Apresentação Agradecemos à presença dos professores do mestrado em Comunicação da Faculdade de Comunicação Social da Universidade do Estado do Rio de Janeiro, aos alunos da graduação e da pós e aos quatro convidados pela gentileza de estarem no campus da Universidade para tratar de um assunto pouco estudado na área de comunicação. Nos currículos antigos, em especial aqueles na década de 1980, havia uma disciplina intitulada Sistemas Internacionais de Comunicação. Hoje esse é um tema ausente da grade de muitos (...) cursos, daí a importância desta palestra organizada pelos alunos, em 2006, da disciplina de Comunicação Internacional do Programa de Pós-graduação em Comunicação – mestrado – da Uerj, que também encerra as atividades da disciplina no semestre. Este encontro faz parte do Seminário de Produção Acadêmica (SPA), no qual os alunos da graduação e da pós-graduação se encontram em algumas ocasiões para debater assuntos pré-agendados. Participam desta mesa os seguintes correspondentes internacionais: Paula Gobbi, presidente da Associação dos Correspondentes de Imprensa Estrangeira no Rio de Janeiro (ACIE), que reúne praticamente todos os correspondentes estrangeiros sediados na cidade; a brasileira Ivani Flora, que trabalha para a rede de televisão SIC, de Portugal; Ana Maria Geres, diretora no Brasil da agência de notícias espanhola EFE, e Krzysztof Gluchowski, correspondente do jornal The Polish Daily, que circula na Grã-Bretanha. (shrink)

We will show that there is a strong form of emergence in cell biology. Beginning with C.D. Broad's classic discussion of emergence, we distinguish two conditions sufficient for emergence. Emergence in biology must be compatible with the thought that all explanations of systemic properties are mechanistic explanations and with their sufficiency. Explanations of systemic properties are always in terms of the properties of the parts within the system. Nonetheless, systemic properties can still be emergent. If the properties of the components (...) within the system cannot be predicted, even in principle, from the behavior of the system's parts within simpler wholes then there also will be systemic properties which cannot be predicted, even in principle, on basis of the behavior of these parts. We show in an explicit case study drawn from molecular cell physiology that biochemical networks display this kind of emergence, even though they deploy only mechanistic explanations. This illustrates emergence and its place in nature. (shrink)

We will show that there is a strong form of emergence in cell biology. Beginning with C.D. Broad’s classic discussion of emergence, we distinguish two conditions sufficient for emergence. Emergence in biology must be compatible with the thought that all explanations of systemic properties are mechanistic explanations and with their sufficiency. Explanations of systemic properties are always in terms of the properties of the parts within the system. Nonetheless, systemic properties can still be emergent. If the properties of the components (...) within the system cannot be predicted, even in principle, from the behavior of the system’s parts within simpler wholes then there also will be systemic properties which cannot be predicted, even in principle, on basis of the behavior of these parts. We show in an explicit case study drawn from molecular cell physiology that biochemical networks display this kind of emergence, even though they deploy only mechanistic explanations. This illustrates emergence and its place in nature. (shrink)

Systems biology is a vigorous and expanding discipline, in many ways a successor to genomics and perhaps unprecendented in its combination of biology with a ...

Mechanistic models in molecular systems biology are generally mathematical models of the action of networks of biochemical reactions, involving metabolism, signal transduction, and/or gene expression. They can be either simulated numerically or analyzed analytically. Systems biology integrates quantitative molecular data acquisition with mathematical models to design new experiments, discriminate between alternative mechanisms and explain the molecular basis of cellular properties. At the heart of this approach are mechanistic models of molecular networks. We focus on the articulation and development of mechanistic (...) models, identifying five constraints which guide the articulation of models in molecular systems biology. These constraints are not independent of one another, with the result that modeling becomes an iterative process. We illustrate the use of these constraints in the modeling of the mechanism for bistability in the lac operon. (shrink)

Investigations into inter-level relations in computer science, biology and psychology call for an *empirical* turn in the philosophy of mind. Rather than concentrate on *a priori* discussions of inter-level relations between 'completed' sciences, a case is made for the actual study of the way inter-level relations grow out of the developing sciences. Thus, philosophical inquiries will be made more relevant to the sciences, and, more importantly, philosophical accounts of inter-level relations will be testable by confronting them with what really happens (...) in science. Hence, close observation of the ever-changing reduction relations in the developing sciences, and revision of philosophical positions based on these empirical observations, may, in the long run, be more conducive to an adequate understanding of inter-level relations than a traditional *a priori* approach. (shrink)

