Mindfulness as a clinical and nonclinical intervention for a variety of symptoms has recently received a substantial amount of interest. Although the application of mindfulness appears straightforward and its effectiveness is well supported, the concept may easily be misunderstood. This misunderstanding may severely limit the benefit of mindfulness-based interventions. It is therefore necessary to understand that the characteristics of mindfulness are based on a set of seemingly paradoxical structures. This article discusses the underlying paradox by disentangling it into five dialectical (...) positions - activity vs. passivity, wanting vs. non-wanting, changing vs. non-changing, non-judging vs. non-reacting, and active acceptance vs. passive acceptance, respectively. Finally, the practical implications for the medical professional as well as potential caveats are discussed. (shrink)

Due to the socio-demographic change in most developed western countries, elderly populations have been continuously increasing. Therefore, preventive and assistive systems that allow elderly people to independently live in their own homes as long as possible will become an economical if not ethical necessity. These respective technologies are being developed under the term "Ambient Assistive Technologies". The EU-funded AAT-project Ambient Lighting Assistance for an Ageing Population has established the long-term goal to create an adaptive system capable of improving the residential (...) lighting conditions of single living elderly persons also aiming at supporting the preservation of their independence. Results of an earlier survey revealed that the elderly perceived their current lighting situation as satisfactory, whereas interviewers assessed in-house lighting as too dark and risk-laden. The overall results of ALADIN showed a significant increase in well-being from the baseline final testing with the new adaptive lighting system. Positive results for wellbeing and life quality suggest that the outcome effects may be attributed to the introduction of technology as well as to social contacts arising from participating in the study. The technological guidance of the study supervisors, in particular, may have produced a strong social reactivity effect that was first observed in the famous Hawthorne experiments in the 1930s. As older adults seem to benefit both from meaningful social contacts as well as assistive technologies, the question arises how assistive technology can be socially embedded to be able to maximize positive health effects. Therefore ethical guidelines for development and use of new assistive technologies for handicapped/older persons have to be developed and should be discussed with regard to their applicability in the context of AAT. (shrink)

Today, the US pursues the global capture of data (understood as a significant engine of growth) by way of bi- and plurilateral trade agreements. However, the project of securing the global free flow of data has been pursued ever since the dawn of digital telecommunication in the 1960s and the US has made significant legal efforts to institutionalise it. These efforts have two phases: In the first 1970s and 80s “freedom of information” phase, the legal justification (and contestation) of the (...) global free flow of data hinged on imagining data as information, and its exchange as a practice of liberty. The second phase began in the late 1990s and continues today. In this phase, the free flow of data is aligned with a free-trade agenda in the context of first e-commerce and, starting in the 2000s, through attempts at creating a global public domain of personal data for the platform economy. The global free flow of data is an intrinsic aspect of informational capitalism. Assuming a constitutive, but not commanding role for law in informational capitalism, we conclude that the US attempt at ensuring free flow for its informational corporations is neither an entirely contingent nor a necessary outcome. It is a product of legal imagination. (shrink)

Some pejoratives are slurs—they target people on the basis of protected characteristics. Other pejoratives are what we can call “cognitive-behavioural pejoratives”: they target contemptible conduct or character, not protected characteristics. These two classes of pejoratives are semantically similar, yet the ethical profiles of their use are radically different. There is an Estonian pejorative that targets people on the basis of a mixture of ethnicity (approximately: Russian) and a cognitive-behavioural trait (approximately: chauvinism). What is the ethical status of the use of (...) such a word: a word that combines properties of ethically very different pejoratives? This paper draws upon interviews with members of the ethnic group that the word’s usage is associated with, and members of the ethnic group targeted by the word, to better understand the laudability and criticizability of various some uses of the pejorative. We defend the view that the pejorative had some plausibly laudable uses during the period when Estonia was annexed by Soviet Russia, and that (even these) uses of the pejorative are in principle susceptible to faults that, when they arise, make use of the word criticizable. (shrink)

We present a new experimental approach using a three-path interferometer and find a tighter empirical upper bound on possible violations of Born’s Rule. A deviation from Born’s rule would result in multi-order interference. Among the potential systematic errors that could lead to an apparent violation we specifically study the nonlinear response of our detectors and present ways to calibrate this error in order to obtain an even better bound.

