyzed based on the Feagin’s denial of human difference. Moreover, by providing some evidence it is proved that the biological difference is just some excuses for the powerful section to gain their egotistic goals. (shrink)

The purpose of this study is to assess the efficacy of transcranial direct current stimulation in patients with treatment-refractory trigeminal neuralgia and examine the utility of neuroimaging methods in identifying markers of such efficacy. Six patients with classical TN refractory to maximal medical treatment, underwent tDCS. All patients underwent pre- and posttreatment functional magnetic resonance imaging during block-design tasks as well as single-shell diffusion MRI acquisition. The precise locations of tDCS electrodes were identified by neuronavigation. Five therapeutic tDCS sessions were (...) carried out for each patient with either anodic or cathodic applications. The Numeric Rating Scale of pain and the Headache Disability Index were used to score the subjective efficacy of treatment. Altered activity of regional sites was identified by fMRI and associated changes in the spinothalamocortical sensory tract were measured by the dMRI indices of fractional anisotropy and mean diffusivity. Fiber counts of the bilateral trigeminal root entry zone were performed as an added measure of fiber loss or recovery. All patients experienced a significant reduction in pain scores with a substantial decline in HDI in the number of contralateral sensory fibers in the STCT with either anodic or cathodic tDCS treatment in four of the six patients. A significant reduction in FA was observed in the ipsilateral REZ in the posttreatment phase in five of the six patients. Preliminary evidence suggests that navigated tDCS presents a promising method for alleviating the pain of TN. Different patterns of activation manifested by anodic and cathodic stimulation require further elaboration to understand their implication. Activation and attenuation of responses at various sites may provide further avenues for condition treatment. (shrink)

ABSTRACT A phenomenon resulting from a computationally irreducible process is supposedly unpredictable except via simulation. This notion of unpredictability has been deployed to formulate some recent accounts of computational emergence. Via a technical analysis of computational irreducibility, I show that computationally irreducibility can establish the impossibility of prediction only with respect to maximum standards of precision. By articulating the graded nature of prediction, I show that unpredictability to maximum standards is not equivalent to being unpredictable in general. I conclude that (...) computational irreducibility fails to fulfill its assigned philosophical roles in theories of computational emergence. (shrink)

In today’s schools, reading in an L2 is a very challenging task, and it is impossible to ignore the role of feedback in optimizing reading achievement. The present study was an attempt to investigate the type of both positive and corrective feedback moves utilized by L2 teachers in L2 reading comprehension classes. The study concentrated on six different kinds of corrective feedback, namely, explicit correction, recast, clarification request, metalinguistic feedback, elicitation, and repetition, as well as four positive feedback techniques: acknowledgment, (...) acceptance, rephrasing, and repetition. To this end, 40 participants were selected from a total population of 52 female EFL learners, aged 20-25, from an English language institute in Iran. In order to ensure the homogeneous entry behavior of the participants in terms of proficiency, the Oxford Placement Test , with reasonable measures of validity and reliability, was used to screen the students. All that happened in reading comprehension classes were audio recorded, transcribed, coded, and analyzed. To ensure about the consistency of the researchers in coding the data, the inter-coder reliability was run using Cronbach’s Alpha. Statistical analysis of the results revealed that repetition was the most frequently provided positive feedback by L2 teachers , followed by rephrasing . Regarding corrective feedback, explicit correction was the most frequent feedback technique and elicitation the second one utilized by L2 teachers . The results of Chi-square test showed that there was a significant difference among the frequencies of the feedback types. Hopefully the findings of this research study would help L2 teachers to have a more profound understanding of what goes on in their classes. (shrink)

There are several models for delivering bad news, the most important and widely used being the SPIKES protocol. Cultural differences in breaking bad news in different societies with different cultures call for special attention. Muslim societies are examples of communities with special cultural and religious requirements. Then, when collecting information about a person's perception of the illness or the incident, consider his or her view of spirituality and the effect of calamities on human transcendence so as to assess the type (...) and amount of information the patient or the family needs. When preparing a suitable setting for delivering bad news, pay attention to the spiritual needs of Muslims such as the possibility of prostration, recitation of Qur'an, and talking to God in private or even aloud. Be aware of, pay attention to, and respect particular religious views of the patient, and if necessary, correctly exploit such views to deliver bad news. Although some Muslim patients may have no demands for transcendence and human growth at the first stage, but over time and after accepting the condition, they will have demands. Therefore, health care providers must provide the necessary facilities for Muslim patients in terms of the required information, setting, and people present in the setting and provide information appropriate to the culture of these patients so as to give an excellent and comprehensive care. (shrink)

