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Giovanni De Grandis [22]Giovanni De De Grandis [1]
  1. Grand Challenges and Small Steps. Introduction to the Special Issue 'Interdisciplinary Integration: The Real Grand Challenge for the Life Sciences?'.Giovanni De Grandis & Sophia Efstathiou - 2016 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 56:39-47.
    This collection addresses two different audiences: 1) historians and philosophers of the life sciences reflecting on collaborations across disciplines, especially as regards defining and addressing Grand Challenges; 2) researchers and other stakeholders involved in cross-disciplinary collaborations aimed at tackling Grand Challenges in the life and medical sciences. The essays collected here offer ideas and resources both for the study and for the practice of goal-driven cross-disciplinary research in the life and medical sciences. We organise this introduction in three sections. The (...)
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  2. Conceptual and terminological confusion around Personalised Medicine: a coping strategy.Giovanni De Grandis & Vidar Halgunset - 2016 - BMC Medical Ethics 17 (1):1-12.
    The idea of personalised medicine (PM) has gathered momentum recently, attracting funding and generating hopes as well as scepticism. As PM gives rise to differing interpretations, there have been several attempts to clarify the concept. In an influential paper published in this journal, Schleidgen and colleagues have proposed a precise and narrow definition of PM on the basis of a systematic literature review. Given that their conclusion is at odds with those of other recent attempts to understand PM, we consider (...)
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  3. When is a Techno-Fix Legitimate? The Case of Viticultural Climate Resilience.Rune Nydal, Giovanni De Grandis & Lars Ursin - 2023 - Journal of Agricultural and Environmental Ethics 36 (1):1-17.
    Climate change is an existential risk reinforced by ordinary actions in afuent societies—often silently present in comfortable and enjoyable habits. This silence is sometimes broken, presenting itself as a nagging reminder of how our habits fuel a catastrophe. As a case in point, global warming has created a state of urgency among wine makers in Spain, as the alcohol level has risen to a point where it jeopardises wine quality and thereby Spanish viticulture. Eforts are currently being made to solve (...)
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  4. Harvesting the Promise of AOPs: An assessment and recommendations.Annamaria Carusi, Mark R. Davies, Giovanni De De Grandis, Beate I. Escher, Geoff Hodges, Kenneth M. Y. Leung, Maurice Wheelan, Catherine Willet & Gerald T. Ankley - 2018 - Science of the Total Environment 628:1542-1556.
    The Adverse Outcome Pathway (AOP) concept is a knowledge assembly and communication tool to facilitate the transparent translation of mechanistic information into outcomes meaningful to the regulatory assessment of chemicals. The AOP framework and associated knowledgebases (KBs) have received significant attention and use in the regulatory toxicology community. However, it is increasingly apparent that the potential stakeholder community for the AOP concept and AOP KBs is broader than scientists and regulators directly involved in chemical safety assessment. In this paper we (...)
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  5.  58
    Fair trade in building digital knowledge repositories: the knowledge economy as if researchers mattered.Giovanni De Grandis - 2020 - Medicine, Health Care and Philosophy 23 (4):549-563.
    Both a significant body of literature and the case study presented here show that digital knowledge repositories struggle to attract the needed level of data and knowledge contribution that they need to be successful. This happens also to high profile and prestigious initiatives. The paper argues that the reluctance of researchers to contribute can only be understood in light of the highly competitive context in which research careers need to be built nowadays and how this affects researchers’ quality of life. (...)
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  6. Practical Integration: the Art of Balancing Values, Institutions and Knowledge. Lessons from the History of British Public Health and Town Planning.Giovanni De Grandis - 2016 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 56:92-105.
    The paper uses two historical examples, public health (1840-1880) and town planning (1945-1975) in Britain, to analyse the challenges faced by goal-driven research, an increasingly important trend in science policy, as exemplified by the prominence of calls for addressing Grand Challenges. Two key points are argued. (1) Given that the aim of research addressing social or global problems is to contribute to improving things, this research should include all the steps necessary to bring science and technology to fruition. This need (...)