The objective of this study was to examine whether the “step back and watch” attitude of mindfulness manifests in less emotional behavior. We hypothesized that the “acceptance” facet of mindfulness, but not the “presence” facet, is negatively associated with the magnitude of emotional behavior in four tests, i.e., rating of words, rating of aversive and neutral pictures, and evaluative conditioning . Additionally, we hypothesized that the acceptance facet is associated with increased reaction time in an emotional Stroop test, and that (...) the presence facet is associated with decreased RT and lower error rate. The sample consisted of N = 247 non-clinical adults and was tested in a cross-sectional study. The results provide partial evidence that the acceptance facet of mindfulness may be associated with less aversive reactions towards aversive stimuli. Future studies should substantiate these findings but also determine their clinical relevance. (shrink)

The book explores two radical changes of cultural and social paradigm that determined the World after 1945 - Modernism and Postmodernism. From the cataclysmic atmosphere emerged the second wave of Modernism. In art this attitude was manifested in the form of a radical break with the aesthetic and stylistic characteristics of prior generations. In architecture the International Style was born, meanwhile similar "universality" was also a characteristic of musical serialism. From the beginning of the 1970s the wheels again began to (...) turn in the other direction. The powerful destructive will of modernism increasingly waivered, and the period after modernism - postmodernism - began. The book answers questions related to the reasons for these turnarounds, their consequences and their implications. (shrink)

This article aims to adapt to Spanish the Relational Needs Satisfaction Scale and to test the factor structure with a clinical and a non-clinical sample. A total of 459 individuals completed the RNSS, a measure of life satisfaction and of psychological wellbeing. Results showed that the translation was adequate. An exploratory and confirmatory factor analysis was conducted followed by the test of three models that confirmed the five-factor structure and the second-order global factor proposed in the original study, and in (...) adaptations to other languages. The advantages and disadvantages of these models are discussed. Correlations of the RNSS with life satisfaction and psychological wellbeing measures were in the expected direction, providing evidence of convergent validity. The Spanish version of the RNSS is a valid and reliable measure of the construct it was intended to measure, though some improvements in item wording could be incorporated and tested. (shrink)

While research on object individuation assumes that even very young children are able to perceive objects as particulars, we argue that the results of relevant studies can be explained in terms of feature discrimination. We propose that children start out navigating the world with a feature‐based ontology and only later become able to individuate objects spatiotemporally. Furthermore, object individuation is a cognitively demanding achievement resting on a uniquely human form of enculturation, namely the acquisition of deictic demonstratives. We conclude by (...) outlining empirical expectations for operationalizations of our proposal. (shrink)

Infinite time register machines (ITRMs) are register machines which act on natural numbers and which are allowed to run for arbitrarily many ordinal steps. Successor steps are determined by standard register machine commands. At limit times register contents are defined by appropriate limit operations. In this paper, we examine the ITRMs introduced by the third and fourth author (Koepke and Miller in Logic and Theory of Algorithms LNCS, pp. 306–315, 2008), where a register content at a limit time is set (...) to the lim inf of previous register contents if that limit is finite; otherwise the register is reset to 0. The theory of these machines has several similarities to the infinite time Turing machines (ITTMs) of Hamkins and Lewis. The machines can decide all ${\Pi^1_1}$ sets, yet are strictly weaker than ITTMs. As in the ITTM situation, we introduce a notion of ITRM-clockable ordinals corresponding to the running times of computations. These form a transitive initial segment of the ordinals. Furthermore we prove a Lost Melody theorem: there is a real r such that there is a program P that halts on the empty input for all oracle contents and outputs 1 iff the oracle number is r, but no program can decide for every natural number n whether or not ${n \in r}$ with the empty oracle. In an earlier paper, the third author considered another type of machines where registers were not reset at infinite lim inf’s and he called them infinite time register machines. Because the resetting machines correspond much better to ITTMs we hold that in future the resetting register machines should be called ITRMs. (shrink)

