In the course of an immune response, antibodies undergo affinity maturation in order to increase their efficiency in neutralizing foreign invaders. Affinity maturation occurs by the introduction of multiple point mutations in the variable region gene that encodes the antigen binding site. This somatic hypermutation is restricted to immunoglobulin genes and occurs at very high rates. The precise molecular basis of this process remains obscure. However, recent studies using a variety of in vivo and in vitro systems have revealed important (...) regulatory regions, base motifs that are preferred targets of mutation and evidence that transcription may play an active role in hypermutation. BioEssays 20:227–234, 1998. © 1998 John Wiley & Sons, Inc. (shrink)

The article proposes to defend the basic income as a pillar of a socio-cultural revolution. This is done exclusively from a literature review and articulation of different works. The introduction section presents the characteristics of a basic income. Section 2 brings how it would mitigate current capitalism problems, which are: increasing inequality, lack of equality of opportunity, means tested social security and its bureaucracy, narrow definition of paid work and future of labor. On Section 3, the author does a literature (...) review to address two common objections against basic income: the cost, and potential labor decrease. Section 4 presents the author argument on three pillars of the socio-cultural revolution: austerity, active citizenship, and solidarity. The article ends with a general conclusion. (shrink)

“Economic man does not ask himself ethical questions”. Yet securities trading inevitably raises many ethical issues, and ethical behaviour may be restricting and costly. Drawing on his economics background and his executive experience in the insurance and pension investment industry, as well as supervisory positions on the European Option Exchange, Dr Goslings analyses the securities markets and their structure, and explores their moral strengths and weaknesses in The Netherlands and elsewhere, before offering some practical recommendations.

The importance of the Low Countries as a centre for the study of foreign languages is well-known. The mutual relationship between the Dutch grammatical tradition and the Western European context has, however, been largely neglected. In this collection of papers on the history of linguistics in the Low Countries the editors have made an effort to present the Dutch tradition in connection with that of the neighbouring countries. Three articles by Claes, Dibbets and Klifman deal with the earliest stages of (...) the development of a grammar for the Dutch vernacular. Several important European figures worked in the Low Countries; their contribution to linguistics is discussed in articles on Vossius (Rademaker), Spinoza (Klijnsmit), and one of the most original phoneticians of European linguistics, Montanus (Hulsker). Vivian Salmon's article is a survey on the relations between English and Dutch linguistics in the field of foreign language teaching. In the 19th century Dutch linguistics had a special relationship with German general and historical linguistics; four articles deal with this period (Jongeneelen, van Driel, le Loux-Schuringa, Noordegraaf). Finally, there are three articles by Kaldewij, Hagen and van Els/Knops on the development of three branches of linguistics in the 20th century: structuralism, dialectology and applied linguistics. This volume should be of interest for all specialists in the history of linguistics in Europe, who are interested in the interdependence of the various traditions. (shrink)

A careful textural analysis of the "euthyphro", this article examines both the dialogues's dramatic situation and what socrates does in conjunction with what he says, and finds among his refutations indications of what he considers the holy to be.

Jan H. Blits’ The Heart of Rome: Ancient Rome’s Political Culture examines the political activities and institutions of pre-Imperial Rome in conjunction with the habits of the hearts and the minds of the Romans. Blits emphasizes treating the writings of ancient historians of Rome as works of thoughtful reflection rather than as works of technical research.

Jan H. Blits’ The Heart of Rome: Ancient Rome’s Political Culture examines the political activities and institutions of pre-Imperial Rome in conjunction with the habits of the hearts and the minds of the Romans. Blits emphasizes treating the writings of ancient historians of Rome as works of thoughtful reflection rather than as works of technical research.

The present article on John Dewey aims at pursuing the traces of the reception of Dewey’s work in France. It is intended as a survey of the writers who have taken note of Dewey and his ideas, and is meant to function as a sort of additive inventory, with no claim to comprehensiveness. Some of the articles mentioned were unfortunately unavailable for direct examination and are thus listed merely for purposes of information.Although the educational and philosophical writings of John Dewey (...) are actually indivisible, Dewey’s oeuvre has not been read in France and Europe generally as of a piece, but has largely been registered in terms of those parts which have relevance to education and teaching. Indicative of this is the fact that it took until 1975 forDemocracy and Education -the book which, in Dewey’s own view, most clearly presented his linking of pedagogy and philosophy — to be published in France. Gérard Delledalle, the translator ofDemocracy and Education, is the only person so far in France to have dealt systematically with the whole of Dewey’s writings. He has translated other works by Dewey and has written several books on him, dealing expressly with Dewey’s philosophy of pragmatism as the foundation of his theory of education.It is actually inadequate to restrict the reception of Dewey’s work to France alone. Rather, one should speak of francophone Europe, for the first translations of Dewey’s educational writings into French were made by Adolphe Ferrière, Ovide Decroly and édouard Claparède — a Swiss, a Belgian, and a Frenchman. It was thanks to them that Dewey’s thoughts on education began to make an impact on the francophone movement for school reform in the early twentieth century.Discussion of his theory of education is typified in France as well by a division into proponents of a concept of ‘learning by doing’ indebted to Dewey and representatives of authoritarian forms of education, which reject Dewey. Although French thought has not yet concerned itself closely with pragmatism, Dewey’s opponents believed that they could denounce him and his theories simply by levelling the charge of “pragmatism.” This dualistic mode of thinking which appears to be deeply rooted in France has proved to be an obstacle to the reception of Dewey and has led to neglect and rejection of his theories. (shrink)

