The National Institutes of Health (NIH) invests over $37 billion per year in support of research to improve human health. All research funded by NIH that involves human subjects is subject to regulatory oversight, requiring institutions to staff and manage Institutional Review Boards (IRBs). IRB members, chairs, and the many associated human subjects protections oversight professionals who support the work of the IRB must navigate complex federal regulations issued by multiple agencies. This book is the industry standard reference work for (...) the research oversight community, providing comprehensive, understandable interpretations of the regulations, clear descriptions of the ethical principles on which the regulations are based, and practical best-practices guidelines for effectively implementing regulatory oversight. (shrink)

The right to teach at university is a distinctive philosophical and legal conundrum but a largely unexplored question. Drawing on Humboltdian principles, the legitimacy of the university teacher stems from their continuing engagement in research rather than possession of academic and teaching qualifications alone. This means that the right to teach needs to be understood as a privilege and implies that it is always provisional, requiring an ongoing commitment to research. Yet, massification of higher education systems internationally has led to (...) the disaggregation of the academic profession with teaching-only positions now increasingly common. University teachers employed to both teach and research face a narrowing set of performative expectations with respect to how ‘research-active’ is defined. This paper challenges these contemporary understandings and, drawing on historical evidence, argues that a broader definition of research and scholarship needs to underpin the basis of the right to teach. (shrink)

Systems Theory analyses the world in terms of communications and divides the natural world into environment and systems. Systems are characterised by their high density of communications and tend to become more complex and efficient with time, usually by means of increased specialisation and coordination of functions. Management is an organisational sub-system which models all necessary aspects of organisational activity such that this model may be used for monitoring, prediction and planning of the organisation as a whole. The function of (...) a specific management system depends on its history of selection by interactions with the environment (which includes other systems). The main function of a management system will be a consequence of the most powerful and sustained selection pressure it has experienced. Systems Theory implies a management science which is quantitative and comparative. It is quantitative because it is based upon the measurement and mapping of communications as the basis of analysis; it is comparative because evaluations relate to specific variables measured in a specific spatio-temporal context and subjected to analytic processes of constrained complexity. Selection processes are broadly responsible for the dominance of management in contemporary Western societies. The complexity of management systems will probably continue to increase for as long as the efficiency-enhancing potential of complexity outweighs its increased transaction costs. (shrink)

In three parts, this volume in the AP-LS series explores the phenomena of captivity and risk management, guided and informed by the theory, method, and policy of psychological jurisprudence. The authors present a controversial thesis that demonstrates how the forces of captivity and risk management are sustained by several interdependent "conditions of control." These conditions impose barriers to justice and set limits on citizenship for one and all. Situated at the nexus of political/social theory, mental health law and jurisprudential ethics, (...) the book examines and critiques constructs such as offenders and victims; self and society; therapeutic and restorative; health; harm; and community. So, too, are three "total confinement" case law data sets on which this analysis is based. The volume stands alone in its efforts to systematically "diagnose" the moral reasoning lodged within prevailing judicial opinions that sustain captivity and risk management practices impacting: (1) the rights of juveniles found competent to stand criminal trial, the mentally ill placed in long-term disciplinary isolation, and sex offenders subjected to civil detention and community re-entry monitoring; (2) the often unmet needs of victims; and (3) the demands of an ordered society. Carefully balancing sophisticated insights with concrete and cutting-edge applications, the book concludes with a series of provocative, yet practical, recommendations for future research and meaningful reform within institutional practice, programming, and policy. (shrink)

After decades of deregulation and innovation, contemporary financial markets remain firmly anchored in law and legal institutions. The idea that private financial actors simply want to escape government oversight and regulation is simplistic as private interests find the coercive powers of the state too useful to forgo. Instead, such actors engage law selectively to create a more certain environment for themselves and their profit-seeking activities. Contract law adds certainty to financial transactions; law shapes how financial actors use information and exploit (...) information technology; law constitutes financial values; and law allows financial institutions to be turned into assets. Law’s application is shaped by changing conceptions of risk, as well as by new business models for financial institutions. (shrink)

Money undergirds market exchange, but the social significance of money goes well beyond the obvious importance of its highly uneven distribution in modern market economies. In addition, modern money imposes an ostensibly precise and unidimensional valuation on social products, processes and relations that often conflicts with other modes of social valuation. In this regard, monetarization is a particular instance of quantification. Money’s status as an official economic metric is the result of a long, contingent, and uneven historical process. Given alternative (...) forms of valuation, people manage and constrain the commensurability of money through a variety of individual, institutional and organizational practices. The social reception of money is active, not passive. A variety of examples are discussed to illustrate and develop these points. (shrink)

This paper elaborates three approaches to the issue of state autonomy, and uses two empirical cases (British and American treasury policy during the 1930s) to illustrate them. The three approaches are the group affiliations approach, which considers the social characteristics of the individuals who work in an organization; the structural dependance approach, which considers the structural position of the organization within a network of resource flows; and a cultural approach, which considers the role of ideology in the determination of organizational (...) autonomy. The application of these three approaches to the two cases gives some support to all three, but the cultural approach proves especially useful in conjunction with the other two. (shrink)

Steven Rose regards oversimplification of biology as the supreme sin, inevitably leading to evil consequences, and requiring an unique distortion of scientific practice to avoid it. To avoid this, he proposes a short-cut to scientific knowledge by defining certain areas of biology that are intrinsically flawed. But this achieves only a subordination of science to politics. There are no general-purpose shortcuts for evaluating the validity of theories, and no substitutes for testing specific theories using relevant evidence.

