The history of the relationship between Jerome and Augustine has often been studied; nevertheless it seems that, even after peace was made between the two, the Stridonian advanced some criticisms of Augustine in relation to the evangelical saying about the camel and the eye. He interprets this as an expression of an absolute impossibility, while for Augustine it indicates only the difficulty of an operation which can be overcome thanks to the intervention of God.

In his Commentarium in Hieremiam, as well as in other contemporary works, Jerome accuses Pelagius of conducting a defamatory campaign against him by accusing him of Origenism, contempt for marriage and more generally, of wishing others ill. Did Jerome really seek to discredit his adversary, or were such accusations even circulating? This paper takes into consideration Pelagius’s surviving works and intends to give – within the limits admitted by the sources – an answer to this question, coming to the conclusion (...) that the conflict between the two writers was not lacking in personal attacks, and that Jerome’s report is thus trustworthy. (shrink)

El artículo aborda el comentario agustiniano a la primera carta de san Juan. Tras una sucinta introducción a la obra de Agustín, presenta los tres tipos de amor de los que en ella habla san Agustín, distinguiendo las connotaciones y características respectivas. Después se ocupa de la unidad de la Iglesia, según aparece en estos tratados, y de las alusiones a los donatistas. Finalmente habla de las cotidianas implicaciones morales del amor.

Major depressive disorder (MDD) is a severe mental illness that affects 5 to 20% of the general population. Current antidepressant drugs exerts only a partial clinical efficacy because approximately 30% of depressed patients failed to respond to these drugs and antidepressants produce remission only in 30% of patients. This can be explained by the fact that the complex pathophysiology of depression has not been completely elucidated, and treatments have been mainly developed following the “monoaminergic hypothesis” of depression without considering the (...) key role of other factors involved in the pathogenesis of MDD, such as the role of chronic stress and neuroinflammation. Chronic stress acts as a risk factor for the development of MDD through the impairment of neurotrophins signaling such as brain-derived neurotrophic factor (BDNF) and transforming-growth-factor-β1 (TGF-β1). Stress-induced depressive pathology contributes to altered BDNF level and function in MDD patients and, thereby, an impairment of neuroplasticity at the regional and circuit level. Recent studies demonstrate that aerobic exercise strongly increases BDNF production and it may contribute as a non-pharmacological strategy to improve the treatment of cognitive and affective symptoms in MDD. Here we will provide a general overview on the possible synergism between physical activity and antidepressants in MDD. Physical activity can synergize with antidepressant treatment by rescuing neurotrophin signaling in MDD patients, promoting neuronal health and recovery of function in MDD-related circuits, finally enhancing pharmacotherapeutic response. This synergism might be particularly relevant in elderly patients with late-life depression, a clinical subgroup with an increased risk to develop dementia. (shrink)