Background: Clinical genomic implementation studies pose challenges for informed consent. Consent forms often include complex language and concepts, which can be a barrier to diverse enrollment, and these studies often blur traditional research-clinical boundaries. There is a move toward self-directed, web-based research enrollment, but more evidence is needed about how these enrollment approaches work in practice. In this study, we developed and evaluated a literacy-focused, web-based consent approach to support enrollment of diverse participants in an ongoing clinical genomic implementation study. (...) Methods: As part of the Cancer Health Assessments Reaching Many (CHARM) study, we developed a web-based consent approach that featured plain language, multimedia, and separate descriptions of clinical care and research activities. CHARM offered clinical exome sequencing to individuals at high risk of hereditary cancer. We interviewed CHARM participants about their reactions to the consent approach. We audio recorded, transcribed, and coded interviews using a deductively and inductively derived codebook. We reviewed coded excerpts as a team to identify overarching themes. Results: We conducted 32 interviews, including 12 (38%) in Spanish. Most (69%) enrolled without assistance from study staff, usually on a mobile phone. Those who completed enrollment in one day spent an average of 12 minutes on the consent portion. Interviewees found the information simple to read but comprehensive, were neutral to positive about the multimedia support, and identified increased access to testing in the study as the key difference from clinical care. Conclusions: This study showed that interviewees found our literacy-focused, web-based consent approach acceptable; did not distinguish the consent materials from other online study processes; and valued getting access to testing in the study. Overall, conducting empirical bioethics research in an ongoing clinical trial was useful to demonstrate the acceptability of our novel consent approach but posed practical challenges. (shrink)

First published in 1962, Reason and Imagination presents collection of fourteen essays dedicated to Marjorie Hope Nicholson and is divided equally between works of her colleagues and of her former students. It contains themes like noble numbers and poetry of devotion, Cromwell as Davidic King, the isolation of the renaissances hero, Milton's dialogue on Astronomy, music, mirth and galenic traditions in England, the Augustan conception of history, Locke and Sterne, and literary criticism and artistic interpretation, to weave a narrative of (...) the history of ideas in the seventeenth and eighteenth century. This book will be an essential read for scholars and researchers of literary history, philosophy, comparative literature, and English literature in general. (shrink)

This paper examines two arguments against the possibility of moral responsibility—the first directly from the work of Galen Strawson and the next inspired by Strawson’s argument. Both of these arguments are found wanting, and their shortcomings are used as a springboard to sketch a positive libertarian view of moral responsibility and defend that view against preliminary objections.

Where is language? Answers to this have attempted to 'incorporate' language in an 'extended mind', through cognition that is 'embodied', 'distributed', 'situated' or 'ecological'. Behind these concepts is a long history that this book is the first to trace. Extending across linguistics, philosophy, psychology and medicine, as well as literary and religious dimensions of the question of what language is, and where it is located, this book challenges mainstream, mind-based accounts of language. Looking at research from the Middle Ages to (...) the present day, and exploring the work of a range of scholars from Aristotle and Galen to Merleau-Ponty and Chomsky, it assesses raging debates about whether mind and language are centred in heart or brain, brain or nervous-muscular system, and whether they are innate or learned, individual or social. This book will appeal to scholars and advanced students in historical linguistics, cognitive linguistics, language evolution and the philosophy of language. (shrink)

This essay situates the French Jesuit missionary Joseph-François Lafitau's (1681–1746) ‘discovery’ of Canadian ginseng within its social, commercial and religious contexts, and illustrates how the missionary's upbringing and education in France shaped the way he perceived nature in the New World. It elucidates the manner in which Lafitau ‘Galenized’ Canadian flora, fauna and peoples. It explores the role of Lafitau's dual enculturation in both a mercantile household and later the Society of Jesus in his application of Galenic categories to (...) Canadian nature. The essay then examines the tensions between localism and universalism in Galenic medicine in the eighteenth century. It links these dichotomies to Lafitau's Galenization of Canadian ginseng. Finally, it suggests that since the Jesuits were prohibited from trading goods they had purchased, they sold medicinal plants they had cultivated themselves, which played a central role in financing the Society's missions in a manner they believed to be morally acceptable. (shrink)