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  7. Pharmacogenomic Inequalities: Strategies for Justice in Biomedical Research and Healthcare.Giovanni De Grandis - 2017 - Diametros 51:153-172.
    The paper discusses the possibility that the benefits of pharmacogenomics will not be distributed equally and will create orphan populations. I argue that since these inequalities are not substantially different from those produced by ‘traditional’ drugs and are not generated with the intention to discriminate, their production needs not be unethical. Still, the final result is going against deep-seated moral feelings and intuitions, as well as broadly accepted principles of just distribution of health outcomes and healthcare. I thus propose two (...)
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  8. Is regulatory innovation fit for purpose? A case study of adaptive regulation for advanced biotherapeutics.Giovanni De Grandis - 2022 - Regulation and Governance 16.
    The need to better balance the promotion of scientific and technological innovation with risk management for consumer protection has inspired several recent reforms attempting to make regulations more flexible and adaptive. The pharmaceutical sector has a long, established regulatory tradition, as well as a long history of controversies around how to balance incentives for needed therapeutic innovations and protecting patient safety. The emergence of disruptive biotechnologies has provided the occasion for regulatory innovation in this sector. This article investigates the regulation (...)
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  9. Conoscenza, azione e antropologia nella filosofia di John Rawls.Giovanni De Grandis - 2003 - Problemata. Quaderni di Filosofia 3:81-139.
  10. Pandemics - Background paper.Giovanni De Grandis & Jasper Littmann - 2011 - Forward Look Archive.
    The background paper provides an introduction to the concept of pandemics and to the ethical and political issues related with pandemic preparedness.
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  11. Measuring Openness and Evaluating Digital Academic Publishing Models: Not Quite the Same Business.Giovanni De Grandis & Yrsa Neuman - 2014 - The Journal of Electronic Publishing 17 (3).
    In this article we raise a problem, and we offer two practical contributions to its solution. The problem is that academic communities interested in digital publishing do not have adequate tools to help them in choosing a publishing model that suits their needs. We believe that excessive focus on Open Access (OA) has obscured some important issues; moreover exclusive emphasis on increasing openness has contributed to an agenda and to policies that show clear practical shortcomings. We believe that academic communities (...)
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  12. The Promise and Perils of Biotech in Personalised Healthcare. Can New Regulatory Pathways Protect the Vulnerable?Giovanni De Grandis - 2018 - Risk and Regulation Magazine 32 (Winter 2018):20-23.
    The paper discusses some of the implications of regulatory innovation in the area of advanced biological therapies and personalised medicine. Benefits, risks and trade-offs are highlighted.
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  13. Rescuing Solidarity from Its Carers. A Response to Professor ter Meulen.Giovanni De Grandis - 2015 - Diametros 43:28-43.
    The paper points out three serious problems in Ruud ter Meulen’s view of solidarity and of its role in healthcare ethics. First, it is not clear whether and to what extent ter Meulen expects normative concepts to be rooted in existing social practices: his criticism of liberal theories of justice seems to imply a different view on this issue than his implicit assumption that normative concepts are independent from social and historical trends. Second, it is not clear at which level (...)
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  14.  41
    La giustizia e il bene.Giovanni De Grandis - 2003 - Teoria Politica (2-3):341-369.
    In this article an attempt is made of presenting the deontological feature of A Theory of Justice under a new light. Through an exploration of the meaning of the priority of the good over the right and of the significance and function of the argument of the congruence between justice and individual good, the differences between teleology and deontology are displayed. Deontology seems to have several advantages: a) it allows for pluralism of values and a richer and deeper understanding of (...)
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  15.  19
    La storia, la morale e la politica in Tucidide.Giovanni De Grandis - 2008 - Teoria Politica (3):31-60.
