In this paper I defend an etiological theory of biological functions (according to which the proper function of a trait is the effect for which it was selected by natural selection) against three objections which have been influential. I argue, contrary to Millikan, that it is wrong to base our defense of the theory on a rejection of conceptual analysis, for conceptual analysis does have an important role in philosophy of science. I also argue that biology requires a normative notion (...) of a "proper function", and that a normative notion is not ahistorical. (shrink)

Looking for an adequate explication of the concept of a biological function, several authors have proposed to link function to design. Unfortunately, known explications of biological design in turn refer to functions. The concept of general design I will introduce here breaks up this circle. I specify design with respect to its ontogenetic role. This allows function to be based on design without making reference to the history of the design, or to the phylogeny of an organism, while retaining the (...) normative aspect of function ascriptions. The concept is applicable to the function and design of technical artifacts as well. Several problems well known with other definitions can be overcome by this approach. (shrink)

The idea that the function of language is its use is commonly ascribed to the Later Wittgenstein. In this paper, I argue that there is textual evidence already coming from the early manuscripts proving that Wittgenstein's philosophical development is culminating in the idea of function as use around 1929–30. I interpret a passage from Ms‐107 in order to show that Wittgenstein's practical turn has sources in different stages of his philosophical development, each of which is dominated by different ideas: the (...) idea of a picture theory; the idea of a phenomenological language and the idea of function as use. (shrink)

It is generally argued that if the wave-function in the de Broglie–Bohm theory is a physical field, it must be a field in configuration space. Nevertheless, it is possible to interpret the wave-function as a multi-field in three-dimensional space. This approach hasn’t received the attention yet it really deserves. The aim of this paper is threefold: first, we show that the wave-function is naturally and straightforwardly construed as a multi-field; second, we show why this interpretation is superior to other interpretations (...) discussed in the literature; third, we clarify common misconceptions. (shrink)

This chapter examines a question at the intersection of the mind-body problem and the analysis of mental representation: the question of the direction of constraint between psychological fact and theory and neurophysiological or physical fact and theory. Does physiology constrain psychology? Are physiological facts more basic than psychological facts? Or do psychological theories, including representational analyses, guide and constrain physiology? Despite the antireductionist bent of functionalist positions, it has generally been assumed that physics or physiology are more basic than, and (...) hence contraining on, psychological fact and theory. Section 1 sketches the intuitions that would lead one to adopt such a view. The chapter then examines whether one-sided constraint has been and should be found in practice. It argues that philosophical analysis of psychological science shows that rigorous functional analyses can be carried out in advance of physiological knowledge. Indeed, in the investigation of sensory perception, ascription of psychological function leads the way in the individuation and investigation of neurophysiology. We shall look at several cases in visual perception (binocular single vision, stereopsis, and color vision), in which psychological results have provided a basis for physiological research. It is tempting to think that the psychological functions that enable physiological investigation would be Wrightian teleofunctions. It is, thus, natural to suppose that psychologists and neurophysiologists have proceeded with a conception of the purpose of a given neural structure, and have viewed neural anatomy and neural activity as the substrate for or instantiation of various properly psychological functions. For example, neuroscientists surely understand that the eye and visual system are for seeing, rather than for detecting an electric discharge in the vicinity of the retina (which sighted humans can do, via the subjective light produced by such discharges), and they guide their investigations of the eye, visual cortex, and intervening pathways accordingly. As a result, they will view rods and cones in the eye as photoreceptors, even though these structures will produce "output" (will respond with hyperpolarization) to other forms of energy. At the same time, there may be cases in which the functions that have guided research are in fact precisely determined input-output functions, whose teleofunctional status is absent or misdescribed. I will argue that in the case of trichromatic color matches, the psychological function involved is an input-output function, and that this result has implications for the description of color vision as a psychological capacity. (shrink)

Hassin recently proposed the “Yes It Can” (YIC) principle to describe the division of labor between conscious and unconscious processes in human cognition. According to this principle, unconscious processes can carry out every fundamental high-level cognitive function that conscious processes can perform. In our commentary, we argue that the author presents an overly idealized review of the literature in support of the YIC principle. Furthermore, we point out that the dissimilar trends observed in social and cognitive psychology, with respect to (...) published evidence of strong unconscious effects, can better be explained by the way how awareness is defined and measured in both research fields. Finally, we show that the experimental paradigm chosen by Hassin to rule out remaining objections against the YIC principle is unsuited to verify the new default notion that all high-level cognitive functions can unfold unconsciously. (shrink)

