The diversity of bone proteoglycan (PG) structure and localisation (pericellular, extracellular in the organic bone matrix) reflects a broad spectrum of biological functions within a unique tissue. PGs play important roles in organizing the bone extracellular matrix, taking part in the structuring of the tissue itself as active regulators of collagen fibrillogenesis. PGs also display selective patterns of reactivity with several constituents including cytokines and growth factors, such as transforming growth factor‐β or osteoprotegerin thereby modulating their bio‐availability and biological activity (...) in the bone tissue. In this review, the complex PG composition in bone will be addressed together with the specific role played by PGs (or their GAGs chains) in bone biology, as regulatory molecules for bone resorption and their involvement in bone tumor development. These roles have been determined after modulation of PG expression or mutations in their corresponding genes, which revealed specific roles for these compounds in bone pathologies (e.g. perlecan or glypican‐3 mutations observed respectively in chondrodysplasia or dysmorphic syndrome). Finally, the potential therapeutic interest of PGs is discussed based on recent data, more particularly on bone tumor‐associated osteolysis as these molecules are involved both in bone resorption and tumor development. BioEssays 29:758–771, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

Dans la production industrielle qui entoure actuellement l'œuvre de Hannah Arendt en France, certains ouvrages se distinguent tant par leur qualité que par leur originalité. C'est le cas de celui de Françoise Collin qui aborde la pensée de Hannah Arendt à travers le prisme de la natalité. Ce qui intéresse F. Collin dans l'œuvre arendtienne, qui irrigue ses propres travaux depuis une quinzaine d'années, c'est la capacité de préserver l'agir en commun dans un monde durablement marqué par...

La mort de Françoise Collin laisse un grand vide sur la scène féministe francophone et internationale. Certes, elle n’était pas qu’une féministe et refusait de se laisser réduire à la posture de la « militante », mais c’est principalement dans ce domaine qu’elle a agi et laissé une empreinte. Elle s’illustre d’abord dans le domaine de la littérature. Déjà, pendant ses études secondaires en pleine Seconde Guerre mondiale, elle avait découvert dans celle-ci une ouverture vers la liberté. Elle s...

In their book on Descartes’s Changing Mind, Peter Machamer and J. E. McGuire argue that Descartes discarded dualism to embrace a kind of monism. Descartes famously proposed that there are two separate substances, mind and body, with distinct attributes of thought and extension. According to Machamer and McGuire, because of the limitations of our intellect, we cannot have insight into the nature of either substance. After reviewing their argument in some detail, I will argue that Descartes did not relinquish his (...) favorite doctrine but may have actually fooled himself about the nature of his dualism. It is my contention that the problem with Cartesian dualism stems from the definition of mind and body as substances and the role of their respective attributes—thought and extension—in the definition of substances. (shrink)

In this timely collection, the authors examine Indigenous peoples' negotiations with different cosmologies in a globalized world. Dussart and Poirier outline a sophisticated theory of change that accounts for the complexity of Indigenous peoples' engagement with Christianity and other cosmologies, their own colonial experiences, as well as their ongoing relationships to place and kin. Contributors to this volume offer fine-grained ethnographic studies that highlight the complex and pragmatic ways in which Indigenous peoples enact their cosmologies and articulate their identity as (...) forms of affirmation. This collection is a major contribution to the anthropology of religion, religious studies, and Indigenous studies worldwide. Contributors: Anne-Marie Colpron, Robert R. Crépeau, Françoise Dussart, Ingrid Hall, Laurent Jérôme, Frédéric Laugrand, James MacKenzie, Caroline Nepton Hotte, Ksenia Pimenova, Sylvie Poirier, Kathryn Rountree, Antonella Tassinari, Petronella Vaarzon-Morel. (shrink)

Philosophe, l'auteur tente de resituer le mouvement de la pensée d'Hannah Arendt, ses grandes articulations et ce qui fait d'elle un auteur majeur et précurseur.