The biological sciences study (bio)complex living systems. Research directed at the mechanistic explanation of the "live" state truly requires a pluralist research program, i.e. BioComplexity research. The program should apply multiple intra-level and inter-level theories and methodologies. We substantiate this thesis with analysis of BioComplexity: metabolic and modular control analysis of metabolic pathways, emergence of oscillations, and the analysis of the functioning of glycolysis.

In 2010, randomized controlled trials (RCTs) of two different biomedical strategies to prevent HIV infection had positive findings. However, despite ongoing very high levels of HIV infection in some countries and population groups, it has been made clear by regulatory authorities that the evidence remains insufficient to support either product being made available outside of research contexts in the developing world for at least two years. In addition, prevention trials in endemic areas will continue to test new interventions against placebo. (...) But the judgments of evidentiary standards are never value-neutral. Using the recent trials and their contexts as case studies, we examine the basis for these decisions, which will potentially delay access to scientific innovation to the people who are most urgently in need of it. (shrink)

Biochemistry and molecular biology have been focusing on the structural, catalytic, and regulatory proper- ties of individual macromolecules from the perspective of clarifying the mechanisms of metabolism and gene expression. Complete genomes of ‘primitive’ living organisms seem to be substantially larger than necessary for metabolism and gene expression alone. This is in line with the findings of silent phenotypes for supposedly important genes, apparent redundancy of functions, and variegated networks of signal transduction and transcription factors. Here we propose that evolutionary (...) optimization has been much more intensive than to lead to the bare minima necessary for autonomous life. Much more complex organisms prevail. Much of this complexity arises in the nonlinear interactions between cellular macromolecules and in subtle differences between paralogs (isoenzymes). The complexity can only be understood when analyzed quantitatively, for which quantitative experimentation is needed in living systems that are as simple and manipulatable as possible, yet complex in the above sense. We illustrate this for the glutamine synthetase cascade in Escherichia coli. By reviewing recent molecular findings, we show that this cascade is much more complex than necessary for simple regulation of ammonia assimilation. Simulations suggest that the function of this complexity may lie in quasi-intelligent behavior, including conditioning and learning. (shrink)

Summary: Based on the book, the overall impression is that systems biology struggles with the limits of first-order cybernetics and tries to overcome it by mixing bottom up and top down methods from classical approaches such as genetics, molecular biology and enzymology. However, the contributors avoid the step from first-order to second-order cybernetics.

CRS(fc) denotes the variety of commutative residuated semilattice-ordered monoids that satisfy (x ⋀ e)k ≤ (x ⋀ e)k+1. A structural characterization of the subdi-rectly irreducible members of CRS(k) is proved, and is then used to provide a constructive approach to the axiomatization of varieties generated by positive universal subclasses of CRS(k).

The faithfulness condition (FC) is a useful principle for inferring causal structure from statistical data. The usual motivation for the FC appeals to theorems showing that exceptions to it have probability zero, provided that some apparently reasonable assumptions obtain. However, some have objected that, the theorems notwithstanding, exceptions to the FC are probable in commonly occurring circumstances. I argue that exceptions to the FC are probable in the circumstances specified by this objection only given the presence of a condition that (...) I label homogeneity, and furthermore that this condition typically does not obtain in the FC’s intended domain of application. (shrink)

Conformational changes of proteins and other biomolecules play a fundamental role in their functional mechanism. Single pair Förster resonance energy transfer offers the possibility to detect these conformational changes and dynamics, and to characterize their underlying kinetics. Using spFRET on microscopes with different modes of detection, dynamic timescales ranging from nanoseconds to seconds can be quantified. Confocal microscopy can be used as a means to analyze dynamics in the range of nanoseconds to milliseconds, while total internal reflection fluorescence microscopy offers (...) information about conformational changes on timescales of milliseconds to seconds. While the existence of dynamics can be directly inferred from the FRET efficiency time trace or the correlation of FRET efficiency and fluorescence lifetime, additional computational approaches are required to extract the kinetic rates of these dynamics, a short overview of which is given in this review. The functional mechanism of proteins is often driven by underlying conformational changes. These intramolecular changes and dynamics can be investigated using single pair Förster resonance energy transfer. The kinetic timescales of the dynamics in the range of nanoseconds to seconds is then quantified using different experimental and analytical implementations. (shrink)