What is the self? Does it exist? If it does exist, what is it like? It's not clear that we even know what we're asking about when we ask these large, metaphysical questions. The idea of the self comes very naturally to us, and it seems rather important, but it's also extremely puzzling. As for the word "self"--it's been taken in so many different ways that it seems that you can mean more or less what you like by it and (...) come up with almost any answer. Galen Strawson proposes to approach the (seeming) problem of the self by starting from the thing that makes it seem there is a problem in the first place: our experience of the self, our experience of having or being a self, a hidden, inner mental presence or locus of consciousness. He argues that we should consider the phenomenology (experience) of the self before we attempt its metaphysics (its existence and nature). And when we have considered what it's like for human beings (assuming we can generalize about ourselves), we need to consider what it might be like for other possible creatures: what's the very least that might count as experience of oneself as a self? This, he proposes, will give us a good idea of what we ought to be looking for when we go on to ask whether there is such a thing-an idea worth following wherever it leads. It leads Strawson to conclude that selves, inner subjects of experience, do indeed exist. But they bear little resemblance to traditional conceptions of the self. (shrink)

This lucid book is the first to be wholly dedicated to Hume's theory of personal identity, and presents a bold new interpretation which bears directly on ...

The sense of the self -- A fallacy of our age -- I have no future -- Luck swallows everything -- You cannot make yourself the way you are -- The silliest claim -- Real naturalism -- The unstoried life -- Two years' time.

Behavioral scientists routinely publish broad claims about human psychology and behavior in the world's top journals based on samples drawn entirely from Western, Educated, Industrialized, Rich, and Democratic (WEIRD) societies. Researchers – often implicitly – assume that either there is little variation across human populations, or that these “standard subjects” are as representative of the species as any other population. Are these assumptions justified? Here, our review of the comparative database from across the behavioral sciences suggests both that there is (...) substantial variability in experimental results across populations and that WEIRD subjects are particularly unusual compared with the rest of the species – frequent outliers. The domains reviewed include visual perception, fairness, cooperation, spatial reasoning, categorization and inferential induction, moral reasoning, reasoning styles, self-concepts and related motivations, and the heritability of IQ. The findings suggest that members of WEIRD societies, including young children, are among the least representative populations one could find for generalizing about humans. Many of these findings involve domains that are associated with fundamental aspects of psychology, motivation, and behavior – hence, there are no obviousa priorigrounds for claiming that a particular behavioral phenomenon is universal based on sampling from a single subpopulation. Overall, these empirical patterns suggests that we need to be less cavalier in addressing questions ofhumannature on the basis of data drawn from this particularly thin, and rather unusual, slice of humanity. We close by proposing ways to structurally re-organize the behavioral sciences to best tackle these challenges. (shrink)

This chapter focuses on one of the common fallacies in Western philosophy: the moralistic fallacy. The moralistic fallacy occurs when one concludes that something is a particular way because it should or ought to be that way. Alternatively, this fallacy occurs when one concludes that something cannot be a particular way because it should not or ought not be that way. The moralistic fallacy is often described as the reverse of the is/ought fallacy, wherein one reasons fallaciously that because things (...) are a particular way, they ought to be that way. Variations of the moralistic fallacy occur whenever any normative claim is used to justify a factual claim about the world, and so the pattern of fallacious reason central to the moralistic fallacy can also be found in legal reasoning, prudential reasoning, or reasoning regarding proper etiquette, aesthetics, humor, or appropriate emotional responses. (shrink)

Contents: Introduction, Bibliography On the Sects for Beginners An Outline of Empiricism On Medical Experience Index of the Persons Mentioned in the Texts Index of the Subjects Mentioned in the Texts.

Galen dominated medicaltheory and practice until the scientific revolution and beyond, through the medieval Schools, and through his influence on Muslim medicine.This is the first major selection of Galen's work in English.

Does all conscious experience essentially involve self-consciousness? In his Subjectivity and Selfhood: Investigating the First-Person, Dan Zahavi answers “yes”. I criticize three core arguments offered in support of this answer—a well-known regress argument, what I call the “interview argument,” and a phenomenological argument. Drawing on Sartre, I introduce a phenomenological contrast between plain experience and self-conscious experience. The contrast challenges the thesis that conscious experience entails self-consciousness.

"First published by Oxford University Press, 1916."--Title page verso.