Standard citation-based bibliometric tools have severe limitations when they are applied to periods in the history of science and the humanities before the advent of now-current citation practices. This paper presents an alternative method involving the extracting and analysis of mentions to map and analyze links between scholars and texts in periods that fall outside the scope of citation-based studies. Focusing on one specific discipline in one particular period and language area—Anglophone philosophy between 1890 and 1979—we describe a procedure to (...) create a mention index by identifying, extracting, and disambiguating mentions in academic publications. Our mention index includes 1,095,765 mention links, extracted from 22,977 articles published in 12 journals. We successfully link 93% of these mentions to specific philosophers, with an estimated precision of 82% to 91%. Moreover, we integrate the mention index into a database named EDHIPHY, which includes data and metadata from multiple sources and enables multidimensional mention analyses. In the final part of the paper, we present four case studies conducted by domain experts, demonstrating the use and the potential of both EDHIPHY and mention analyses more generally. (shrink)

BackgroundEverybody has the right to decide whether to receive specific medical treatment or not and to provide their free, prior and informed consent to do so. As dementia progresses, people with Alzheimer’s dementia (PwAD) can lose their capacity to provide informed consent to complex medical treatment. When the capacity to consent is lost, the autonomy of the affected person can only be guaranteed when an interpretable and valid advance directive exists. Advance directives are not yet common in Germany, and their (...) validity is often questionable. Once the dementia diagnosis has been made, it is assumed to be too late to write an advance directive. One approach used to support the completion of advance directives is ‘Respecting Choices’®—an internationally recognised, evidence-based model of Advance Care Planning (ACP), which, until now, has not been evaluated for the target group of PwAD. This study’s aims include (a) to investigate the proportion of valid advance directives in a memory clinic population of persons with suspected AD, (b) to determine the predictors of valid advance directives, and (c) to examine whether the offer of ACP can increase the proportion of valid advance directives in PwAD.MethodWe intend to recruit at leastN = 250 participants from two memory clinics in 50 consecutive weeks. Of these, the first 25 weeks constitute the baseline phase (no offer of ACP), the following 25 weeks constitute the intervention phase (offer of ACP). The existence and validity of an advance directive will be assessed twice (before and after the memory clinic appointment). Moreover, potential predictors of valid advance directives are assessed.DiscussionThe results of this study will enhance the development of consent procedures for advance directives of PwAD based on the ACP/Respecting Choices (R) approach. Therefore, this project contributes towards increasing the autonomy and inclusion of PwAD and the widespread acceptance of valid advance directives in PwAD.Trial RegistrationDRKS, DRKS00026691, registered 15th of October 2021,https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00026691. (shrink)

Spirituality is a topic of recent interest. Mindfulness, for example, a concept derived from the Buddhist tradition, has captivated the imagination of clinicians who package it in convenient intervention programs for patients. Spirituality and religion have been researched with reference to potential health benefits. Spirituality can be conceptualised as the alignment of the individual with the whole, experientially, motivationally and in action. For spirituality to unfold its true potential it is necessary to align this new movement with the mainstream of (...) science, and vice versa. Hence, both a historical review, and a systematic attempt at integration is called for, which we are trying to give here. It is useful to go back to one of the roots: parapsychology. Parapsychology was founded as a counter movement to the rising materialist paradigm in the 19th century. Adopting the methods of the natural sciences, it tried to prove the direct influence of consciousness on matter. After 125 years this mission must be declared unaccomplished. Surveying the database of parapsychological research it is obvious that it will not convince sceptics: Although there are enough exceptional findings, it has in general not been possible to reproduce them in replication experiments. This is, however, a characteristic signature of a category of effects which we call effects of generalised entanglement, predicted by a theoretical model analogous to quantum theory. Using this perspective, parapsychological effects can be understood, and the original aim of the founding fathers can be recovered, as well as a new, systematic understanding of spirituality be gained. Generalised entanglement is a formal and scientific way of explaining spirituality as alignment of an individual with a whole, which, according to the model, inevitably leads to non-local correlations. (shrink)

How does the human brain link relational concepts to perceptual experience? For example, a speaker may say “the cup to the left of the computer” to direct the listener's attention to one of two cups on a desk. We provide a neural dynamic account for both perceptual grounding, in which relational concepts enable the attentional selection of objects in the visual array, and for the generation of descriptions of the visual array using relational concepts. In the model, activation in neural (...) populations evolves dynamically under the influence of both inputs and strong interaction as formalized in dynamic field theory. Relational concepts are modeled as patterns of connectivity to perceptual representations. These generalize across the visual array through active coordinate transforms that center the representation of target objects in potential reference objects. How the model perceptually grounds or generates relational descriptions is probed in 104 simulations that systematically vary the spatial and movement relations employed, the number of feature dimensions used, and the number of matching and nonmatching objects. We explain how sequences of decisions emerge from the time‐ and state‐continuous neural dynamics, how relational hypotheses are generated and either accepted or rejected, followed by the selection of new objects or the generation of new relational hypotheses. Its neural realism distinguishes the model from information processing accounts, its capacity to autonomously generate sequences of processing steps distinguishes it from deep neural network accounts. The model points toward a neural dynamic theory of higher cognition. (shrink)