Religiosity has been linked with prosocial behavior and a preference for religious ingroups over outgroups. Yet, there are important differences in religious people’s beliefs, values, and practices. Fundamental and quest orientation toward religion may differentially predict intergroup bias in prosociality. Also, individualizing and binding moral foundations may have diverse effects on ingroup and outgroup bias in helping, as moral foundations theory suggests that individualizing and binding foundations differ in how much they focus on ingroup and outgroup moral considerations. In this (...) study, we examined the relationship between religious dimensions, moral foundations, prosocial behavior, and intergroup bias in helping. We found evidence for the effect of individualizing foundations, religious fundamentalism, and quest religion above and beyond demographics and other religious dimensions on intergroup bias in helping. Furthermore, there were independent positive effects of individualizing foundations, religious activity, and age, and independent negative effects of female gender and religious fundamentalism on prosocial behavior. This study provides a more nuanced understanding of the relations between religion, prosociality, and moral intuitions in a Muslim context. (shrink)

Vaccines are responsible for many global public health successes, such as the eradication of smallpox and significant reductions in other serious infections like diphtheria, pertussis, tetanus, polio and measles. However, mass vaccination has also been the subject of various ethical controversies for decades. Several factors need to be considered before any vaccine is deployed at national programme like the potential burden of disease in the country or region, the duration of the protection conferred, herd immunity in addition to individual protection, (...) vaccine-related risks, financing and the logistical feasibility of the large-scale vaccination. Moreover, several ethical dilemmas revolve around authority and mandates for vaccination, informed consent, benefits vs. risks, and disparities in access to vaccination. This review paper aims to elaborate the ethical issues involved in mass vaccination programme and present some additional challenges in the context of a resource-poor settings of public health in Bangladesh. (shrink)

Biotechnology is the use of living systems and organisms to develop or make products, or any technological application that uses biological systems, living organisms or derivatives to make or modify products or processes for specific use. Biotechnology is a constantly evolving field of modern science. New tools and products developed by biotechnologists are useful in research, agriculture, industry and healthcare. Although it has many benefits including lowering our environmental footprint, and helping in diagnosis and treatment of diseases, it comes with (...) its all-possible disadvantages. The four main societal concerns revolve around are ethical, safety, bioterrorism and environmental issues. This paper aims to describe those societal concerns raised by applications of biotechnology and possible regulations related to biotech innovations and policy implementation. (shrink)

This article describes the UniversAAL platform, an open platform intended to facilitate the development, distribution, and deployment of technological solutions for Ambient assisted living. The platform is intended to benefit end users, authorities with responsibility for AAL, and organizations involved in the development and deployment of AAL services. It consists of an extensive set of resources aimed at these different groups. The resources are classified into three main groups: runtime support, development support, and community support. The article presents the benefits (...) that can be expected from the widespread adoption of the platform. The article also describes progress on prototype implementations of some of the software resources, and the results of initial evaluations of the platform. The work is partially based on results from earlier European Union-funded research projects in the area. (shrink)

Social innovation has a great chance to overcome problems in complex environments. Individuals’ concern for environmental, social, and ethical issues has gradually grown, prompting the rise of new types of consumers, who shift their environmental concerns into action. Social entrepreneurship participants mostly act as beneficiaries and initiators in the process of social innovation. Social exchange theory explains the linkage between individual psychological factors and personal social cognitive perceptions that inspire social innovation intention. The current research framework is constructed to inspect (...) the individual mental process of psychological motivation associated with social innovation intention. The purpose is to understand the relationships between the psychological level of moral idealism, ecological concern, and prior experience on cognitive perceptions of social worth; subsequently, social worth, prosocial motivation, perspective-taking, and positive feelings are examined to discover their influence on social innovation behavioral intention. The transmitting role of social worth exercises a transformative function between participants’ psychological motivation, social cognition, and social innovation intention. The research is conducted using partial least squares analysis software. The research results reinforce our understanding of theories of individual psychological motivations on social innovation. The findings also offer some suggestions for sustainability education to social enterprise practitioners with respect to recruiting young people and continuing to generate new ideas. (shrink)