This chapter focuses on four areas Aristotle considered when determining what something really was, namely, essence, predicates, judgments, and potentials. Understanding and employing these concepts in our own concept of monster will help us avoid our currently tainted love of Supernatural. According to Aristotle, there are essential and accidental aspects of being. In the simplest terms, the essential aspects are the things that could not change about something, while the accidental aspects are things that could change. Aristotle's third taxonomy of (...) being is found in judgments of truth and falsity about a thing. These judgments can apply to questions of essence, accident, or any of the categories. Any question about the essential nature of monsters requires an answer that applies to all monsters. (shrink)

According to Christian theology, after being properly judged, bad souls are damned to Hell for eternity after being judged. Supernatural differs in that some of the souls in Hell weren't even judged, they just made very bad deals. But regardless of whether you think the mythos of Supernatural is even correct on this point, the fact that we recognize these are very bad deals should tell us something about the choices that land us in Hell. Our attitudes toward the experience (...) of punishment highlight an interesting feature about Hell in Supernatural—a person in Hell might not be there because they lived a bad life, but because they made a really bad deal with a demon. There is a problem with justifying Hell's existence this way, which our “deals with demons” examples from Supernatural make clear. Without a doubt, Hell is fundamental to Supernatural, but is definitely not a justifiable punishment. (shrink)

Introduction -- A default position -- Experience -- The character of experience -- Understanding-experience -- A note about dispositional mental states -- Purely experiential content -- An account of four seconds of thought -- Questions -- The mental and the nonmental -- The mental and the publicly observable -- The mental and the behavioral -- Neobehaviorism and reductionism -- Naturalism in the philosophy of mind -- Conclusion: The three questions -- Agnostic materialism, part 1 -- Monism -- The linguistic argument (...) -- Materialism and monism -- A comment on reduction -- The impossibility of an objective phenomenology -- Asymmetry and reduction -- Equal-status monism -- Panpsychism -- The inescapability of metaphysics -- Agnostic materialism, part 2 -- Ignorance -- Sensory spaces -- Experience, explanation, and theoretical integration -- The hard part of the mind-body problem -- Neutral monism and agnostic monism -- A comment on eliminativism, instrumentalism, and so on -- Mentalism, idealism, and immaterialism -- Mentalism -- Strict or pure process idealism -- Active-principle idealism -- Stuff idealism -- Immaterialism -- The positions restated -- The dualist options -- Frege's thesis -- Objections to pure process idealism -- The problem of mental dispositions -- Mental -- Shared abilities -- The sorting ability -- The definition of mental being -- Mental phenomena -- The view that all mental phenomena are experiential phenomena -- Natural intentionality -- E/c intentionality -- The experienceless -- Intentionality and abstract and nonexistent objects -- Experience, purely experiential content, and n/c intentionality -- Concepts in nature -- Intentionality and experience -- Summary with problem -- Pain and pain -- The neo-behaviorist view -- A linguistic argument for the necessary connection between pain and behavior -- A challenge -- The Sirians -- N.N. Novel -- An objection to the Sirians -- The Betelgeuzians -- The point of the Sirians -- Functionalism, naturalism, and realism about pain -- Unpleasantness and qualitative character -- The weather watchers -- The rooting story -- What is it like to be a weather watcher? -- The aptitudes of mental states -- The argument from the conditions for possessing the concept of space -- The argument from the conditions for language ability -- The argument from the nature of desire -- Desire and affect -- The argument from the phenomenology of desire -- Behavior -- A hopeless definition -- Difficulties -- Other-observability -- Neo-behaviorism -- The concept of mind. (shrink)

Since the very beginning, Confucianism has been troubled by a serious gap between its political ideals and the reality of societal circumstances. Contemporary Confucians must develop a viable method of governance that can retain the spirit of the Confucian ideal while tackling problems arising from nonideal modern situations. The best way to meet this challenge, Joseph Chan argues, is to adopt liberal democratic institutions that are shaped by the Confucian conception of the good rather than the liberal conception of (...) the right.Confucian Perfectionism examines and reconstructs both Confucian political thought and liberal democratic institutions, blending them to form a new Confucian political philosophy. Chan decouples liberal democratic institutions from their popular liberal philosophical foundations in fundamental moral rights, such as popular sovereignty, political equality, and individual sovereignty. Instead, he grounds them on Confucian principles and redefines their roles and functions, thus mixing Confucianism with liberal democratic institutions in a way that strengthens both. Then he explores the implications of this new yet traditional political philosophy for fundamental issues in modern politics, including authority, democracy, human rights, civil liberties, and social justice.Confucian Perfectionism critically reconfigures the Confucian political philosophy of the classical period for the contemporary era. (shrink)