Hubertus Kohle ist ein Kunsthistoriker und Hochschullehrer, der sich besonders mit seinen Forschungen zur Kunst der europäischen Aufklärung und des 19. Jahrhunderts in Deutschland einen Namen gemacht hat. Schon früh hat er seine Disziplin digitalen Verfahren und Konzepten geöffnet und setzt sich seit Jahren für das elektronische Publizieren im Open Access ein. Aktuell widmet er sich als einer der beiden Leiter des renommierten DFG-Schwerpunktprogramms „Das digitale Bild“ auch fachübergreifend dem Thema des Digitalen. Anlässlich seines 60. Geburtstags ehren ihn zahlreiche Freunde (...) und akademische Weggefährten mit der vorliegenden Festschrift, die inhaltlich an die Schwerpunkte seines kunsthistorischen Wirkens anknüpft – von den analogen Anfängen, die der Kunst des Aufklärungszeitalters gewidmet waren, bis hin zum aktuellen Feld der „Digitalen Kunstgeschichte“. Diese Festgabe versteht sich als experimentelle Online-Publikation, die dem Jubilar zum Geburtstagstermin in einer ersten Version rein virtuell präsentiert wird. Da es sich dabei bewusst um ein „digital work in progress“ handelt, werden später weitere Beiträge ergänzt (im Inhaltsverzeichnis im unteren Abschnitt zu finden), die die Festschrift zu einem finalen E-Book komplettieren, das dann Ende 2019 parallel auch als eine analoge Buchausgabe erhältlich ist. (shrink)

Advancements in computing, instrumentation, robotics, digital imaging, and simulation modeling have changed science into a technology-driven institution. Government, industry, and society increasingly exert their influence over science, raising questions of values and objectivity. These and other profound changes have led many to speculate that we are in the midst of an epochal break in scientific history. -/- This edited volume presents an in-depth examination of these issues from philosophical, historical, social, and cultural perspectives. It offers arguments both for and against (...) the epochal break thesis in light of historical antecedents. Contributors discuss topics such as: science as a continuing epistemological enterprise; the decline of the individual scientist and the rise of communities; the intertwining of scientific and technological needs; links to prior practices and ways of thinking; the alleged divide between mode-1 and mode-2 research methods; the commodification of university science; and the shift from the scientific to a technological enterprise. Additionally, they examine the epochal break thesis using specific examples, including the transition from laboratory to real world experiments; the increased reliance on computer imaging; how analog and digital technologies condition behaviors that shape the object and beholder; the cultural significance of humanoid robots; the erosion of scientific quality in experimentation; and the effect of computers on prediction at the expense of explanation. -/- Whether these events represent a historic break in scientific theory, practice, and methodology is disputed. What they do offer is an important occasion for philosophical analysis of the epistemic, institutional and moral questions affecting current and future scientific pursuits. (shrink)

Studies of the familial association of physical activity and sedentary behavior have increased in recent years. However, there is a lack of studies that have objectively examined the correlates between parents, grandparents, and childrens' PA. Therefore, the purpose of this study was to measure PA using accelerometers to determine the extent to which PA and SB correlate among parents, grandparents, and children. A sample of 169 children between 11 and 14 years, 225 parents, and 52 grandparents were recruited for the (...) current study. Accelerometers RM42 were used to determine PA levels of children, parents, and grandparents. Epoch length was 6 s. Mothers' moderate-to-vigorous PA was associated with children's MVPA of children's MVPA. In contrast, grandfathers' sedentary behavior was a significant predictor of children's sedentary behavior. The results of the current study suggest that parental involvement in PA, particularly by mothers, is important for children's PA and, accordingly, healthy outcomes. (shrink)

At first glance the three eukaryotic protein translocation machineries – the ER‐associated degradation (ERAD) transport apparatus of the endoplasmic reticulum, the peroxisomal importomer and SELMA, the pre‐protein translocator of complex plastids – appear quite different. However, mechanistic comparisons and phylogenetic analyses presented here suggest that all three translocation machineries share a common ancestral origin, which highlights the recycling of pre‐existing components as an effective evolutionary driving force.Editor's suggested further reading in BioEssays ERAD ubiquitin ligases Abstract.