Fluorescence correlation spectroscopy (FCS) is a powerful technique to measure concentrations, mobilities, and interactions of fluorescent biomolecules. It can be applied to various biological systems such as simple homogeneous solutions, cells, artificial, or cellular membranes and whole organisms. Here, we introduce the basic principle of FCS, discuss its application to biological questions as well as its limitations and challenges, present an overview of novel technical developments to overcome those challenges, and conclude with speculations about the future applications of fluorescence fluctuation (...) spectroscopy. (shrink)

Abstract: Nietzsche’s famously wrote that “consciousness is a surface” (EH, Why I am so clever, 9: 97). The aim of this paper is to make sense of this quite puzzling contention—Superficiality, for short. In doing this, I shall focus on two further claims—both to be found in Gay Science 354—which I take to substantiate Nietzsche’s endorsement of Superficiality. The first claim is that consciousness is superfluous—which I call the “superfluousness claim” (SC). The second claim is that consciousness is the source (...) of some deep falsification—which I call the “falsification claim” (FC). I shall start by considering Nietzsche’s notion of consciousness. Here, I shall argue that the kind of consciousness he is concerned with is in fact self-consciousness and that he put forward a higher-order theory of it. Then, I shall address the two claims. Regarding (FC), my proposal will be that, according to Nietzsche, the content of (self-)conscious mental states is falsified in virtue of its being articulated propositionally. Regarding (SC), I shall claim that it is best read as a weak version of epiphenomenalism about conscious causation. In addressing both points, I shall discuss in particular the influential reading of Nietzsche’s theory of consciousness offered by Katsafanas (2005). (shrink)

We examine how degrees of computably enumerable equivalence relations under computable reduction break down into isomorphism classes. Two ceers are isomorphic if there is a computable permutation of ω which reduces one to the other. As a method of focusing on nontrivial differences in isomorphism classes, we give special attention to weakly precomplete ceers. For any degree, we consider the number of isomorphism types contained in the degree and the number of isomorphism types of weakly precomplete ceers contained in the (...) degree. We show that the number of isomorphism types must be 1 or ω, and it is 1 if and only if the ceer is self-full and has no computable classes. On the other hand, we show that the number of isomorphism types of weakly precomplete ceers contained in the degree can be any member of $[0,\omega ]$. In fact, for any $n \in [0,\omega ]$, there is a degree d and weakly precomplete ceers ${E_1}, \ldots,{E_n}$ in d so that any ceer R in d is isomorphic to ${E_i} \oplus D$ for some $i \le n$ and D a ceer with domain either finite or ω comprised of finitely many computable classes. Thus, up to a trivial equivalence, the degree d splits into exactly n classes.We conclude by answering some lingering open questions from the literature: Gao and Gerdes [11] define the collection of essentially FC ceers to be those which are reducible to a ceer all of whose classes are finite. They show that the index set of essentially FC ceers is ${\rm{\Pi }}_3^0$-hard, though the definition is ${\rm{\Sigma }}_4^0$. We close the gap by showing that the index set is ${\rm{\Sigma }}_4^0$-complete. They also use index sets to show that there is a ceer all of whose classes are computable, but which is not essentially FC, and they ask for an explicit construction, which we provide.Andrews and Sorbi [4] examined strong minimal covers of downwards-closed sets of degrees of ceers. We show that if $\left$ is a uniform c.e. sequence of non universal ceers, then $\left\{ {{ \oplus _{i \le j}}{E_i}|j \in \omega } \right\}$ has infinitely many incomparable strong minimal covers, which we use to answer some open questions from [4].Lastly, we show that there exists an infinite antichain of weakly precomplete ceers. (shrink)

This paper will be concerned with the conjunctive interpretation of a family of disjunctive constructions. The relevant conjunctive interpretation, sometimes referred to as a “free choice effect,” (FC) is attested when a disjunctive sentence is embedded under an existential modal operator. I will provide evidence that the relevant generalization extends (with some caveats) to all constructions in which a disjunctive sentence appears under the scope of an existential quantifier, as well as to seemingly unrelated constructions in which conjunction appears under (...) the scope of negation and a universal quantifier. (shrink)