This article addresses the Egyptian women's movement of the 1950s–1970s through a recent film entitled Four Women of Egypt, which focuses on the lives of four prominent Egyptian women active in the movement during that period. Using the concept of political memory, the article traces some of the major debates within the women's movement throughout this era. By focusing on the ways in which these women conceptualize the geopolitical, I show that the twin concepts of imperialism and capitalism were central (...) to the ways in which they understood gender. The result was a complex understanding of how gender intersected with Egypt's position within a broader global system of imperial capitalism. Following the transition in the 1970s to an open-market economy, the women's movement shifted away from critiques of imperialism and capitalism. This shift can be understood Primarily in terms of geopolitics, specifically the rise of neoliberalism in Egypt. New neoliberal policies had dramatic effects on the women's movement, showing why both the rise and fall of the movement must be contextualized geopolitically and transnationally. (shrink)

Nonlinear evolution equations widely describe phenomena in various fields of science, such as plasma, nuclear physics, chemical reactions, optics, shallow water waves, fluid dynamics, signal processing, and image processing. In the present work, the derivation and analysis of Lie symmetries are presented for the time-fractional Benjamin–Bona–Mahony equation with the Riemann–Liouville derivatives. The time FBBM equation is reduced to a nonlinear fractional ordinary differential equation using its Lie symmetries. These symmetries are derivations using the prolongation theorem. Applying the subequation method, we (...) then use the integrating factor property to solve the NLFODE to obtain a few travelling wave solutions to the time FBBM. (shrink)

Moral judgment is a complex cognitive process that partly depends upon social and individual cultural values. There have been various efforts to categorize different aspects of moral judgment, but most studies depend upon rare dilemmas. We recruited 25 subjects from Tehran, Iran, to rate 150 everyday moral scenarios developed by Knutson et al. Using exploratory factor analysis, we observed that the same moral dimensions were driven by the same moral cognitive factors in Iranian vs. American studies. However, there were minor (...) differences in the factor loadings between the two cultures. Furthermore, based on the EFA results, we developed a short form of the questionnaire by removing eleven of the fifteen scenarios from each of the ten categories. These results could be used in further studies to better understand the similarities and differences in moral judgment in everyday interactions across different cultures. (shrink)

A comparative discussion on "Spiritual Health", as one of the most imperative health fundamentals was initiated. This concept has recently been added to the previous health constituents including physical, psychological and social aspects by the World Health Organization. The words "spiritual" and "health" for many people are two separate and independent issues, while they are inextricably linked. Spirituality in health is not material in nature but belongs to the realm of ideas that have arisen in the minds of human beings, (...) particularly ennobling ideas. Considering the important role which spiritual health plays in our overall sense of happiness and fulfillment as well as the direct connection between spiritual wellness and physical health, the perspectives adopted by Rene Descartes, as the "father of philosophy and modern Humanism" and Allameh Tabatabaee, as the "representative of Islamic philosophy" were compared in the present study. Due to his humanistic perspective, Descartes holds that spiritual health is of an abstract nature and is solely connectedwith human's conscience and intellectual insight indication of a naturalistic (materialistic) interpretation of humans,but it is not concerned with humans' desires, behavior and ultra-humanistic realm. Tabatabaee believes that spiritual health depends on humans'ultra‐naturalistic realm and meaning‐seeking nature, i.e. the acceptance of absolute reality principle (God) as the meaning of life that aside from correcting humans' insight and outlook assigns direction to his behavior and attitude. (shrink)

This article is an up-dated version of Gordon Brown's ontological approach to education. It tests the hypothesis that Roy Bhaskar's critical realism can successfully underpin education by applying...

Introduction -- What and how can we learn from the Quran: a critical rationalist perspective -- A critical rationalist approach to religion -- A critical assessment of the programmes of producing "Islamic science" and "Islamisation of science/knowledge" -- Faqih as engineer: a critical assessment of fiqh's epistemological status -- A critical assessment of the method of interpretation of the Quran by the Quran, in the light of Allameh Tabatabaei's Tafsir al-mizan -- The disenchantment of reason: an anti-rational trend in (...) modern Shiʻi thought- the Tafkikis -- Islamic philosophy: past, present, and future -- Doctrinal certainty: a major contributory factor to "secular" and "religious" violence in the political sphere -- Islam, Christianity, and Judaism: can they ever live peacefully together? -- The shape of the coming global civil society: suggestions for a possible Islamic perspective. (shrink)