The same aggressive act will – all else being equal – have a different behavioral significance according to whether it is performed by a man or a woman. Such a perspective should have profound implications for legal and psychiatric practice, and for social policy in general.

The “somatic marker mechanism” (SMM; Damasio 1994) is proposed as the cognitive and neural basis of the theory of mind mechanism. The SMM evolved for evaluating the intentions, dispositions, and relationships of conspecifics; hence, it is adaptive in the social domain. It is predicted that chimpanzees will indeed have theory of mind (ToM) ability, but that this will be socially domain-specific. Domain-general ToM will be found only in primates with abstract, symbolic language (adult humans). Putative ToM tests require revision in (...) the light of these distinctions. (shrink)

Recent experiments have begun to decipher the molecular dialog that mediates differentiation at sites of synaptic between neurons and their targets. It had been hypothesized that the protein agrin is released by axon terminals at embryonic neuromuscular junctions and binds to a receptor on the myofiber surface to trigger postsynaptic differentiation. Now a genetic ‘Knockout’ experiment has confirmed the essential role of agrin in signaling between developing nerve and muscle(1). A second ‘knockout’ has shown that the muscle‐specific receptor tyrosine kinase (...) MuSK is a critical element in the agrin‐induced signaling cascade(2). Additional results suggest that MuSK may comprise a portion of the agrin receptor(3). (shrink)

While valuable work has been done addressing clinical ethics within established healthcare systems, we anticipate that the projected growth in acquisitions of community hospitals and facilities by large tertiary hospitals will impact the field of clinical ethics and the day-to-day responsibilities of clinical ethicists in ways that have yet to be explored. Toward the goal of providing clinical ethicists guidance on a range of issues that they may encounter in the systematization process, we discuss key considerations and potential challenges in (...) implementing system-wide ethics consultation services. Specifically, we identify four models for organizing, developing, and enhancing ethics consultation activities within a system created through acquisitions: train-the-trainer, local capacity-building, circuit-riding, and consolidated accountability. We note each model’s benefits and challenges. To our knowledge, this is the first paper to consider the broader landscape of issues affected by consolidation. We anticipate that clinical ethicists, volunteer consultants, and hospital administrators will benefit from our recommendations. (shrink)

Several recent authors have recommended that “sense of place” should become an important concept in our evaluation of environmental policies. In this paper, we explore aspects of this concept, arguing that it may provide the basis for a new, “place-based” approach to environmental values. This approach is based on an empirical hypothesis that place orientation is a feature of all people’s experience of their environment. We argue that place orientation requires, in addition to a home perspective, a sense of the (...) space around the home place and that this dual aspect can be modeled using a “hierarchical” methodology. We propose a “triscalar,” place-oriented system for the analysis of environmental values, explore the characteristics of place-orientation through several examples, and employ these characteristics to distinguish acceptable and unacceptable aspects of the NIMBY (not-in-my-backyard) idea. (shrink)

Recent work in artificial intelligence, or AI, has produced programs capable of serious intellectual work in science. Results from AI are used to show that there exist mechanized procedures for discovering hypotheses and that these methods often lead to plausible hypotheses. The question to be answered is: By what methods can a computer program find plausible explanations of empirical data? To answer this, the common metaphor of search for describing several AI programs is examined followed by a look at examples (...) of programs actually constructed. Five types of search considered are: random, exhaustive, selective, heuristic, and opportunistic search. From there, the paper generalizes to some conclusions about mechanizing hypothesis formation. (shrink)

Several recent authors have recommended that “sense of place” should become an important concept in our evaluation of environmental policies. In this paper, we explore aspects of this concept, arguing that it may provide the basis for a new, “place-based” approach to environmental values. This approach is based on an empirical hypothesis that place orientation is a feature of all people’s experience of their environment. We argue that place orientation requires, in addition to a home perspective, a sense of the (...) space around the home place and that this dual aspect can be modeled using a “hierarchical” methodology. We propose a “triscalar,” place-oriented system for the analysis of environmental values, explore the characteristics of place-orientation through several examples, and employ these characteristics to distinguish acceptable and unacceptable aspects of the NIMBY (not-in-my-backyard) idea. (shrink)