In recent years, many philosophers of science have attempted to articulate a theory of non-epistemic emergence that is compatible with mechanistic explanation and incompatible with reductionism. The 2005 account of Fred C. Boogerd et al. has been particularly influential. They argued that a systemic property was emergent if it could not be predicted from the behaviour of less complex systems. Here, I argue that Boogerd et al.'s attempt to ground emergence in complexity guarantees that we will see emergence, (...) but at the cost of rendering it either trivial or epistemic. There are three basic problems. First, neither the measures of complexity explicitly mentioned by Boogerd et al. nor the most popular measures in the literature can do the practical and theoretical work that they assign to complexity. Second, I argue that while the success of their view depends on restricting the base of information available to the reductionist, this cannot be done in a way that is metaphysically neutral with respect to emer.. (shrink)

The fact that the permeability between family and work scopes produces work-family conflict (WFC) is well established. As such, this research aims to check whether the unequal involvement in household chores between men and women is associated with increased WFC in women and men, interpreting the results also from the knowledge that arise from gender studies. A correlational study was carried out by means a questionnaire applied to 515 subjects (63% men) of two independent samples of Spanish men and women (...) without emotional relationship, who lived with their heterosexual partner. As expected, results firstly show unequal involvement in household chores by women and men as it is higher in women that in men, and the perception of partner involvement is lower in women that in men. Secondly, those unequal involvements relate differently to men and women on different ways of work-family interaction. They do not increase WFC in women comparing to men, although there are tangentially significant differences in work conflict (WC) and statistically significant in family conflict (FC). However, perception of partner involvement on household chores increases WFC both in men and in women but not WC nor FC. Nevertheless, increase on marital conflict (MC) by domestic tasks neither affect in a significant way WFC in women nor in men, but increase WC in both women and men and FC only in women. Results also confirm that subject involvement on household chores is not a significant predictor of WFC in women nor in men, and that MC by domestic tasks is a statistically significant predictor in women of WFC and FC, but not in men. Thus, results show that traditional gender roles still affect the way men and women manage the work and family interaction, although the increased WFC due to involvement in housework is not exclusive to women, but also occurs in men. Personal and institutional recommendations are made on the basis of these results to cope with these conflicts. (shrink)

In this paper we reconsider the issue of free choice and the role of the wh-morphology employed in it. We show that the property of being an interrogative wh-word alone is not sufficient for free choice, and that semantic and sometimes even morphological definiteness is a pre-requisite for some free choice items (FCIs) in certain languages, e.g. in Greek and Mandarin Chinese. We propose a theory that explains the polarity behaviour of FCIs cross-linguistically, and allows indefinite (Giannakidou 2001) as well (...) as definite-like FCIs. The difference is manifested as a lexical distinction in English between any (indefinite) and wh-ever (definite); in Greek it appears as a choice between a FCI nominal modifier (taking an NP argument), which illustrates the indefinite option, and a FC free relative illustrating the definite one. We provide a compositional analysis of Greek FCIs in both incarnations, and derive in a parallel manner the Chinese FCIs. Here the definite versus indefinite alternation is manifested in the presence or absence of dōu, which we take to express the maximality operator. It is thus shown that what we see in the morphology of FCIs in Greek is reflected in syntax in Chinese. Our analysis has important consequences for the class of so-called wh-indeterminates. In the context of current proposals, free choiceness is taken to come routinely from interrogative semantics, and wh-indeterminates are treated as question words which can freely become FCIs (Kratzer and Shimoyama 2002). Our results from Mandarin and Greek emphasize that wh-indeterminates do not form a uniform class in this respect, and that interrogative semantics alone cannot predict either sensitivity of free choice to definiteness, or the polarity behaviour of FCIs. (shrink)