The paper argues that in order to understand the nature of technological knowledge (i.e., knowledge of technical artefacts as distinct from knowledge of natural objects) it is necessary to develop an epistemology of technical functions. This epistemology has to address the problem of the meaning of the notion of function. In the dominant interpretations, functions are considered to be dispositions, comparable to physical dispositions such as fragility and solubility. It is argued that this conception of functions is principally flawed. With (...) the help of Carnap’s analysis of dispositional terms it is shown that there is a fundamental difference between physical dispositional terms and functional dispositional terms. This difference concerns the issue of the normativity; with regard to functional dispositions, it makes sense to construct normative statements of a particular kind, with regard to physical dispositions it does not. (shrink)

Philosophers of biology usually distinguish historical and systemic accounts of functions. In many areas of experimental biology the "systemic" account is often the most relevant. Yet there are problems this account does admittedly not face up to very well. My contention is that, though two minor problems are irredeemably unsolvable for the systemic account of function, the major ones can be solved by assuming that 'function' denotes (directly) a causal role in a model and (indirectly) the corresponding process in nature. (...) I try to show this through the analysis of the hypothalamus-pituitary-adrenal axis of stress. (shrink)

It follows from the temporal nature of mind—the main concern of this essay—that mind functions are not localized in brain space.“ Time is extendedness, probably of the mind itself”, concludes Saint Augustine in Book XI of his Confessions (26.33), and, in our days, this extendedness can be made visible through an oscilloscopic “line” or trace of slow potentials. These graded, additive (not all-or-none) autorhythmic and seemingly self-generating potentials are primary events recorded at synapses. Autorhythmic brain structures (Zabara, 1973) appear to (...) be the source of time frames, while a change in time frames (as reflected in the EEG) leads to synchronization and desynchronization of brain structures respectively. Synchronization forms a homogeneous time domain, such as obtained during rhythmic exercises, chanting, listening to music and mental processes that are the hallmark of religious practices (Rogers, 1973). Desynchronization of brain structures on the other hand marks a functional independence of neuronal elements with each element available for separate channels of data processing, for example, during hallucinogenic drug-induced central sympathetic arousal, that is, a waking dream state (Fischer, 1979). (shrink)

In quantum mechanics, the wavefunction predicts probabilities of possible measurement outcomes, but not which individual outcome is realised in each run of an experiment. This suggests that it describes an ensemble of states with different values of a hidden variable. Here, we analyse this idea with reference to currently known theorems and experiments. We argue that the ψ-ontic/epistemic distinction fails to properly identify ensemble interpretations and propose a more useful definition. We then show that all local ψ-ensemble interpretations which reproduce (...) quantum mechanics violate Statistical Independence. Theories with this property are commonly referred to as superdeterministic or retrocausal. Finally, we explain how this interpretation helps make sense of some otherwise puzzling phenomena in quantum mechanics, such as the delayed choice experiment, the Elitzur-Vaidman bomb detector, and the Extended Wigner's Friends Scenario. (shrink)

In this paper we study collective identity functions that deal with formation of clubs. Usually the choice offered to individuals is to cast a vote in favor of qualification or not, and the final outcome is qualification or non-qualification. In this context we show that independent collective identity functions are naturally characterized by voting rules, and in particular, consent rules can be represented by one single collection of weighted majorities. In addition, we consider the extended model where voters are allowed (...) to abstain and we distinguish between disqualification and a neutral outcome. We show that this environment allows agents to act in different capacities that cannot be distinguished in the original formulation of the problem. (shrink)

Some entangled states have nonnegative Wigner representative function. The latter allow being viewed as a distribution function of local hidden variables. It is argued herewith that the interpretation of expectation values using such distribution functions as local hidden variable theory requires restrictions pertaining to the observables under study. The reasoning lead to support the view that violation of Bell’s inequalities that is always possible for entangled states hinges not only on the states involved but also whether the dynamical variables have (...) their values defined even when they cannot be measured. (shrink)