AimIf we want to understand people’s satisfaction in their relationships, it is essential to have a valid and reliable measure of relational needs satisfaction. The aim of this study was to test the factor structure of the Czech version of the Relational Needs Satisfaction Scale as well as the scale’s measurement invariance and convergent validity.MethodIn total, 419 adults answered a battery of measures, including the RNSS, in an online survey. Confirmatory factor analysis was conducted to test the factor structure and (...) the measurement invariance of the RNSS across gender and age. A correlational analysis was conducted to assess the convergent validity.ResultsThe five-factor structure of the RNSS was confirmed. Furthermore, support for a second-order global relationship satisfaction factor was found. The hierarchical model was strictly invariant with respect to gender and age. Furthermore, the RNSS demonstrated an expected pattern of correlations with the reference instruments.ConclusionThe Czech version of the RNSS can be considered a valid and reliable method. (shrink)

This collection of essays by Gregor Sebba (1905-1985) reflects the curiosity and insight of his mind. The range of topics is wide, including philosophy and the history of ideas, literature and art; yet there is a single underlying theme - human creativity and the search for truth - pursued along paths as diverse as Greek tragedy, Eric Voegelin's concept of order in history, and the poetry of Rainer Maria Rilke and T.S.Eliot.

BackgroundStress is a major risk factor for the impairment of psychological well-being. The present study aimed to evaluate the empirical evidence of the Transactional Stress Model proposed by Lazarus and Folkman in patients with psychosomatic health conditions.MethodsA structural equation model was applied in two separate subsamples of inpatients from the Department of Psychosomatic Medicine for consecutive model building and confirmatory analyses using self-reported health status information about perceived stress, personal resources, coping mechanisms, stress response, and psychological well-being.ResultsThe initial model was (...) created to reflect the theoretical assumptions by Lazarus and Folkman about their transactional stress concept. This model was modified until a sufficient model fit was reached. The modified model was confirmed in a second sample. Perceived external stressors and personal resources explained 91% of the variance of the stress response, which was closely related to symptoms of depression. The attenuating effect of resources on stress response was higher than the impact of perceived stressors on stress response.ConclusionThe empirical data largely confirmed the theoretical assumption of the Transactional Stress Model, which was first presented by Lazarus and Folkman, in patients with a wide range of psychosomatic conditions. However, data analyses were solely based on self-reported health status. Thus, proposed inner psychological mechanisms such as the appraisal process could not be included in this empirical validation. The operationalization and understanding of coping processes should be further improved. (shrink)

Die Pluralität theologischer Denkansätze wurde in jüngster Zeit mit einem Exklusivitätsanspruch von Teilen Analytischer Theologie konfrontiert. Vertreter*innen 'kontinentaler' Theologie sehen sich dadurch zu einem Metadiskurs über die Frage herausgefordert, wie Theologie heute grundsätzlich zu formatieren ist. In diesem Band treten Positionen zum ersten Mal in einen direkten argumentativen Austausch.

This volume considers the exchange between the Neo-Kantian tradition in German philosophy and the sciences from the last third of the nineteenth century to the Great war and partly beyond. During this period, various scientific disciplines underwent modernisation processes characterised by an increasing empirical inclination and a decline in the influence of metaphysics, the pluralisation of theories, and the historical and pragmatic revitalisation of scientific claims against philosophy. The various contributions look at the ways in which a certain 'Kantian orthodoxy' (...) was influenced by these new developments and whether (and how) itself had some impact on the development of the sciences. The volume is not limited to the 'exact sciences' of mathematics and physics, which are particularly important for the Kantian tradition, but also takes into account less recognised disciplines such as biology, chemistry, technology and psychology. It is complemented by contributions that contrast Neo-Kantianism with other 'scientific philosophies' of the period in question. (shrink)