Poetics and politics: these two key words are the names of the two main axes of Jacques Taminiaux’s work as a whole. They are also the title of the first chapter of his Maillons herméneutiques of 2009. In that work, he goes through a chain of 14 “links” to show that each of them consists in “cross-checkings” of different interpretive designs, all of which have to do, in a more or less direct manner, of this intercrossing of art and politics (...) which, ever since his first book, has been central to his thought. As he himself recalls, the analysis of such “cross-checkings” was already the focus of his first book, La nostalgie de la Grèce à l’aube de l’idéalisme allemand. In this book, in which Taminiaux shows how ancient Greece became an indispensable reference for German thinkers at the end of the eighteenth century, Taminiaux demonstrates how Hölderlin and Hegel, in their respective itineraries of thought, were profoundly influenced by Schiller’s nostalgia for Greece, as expressed in Schiller’s famous poem of 1788 about Die Götter Griechenlandes, The Gods of Greece. (shrink)

Wittgenstein's Folly: Philosophy, Psychoanalysis and Language Games presents a dialogue between the philosopher Ludwig Wittgenstein, the author Françoise Davoine, and Davoine's patients with extreme lived experience. The book begins with Davoine's seminar at the École des Hautes Études en Sciences Sociales in Paris, which is attended by Wittgenstein. He then accompanies Davoine on visits to colleagues at the Austen Riggs Center in Massachusetts, in California, on a Sioux reservation in South Dakota, and at Freud's house in Vienna. The dialogic form (...) of the book allows a performance centered on the psychotherapy of madness and trauma, in which Wittgenstein takes the floor. Davoine introduces us to a contemporary Feast of Fools and creates new language games with madness, enlarging the scope of psychoanalytic approaches to authors like Wittgenstein. The chapters of this book closely resemble short plays in which a conversation with living human beings or with characters from philosophy, literature, science, and the arts encounter one another and begin to open new ways of speaking that can render the "mad" more familiar and more manageable. Wittgenstein's Folly: Philosophy, Psychoanalysis and Language Games will be of great interest to psychoanalysts and to academics and students engaged in psychoanalytic studies, philosophy and trauma-related studies. (shrink)

This article analyzes the value of geometric models to understand matter with the examples of the Platonic model for the primary four elements (fire, air, water, and earth) and the models of carbon atomic structures in the new science of crystallography. How the geometry of these models is built in order to discover the properties of matter is explained: movement and stability for the primary elements, and hardness, softness and elasticity for the carbon atoms. These geometric models appear to have (...) a double quality: firstly, they exhibit visually the scientific properties of matter, and secondly they give us the possibility to visualize its whole nature. Geometrical models appear to be the expression of the mind in the understanding of physical matter. (shrink)

Fragments of painted plaster found in the destruction layer of three first floor rooms in the House of Seals and of one first floor room of the House of the Sword had broken from the ceiling. They allow the restoration of the schema in the room of the House of the Sword and of two of the rooms in the House of Seals, the latter in colour. Composed of bands surrounding a quadrangular field, these décorations, evoking carpets stretched on the (...) ceiling, are richer (costly pigments, gold leaf) and more complex (some fifteen motifs) than those in tombs of the same period, which adopted the same « carpet » composition and which borrowed from the same repertoire, often confirmed by the textiles. Since we know of no other ceiling decoration in habitation rooms, it is unwise to contrast the exuberance of these ceilings with the tomb ceilings. The room that could not be restored had moreover a much more perfunctory decoration. (shrink)

Tri‐methylation of lysine 4 on histone H3 (H3K4me3) is a near‐universal chromatin modification at the transcription start site of active genes in eukaryotes from yeast to man and its levels reflect the amount of transcription. Because of this association, H3K4me3 is often described as an ‘activating’ histone modification and assumed to have an instructive role in the transcription of genes, but the field is lacking a conserved mechanism to support this view. The overwhelming finding from genome‐wide studies is that actually (...) very little transcription changes upon removal of most H3K4me3 under steady‐state or dynamically changing conditions, including at mammalian CpG island promoters. Instead, rather than a major role in instructing transcription, time‐resolved experiments provide more evidence supporting the deposition of H3K4me3 into chromatin as a result of transcription, influencing processes such as memory of previous states, transcriptional consistency between cells in a population and transcription termination. -/- . (shrink)

The prominence and peculiarity of color in French symbolist verse have often been noted. Yet the dominance of color in symbolism is not the result of aesthetic preference or mere poetic technique, as has been previously argued; rather, color functions, with the synaesthetic poetic context of which it is an integral part, as the direct manifestation of a particular metaphysical stance. Color leads to the heart of what symbolism is, for it is the paradigmatic literary expression of a general spiritual (...) crisis—a crisis in epistemology. The nineteenth century extended seventeenth-century empiricism—an empiricism which had invented mathematical measurement as the gauge of reality and which resulted in a predilection to see most authentic knowledge as quantifiable. The logical corollary of such a predilection is that all sensory experience is regarded as suspect. Newtonian physics had rationalized the laws of the universe in reducing its properties to atomical structures and laws of motion. Nothing, it seemed, was left unexplained. Those areas of perception which remained unquantifiable were dispelled as illusion or attributed to the necessary limitations of the human mind. The theories of John Locke act as a kind of historical watershed in this regard: they are the classic philosophic expression of the disjunction between sensory experience and knowledge which, in its nineteenth-century versions, would lead to the symbolist revolt. Françoise Meltzer is a professor of French literature and of comparative literature at the University of Chicago. Her previous contribution to Critical Inquiry is the translation of Christian Metz's "Trucage and the Film" . She is the author of The Trial of Psychoanalysis, Salome and the Dance of Writing, and Hot Property: The Stakes and Claims of Literary Originality. (shrink)

