As prototypical incentive with biological meaning, food illustrates the distinction between money as tool and money as drug. However, consistent neuroscience results challenge this view of food as intrinsic value and opposite to drugs of abuse. The scarce availability over evolutionary time of both food and money may explain their similar drug-like non-satiability, suggesting an integrated mechanism for generalized reinforcers. (Published Online April 5 2006).

A large interest has been dedicated in recent years to the study of models for textual databases amenable to an effective integration of search and navigation functions. In the field of legal databases the need for sophisticated models is emphasised by the need to relate and combine in an effective way different types of texts, in order to solve legal problems.In our research we have analysed several existing models, each providing specific benefits and exhibiting corresponding limitations, under both a functional (...) and economical viewpoint. (shrink)

Cultural Consultation is a clinical process that emerged from anthropological critiques of mental healthcare. It includes attention to therapeutic communication, research observations and research methods that capture cultural practices and narratives in mental healthcare. This essay describes the work of a Cultural Consultation Service (ToCCS) that improves service user outcomes by offering cultural consultation to mental health practitioners. The setting is a psychiatric service with complex and challenging work located in an ethnically diverse inner city urban area. Following a period (...) of 18 months of cultural consultation, we gather the dominant narratives that emerged during our evaluation of our service. Results: These narratives highlight how culture is conceptualized and acted upon in the day-to-day practices of individual health and social care professionals, specialist psychiatric teams and in care systems. The findings reveal common narratives and themes about culture, ethnicity, race and their perceived place and meaningfulness in clinical care. These narratives express underlying assumptions and covert rules for managing, and sometimes negating, dilemmas and difficulties when considering “culture” in the presentation and expression of mental distress. The narratives reveal an overall “culture of understanding cultural issues” and specific “cultures of care”. These emerged as necessary foci of intervention to improve service user outcomes. Conclusion: Understanding the cultures of care showed that clinical and managerial over-structuring of care prioritises organisational proficiency, but it leads to inflexibility. Consequently, the care provided is less personalised and less accommodating of cultural issues, therefore, professionals are unable to see or consider cultural influences in recovery. (shrink)

Extramural funding provides major support for biomedical research in academia, and National Institutes of Health (NIH) grants often constitute direct evaluation criteria for promotions and tenure. Therefore, NIH budget trends influence long‐term scientific strategies and career decisions, as well as the progress of science itself. Our analysis of the last 37 years of NIH awards, however, reveals that the success rate of grant applications submitted for funding is negatively related to the total yearly amount of (inflation‐adjusted) NIH extramural expenditure. Instead, (...) as might be expected, the ratio between available funding and the number of submission directly predicts the probability of winning support in any given year. We purport that the considerable success rate variability can be parsimoniously explained by a proportional but delayed reaction of the number of applications to budget fluctuations. As a counterintuitive consequence, grant proposals conceived during lean periods might stand the best chance of success. BioEssays 29:933–936, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

No one knows yet how to organize, in a simple yet predictive form, the knowledge concerning the anatomical, biophysical, and molecular properties of neurons that are accumulating in thousands of publications every year. The situation is not dissimilar to the state of Chemistry prior to Mendeleev's tabulation of the elements. We propose that the patterns of presence or absence of axons and dendrites within known anatomical parcels may serve as the key principle to define neuron types. Just as the positions (...) of the elements in the periodic table indicate their potential to combine into molecules, axonal and dendritic distributions provide the blueprint for network connectivity. Furthermore, among the features commonly employed to describe neurons, morphology is considerably robust to experimental conditions. At the same time, this core classification scheme is suitable for aggregating biochemical, physiological, and synaptic information. (shrink)

El presente trabajo trata de reconstruir la evolución diacrónica del análisis gramsciano de la Reforma y el Renacimiento tal y como este se entrecruza con una doble problemática: la revalorización de las abstracciones en la filosofía de la praxis y la constitución fallida de un Estado-nación moderno en la Italia del Siglo XVI. En la segunda parte, analizamos los aspectos lingüísticos del problema, centrándonos en el Proemio de Graziadio I. Ascoli, una fuente hasta hoy no estudiada de la (...) cuestión de la Reforma. A partir de ahí, ensayamos una lectura diacrónica en la que el abordaje gramsciano del "problema de la lengua" evoluciona de forma paralela a la revalorización de las abstracciones antes descrita. (shrink)