The first scene-by-scene philosophical study of any Shakespeare play, this book demonstrates why Shakespeare's poetic writings still arouse and sustain serious inquiry and reflection. Using a combination of philosophical rigor, political insight, and textual thoroughness, Jan H. Blits delineates the competing forms of virtue within Macbeth--the courageous public virtue of warriors like Macbeth and the internal Christian virtue evoked by Duncan. This new interpretation of Macbeth explains crucial paradoxes overlooked by previous scholars and will serve as a model for future (...) scholarship in the field. (shrink)

Concepts that include the participation and empowerment of workers are becoming increasingly important nowadays. In many of these concepts, the formal responsibility is delegated to teams. Does this imply that the normative responsibility for the actions of teams is also delegated? In this article we will reflect on the difference between holding a person accountable and bearing responsibility. A framework is elaborated in order to analyse the accountability and responsibility of teams. In this framework, the emergence of a collective mind, (...) and the organisational factors that influence the extent to which teams have the possibility of acting in a responsible way play an important role. It shows that teams can bear responsibilities that could never be carried by a group of individuals. The framework is used to analyse two sample cases with self- managing teams in production facilities. The authors discuss the implications for the theory and practice of self- managing teams and the allocation of responsibility between individuals, teams and the organisation. (shrink)

Argumentation as the public exchange of reasons is widely thought to enhance deliberative interactions that generate and justify reasonable public policies. Adopting an argumentation-theoretic perspective, we survey the norms that should govern public argumentation and address some of the complexities that scholarly treatments have identified. Our focus is on norms associated with the ideals of correctness and participation as sources of a politically legitimate deliberative outcome. In principle, both ideals are mutually coherent. If the information needed for a correct deliberative (...) outcome is distributed among agents, then maximising participation increases information diversity. But both ideals can also be in tension. If participants lack competence or are prone to biases, a correct deliberative outcome requires limiting participation. The central question for public argumentation, therefore, is how to strike a balance between both ideals. Rather than advocating a preferred normative framework, our main purpose is to illustrate the complexity of this theme. (shrink)

The human soul is for pre-modern philosophers the cause of both thinking and life. This double aspect of the soul, which makes man a rational animal, expresses itself above all in human action. Deadly Thought: 'Hamlet' and the Human Soul traces Hamlet's famous inability to act to his inability to hold together these twin aspects of the soul.

New Heaven, New Earth is a philosophical study ofAntony and Cleopatra. Showing that the play is as much a history play as a love story, it closely examines Shakespeare's presentation of the transition from the pagan to the Christian world—from the aftermath of the collapse of the Roman Republic and the decline of the pagan gods to the emergence of the Roman Empire and the conditions giving rise to Christianity.

New Heaven, New Earth is a philosophical study ofAntony and Cleopatra. Showing that the play is as much a history play as a love story, it closely examines Shakespeare's presentation of the transition from the pagan to the Christian world_from the aftermath of the collapse of the Roman Republic and the decline of the pagan gods to the emergence of the Roman Empire and the conditions giving rise to Christianity.

The present article on John Dewey aims at pursuing thetraces of the reception of Dewey's work in France. Itis intended as a survey of the writers who have takennote of Dewey and his ideas, and is meant to functionas a sort of additive inventory, with no claim tocomprehensiveness. Some of the articles mentioned wereunfortunately unavailable for direct examination andare thus listed merely for purposes of information.

The implementation of a National Ecological Network poses a significant challenge to the Dutch government. The establishment of this ecological network has led to conflicts among various interest groups in the public sphere, each of which defends its own interests. In this struggle for recognition communication fulfils an important role. This article contends that the discourse about nature is driven by deep frames, is comprised of values and is rooted in world-views. The insight that worldviews play a role elucidates the (...) various positions in the debate and shows normative dimensions in communication. This article argues that the network society, more than ever, requires the government to be explicit about its normative choices. (shrink)

Drawing on the mood-behaviour model (Gendolla, 2000), two studies investigated informational effects of mood on effort-related cardiovascular response. Experiment 1 manipulated mood state (positive, negative) and task difficulty (easy, difficult, extremely difficult). Effects on cardiovascular reactivity were as expected: On the easy level, reactivity was weak in a positive mood, but strong in a negative mood; on the difficult level, reactivity was strong in a positive mood, but weak in a negative mood; on the extremely difficulty level mood had no (...) effect. Experiment 2 manipulated mood only. As predicted, subjective demand and cardiovascular response were both higher in a negative mood than in a positive mood and the mood effect on cardiovascular response diminished after statistically controlling for the demand appraisals. Neither study revealed any mood effects on cardiovascular response during the mood inductions. (shrink)

Twenty Years After Communism is concerned with the explosion of a politics of memory triggered by the fall of state socialism in Eastern Europe, and it takes a comparative look at the ways that communism and its demise have been commemorated by major political actors across the region.

This volume explores how Catholicism began and continues to open its doors to the wider world and to other confessions in embracing ecumenism, thanks to the vision and legacy of the Second Vatican Council. It explores such themes as the twentieth century context preceding the council; parallels between Vatican II and previous councils; its distinctively pastoral character; the legacy of the council in relation to issues such as church-world dynamics, as well as to ethics, social justice, economic activity. Several chapters (...) discuss the role of women in the church before, during, and since the council. Others discern inculturation in relation to Vatican II. The book also contains a wide and original range of ecumenical considerations of the council, including by and in relation to Free Church, Reformed, Orthodox, and Anglican perspectives. Finally, it considers the Council’s ongoing promise and remaining challenges with regard to ecumenical issues, including a groundbreaking essay on the future of ecumenical dialogue by Cardinal Walter Kasper. (shrink)