Two Members of BBS awarded Erasmus Mundus Master of Bioethics -/- Shamima Parvin Lasker, Professor and Head, Department of Anatomy, City Dental College, Dhaka & General Secretary of BBS and Dr Abu Sadat Mohammad Nurunnabi, Lecturer of Anatomy, Dhaka Medical College, Dhaka & Life member of BBS awarded Master of Bioethics in 2012. Both they are the scholars of Erasmus Mundus Master of Bioethics. Degree was awarded by K.U.Leuven, Belgium, Radboud Universiteit Nijmegen, Netherlands and Università degli Studi di Padova, Italy. (...) -/- Prof Shamima’s research was on “Attitudes Toward Surrogacy Around Muslim World” under supervision of Dr Marcello Ghilardi, University of padova , Italy whereas Dr Nurunnabi worked on Prospects and Problems of Stem Cell Research in Bangladesh: Can Equity and Justice be Maintained in Context of Public Health Demand? under supervision of Professor Evert van leeuwen, Chair of the Section Ethics, IQ healthcare, Philosophy and History of Medicine, Radboud University, Nijmegen Medical Centre, Netherlands. -/- Thanks and congratulations for them and for their outstanding achievements on behalf of all the Members of the Bangladesh Bioethics Society. -/- . (shrink)

Kuzey Afrika’da kurulan bilâhare Endülüs bölgesini topraklarına dahil eden Murâbıtlar Devleti 448-543 yılları arasında hüküm sürmüştür. Murâbıtlar Devleti’nin temeli Kuzey Afrika’daki kabileler arasında irşad ve tebliğ faaliyetinde bulunan ve bu maksatla bir ribat kuran Mâlikî fakihi Abdullah b. Yâsîn tarafından atılmıştır. Mâlikî mezhebine mensup olan ve bu mezhebin esas alınması hususunda büyük hassasiyet gösteren Murâbıtlar Devleti emîrleri devletin kuruluş gayesine sadık kalmışlar, karar alırken fakihlere danışmışlar, onların fetvâları ve tavsiyeleri doğrultusunda devleti yönetmişlerdir. Bu durum fakihlerin tesir sahasının oldukça geniş olmasına (...) sebebiyet vermiştir. Murâbıtlar Devleti, fakihlerin bu devlette büyük bir otoriteye sahip olmaları ve bilhassa onların fetvâları ile vuku bulan hadiseler sebebiyle yıkılışından itibaren çeşitli değerlendirmelere konu olmuştur. Bu devlete son vererek bu devletin topraklarında hüküm süren Muvahhidler, müsteşrikler ve bir kısım araştırmacılar Murâbıtlar Devleti’ne tamamen olumsuz bir bakış açısıyla yaklaşmış, çeşitli ithamlarda bulunmuşlardır. Diğer taraftan bilhassa son dönemlerde bu suçlamalara cevap niteliği taşıyan çalışmalar da yapılmış, eserler ortaya konulmuştur. Bu çalışmada öncelikle Murâbıtlar Devleti’nde en önemli makam olarak kabul edilen kādılık makamını ihraz eden fakihlerin yetki ve sorumlulukları hakkında bilgi verilmiştir. Sonrasında devletin zirve döneminde hüküm sahibi olmuş Yûsuf b. Taşfîn ve Ali b. Yûsuf b. Taşfîn’in fakihlerle ilişkileri ile fakihlerin bu emîrlerin döneminde cereyan eden önemli hadise ve kararlardaki rolü ele alınmıştır. Çalışmanın son kısmında ise Murâbıtlar Devleti’nde fakihlerin konumu ve etkisi ile alakalı olarak yapılan değerlendirmelere yer verilmiştir. (shrink)

The rise of Islamic activism in Egypt during the 1970s relied in large part on the production and mass dissemination of religiously oriented periodicals. Islamic social movement organizations ranging from the established al-Gamʿiyya al-Sharʿiyya to the revived Muslim Brotherhood utilized magazines to inform, orient, and mobilize Egyptians while engaging the state directly during Anwar al-Sadat’s ‘Infitah’. By comparing the framing processes within three of the most prominent Islamist periodicals of this period, this article investigates the process by which movement leaders (...) actively constructed the frames around which activists recruited and mobilized supporters. I argue that Islamist magazines attempted to offer historical continuity with prior movements, authenticity in their teaching of religious thought and practice, and a reframing of a political agenda that was traditionally dominated by state institutions. More significantly, by forging a message that attempted to unify all of these elements, these publications aided in the construction of new communities of believers that charted the course for the next era of Islamic activism in Egypt. (shrink)