I argue against two popular claims. The first is a descriptive, empirical thesis about the nature of ordinary human experience: ‘each of us constructs and lives a “narrative” . . . this narrative is us, our identities’ (Oliver Sacks); ‘self is a perpetually rewritten story . . . in the end, we become the autobiographical narratives by which we “tell about” our lives’ (Jerry Bruner); ‘we are all virtuoso novelists. . . . We try to make all of our material (...) cohere into a single good story. And that story is our autobiography. The chief fictional char- acter . . . of that autobiography is one’s self’ (Dan Dennett). The second is a normative, ethical claim: we ought to live our lives narratively, or as a story; a ‘basic condition of making sense of ourselves is that we grasp our lives in a narrative’ and have an understanding of our lives ‘as an unfolding story’ (Charles Taylor). A person ‘creates his identity [only] by forming an autobiographical narrative – a story of his life’, and must be in possession of a full and ‘explicit narrative [of his life] to develop fully as a person’ (Marya Schechtman). (shrink)

Joseph J. Fins calls for a reconsideration of severe brain injury treatment, including discussion of public policy and physician advocacy.

Where we begin: from Mennonite to Manhattan -- How we know: the quest for certainty -- What there is: the nature of existence -- What's divine: the experience of God -- Who we are: the human challenge -- Keeping the faith: the necessity of religion -- What we receive: the discipline of gratitude -- How we should live: the source of ethics -- What we owe: an ethic of gratitude -- When we're satisfied: ultimate meaning.

On the whole, we continue to believe firmly both that we have free will and that we are morally responsible for what we do. Here, the author argues that there is a fundamental sense in which there is no such thing as free will or true moral responsibility (as ordinarily understood). Devoting the main body of his book to an attempt to explain why we continue to believe as we do, Strawson examines various aspects of the "cognitive phenomenology" of freedom--the (...) nature, causes, and consequences of our deep commitment to belief in freedom. (shrink)

Rigid designators for concrete objects and for properties -- On the coherence of the distinction -- On whether the distinction assigns to rigidity the right role -- A uniform treatment of property designators as singular terms -- Rigid appliers -- Rigidity - associated arguments in support of theoretical identity statements: on their significance and the cost of its philosophical resources -- The skeptical argument impugning psychophysical identity statements: on its significance and the cost of its philosophical resources -- The skeptical (...) argument further examined: on resources, allegedly overlooked, for confirming psychological identities. (shrink)

José Benardete developed a famous paradox involving a beginningless set of items each member of which satisfies some predicate just in case no earlier member satisfies it. The Grim Reaper version of this paradox has recently been employed in favor of various finitist metaphysical theses, ranging from temporal finitism to causal finitism to the discrete nature of time. Here, I examine a new challenge to these finitist arguments—namely, the challenge of implying that the future cannot be endless. In particular, I (...) develop future-oriented Benardete paradoxes and examine their epistemic symmetry with past-oriented paradoxes. (shrink)

Introduction -- Instrumental rationality -- Social order -- Deontic constraint -- Intentional states -- Preference noncognitivism -- A naturalistic perspective -- Transcendental necessity -- Weakness of will -- Normative ethics.

Method of Medicine, a systematic and comprehensive account of the principles of treating injury and disease and one of Galen's greatest and most influential works.

Benardete paradoxes involve a beginningless set each member of which satisfies some predicate just in case no earlier member satisfies it. Such paradoxes have been wielded on behalf of arguments for the impossibility of an infinite past. These arguments often deploy patchwork principles in support of their key linking premise. Here I argue that patchwork principles fail to justify this key premise.

The paper argues that normative reasons are of two fundamental kinds, practical which are value related, and adaptive, which are not related to any value, but indicate how our beliefs and emotions should adjust to fit how things are in the world. The distinction is applied and defended, in part through an additional distinction between standard and non-standard reasons (for actions, intentions, emotions or belief).

I defend a new argument for causal finitism, the view that nothing can have an infinite causal history. I begin by defending a number of plausible metaphysical principles, after which I explore a host of novel variants of the Littlewood-Ross and Thomson’s Lamp paradoxes that violate such principles. I argue that causal finitism is the best solution to the paradoxes.