N6‐methyladenine (6mA) is one of the most abundant types of DNA methylation, and plays an important role in bacteria; however, its roles in higher eukaryotes, such as plants, insects, and mammals, have been considered less important. Recent studies highlight that 6mA does indeed occur, and that it plays an important role in eukaryotes, such as worm, fly, and green algae, and thus the regulation of 6mA has emerged as a novel epigenetic mechanism in higher eukaryotes. Despite this intriguing development, a (...) number of important issues regarding its biological roles are yet to be addressed. In this review, we focus on the 5mC and 6mA modifications in terms of their production, distribution, and the erasure of 6mA in higher eukaryotes including mammals. We perform an analysis of the potential functions of 6mA, hence widening understanding of this new epigenetic mark in higher eukaryotes, and suggesting future studies in this field. (shrink)

Evidence for unconscious semantic representation suggests that a cognitive unconscious exists. Phenomenal consciousness cannot easily be shown to deal with complex cognitive operations such as those involved in language translation and creativity. A self-organising phenomenal consciousness that controls brain functions also runs into mind/body problems (well recognised in the consciousness studies literature) that Perruchet & Vinter must address.

Given a belief function ? on the set of all subsets of prizes, how should ? values be understood as a decision alternative? This paper presents and characterizes an induced-measure interpretation of belief functions.

Cytokinins are plant hormones that have, among many other functions, senescence‐modulatory effects in plant tissue. This is evident not only from biochemical data, but is vividly illustrated in the “green island” phenotype in plant leaves caused by cytokinins released for example by leaf mining insects or microbial pathogens. It is beyond doubt that, in addition to their roles in plants, cytokinins also provoke physiological and developmental effects in animals. It is hypothesized that the recently much discussed modification of plant metabolism (...) by insects and associated microbes via cytokinin signals has a counterpart in direct cytokinin signalling that interferes with the animals’ hormonal systems and impacts their population dynamics. (shrink)

Mothers with prenatal substance use disorder often show broad deficits in their reflective functioning, implying severe risk for the relationship with their baby. Two different types of prenatal maternal RF may be important for parenting: adult attachment-focused-RF, regarding parent's own childhood experiences, and parenting-focused RF regarding their own current process of becoming a parent. However, their inter-relations and potentially different roles for parenting intervention outcomes are not clear. This study examined the associations between mothers' prenatal AAI-RF and pre- and (...) post-natal PRF, and their role in mother-infant interaction and substance use as treatment outcomes. The participants were 57 treatment-enrolled pregnant mothers with SUD and 50 low-risk comparison mothers. AAI-RF was measured with the Adult Attachment Interview. For a subsample of 30 mothers with SUD, PRF was measured with Pregnancy Interview, and with Parent Development Interview at 4 months. Mother-infant interaction was measured with Emotional Availability Scales at 4 and 12 months, and maternal substance use by post-natal substance relapses. Prenatal AAI-RF and pre- and post-natal PRF were highly associated with each other. Only higher prenatal PRF predicted better mother-infant interaction quality at 4 months and less substance use during the child's first year. Interestingly, prenatal PRF and AAI-RF predicted opposite changes in mother-infant interaction: lower prenatal PRF, but higher AAI-RF predicting more positive change. AAI-RF was especially associated with a change in maternal intrusiveness and hostility, indicating that it represents a more general regulatory tendency. Further studies are needed in larger and lower-risk samples. Our results suggest, however, that AAI-RF and PRF are partially distinct and should be uniquely targeted in perinatal interventions. (shrink)

In the Greek/Indian period, it is noticeable that different radii were used in connection with the chord. This manner continued in the Indian period with the sine, i.e. different sine tables existed. But throughout the Arabic-Islamic period, there was stability in the radius (for the sine). At the time of al-Batt new terms were introduced, not as functions of angles but as lengths, and again different tables for the same term. Here these terms were not bounded to the circle, and (...) the term miqythe radiusfunctions al-Waf’s time, there was an advancement by introducing the new terms as functions of angles, and they were immediately bounded to the circle, and instead of having two circles in the same figure, a kind of unity appeared, and again there was stability in the value of r, and therefore only one table for each function, and thus the new functions started to appear more abstract than practical as the sine did before, and this unity remained fixed in the modern times. (shrink)

Kubovy and Epstein's main quarrel is with the concept of “internalization.” I argue that they underestimate the aptness of this metaphor. In particular, an emulator which predicts unfolding events can be described as an internalization of external structures. Further, an emulator may use motoric as well as perceptual resources, which lends support to Hecht's proposal. [Hecht; Kubovy & Epstein].