La loi dite loi Taubira fut votée le 10 mai 2001 par les élus de la République. L’article 1 de cette loi précisait : « La République française reconnaît que la traite négrière transatlantique et l’ esclavage perpétrés à partir du XVe siècle contre les populations africaines déportées en Europe, aux Amériques et dans l’océan Indien constituent un crime contre l’humanité.

Début 1871, Helmholtz donne une conférence à Heidelberg, devant un public de non spécialistes, sur « la genèse du système planétaire », dont le sujet sera ce qu’il appelle la théorie de Kant-Laplace. Plutôt que de commencer par expliquer ce qu’il faut entendre par cette dernière, Helmholtz expose devant ses auditeurs la représentation que l’on se fait désormais de la formation des corps célestes et de leur devenir probable, en s’appuyant sur les progrès des connaissances, la découverte de nouvelles lois, (...) l’usage d’instruments de plus en plus perfectionnés. C’est ainsi que la validité de l’hypothèse de Kant et de Laplace se trouve confirmée a posteriori et leur audace légitimée. Aussi, la démarche adoptée par Helmholtz relativise-t-elle implicitement, et peut-être à son insu, la rigueur postulée de la bonne méthode scientifique. La cosmogonie esquissée par Helmholtz ressemble à un spectacle bien étudié dont les auditeurs sont les spectateurs, les savants, les acteurs, et la science épurée, l’enjeu. L’analyse de ce texte a donc pour objectif principal d’identifier et de rappeler les éléments contextuels qui lui confèrent son épaisseur, depuis la guerre franco-prussienne jusqu’aux tensions idéologiques, philosophiques, scientifiques qui en sont l’arrière-plan. (shrink)

We show in this paper that the theory of ordinal addition of any fixed ordinal ωα, with α less than ωω, admits a quantifier elimination. This in particular gives a new proof for the decidability result first established in 1965 by R. Büchi using transfinite automata. Our proof is based on the Ehrenfeucht games, and we show that quantifier elimination go through generalized power.RésuméOn montre ici que, pour tout ordinal α inférieur à ωω, la théorie additive de ωα admet une (...) élimination des quantificateurs. On obtient ainsi une nouvelle preuve de la décidabilité de ces théories . On utilise ici les jeux d'Ehrenfeucht, avec un formalisme à la Ferrante et Rackoff, et on montre que le fait d'admettre une élimination des quantificateurs se transmet par produit généralisé. (shrink)

We show here that the first order theory of the positive integers equipped with multiplication remains decidable when one adds to the language the usual order restricted to the prime numbers. We see moreover that the complexity of the latter theory is a tower of exponentials, of height O(n).

The evolutionary origins of several vertebrate organs are still controversial. The thyroid is classically thought to derive directly from the endostyle (a pharyngeal organ found in urochordates, cephalochordates and lampreys). Several molecular and biochemical lines of evidence agree with this scenario. However, a recent paper,1 describing the expression of a FoxE ortholog in amphioxus, suggests that some molecular pathways might actually have been recruited from an adjacent region of the pharynx. Although additional data from urochordates and lamprey are needed to (...) confirm this hypothesis; these results propose an interesting new scenario for thyroid evolution that involved the reorganisation of genetical and morphological features in the pharyngeal endoderm in order to give rise to a entirely new organ. They also give an indication that the ancestral role of the FoxE gene family was probably limited to the differentiation of part of the pharynx. BioEssays 24:696–699, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

