Rita Bottino,1 Santosh Nagaraju,2 Vikas Satyananda,2 Hidetaka Hara,2 Martin Wijkstrom,2 Massimo Trucco,1 David KC Cooper2 1Institute of Cellular Therapeutics, Allegheny Health Network, 2Thomas E Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA: Diabetes mellitus is increasing worldwide. Type 1 diabetes can be treated successfully by islet allotransplantation, the results of which are steadily improving. However, the number of islets that can be obtained from deceased human donors will never be sufficient to cure more than a (...) very small percentage of patients who might benefit from transplantation. Although there are some differences in glucose metabolism between pigs and humans, the use of pigs could provide an unlimited supply of islets, and the insulin produced would undoubtedly control glucose levels. Transplantation of islets into the portal vein results in islets residing in the liver; however, an early inflammatory response and rejection remain problematic, even when the recipient is receiving immunosuppressive therapy. In the long term, immunosuppressive drugs may exhibit toxicities to patients and specifically harm the islet cells. In contrast, encapsulation techniques provide islets with a physical barrier that prevents antibodies binding to the islet graft while still allowing insulin to be released into the recipient's circulation; in theory, patients receiving encapsulated grafts might not require exogenous immunosuppressive therapy. Nonhuman primates with encapsulated pig islet transplants have remained insulin-independent for several weeks, but long-term efficacy remains uncertain. Furthermore, techniques are now available to knock out genes from the pig and/or insert human genes, thus rendering the antigenic structure of pigs closer to that of humans, and providing protection from the human immune response. Islet transplantation from genetically engineered pigs has been followed by insulin independence in a small number of nonhuman primates for greater than 1 year. Neonatal islets have some advantages over adult islets in that they are easier to isolate and culture, and have the ability to proliferate during the first few months after transplantation. In 2009, the International Xenotransplantation Association set up a group to encourage and advise on clinical trials of pig islet xenotransplantation; this group's guidelines are discussed. Clinical trials of encapsulated pig islets are already under way. Keywords: diabetes, islets, pancreatic, pig, xenotransplantation. (shrink)

This ground-breaking and timely book explores how big data, artificial intelligence and algorithms are creating new types of agency, and the impact that this is having on our lives and the rule of law. Addressing the issues in a thoughtful, cross-disciplinary manner, the authors examine the ways in which data-driven agency is transforming democratic practices and the meaning of individual choice. Leading scholars in law, philosophy, computer science and politics analyse the latest innovations in data science and machine learning, assessing (...) the actual and potential implications of these technologies. They investigate how this affects our understanding of such concepts as agency, epistemology, justice, transparency and democracy, and advocate a precautionary approach that takes the effects of data-driven agency seriously without taking it for granted. Scholars and students of law, ethics and philosophy, in particular legal, political and democratic theory, will find this book a compelling and invaluable read, as will computer scientists interested in the implications of their own work. It will also prove insightful for academics and activists working on privacy, fairness and anti-discrimination. Contributors include: J.E. Cohen, G. de Vries, S. Delacroix, P. Dumouchel, C. Ess, M. Garnett, E.H. Gerding, R. Gomer, C. Graber, M. Hildebrandt, C. Maple, K. O'Hara, P. Ohm, m.c. schraefel, D. Stevens, N. van Dijk, M. Veale. (shrink)

We study the problem of the approach to equilibrium in a macroscopic quantum system in an abstract setting. We prove that, for a typical choice of “nonequilibrium subspace”, any initial state (from the energy shell) thermalizes, and in fact does so very quickly, on the order of the Boltzmann time τ B := h/(k B T ). This apparently unrealistic, but mathematically rigorous, conclusion has the important physical implication that the moderately slow decay observed in reality is not typical in (...) the present setting. (shrink)

In the last few years H.G. Callaway has produced several helpful editions of some important texts by Emerson. Emerson's Conduct of Life was originally published in 1860, and it has appeared in a number of editions since then, but Callaway's edition has several noteworthy features that cause it to stand out from the crowd and make it an important contribution to Emerson studies. This is a rare volume that will serve students, academic philosophers, and causal readers alike: a critical edition (...) of a less-familiar text that is attractive to ordinary readers without sacrificing scholarly rigor. (shrink)

The growth of information acquisition, storage and retrieval capacity has led to the development of the practice of lifelogging, the undiscriminating collection of information concerning one’s life and behaviour. There are potential problems in this practice, but equally it could be empowering for the individual, and provide a new locus for the construction of an online identity. In this paper we look at the technological possibilities and constraints for lifelogging tools, and set out some of the most important privacy, identity (...) and empowerment-related issues. We argue that some of the privacy concerns are overblown, and that much research and commentary on lifelogging has made the unrealistic assumption that the information gathered is for private use, whereas, in a more socially-networked online world, much of it will have public functions and will be voluntarily released into the public domain. (shrink)

The joy of intimacy--with yourself, with others, and with the whole universe. The long-awaited first book from a prominent modern American Zen teacher. For Roshi Pat Enkyo O'Hara, intimacy is what Zen practice is all about: the realization of the essential lack of distinction between self and other that inevitably leads to wisdom and compassionate action. She approaches the practice of intimacy beginning at its most basic level--the intimacy with ourselves that is the essential first step. She then shows (...) how to bring intimacy into our relationships with others, starting with those dearest to us and moving on to those who don't seem dear at all. She then shows how to grow in intimacy so that we include everyone around us, all of society, the whole world and all the beings it contains. Each chapter is accompanied by practices she uses with her students at the Village Zendo for manifesting intimacy in our lives. (shrink)

Shōwashi e no renketsu -- Higashi Ajia kara no me -- Tennō to iu jiba -- Watashi no kaikōki -- Jikokuhyō katate ni ekisoba o.

本書は、2013年4月1日から2015年3月31日までの2年間、『みすず』誌に連載された「日記」を一書にしたものである。大学人としての仕事や作家として執筆に追われながら、政治学者として世の動向を分析し 、皇室の動きを観察し、鉄道旅行をする。日常から時代を解読する試み。.

In recent work MacPherson argues that the standard method of modeling belief logically, as a necessity operator in a modal logic, is doomed to fail. The problem with normal modal logics as logics of belief is that they treat believers as "ideal" in unrealistic ways (i.e., as omnidoxastic); however, similar problems re-emerge for candidate non-normal logics. The authors argue that logics used to model belief in artificial intelligence (AI) are also flawed in this way. But for AI systems, omnidoxasticity is (...) impossible because of their finite nature, and this fact can be exploited to produce operational models of fallible belief. The relevance of this point to various philosophical views about belief is discussed. (shrink)