    History, Ethics and Politics in Thucydides - The paper analyses Thucydides’s views on history, ethics and politics trying to highlight how they affect each other. Thucydides has a tragic conception of history, according to which, notwithstanding the presence of some constants, human vicissitudes are open to unpredictability and chance. This view is closely related to Thucydides moral outlook, which is interpreted as a version of moral pluralism that recognises two mutually incompatible families of values: those related with greatness and success, (...)
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  16.  51
    Making Sense of A Theory of Justice.Giovanni De Grandis - 2001 - Croatian Journal of Philosophy 1 (3):283-306.
    The primary aim of this interpretive essay is to reconstruct some of the most important features of Rawls’s theory of justice, and to offer a hypothesis about how its assumptions and arguments are tied together in a highly structured construction. An almost philological approach is adopted to highlight Rawlsian ideas. First, I consider in what sense Rawls is an individualist and in what sense he is not. Fromthis I conclude that he ought not be charged of psychological egoism or atomism. (...)
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  17. The Return of Quarantinism and How to Keep It in Check: From Wishful Regulations to Political Accountability.Giovanni De Grandis - 2010 - Dissertation, University College London
    Concerns about emerging and re-emerging infectious diseases have given a new lease of life to quarantinist measures: a series of time-honoured techniques for controlling the spread of infectious diseases through breaking the chain of human contagion. Since such measures typically infringe individual rights or privacy their use is subject to legal regulations and gives rise to ethical and political worries and suspicions. Yet in some circumstances they can be very effective. After considering some case studies that show how epidemics are (...)
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  18.  89
    A Starting Point for a Practical and Methodological Discussion. [REVIEW]Giovanni De Grandis - 2013 - (Ibidem) le Letture di Planum. The Journal of Urbanism (1):34-47.
    The paper is a critical discussion of Susan Fainstein's "The Just City". The review points out some weaknesses of Fainstein's three-dimensional account of justice, because the dimension of equity dominates over those of democracy and diversity. Moreover, the reasons for focusing on the just city instead of the good city are questioned. The review discusses two further important issues emerging from Fainstein's book: 1) the ethos of planners and, more generally, the role of experts in policy making; 2) the use (...)
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  19.  29
    Rationality in Action. [REVIEW]Giovanni de Grandis - 2002 - Croatian Journal of Philosophy 2 (3):370-374.
  20.  34
    Review of: Ethics in Technology: a Philosophical Study: Topi Heikkerö 2012 (Lanham MD, Lexington Books) ISBN 978073995918. 246 pp. [REVIEW]Giovanni De Grandis - 2018 - NanoEthics 12 (1):75-78.
  21.  35
    The Impact of the Internet on Our Moral Lives R. J. Cavalier ,The Impact of the Internet on Our Moral Lives, 249 pp., $26.95/£16.75 paperback. [REVIEW]Giovanni De Grandis - 2006 - Politics and Ethics Review 2 (2):224-226.
  22. The Rise (and Fall?) of Normative Ethics’, Critical Notice of Sergio Cremaschi’s L’etica del Novecento. [REVIEW]Giovanni De Grandis - 2006 - Etica E Politica (1):1-12.
    Sergio Cremaschi’s L’etica del Novecento offers a clear and careful account of the development of ethical theory in English-language and German Philosophy. The focus on meta-ethics and normative concerns allows the author to offer a very concise, reliable and comprehensive overview of philosophical ethics. In this respect the book effectively fills the gap left by the lack of a good, updated history of ethics. Although those qualities establish Cremaschi’s work as a valuable reference book, a few doubts are raised about (...)
     
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  23.  15
    Un maquillage molto leggero. Considerazioni sulla riformulazione della giustizia come equita’ di John Rawls. [REVIEW]Giovanni De Grandis - 2002 - Etica E Politica 4 (1).
    In this review of Rawls’ last publication two aims are pursued. First, an attempt is made to clarify how this new work makes the deep structure of the theory emerge, thus indicating the way the different arguments, assumptions and conceptions are strictly intertwined. The main point is to show that the overlapping consensus does not bear a foundational role, since justification rests on the combined work of reflective equilibrium and of the original position. The possibility of an overlapping consensus simply (...)
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