oise Baylis, 1234 Le Marchant Street, Halifax, Nova Scotia, Canada B3H 3P7. Tel.: (902)-494–2873; Fax: (902)-494-2924; Email: francoise.baylis{at}dal.ca ' + u + '@' + d + ' '//--> . Abstract Recently, there has been a growing interest in public health and public health ethics. Much of this interest has been tied to efforts to draw up national and international plans to deal with a global pandemic. It is common for these plans to state the importance of drawing upon a well-developed (...) ethics framework and we argue that this framework should reflect the values and insights of feminist relational theory. More specifically, we argue that pandemic planning must be squarely situated in the larger realm of public health and that an ethics framework for public health will be one that recognizes the need to pay particular attention to the vulnerability of subpopulations lacking in social and economic power. We propose an ethics framework for public health that builds on the notions of relational personhood (including relational autonomy and social justice) and relational solidarity. In this way, we aim for a public health ethics that, as appropriate, promotes the public interest and the common good. CiteULike Connotea Del.icio.us What's this? (shrink)

Suddenly, COVID-19 has changed the world and the way people work. Companies had to accelerate something they knew was imminent in the future, but not immediate and extremely humongous. This situation poses a huge challenge for companies to survive and thrive in this complex business environment and for employees, who must adapt to this new way of working. An effective e-leadership, which promotes companies’ adaptability, is needed. This study investigates the existing knowledge on teleworking and e-leadership; and analyzes the supposed (...) challenges. The literature review shows that companies with effective e-leadership can view teleworking as an opportunity. It is advantageous for not only companies’ productivity but also the environment and people who work remotely. However, a traditional or no leadership can result in some risks. Thriving in remote work environments implies that managers must adjust the companies’ structure, making them less hierarchical, and developing new abilities to establish a strong and trustworthy relationship with their employees to maintain their competitiveness, while retaining a genuine concern for their employees’ well-being. Similarly, successful e-leadership must be able to consolidate and lead effective virtual teams to accomplish organizational goals. This study contributes to the literature and leaders during the pandemic. (shrink)

Les premières mythographies de l’Europe néo-latine, depuis la Genealogia deorum de Boccace, considèrent l’histoire des dieux sur le modèle des généalogies humaines, en cherchant à recomposer « la lignée de Saturne ». Les premiers historiens de la Grèce, comme les poètes, inventèrent des généalogies mythiques pour inscrire l’origine des hommes dans l’histoire de leur relation aux dieux. Que fondent les généalogies divines ? Non seulement des structures religieuses, non seulement la raison même des sociétés humaines, mais encore la préhistoire de (...) l’humanité. Mais si les engendrements divins donnent sens aux relations entre les hommes et les dieux, c’est l’histoire des commencements du monde que les mythographes cherchent à comprendre en interrogeant l’articulation des généalogies divines et humaines. Depuis que, dans le Timée, Platon a associé mythologia et genealogia comme deux modes de discours « archéologiques », les mythographes ont ouvertement revendiqué un savoir sur le monde qui se définit comme une synthèse des « sciences de la nature ».Mythologia, Genealogia, Archaiologia:A Paleontological Scope for Mythography. The first European mythographical treatises in the Middle Ages and Renaissance, since Boccaccio’s Genealogia deorum, were determined by a genealogical method, looking at the history of the gods with human patterns and seeking the reconstruction of “Saturn’s lineage”. The early Greek mythographers, like the poets, imagined various genealogies for seeking out the origins of humanity through their relationships with gods. What is founded on divine genealogies? Not only religious structures, nor only the true ratio of human sociability, but a human paleon­tology too. By interpreting filiations as a system of connexions between gods and humans, the mythographers aimed at understanding the protohistory of the universe. Since Plato’s Timaeus associated mythologia and genealogia as two modes of “archaeological” discourse, mythographers have wanted to assert their own “physical science” as a whole synthetic perception of the natural world. (shrink)

À partir de l'étude de la constitution et de l'histoire des archives du parlement de Paris et de leur traitement archivistique, ainsi que des multiples collections de copies et d'extraits dont elles ont été l'objet, cet article propose une réflexion sur la manière dont ce fonds d'archives, qui allie une exceptionnelle importance matérielle et historique et une particulière complexité, a pu être traité par les archivistes et utilisé par les chercheurs, ainsi que sur les perspectives qu'il peut ouvrir à la (...) recherche. Ces archives du Parlement illustrent en effet toute la gamme des problèmes de conservation, de traitement, de communication au public et d'exploitation et rendent particulièrement manifeste la complémentarité et l'interpénétration nécessaires, voire la confusion, des approches historique et archivistique ; elles démontrent que la connaissance par les chercheurs de l'histoire du fonds d'archives va bien au-delà de la simple pratique archivistique et contribue à la perception de la documentation comme« source» d'histoire. (shrink)