The primary theoretical focus of this paper is on Free Choice uses of any, in particular on two phenomena that have remained largely unstudied. One involves the ability of any phrases to occur in affirmative episodic statements when aided by suitable noun modifiers. The other involves the difference between modals of necessity and possibility with respect to licensing of any. The central thesis advanced here is that FC any is a universal determiner whose domain of quantification is not a set (...) of particular individuals but the set of possible individuals of the relevant kind. In a theory of genericity utilizing situations, an any phrase can be seen as having a universal quantifier binding the situation variable of the common noun. This inherent genericity is argued to be at the heart of the intuition that any statements support counterfactual inferences and do not involve existential commitments. A conflict in presuppositions is shown to account for the incompatibility of unmodified any phrases in affirmative episodic statements and the crucial role played by modification in ameliorating this clash is explicated. In the case of modals of necessity, the interaction between the universal force of any and the particular modal base is shown to be crucial. In view of these facts it is argued that FC any is not directly licensed by modal or generic operators as generally assumed but that its felicitous use is sensitive to the pragmatics of epistemic modality. Turning to its polarity sensitive uses, language internal as well as crosslinguistic evidence is presented to distinguish it from FC any in having the existential quantificational force typical of indefinites. The paper concludes by suggesting that the common tie between them is that they both occur in statements that apply to a class of entities, rather than to particular members of the class. (shrink)

In this essay, I argue for the rejection of Vihvelin's ‘Three-fold Classification’ , a nonstandard taxonomy of free-will compatibilism, incompatibilism, and impossibilism. Vihvelin is right that the standard taxonomy of these views is inadequate, and that a new taxonomy is needed to clarify the free-will debate. Significantly, Vihvelin notes that the standard formal definition of ‘incompatibilism’ does not capture the historically popular view that deterministic laws pose a threat to free will. Vihvelin's proposed solution is to redefine ‘incompatibilism.’ However, Vihvelin's (...) formal definition of ‘incompatibilism’ is flawed according to her own arguments. In addition, Vihvelin's characterization of ‘compatibilism’ is incomplete, and at least two important free-will views are missing from her proposed taxonomy. Given the problems with Vihvelin's arguments for 3-FC, her novel view of the dialectic between the major free-will views lacks support. (shrink)

Foundational projects disagree on whether pure and applied mathematics should be explained together. Proponents of unified accounts like neologicists defend Frege’s Constraint (FC), a principle demanding that an explanation of applicability be provided by mathematical definitions. I reconsider the philosophical import of FC, arguing that usual conceptions are biased by ontological assumptions. I explore more reasonable weaker variants — Moderate and Modest FC — arguing against common opinion that ante rem structuralism (and other) views can meet them. I dispel doubts (...) that such constraints are ‘toothless’, showing they both assuage Frege’s original concerns and accommodate neo-logicist intents by dismissing ‘arrogant’ definitions. (shrink)

This paper presents an analysis of negative polarity items (NPIs) in Hindi. It is noted that NPIs in this language are composed of a (weak) indefinite plus a particle bhii meaning ‘even’. It is argued that the compositional semantics of this combination explains their behavior as NPIs as well as their behavior as free choice (FC) items. I assume that weak Hindi indefinites like ek and koi are to be viewed as a predicate that I call one, a predicate that (...) is true of everything that exists. I further assume that bhii exhibits association with focus with the indefinite, and that this leads to contradictory implicatures in positive contexts. The behavior of these phrases in a variety of syntactic contexts is discussed, including constructions like correlatives. Finally, I provide a comparison with analyses of English any, and discuss the relevance of the analysis presented here for that of any. (shrink)

This paper deals with the interpretation and distribution of universal Free Choice (FC) items, such as English FC any or Spanish cualquiera. Crosslinguistically, universal FC items can be characterized as follows. First, they have a restricted distribution. Second, they express freedom of choice: the sentence You can take any card conveys the information that the addressee is free to pick whichever card she chooses. Under standard assumptions, the truth conditions of sentences like You can take any card are taken to (...) be captured by formalizations in which a universal quantifier ranging over individuals has wide scope over the possibility modal. The crucial observation that informs the account in this paper is that this type of formalization cannot capture the freedom of choice component. I will argue that in order to derive the right interaction between possibility modals and FC items, we need to add an exclusiveness condition to the standard wide scope paraphrases. The same proposal that guarantees freedom of choice will automatically account for the distribution restrictions of FC items. The formal implementation of this proposal is cast in the Hamblin semantics proposed in Kratzer and Shimoyama (Indeterminate phrases: The view from Japanese, 2002). (shrink)