Let Ln be a sentential language with n atomic sentences {A1, . . . , An}. Let Sn = {s1, . . . , s2n} be the set of 2n state descriptions of Ln, in the following, canonical lexicographical truth-table order: State Description A1 A2 · · · An−1 An T T T T T s1 = A1 & A2 & · · · &An−1 & An T T T T F s1 = A1 & A2 & · · · (...) &An−1 & ¬An T T T F T s3 = A1 & A2 & · · · & ¬An−1 & An T T T F F s4 = A1 & A2 & · · · & ¬An−1 & ¬An.. (shrink)

The wavefunction is the central mathematical entity of quantum mechanics, but it still lacks a universally accepted interpretation. Much effort is spent on attempts to probe its fundamental nature. Here I investigate the consequences of a matter ontology applied to spherical masses of constant bulk density. The governing equation for the center-of-mass wavefunction is derived and solved numerically. The ground state wavefunctions and resulting matter densities are investigated. A lowering of the density from its bulk value is found for low (...) masses due to increased spatial spreading. A discussion of the possibility to experimentally observe these effects is given and the possible consequences for choosing an ontological interpretation for quantum mechanics are commented upon. (shrink)

There are legitimate worries about gaps between scientific evidence of brain states and function (for example, as evidenced by fMRI data) and legal criteria for determining criminal culpability. In this paper I argue that behavioral evidence of capacity, motive and intent appears easier for judges and juries to use for purposes of determining criminal liability because such evidence triggers the application of commonsense psychological (CSP) concepts that guide and structure criminal responsibility. In contrast, scientific evidence of neurological processes and function (...) – such as evidence that the defendant has a large brain tumor – will not generally lead a judge or jury to directly infer anything that is relevant to the legal determination of criminal culpability . (Vincent 2008) In these cases, an expert witness will be required to indicate to the fact-finder what this evidence means with regard to mental capacity; and then another inference will have to be made from this possible lack of capacity to the legal criteria for guilt, cast in CSP terms.<br><br>To reliably link evidence of brain function and structure and assessment of criminal responsibility, we need to re-conceptualize the mental capacities necessary for responsibility, particularly those that are recognized as missing or compromised by the doctrines of “legal capacity” (Hart 1968) and “diminished capacity.” I argue that formulating these capacities as executive functions within the brain can provide this link. I further claim that it would be extremely useful to consider evidence of executive function as related to the diminished capacity doctrine at sentencing. This is because it is primarily at this stage in criminal proceedings where the use of the diminished capacity doctrine is most prevalent, as evidenced by the recent Supreme Court cases of Atkins v. Virginia (536 U.S. 304 (2002)) and Roper v. Simmons (543 U.S. 551 (2005)).<br>. (shrink)

In contrast to theoretical discussions about potential professional liability of clinical ethicists, this report gives the results of empirical data gathered in a national survey of clinical medical ethicists. The report assesses the types of activities of clinical ethicists, the extent and types of their professional liability coverage, and the influence that concerns about legal liability has on how they function as clinical ethicists. In addition demographic data on age, sex, educational background, etc. are reported. The results show that while (...) nearly one third (28.9%) of the ethicists regularly make recommendations about patient care, only 10.8% of them regularly make entries in the medical record; only approximately half (53.0%) of them are covered by professional liability (malpractice) insurance; and the vast majority (84.3%) of them say that concerns about legal liability do not influence the way they function as clinical ethicists. (shrink)

