Suspended sediment modeling is an important subject for decision-makers at the catchment level. Accurate and reliable modeling of suspended sediment load is important for planning, managing, and designing of water resource structures and river systems. The objective of this study was to develop artificial intelligence- based ensemble methods for modeling SSL in Katar catchment, Ethiopia. In this paper, three single AI-based models, that is, support vector machine, adaptive neurofuzzy inference system, feed-forward neural network, and one conventional multilinear regression modes, were (...) used for SSL modeling. Besides, four different ensemble methods, neural network ensemble, ANFIS ensemble, weighted average ensemble, and simple average ensemble, were developed by combining the outputs of the four single models to improve their predictive performance. The study used two-year discharge and SSL data for training and verification of the applied models. Determination coefficient and root mean square error were used to evaluate the performances of the developed models. Based on the performance measure results, the ANFIS model provides higher efficiency than the other developed single models. Out of all developed ensemble models, the nonlinear ANFIS model combination method was found to be the most accurate method and could increase the efficiency of SVM, MLR, ANFIS, and FFNN models by 19.02%, 37%, 9.73%, and 16.3%, respectively, at the verification stage. Overall, the proposed ensemble models in general and the AI-based ensemble in particular provide excellent performance in SSL estimation. (shrink)

Predicting suspended sediment load in water resource management requires efficient and reliable predicted models. This study considers the support vector regression method to predict daily suspended sediment load. Since the SVR has unknown parameters, the observer-teacher-learner-based Optimization method is integrated with the SVR model to provide a novel hybrid predictive model. The SVR combined with the genetic algorithm is used as an alternative model. To explore the performance and application of the proposed models, five input combinations of rainfall and discharge (...) data of Cham Siah River catchment are provided. The predictive models are assessed using various numerical and visual indicators. The results indicate that the SVR-OTLBO model offers a higher prediction performance than other models employed in the current study. Specifically, SVR-OTLBO model offers highest Pearson correlation coefficient, Willmott’s Index, ratio of performance to IQ, and modified index of agreement and the lowest relative root mean square error in comparison with SVR-GA and SVR models, respectively. (shrink)

Radicalism and theological integrity -- Radicals and radicalism -- Tradition and traditions -- Theology and the given -- Resources and reconstructions -- Theological responsibility -- The supernatural -- Towards theological method.

In a secular age that offers a buffet of spiritualities focused on the self and on personal transformation, leading practical theologian Andrew Root shows the difference between these reigning mysticisms and an authentic Christian view of transformation.

This month the American Journal of Bioethics examines the intersectionality of medicine, ethics, and race. In “Race, Power, and COVID-19: A Call for Advocacy Within Bioethics,” Mithani and colleagu...

This book is a critical introduction to the philosophy of social science. While most social scientists maintain that the social sciences should stand free of politics, this book argues that they should be politically partisan. Root offers a clear description and provocative criticism of many of the methods and ideals that guide research and teaching in the social sciences.

It is natural for us — living after the Darwinian Revolution and the neo-Darwinian synthesis — to consider the adoption of evolution by natural selection as unconditionally rational, because it now seems the best theory or explanation of many phenomena. Nonetheless, if we take historical inquiry seriously, as allowing us to probe into the ground of our knowledge, the roots of even this “rational” Darwinism might be unearthed. Darwinian doctrine betrays a deceptive desire for unity and simplicity of principle, (...) and belief that the mechanistic aspect of nature is of the highest significance. Such crucial but questionable presuppositions are more easily discerned historically, insofar as they chronologically preceded Darwin's particular theoretical conviction and were even set off as a metaphysics of divine law.We have seen how Darwin's teaching about nature emerged within that theistic metaphysics. It emerged in a prior metaphysical debate in his mind between the contemporary belief in special creations and the belief in a designed hierarchy of physical laws. One can hardly deny that Darwin favored the superior side in this contest; but the contest was a narrow one whose basic premises he never clearly criticized. On the one hand, of course, his conviction about a lawful genesis inspired him to take a broad view of things and to seek out important general phenomena. But, on the other hand, it ensured that his new empirical notions would be easily drawn into the preferred cosmology. Historically, this seems to have occurred in Darwin's adoption of Malthus' principle of population and his extension of it to the whole account of descent: Malthusianism was readily attached to an ultimate scheme of things. Consequently, the key concepts that Darwin developed out of his Malthusian views — “perfect adaptation” and “selection” — reflect his cosmological prepossession, his desire to express a total and teleological process of creation. Perhaps our most valuable, and most undervalued, token of Darwin's metaphysical orientation is his reliance on a human technique (selective breeding) to explain “Nature's” way. In sum, to understand Darwin's faith in his “grand view of life,” we should not ignore the metaphysics that preceded and structured it, the metaphysics that linked the principles of contemporary science to primordial creation. Nor should we fail to see that such a metaphysics leads natural philosophy into a shadowy realm, where system can come to look like science, and one insight like an absolute. (shrink)