We show how one can obtain solutions to the Arzelà‐Ascoli theorem using suitable applications of the Bolzano‐Weierstraß principle. With this, we can apply the results from and obtain a classification of the strength of instances of the Arzelà‐Ascoli theorem and a variant of it. Let be the statement that each equicontinuous sequence of functions contains a subsequence that converges uniformly with the rate and let be the statement that each such sequence contains a subsequence which converges uniformly but (...) possibly without any rate. We show that is instance‐wise equivalent, over, to the Bolzano‐Weierstraß principle and that is instance‐wise equivalent, over, to, and thus to the strong cohesive principle (). Moreover, we show that over the principles, and are equivalent. (shrink)

We investigate the provability or nonprovability of certain ordinary mathematical theorems within certain weak subsystems of second order arithmetic. Specifically, we consider the Cauchy/Peano existence theorem for solutions of ordinary differential equations, in the context of the formal system RCA 0 whose principal axioms are ▵ 0 1 comprehension and Σ 0 1 induction. Our main result is that, over RCA 0 , the Cauchy/Peano Theorem is provably equivalent to weak Konig's lemma, i.e. the statement that every infinite {0, 1}-tree (...) has a path. We also show that, over RCA 0 , the Ascoli lemma is provably equivalent to arithmetical comprehension, as is Osgood's theorem on the existence of maximum solutions. At the end of the paper we digress to relate our results to degrees of unsolvability and to computable analysis. (shrink)

In this paper a new method, elimination of Skolem functions for monotone formulas, is developed which makes it possible to determine precisely the arithmetical strength of instances of various non-constructive function existence principles. This is achieved by reducing the use of such instances in a given proof to instances of certain arithmetical principles. Our framework are systems ${\cal T}^{\omega} :={\rm G}_n{\rm A}^{\omega} +{\rm AC}$ -qf $+\Delta$ , where (G $_n$ A $^{\omega})_{n \in {\Bbb N}}$ is a hierarchy of (weak) subsystems (...) of arithmetic in all finite types (introduced in [14]), AC-qf is the schema of quantifier-free choice in all types and $\Delta$ is a set of certain analytical principles which e.g. includes the binary König's lemma. We apply this method to show that the arithmetical closures of single instances of $\Pi^0_1$ -comprehension and -choice contribute to the growth of extractable bounds from proofs relative to ${\cal T}^\omega$ only by a primitive recursive functional in the sense of Kleene. In subsequent papers these results are widely generalized and the method is used to determine the arithmetical content of single sequences of instances of the Bolzano-Weierstraß principle for bounded sequences in ${\Bbb R}^d$ , the Ascoli-lemma and others. (shrink)

Social and cultural difference. "Only historicize": history, material culture (food, clothes, books), and the future of Dante studies -- Dante's sympathy for the other, or the non-stereotyping imagination: sexual and racialized others in the Commedia -- Contemporaries who found heterodoxy in Dante: Cecco d'Ascoli, Boccaccio, and Benvenuto da Imola on Fortuna and Inferno 7.89 -- Dante's limbo and equity of access: non-Christians, children, and criteria of inclusion and exclusion, form Inferno 4 to Paradiso 32 -- Metaphysical difference. Toward a (...) Dantean theology of eros: form Dante's lyrics to the Paradiso -- Amicus eius: Dante and the semantics of friendship -- Paradiso and the mimesis of ideas: realism versus reality -- Dante squares the circle: textual and philosophical affinities of Monarchia and Paradiso (Solutio distinctiva in Mon. 3.4.17 and Par. 4.94-114) -- Difference as punishment or difference as pleasure: from the tower of Babel in De vulgari eloquentia to the death of Babel in Paradiso 26 -- Aristotelian disruptions 1: wealth and society. Aristotle's Mezzo, courtly Misura, and Dante's Canzone "Le doci rime": humanism, ethics, and social anxiety -- Dante and wealth, between Aristotle and Cortesia: from the moral Canzoni "Le dolci rime" and "Poscia ch'amor" through Convivio to Inferno 6 and 7 -- Aristotelian disruptions 2: love and compulsion. Archeology of the Donna Gentile: the importance of disconversion in conversion narratives -- Dante and Cecco d'Ascoli on love and compulsion: the epistle to Cino, "Io sono stato," the third heaven -- "Voi che 'ntendendo il terzo ciel movete," a dramatization of "utrum de passione in passionem possit anima transformari": conflict, compulsion, consent, conversion -- Critical philology and Italian cultural history. The case of the lost original ending of Dante's Vita nuova: more notes toward a critical philology -- Critical philology and Dante's Rime. (shrink)

Introduzione.--Federico Enrico Jacobi.--Carlo Leonardo Reinhold.--Enesidemo (Graziadio Ernesto Schulze).--Sigismondo Beck.--Salomone Maimon.--Conclusione.