In his late fragment, ‘Sources of Knowledge of Mathematics and Natural Sciences’ Frege laments the tendency to confuse functions with objects and says, ‘It is here that the tendency of language by its use of the definite article to stamp as an object what is a function and hence a non-object, proves itself to be the source of inaccurate and misleading expressions and also of errors of thought. Probably most of the impurities that contaminate the logical source of knowledge have (...) their origins in this.’ This paper applies Frege’s logical insights to a series of influential modal arguments for the existence of souls or minds, in order to demonstrate that they hinge on the error of treating functions as objects. Related arguments have also resulted in the claim that identity statements are necessary, and that apparent identities ‘really’ involve relations of constitution. Here it is argued that once we recognise that all these arguments involve the assimilation of objects and concepts (which Frege identifies with functions) they can be seen to be defective. (shrink)

This study examines the symbolic use of stone beyond its basic function as a construction material in architecture. It investigates the meaning of stone using Iraqi Kurdistan residential architecture as a case study. The theoretical framework of the study is developed through the content analysis method, by applying Hershberger’s basic model of meaning, and by exploring Krampen’s writings on semiotics in architecture. The relevant theoretical framework was tested through systematic physical observation of selected houses in Iraqi Kurdistan and by using (...) the inductive reasoning method. The study recognises that stone, beyond being a construction material, conveys the symbolic meaning of “power,” “wealth,” and “belonging” in contemporary houses of Iraqi Kurdistan. Based on that, a meaningful situation model was created to evaluate the phenomenon. The model can also be useful in analysing similar cases and research situations. (shrink)

This paper discusses idiomatic expressions like ‘that says it all’, ‘that says a lot’ etc. when used in presenting an argument. These expressions are instantiations of the grammatical pattern that says Q, in which Q is an indefinite quantifying expression. By making use of the pragma-dialectical theory of argumentation and the linguistic theory of construction grammar it is argued that instantiations of that says Q expressing positive polarity can fulfil the role of an argumentation’s linking premise. Furthermore, an analysis of (...) these expressions as presentational devices shows that an arguer can use them for strategic reasons, i.e. to leave the exact formulation of the standpoint implicit and to present the argument as self-evident. Using these devices derails into fallaciousness when the context offers insufficient clues to reconstruct the standpoint or when the argument does not offer the kind of support that would be required by the specific instantiation of Q. The argumentative function of instantiations of that says Q expressing negative polarity is that an antagonist can use them to attack the justificatory power of the protagonist’s argument. (shrink)

A straightforward explanation of fundamental tenets concerning the quantum mechanical wave function results in the thesis that the quantum mechanical wave function is a link between human cognition and the physical world. The way in which physicists have not accepted this explanation is discussed, and some of the roots of the problem are explored. The basis for an empirical test as to whether the wave function is a link between human cognition and the physical world is provided through developing an (...) experiment incorporating methodology from psychology and physics. Research in psychology and physics that relied on this methodology indicates that it is likely that Einstein, Podolsky, and Rosen's theoretical result that mutually exclusive wave functions can simultaneously apply to the same concrete physical circumstances can be implemented on an empirical level. (shrink)

Dicer is a key player in microRNA (miRNA) and RNA interference (RNAi) pathways, processing miRNA precursors and doublestranded RNA into ~21-nt-long products ultimately triggering sequence-dependent gene silencing. Although processing of substrates in vertebrate cells occurs in the cytoplasm, there is growing evidence suggesting Dicer is also present and functional in the nucleus. To address this possibility, we searched for a nuclear localization signal (NLS) in human Dicer and identified its C-terminal double-stranded RNA binding domain (dsRBD) as harboring NLS activity. We (...) show that the dsRBD-NLS can mediate nuclear import of a reporter protein via interaction with importins β, 7, and 8. In the context of full-length Dicer, the dsRBD-NLS is masked. However, duplication of the dsRBD localizes the full-length protein to the nucleus. Furthermore, deletion of the N-terminal helicase domain results in partial accumulation of Dicer in the nucleus upon leptomycin B treatment, indicating that CRM1 contributes to nuclear export of Dicer. Finally, we demonstrate that human Dicer has the ability to shuttle between the nucleus and the cytoplasm. We conclude that Dicer is a shuttling protein whose steady-state localization is cytoplasmic. (shrink)