Real kinds or categories, according to conventional wisdom, enter into lawlike generalizations, while nominal kinds do not. Thus, gold but not jewelry is a real kind. However, by such a criterion, few if any kinds or systems of classification employed in the social science are real, for the social sciences offer, at best, only restricted generalizations. Thus, according to conventional wisdom, race and class are on a par with telephone area codes and postal zones; all are nominal rather than real. (...) I propose an account of real kinds that recognizes the current reality of race but not zip codes and shows how a kind can be both constructed and real. One virtue of such an understanding of realism is the light shed on our current practice of racial classification. Race is not a real biological kind but neither is race a myth or illusion. However, the question of whether a social kind is real is separate from whether the category is legitimate. W. E. B. Du Bois maintained that while there are no biological races, race is real and should be conserved. My aim, in this paper, is not to argue for the legitimacy or conservation of race but to defend Du Bois's idea that kinds of people can be both made up and real and provide an understanding of realism that does justice to the social sciences. (shrink)

Race is a prominent category in medicine. Epidemiologists describe how rates of morbidity and mortality vary with race, and doctors consider the race of their patients when deciding whether to test them for sickle‐cell anemia or what drug to use to treat their hypertension. At the same time, critics of racial classification say that race is not real but only an illusion or that race is scientifically meaningless. In this paper, I explain how race is used in medicine as a (...) proxy for genes that encode drug metabolizing enzymes and how a proper understanding of race calls into doubt the practice of treating race as a marker of any medically relevant genetic trait. (shrink)

In the present paper some tools are given to state the exact number of roots for some simple classes of exponential terms . The result were obtained by generalizing Sturm's technique for real closed fields. Moreover for arbitrary non-zero terms t certain estimations concerning the location of roots of t are given. MSC: 03C65, 03C60, 12L12.

The biomedical sciences employ race as a descriptive and analytic category. They use race to describe differences in rates of morbidity and mortality and to explain variations in drug sensitivity and metabolism. But there are problems with the use of race in medicine. This article identifies a number of the problems and assesses some solutions. The first three sections consider how race is defined and whether the racial data used in biomedical research are reliable and valid. The next three sections (...) explain why racial variation in disease, including genetic disease, is not evidence that race is biological. The final section explains how a proper understanding of the role of race in medicine bears on public policy. (shrink)

Two conundrums puzzle COVID‐19 investigators: 1) morbidity and mortality is rare among infants and young children and 2) rates of morbidity and mortality exhibit large variances across nations, locales, and even within cities. It is found that the higher the rate of pneumococcal vaccination in a nation (or city) the lower the COVID‐19 morbidity and mortality. Vaccination rates with Bacillus Calmette–Guerin, poliovirus, and other vaccines do not correlate with COVID‐19 risks, nor do COVID‐19 case or death rates correlate with number (...) of people in the population with diabetes, obesity, or adults over 65. Infant protection may be due to maternal antibodies and antiviral proteins in milk such as lactoferrin that are known to protect against coronavirus infections. Subsequent protection might then be conferred (and correlate with) rates of Haemophilus influenzae type B (Hib) (universal in infants) and pneumococcal vaccination, the latter varying widely by geography among infants, at‐risk adults, and the elderly. Also see the video abstract here https://youtu.be/GODBYRbPL00. (shrink)

I propose a T‐cell receptor (TcR)‐based mechanism by which immunity mediates both “genetic self” and “microbial self” thereby, connecting microbiome disease with autoimmunity. The hypothesis is based on simple principles. First, TcR are selected to avoid strong cross‐reactivity with “self,” resulting in selection for a TcR repertoire mimicking “genetic self.” Second, evolution has selected for a “microbial self” that mimics “genetic self” so as to share tolerance. In consequence, our TcR repertoire also mimics microbiome antigenicity, providing a novel mechanism for (...) modulating tolerance to it. Also, the microbiome mimics the TcR repertoire, acting as a secondary immune system. I call this TcR‐microbiome mimicry “holoimmunity” to denote immune tolerance to the “holobiont self.” Logically, microbiome‐host mimicry means that autoimmunity directed at host antigens will also attack components of the microbiome, and conversely, an immunological attack on the microbiome may cross‐react with host antigens producing “holoautoimmunity.”. (shrink)

Studies in the social and biomedical sciences of racial differences in socioeconomic status or health within a population view the race of members as fixed and look for a difference in the frequency of a trait like average income or disease risk between racial subgroups. But, as I explain in this paper, there are good reasons to allow the race of members to vary with the trait whose variation within the population is to be described or explained. According to such (...) a view of race, racial categories are more scientifically significant if membership in the categories is allowed to vary with differences in scientific interest rather than held constant across a variety of interests. (shrink)

Examines the processes of scientific creativity and discovery, and proposes a model of scientific development.