The SARS-CoV-2 pandemic has highlighted the interdependency of healthcare systems and research organizations on manufacturers and suppliers of personnel protective equipment and the need for well-trained personnel who can react quickly to changing working conditions. Reports on challenges faced by research laboratory workers are rare in contrast to the lived experience of hospital health care workers. We report on experiences gained by RLWs who significantly contributed to combating the pandemic under particularly challenging conditions due to increased workload, sickness and interrupted (...) PPE supply chains. RLWs perform a broad spectrum of work with SARS-CoV-2 such as autopsies, establishment of virus cultures and infection models, development and verification of diagnostics, performance of virus inactivation assays to investigate various antiviral agents including vaccines and evaluation of decontamination technologies in high containment biological laboratories. Performance of autopsies and laboratory work increased substantially during the pandemic and thus led to highly demanding working conditions with working shifts of more than eight hours working in PPE that stressed individual limits and also the ergonomic and safety limits of PPE. We provide detailed insights into the challenges of the stressful daily laboratory routine since the pandemic began, lessons learned, and suggest solutions for better safety based on a case study of a newly established HCBL designed for autopsies and research laboratory work. Reduced personal risk, increased resilience, and stress resistance can be achieved by improved PPE components, better training, redundant safety measures, inculcating a culture of safety, and excellent teamwork. (shrink)

The requirement of naturalness has long served as an influential constraint on model-building in theoretical particle physics. Yet there are many ways of understanding what, precisely, this requirement amounts to, from restrictions on the amount of fine-tuning that a model can exhibit, to prohibitions on sensitive dependence between physics at different scales, to the requirement that dimensionless parameters defining the Lagrangian of a theory all be of order one unless they are protected by a symmetry. This workshop aims to clarify (...) the relationships among these concepts of naturalness and their connection to the hierarchy problem, as well as to assess arguments for and against imposing various forms of naturalness as a requirement on particle physics model-building. (shrink)

BackgroundThe UN Convention on the Rights of Persons with Disabilities, and the reformed guardianship law in Germany, require that persons with a disability, including people with dementia in Alzheimer’s disease (PwAD), are supported in making self-determined decisions. This support is achieved through communication. While content-related communication is a deficit of PwAD, relational aspects of communication are a resource. Research in supported decision-making (SDM) has investigated the effectiveness of different content-related support strategies for PwAD but has only succeeded in improving understanding, (...) which, although one criterion of capacity to consent, is not sufficient to ensure overall capacity to consent. The aim of the ‘spatial intervention study’ of the DECIDE project is to examine an innovative resource-oriented SDM approach that focuses on relational aspects. We hypothesise that talking to PwAD in their familiar home setting (as opposed to a clinical setting) will reduce the complexity of the decision-making process and enhance overall capacity to consent. MethodsPeople with a suspected or confirmed diagnosis of dementia in Alzheimer’s disease will be recruited from two memory clinics (N = 80). We will use a randomised crossover design to investigate the intervention effect of the decision-making place on capacity to consent. Besides reasoning capacity, which is part of overall capacity to consent and will be the primary outcome, various secondary outcomes (e.g., other aspects of capacity to consent, subjective task complexity, decisional conflict) and suspected moderating or mediating variables (e.g., meaning of home, demographic characteristics) will be assessed.DiscussionThe results of the study will be used to develop a new SDM strategy that is based on relational resources for PwAD. If a change in location achieves the anticipated improvement in capacity to consent, future research should focus on implementing this SDM strategy in a cost-effective manner in clinical practice.Trial registration: DRKS00030799. (shrink)

The discovery of the Higgs boson in 2012 at CERN completed the experimental confirmation of the Standard Model particle spectrum. Current theoretical insights and experimental data are inconclusive concerning the expectation of future discoveries. While new physics may still be within reach of the LHC or one of its successor experiments, it is also possible that the mass of particles beyond those of the Standard Model is far beyond the energy reach of any conceivable particle collider. We thus have to (...) face the possibility that the age of “on-shell discoveries” of new particles may belong to the past and that we may soon witness a change in the scientists’ perception of discoveries in fundamental physics. This article discusses the relevance of this questioning and addresses some of its potential far-reaching implications through the development, first, of a historical perspective on the concept of particle. This view is prompt to reveal important specificities of the development of particle physics. In particular, it underlines the close relationship between the evolution of observational methods and the understanding of the very idea of particle. Combining this with an analysis of the current situation of high-energy physics, this leads us to the suggestion that the particle era in science must undergo an important conceptual reconfiguration. (shrink)