Countries are ranked on many criteria, the results of which can have far-reaching ethical and practical implications, particularly for emerging nations seeking role models. One highly influential ranking, the World Economic Forum’s Global Competitiveness Report, has been criticized for containing multiple methodological, conceptual, and logical flaws that bias competitiveness rankings toward countries that favor neoliberalism. Using datasets not afflicted by such flaws, we examine Bergsteiner and Avery’s :391–410, 2012) prediction that competitiveness scores of the USA and the UK are substantially (...) overstated. Results of re-ranking 104 countries using 29 economic, environmental, and social datasets from reputable sources support this assertion, with the USA showing the greatest discrepancy on a 100-point scale between its 2013–2014 GCR score and our study’s 2013 score, and the UK falling from GCR score 9 to 40. We explore reasons for this discrepancy, including examining the relationship between a country’s neoliberal traditions and its rankings on the indicators. (shrink)

The renin-angiotensin system (RAS) is critical in sodium and blood pressure (BP) regulation, and in cardiovascular-renal (CVR) diseases and therapeutics. As a contribution to SAPHIR project, we present a realistic computer model of renin production and circulating RAS, integrated into Guyton’s circulatory model ( GCM ). Juxtaglomerular apparatus, JGA , and Plasma modules were implemented in C ++/M2SL (Multi-formalism Multi-resolution Simulation Library) for fusion with GCM . Matlab © optimization toolboxes were used for parameter identification. In JGA , renin production (...) and granular cells recruitment (GCR) are controlled by perfusion pressure (PP), macula densa (MD), angiotensin II (Ang II), and renal sympathetic activity (RSNA). In Plasma , renin and ACE (angiotensin-converting enzyme) activities are integrated to yield Ang I and II. Model vs. data deviation is given as normalized root mean squared error (nRMSE; n points). Identification: JGA and Plasma parameters were identified against selected experimental data. After fusion with GCM : (1) GCR parameters were identified against Laragh’s PRA-natriuresis nomogram; (2) Renin production parameters were identified against two sets of data ([renin] transients vs. ACE or renin inhibition). Finally, GCR parameters were re-identified vs. Laragh’s nomogram (nRMSE 8%, n = 9). Validation: (1) model BP, PRA and [Ang II] are within reported ranges, and respond physiologically to sodium intake; (2) short-term Ang II infusion induces reported rise in BP and PRA. The modeled circulating RAS, in interaction with an integrated CVR, exhibits a realistic response to BP control maneuvers. This construction will allow for modelling hypertensive and CVR patients, including salt-sensitivity, polymorphisms, and pharmacotherapeutics. (shrink)

The possibility of social and technological collapse has been the focus of science fiction tropes for decades, but more recent focus has been on specific sources of existential and global catastrophic risk. Because these scenarios are simple to understand and envision, they receive more attention than risks due to complex interplay of failures, or risks that cannot be clearly specified. In this paper, we discuss the possibility that complexity of a certain type leads to fragility which can function as a (...) source of catastrophic or even existential risk. The paper first reviews a hypothesis by Bostrom about inevitable technological risks, named the vulnerable world hypothesis. This paper next hypothesizes that fragility may not only be a possible risk, but could be inevitable,and would therefore be a subclass or example of Bostrom’s vulnerable worlds. After introducing the titular fragile world hypothesis, the paper details the conditions under which it would be correct, and presents arguments for why the conditions may in fact may apply. Finally, the assumptions and potential mitigations of the new hypothesis are contrasted with those Bostrom suggests. (shrink)

A new book by Phil Torres, Morality, Foresight, and Human Flourishing: An Introduction to Existential Risks, is reviewed. Morality, Foresight and Human Flourishing is a primer intended to introduce students and interested scholars to the concepts and literature on existential risk. The book’s core methodology is to outline the various existential risks currently discussed in different disciplines and provides novel strategies for risk mitigation. The book is stylistically engaging, lucid and academically current, providing both novice readers and seasoned scholars with (...) an easy-to-read introduction to risk studies. The book is by far the most engaging and comprehensive volume on risk studies aimed at captivating new scholars to the field. (shrink)