The viral and cellular forms of the Src protein tyrosine kinases take a prototypic role in oncology and signal transduction research, by virtue of being holders of an impressive number of ‘firsts’. Our understanding of the biochemistry and physiology of Src has therefore always been used as a reference for our general advancement in the field of protein phosphorylation and growth control. The recent solution of the crystal structure of two members of the Src family(1,2) represents a milestone in these (...) disciplines and, as usual, provides a general lookout post for developments to come. (shrink)

There is increasing evidence to suggest that cytoplasmic tyrosine kinases of the Src family have a pivotal role in the regulation of a number of cellular processes. Members of this family have been implicated in cellular responses to a variety of extracellular signals, such as those arising from growth factors and cell‐cell interactions, as well as in differentiative and developmental processes in both vertebrates and invertebrates. A better understanding of the regulation and of the structure‐function relationships of these enzymes might (...) aid in the development of specific ways to interfere with their action, as well as serving as a paradigm for regulation of other protein tyrosine kinases that have SH2 and SH3 domains. In this review we will first discuss the regulation of Src family protein tyrosine kinases, with particular emphasis on their SH2 and SH3 domains. We will then briefly review other non‐receptor protein tyrosine kinases that have SH2 and SH3 domains. (shrink)

In this paper, I assess critically the recent debate on corrective duties across moral and legal philosophy. Two prominent positions have emerged: the Kantian rights-based view (holding that what triggers corrections is a failure to respect others' right to freedom) and the so-called continuity view (correcting means attempting to do what one was supposed to do before). Neither position, I try to show, offers a satisfactory explanation of the ground (why correct?) and content (how to correct?) of corrective duties. In (...) the final section, I suggest that it is probably better to restrict the label “corrective duties” to duties generated by interpersonal wronging. (shrink)

In this paper, in line with the general framework of value-sensitive design, we aim to operationalize the general concept of “Meaningful Human Control” in order to pave the way for its translation into more specific design requirements. In particular, we focus on the operationalization of the first of the two conditions investigated: the so-called ‘tracking’ condition. Our investigation is led in relation to one specific subcase of automated system: dual-mode driving systems. First, we connect and compare meaningful human control with (...) a concept of control very popular in engineering and traffic psychology, and we explain to what extent tracking resembles and differs from it. This will help clarifying the extent to which the idea of meaningful human control is connected to, but also goes beyond, current notions of control in engineering and psychology. Second, we take the systematic analysis of practical reasoning as traditionally presented in the philosophy of human action and we adapt it to offer a general framework where different types of reasons and agents are identified according to their relation to an automated system’s behaviour. This framework is meant to help explaining what reasons and what agents play a role in controlling a given system, thereby enabling policy makers to produce usable guidelines and engineers to design systems that properly respond to selected human reasons. In the final part, we discuss a practical example of how our framework could be employed in designing automated driving systems. (shrink)

Contemporary brain reading technologies promise to provide the possibility to decode and interpret mental states and processes. Brain reading could have numerous societally relevant implications. In particular, the private character of mind might be affected, generating ethical and legal concerns. This paper aims at equipping ethicists and policy makers with conceptual tools to support an evaluation of the potential applicability and the implications of current and near future brain reading technology. We start with clarifying the concepts of mind reading and (...) brain reading, and the different kinds of mental states that could in principle be read. Subsequently, we devise an evaluative framework that is composed of five criteria-accuracy, reliability, informativity, concealability and enforceability-aimed at enabling a clearer estimation of the degree to which brain reading might be realistically deployed in contexts where mental privacy could be at stake. While accuracy and reliability capture how well a certain method can access mental content, informativity indicates the relevance the obtainable data have for practical purposes. Concealability and enforceability are particularly important for the evaluation of concerns about potential violations of mental privacy and civil rights. The former concerns the degree with which a brain reading method can be concealed from an individual’s perception or awareness. The latter regards the extent to which a method can be used against somebody’s will. With the help of these criteria, stakeholders can orient themselves in the rapidly developing field of brain reading. (shrink)

Recent Libet-style experiments are of limited relevance to the debate about free action and free will, and should be understood as investigations of arbitrary actions or guesses. In Libet-style experiments, the concept of 'free action' is commonly taken to refer to a 'self-initiated voluntary act', where the self prompts an action without being prompted. However, this idea is based on the problematic assumption that the conscious self needs to be free from every constraint in order to be actually free. We (...) maintain that a fundamental condition for free action is the presence of reasons to act responsibly. By analyzing a recent neuroscientific experiment, we indicate how its results could be interpreted as indicating how free action operationalization is inappropriately focusing on arbitrary actions. Hence, the way free action has been experimentally studied may have had a misleading influence on the debate about free will. (shrink)

This book shows how the Church Fathers, especially the Cappadocians in the 4th century, rethought Greek metaphysics, in particular relation, an extremely topical category. It offers a perspective to those who study philosophy, particularly in Late-Antiquity, and to those who study patristics and systematic theology.