The members of the Six gene family were identified as homologues of Drosophila sine oculis which is essential for compound-eye formation. The Six proteins are characterized by the Six domain and the Six-type homeodomain, both of which are essential for specific DNA binding and for cooperative interactions with Eya proteins. Mammals possess six Six genes which can be subdivided into three subclasses, and mutations of Six genes have been identified in human genetic disorders. Characterization of Six genes from various animal (...) phyla revealed the antiquity of this gene family and roles of its members in several different developmental contexts. Some members retain conserved roles as components of the Pax-Six-Eya-Dach regulatory network, which may have been established in the common ancestor of all bilaterians as a toolbox controlling cell proliferation and cell movement during embryogenesis. Gene duplications and cis-regulatory changes may have provided a basis for diverse functions of Six genes in different animal lineages. (shrink)

The human genome consists of more than 3 billion base pairs built from four different nucleotides that hold the genetic information for the entire organism. The genome is commonly divided into coding and noncoding DNA sequences, with coding DNA sequences defined as those that can be transcribed into mRNA and translated into proteins, or genes. The genetic code determines the impact of a nucleotide change in a gene on the protein sequence and function, and it is essential to understanding the (...) genetic basis of many congenital diseases. The Human Genome Project has accelerated our understanding about the genome function. We now know that our genome consists of 20,000–25,000 genes that occupy only.. (shrink)

The relationship between traumatic life events and increased suicide risk has been well reported in literature. However, the complex nature of suicidality phenomena still hinders our ability to comprehend the mediation mechanism underlying this association. In this study, we examined the mediating role of adult attachment and reflective functioning in the relationship between traumatic life events and suicidal ideation. Nine hundred and fifty Italian adults completed an online survey evaluating traumatic life events, adult attachment, reflective functioning and suicidal (...) ideation. The path analysis showed that the positive relationship between traumatic life events and suicidal ideation was partially mediated by attachment anxiety and reflective functioning. From a clinical point of view, these results support the relevance of evaluating and improving patients’ ability to mentalize as a part of psychotherapeutic intervention aimed at reducing suicidality in people with a history of traumatic experiences and attachment anxiety. (shrink)

Beginning with a review the logically first stages in the project of Random Dynamics, hoping for all laws nature being emergent, we also review what can be considered a consequence of Random Dynamics, a model—by myself and Masao Ninomiya—, which in principle predicts the initial conditions in such a way as to minimize a certain functional of the history of the Universe through both past and future. This functional is indeed the imaginary part of the action, which exists (only) in (...) our model of complex action. The main point of the present is to suggest this complex action model to be also helpfull in solving some problems for quantum mechanics. Especially as our model almost makes it possible in principle to calculate the full history of the universe, it even makes it in principle calculable, which one among several measurement results in a quantum experiment will actually be realized!Our “complex action model” thus is a special case of superdeterminism—in Bells way—and does not have true causality, but rather even in some cases true backward causation. In fact we claim in our model that the SSC(Superconducting Supercollider) were stopped by the US Congress due to the backward causation from the big amounts of Higgs particles, which it would have produced, if it had been allowed to run. The noumenon (“das Ding an sich”) in our model is the Feyman path integrand or better some fundamental quantities determined from second order effects of the latter integrand. The quantum mechanics interpretation here is strongly similar to the much criticized “transactional interpretation” by John Cramer (Rev. Mod. Phys. 58:647–688, 1986), but we might respond to some of the criticism. (shrink)

The Hamilton–Jacobi (HJ) equation for the action function plays a fundamental role in classical mechanics. A known consequence of the HJ equation is a blow-up of a disturbed free-particle solution. Following the idea of Sivashinsky, we formulate an extension of the HJ equation in which perturbations eventually evolve into a finite autosoliton associated with an elementary particle. A novel element of the model is stability of the autosoliton. We link uncertainties in the position and momentum of a particle to a (...) width and amplitude of the autosoliton. We formulate restrictions on the coefficients of the model and compare the model with some existing theories of extended elementary objects. (shrink)

Does joining groups trigger a cascade of psychological processes that can result in a loss of individuality and lead to such outcomes as social loafing and poor decision-making? Rather than privileging the self comprising primarily individual qualities as the “true self,” a multilevel, multicomponent approach suggests that, in most cases, personal and collective identities are integrated and mutually sustaining.