Behavioral scientists routinely publish broad claims about human psychology and behavior in the world's top journals based on samples drawn entirely from Western, Educated, Industrialized, Rich, and Democratic (WEIRD) societies. Researchers – often implicitly – assume that either there is little variation across human populations, or that these “standard subjects” are as representative of the species as any other population. Are these assumptions justified? Here, our review of the comparative database from across the behavioral sciences suggests both that there is (...) substantial variability in experimental results across populations and that WEIRD subjects are particularly unusual compared with the rest of the species – frequent outliers. The domains reviewed include visual perception, fairness, cooperation, spatial reasoning, categorization and inferential induction, moral reasoning, reasoning styles, self-concepts and related motivations, and the heritability of IQ. The findings suggest that members of WEIRD societies, including young children, are among the least representative populations one could find for generalizing about humans. Many of these findings involve domains that are associated with fundamental aspects of psychology, motivation, and behavior – hence, there are no obviousa priorigrounds for claiming that a particular behavioral phenomenon is universal based on sampling from a single subpopulation. Overall, these empirical patterns suggests that we need to be less cavalier in addressing questions ofhumannature on the basis of data drawn from this particularly thin, and rather unusual, slice of humanity. We close by proposing ways to structurally re-organize the behavioral sciences to best tackle these challenges. (shrink)

It is widely supposed that David Hume invented and espoused the "regularity" theory of causation, holding that causal relations are nothing but a matter of one type of thing being regularly followed by another. It is also widely supposed that he was not only right about this, but that it was one of his greatest contributions to philosophy. Strawson here argues that the regularity theory of causation is indefensible, and that Hume never adopted it in any case. Strawson maintains that (...) Hume did not claim that causation in the natural world is just a matter of regular succession, that such a dogmatic metaphysical claim about the nature of reality would have been utterly contrary to his fundamental philosophical principles, and that he rightly took it for granted that there was more to causation than regularity of succession, claiming only that regularity of succession was all that we could ever know of causation. (shrink)

Rapid advances in high throughput genomic technologies and next generation sequencing are making medical genomic research more readily accessible and affordable, including the sequencing of patient and control whole genomes and exomes in order to elucidate genetic factors underlying disease. Over the next five years, the Human Heredity and Health in Africa (H3Africa) Initiative, funded by the Wellcome Trust (United Kingdom) and the National Institutes of Health (United States of America), will contribute greatly towards sequencing of numerous African samples for (...) biomedical research. (shrink)

What does it mean to listen to someone respectfully, that is, insofar as they are due recognition respect? This paper addresses that question and gives the following answer: it is to listen in such a way that you are open to being surprised. A specific interpretation of this openness to surprise is then defended.

The thesis of self-elusiveness says, roughly, that the self fails to be phenomenally manifest from the first-person perspective. This thesis has a long history. Yet many who endorse it do so only in a very specific sense. They say that the self fails to be phenomenally manifest as an object from the first-person perspective; they say that self-experience is not a species of ‘object-consciousness’. Yet if consciousness outstrips object-consciousness, then we are left with the possibility that there is another sense (...) in which the self is phenomenally manifest. Alas, efforts to articulate just what this form of self-experience comes to—often a holy grail of sorts for those in, and influenced by, the phenomenological tradition—have remained stubbornly obscure. This essay attempts a partial remedy. Taking a cue from Bernard Lonergan, I suggest that self-experience, while not a species of object-consciousness, is nonetheless partially grounded in it. The result is a view that is compatible with self-experience being representational and relational, contra tradition. (shrink)

Real Materialism is a collection of highly original essays on a set of related topics in philosophy of mind and metaphysics: consciousness and the mind-body problem; our knowledge of the world; the nature of the self or subject; free will and moral responsibility; the nature of thought and intentionality; causation and David Hume.

Analytic debates about truth are wide-ranging, but certain key themes tend to crop up time and again. The three themes that we will examine in this paper are (i) the nature and behaviour of the ordinary concept of truth, (ii) the meaning of discourse about truth, and (iii) the nature of the property truth. We will start by offering a brief overview of the debates centring on these themes. We will then argue that cross-linguistic experimental philosophy has an indispensable yet (...) underappreciated role to play in all of these debates. Recognising the indispensability of cross-linguistic experimental philosophy should compel philosophers to significantly revise the ways in which they inquire about truth. It should also prompt analytic philosophers more generally to consider whether similar revisions might be necessary elsewhere in the field. (shrink)