We study how to postpone the application of the reductio ad absurdum rule (RAA) in classical natural deduction. This technique is connected with two normalization strategies for classical logic, due to Prawitz and Seldin, respectively. We introduce a variant of Seldin’s strategy for the postponement of RAA, which induces a negative translation from classical to intuitionistic and minimal logic. Through this translation, Glivenko’s theorem from classical to intuitionistic and minimal logic is proven.

We study how to postpone the application of the reductio ad absurdum rule ) in classical natural deduction. This technique is connected with two normalization strategies for classical logic, due to Prawitz and Seldin, respectively. We introduce a variant of Seldin’s strategy for the postponement of \, which induces a negative translation from classical to intuitionistic and minimal logic. Through this translation, Glivenko’s theorem from classical to intuitionistic and minimal logic is proven.

«Stare insieme, sulla faccia della terra, è diventato un compito quotidiano. (…) Sicuramente il terzo millennio sarà ricordato per aver iniziato un tratto di questa storia: la storia della convivenza degli esseri umani al plurale su tutta la terra». Il rebus pluralista è il problema per eccellenza del nostro tempo. Il problema è forse risolvibile. La libertà individuale e la giustizia sociale, la dignità della persona e la cultura, nella sua pluralità storica di forme morali, religiose, linguistiche e civili, possono (...) convivere, anzi convivono in una miracolosa quanto ovvia sintesi: la natura umana. La filosofia politica e del diritto, la scienza politica, la storia delle idee e i vari metodi delle scienze sociali suggeriscono nelle pagine che seguono alcune risposte, pongono ulteriori dubbi e propongono nuove domande. (shrink)

Su Friedrich Nietzsche e il suo pensiero è stato scritto tutto il possibile, ma, come scriveva Mazzino Montinari «questa vita è più nascosta che mai e presenta in ogni sua fase una quantità di interrogativi senza risposta sicura». Accade infatti che in genere le biografie nietzschiane accennino fugacemente alle sue opere e le analisi filosofiche non si occupino che occasionalmente della sua vita. Lo scopo di questo libro è di superare questa dicotomia descrivendo la sua umana realtà senza sacrificarne il (...) pensiero, facendo parlare lui stesso, attraverso le sue opere e i suoi scritti privati, non dimenticando che Nietzsche è stato, in primo luogo, un filologo e che a suo dire la filologia è essenzialmente «il voler capire ciò che l'autore dice». (shrink)

The brains of higher mammals are extraordinary integrative devices. Signals from large numbers of functionally specialized groups of neurons distributed over many brain regions are integrated to generate a coherent, multimodal scene. Signals from the environment are integrated with ongoing, patterned neural activity that provides them with a meaningful context. We review recent advances in neurophysiology and neuroimaging that are beginning to reveal the neural mechanisms of integration. In addition, we discuss concepts and measures derived from information theory that lend (...) a theoretical basis to the notion of complexity as integration of information and suggest new experimental tests of these concepts. (shrink)

In juxtaposition with the myth and tragedy of Ovid’s Medea, this paper investigates the possibility within the Kantian conception of agency of understanding moral evil as acting against one’s better judgment. It defends the thesis that in Kant self-deception, i. e. the intentional untruthfulness to oneself, provides the fundamental structure for choosing against the moral law. I argue that, as Kant’s thought progresses, self-deception slowly proceeds to become the paradigmatic case of moral evil. This is discussed with regard to two (...) important topics in his later moral philosophy: the doctrine of radical evil and the crucial role of the duty of truthfulness in ethics. The inquiry into Kant’s theory of conscience unfolds both against this theoretical background and in light of its historical roots in the polemic against casuistry and probabilism. This contribution closes with a brief look at the tools Kant implements to counter this tendency to self-deception in moral judgment and particularly at the role casuistry plays within his conception of moral education. (shrink)

