a doubtful law does not bind -- Second corollary : uncertain law cannot impose certain obligation -- Commentary on the Treatise on conscience.

‘Smart’ contrast agents (CA) exhibit dynamic and reversible modulation of their relaxivity by specific physiological or biochemical triggers such as changes in pH, Ca2+ concentration or enzymatic activity (1-3). The extracellular concentration of Ca2+ plays important role in physiological and pathological processes in the nervous system. This led to the designing of a chelating system in which relaxivity is influenced as a function of Ca2+ concentration by changing coordination number around the paramagnetic metal ion. We synthesized a novel bifunctional bismacrocycle (...) [Gd-(DO3A-DTPA- DO3A); Fig.] based on DO3A-EA [{4,7-Bis-carboxymethyl-10-(2-aminoethyl)-1,4,7,10-tetraazacyclododec-1-yl}-acetic acid] coupled to DTPA-bis-anhydride via a flexible alkyl spacer to form the.. (shrink)

L’étude architecturale du Pythion a porté en 2014 sur l’association de la frise et de la corniche latérale, en 2015 sur l’appareil des murs. La frise et la corniche latérale Douze blocs ou fragments d’une frise ionique continue, sculptée en haut‑relief, ont été conservés (fig. 39). Ils mesurent 88,10 cm à 90,50 cm de long, 54,80 cm à 55,70 cm de haut, ca 72 cm de profondeur, reliefs compris, et ca 65 cm sans les reliefs. Cette dernière dimension exclut qu’on (...) les restitue sur les murs du prost... (shrink)