ABSTRACT This article analyses the abbé de Saint-Pierre as a mediator of ideas between France and England. The political proposal of the Projet pour rendre la paix perpétuelle en Europe circulated in Great Britain just before the signing of the peace treaties of Utrecht and Aachen, attesting the influence that Saint-Pierre’s proposal exerted on British thought and politics. The abbé was engaged in dialogue with Quaker pacifists and, in particular, with the projects put forward by William Penn and John Bellers, (...) both theorists of a ‘European State’. After examining the relationship between Penn’s Essay and Saint-Pierre’s ideas, the article will demonstrate how elements of Bellers’s Some Reasons found their way into the Projet with numerous convergences of lexicon and content suggesting that the abbé had drawn inspiration from Bellers. Quaker ideas on politics had a greater effect on Saint-Pierre’s conception of peace and international relations than is commonly recognized. In fact, there was a constant intellectual exchange between the abbé and British political, economic and philosophical thought. (shrink)

This paper discusses a recent puzzle concerning the notions of boundary parthood and dependence, and offers a new solution. The puzzle was originally presented by Jeroen Smid and successively elaborated upon by Claudio Calosi. I first reformulate some of the troublesome premises. Particularly, whereas Smid and Calosi discuss the puzzle in terms of an underspecified notion of dependence, I propose to construe it in terms of the notion of grounding. In this manner, the dependence relation inherently carries an asymmetry, and (...) we can effectively utilize its four places. The solution I advance precisely takes advantage of this feature of dependence. My proposal avoids the contradiction while still respecting the intuitions driving the original premises. It is also fully compatible with boundaries being only generically dependent on their wholes. (shrink)

The capabilities approach is the theory according to which, in order to assess people's quality of life and reflect on the basic political entitlements, we should consider what people are capable of doing and being. Focusing mostly on Nussbaum's account, a number of scholars analysed the metaethical structure underlying the approach, showing her Aristotelian and Kantian sources. This article explores another aspect of Nussbaum's theory which has so far been somewhat overlooked: the role of emotions in the justification and motivational (...) support of the approach. After showing the importance Nussbaum places on compassion (and other benevolent emotions) to warrant her moral theory, I argue that – assuming her own cognitive account of compassion – her argument begs the question. I will then contend that Nussbaum's case does not have the inner tools to overcome such a circularity, trying to suggest, in conclusion, a possible way out which is consistent with it. (shrink)

The philosophy of emotions has long been dominated by the view called «cognitivism». According to it, emotions are characterized not by mere physical impulses but by a cognitive evaluation of their object. However, despite their success, cognitive theories have to deal with various objections and are divided on how to answer to them. In this essay I want to defend the form of cognitivism claimed by Martha Nussbaum from the most common criticisms. After a brief summary of her account, I (...) confront some of the objections that have been raised against it. In Section 2 I deal with the classic problem of emotions in infants and animals, which lack linguistic abilities. Later, I confront the potential problem represented by cases in which one’s emotion and reasoned judgment seem to differ: in paragraph 3 I consider irrational phobias and fears, to show how they can be accounted for in terms of judgments and thoughts, and not only of perceptions; in paragraph 4 I deal with the objection that «judgementalist» theories violate the «principle of charity», for they ascribe an excessive irrationality to people. I argue that experimental evidence suggest that it is not implausible to assume that people have contradictory beliefs under conditions of uncertainty, and that perceptual theories of emotion fail to account for some fundamental aspects of these phenomena. Finally, in paragraph 5, I deal with the objection according to which a cognitive-evaluative theory cannot explain the sense of passivity that we commonly experience in emotions. (shrink)

The global pandemic has levied a heavy toll on humanity, but in its wake appears a great opportunity. Amidst what he calls a crisis of modernity, Giulio Maspero points to a phenomenon that can be seen in plain sight. "The absence of personal relationships highlighted by the health crisis exposes the consequences of the modern matrix, which, having lost its Christian element, now risks transforming itself into a digital matrix, substantially configuring itself as a technognosis." Without Trinitarian framework ancient (...) and new idols emerge, as the Covid-19 tragedies have shown. Yet post-pandemic must be a moment of clarity and realism, as we can see how necessary it is that humanity place itself in relation to something beyond. The post-modern journey, however, must be in the spirit of Christian humanism or else any so-called progress will no longer be unable to speak authentically of our humanity. That is to say, the relational dimension of human life will be erased right along with the other ills that plague our earth. (shrink)