There are well-known problems for formalist accounts of game-play with regards to cheating. Such accounts seem to be committed to cheaters being unable to win–or even play–the game, yet it seems that there are instances of cheaters winning games. In this paper, I expand the discussion of such problems by introducing cases of pre-game cheating, and see how a formalist–specifically a Suitsian–account can accommodate such problems. Specifically, I look at two (fictional) examples where the alleged game-players cheat prior to a (...) game-instance in such as a way as to cast doubt on whether the alleged game-players are truly playing the game. To escape the worries brought about by these examples of pre-game cheating, I will appeal to the concept of nested games. This concept will give us the needed tools to explain how the alleged players are cheating and how the alleged players are players. On the whole, this discussion should help illuminate some important issues with regards to cheating and rules on a Suitsian account of game-play, and help give support for formalist accounts more generally. (shrink)

What is it for someone to be part of a game? While significant work has been done on the concept of playing a game, less has been done on the concept of being part of a game. This paper looks at how someone’s status of being part of a game can be distinguished from their status of playing a game, and then introduces a new taxonomy for the different ways in which someone can be part of a game.

IN SECTION X OF "AN INQUIRY CONCERNING HUMAN UNDERSTANDING", DAVID HUME RAISES TWO QUESTIONS ABOUT MIRACLES AND THEIR RELATION TO TESTIMONY. FIRST, HE ASKS WHETHER IT COULD EVER BE REASONABLE TO BELIEVE ON THE BASIS OF TESTIMONY THAT NATURE DOES NOT FIT THE IMAGE OF OUR SCIENCE, AND, SECOND, HE ASKS WHETHER IT COULD EVER BE REASONABLE TO BELIEVE ON THE BASIS OF TESTIMONY THAT NATURE IS NOT UNIFORM. HUME’S ANSWER TO THE FIRST QUESTION IS ’YES’ AND HIS ANSWER TO (...) THE SECOND IS ’NO’. HUME THINKS THAT A ’NO’ TO THE SECOND QUESTION SHOWS THAT BELIEF IN THE CHRISTIAN RELIGION IS LESS REASONABLE THAN A BELIEF IN MODERN SCIENCE. HOWEVER, HUME’S ’NO’ SEEMS TO OPPOSE HIS EMPIRICISM AND HIS BELIEF THAT THERE ARE NO NECESSARY TRUTHS ABOUT ANY MATTER OF FACT OR EXPERIENCE. THE POINT OF THIS PAPER IS TO SHOW THAT HUME CAN PROVE THAT THERE CAN BE NO TESTIMONY OF SUCH A QUANTITY OR QUALITY TO MAKE IT REASONABLE TO BELIEVE THAT NATURE IS NOT UNIFORM AND, AS RESULT, NO TESTIMONY TO MAKE IT REASONABLE TO. (shrink)

The purpose of this article is to integrate two outstanding problems within the philosophy of science. The first concerns what role aesthetics plays in scientific thinking. The second is the problem of how logically testable ideas are generated (the so-called "psychology of research" versus "logic of (dis)proof" problem). I argue that aesthetic sensibility is the basis for what scientists often call intuition, and that intuition in turn embodies (in a literal physiological sense) ways of thinking that have their own meta-logic. (...) Thus, aesthetics is a form of cognition. Scientists think not in equations or words or other logical abstractions, but emotionally and sensually, using visual and aural images, kinesthetic and other proprioceptive feelings, sensations, patterns, and analogies. These aesthetic forms of thinking have their own logics that I call "synosia", from the root words synaesthesia (a combining of senses) and gnosis, "to know". Synosia denotes understanding that integrates feeling that one knows with feeling what one knows. Eminent scientists universally describe an explicitly secondary process in which such personal knowledge must be "translated" into a formal language, such as words or equations, in order to be communicated to other people. Many of the unsolved problems that philosophers of science (as well as psychologists and artificial intelligence researchers) have had in making sense of scientific thinking have arisen from confusing the form and content of the final translations with the hidden means by which scientific insights are actually achieved. (shrink)

Sport provides an arena for human flourishing. For some, this pursuit of a meaningful life through sport involves the use of non-human animals, not least of all through sport hunting. This paper will take seriously that sport – including sport hunting – can provide a meaningful arena for human flourishing. Additionally, it will accept for present purposes that animals are of less moral value than humans. This paper will show that, even accepting these premises, much use of animals for sport (...) – including sport hunting – is unacceptable. Nonetheless it will show that there can be acceptable ways of using animals as part of a human’s meaningful life pursuits through sport, albeit in a more limited fashion than many sportspersons currently accept. (shrink)

This paper argues that realism issue in the social sciences is not one that can be decided by general philosophical arguments that evaluate entire domains at once. The realism issue is instead many different empirical issues. To defend these claims, I sort issues that are often run together, explicate and criticize several standard realist and antirealist arguments about the social sciences, and use the example of the productive/nonproductive distinction to illustrate the approach to realism questions that I favor.

The origin of homochirality in molecules characterizing living systems has remained a mystery since Pasteur's recognition of the problem some 150 years ago.2-5 Most theories also assume that homochirality emerged in one class of molecules (e.g. ribose) from which it was enriched in other molecules (e.g. amino acids) as well.2-5 I propose a novel, experimentally testable hypothesis describing a process by which selective chirality in amino acids and ribonucleotides emerged simultaneously and hand-in-hand with the origin and directionality of the genetic (...) code within a system of interactions involving amino acids, peptides, nucleotide bases, their sugars and polynucleotides. BioEssays 29:689–698, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

Scott Kretchmar recently put forth a new definition of what it is to play a game. Unfortunately, it must be rejected. In this paper, I show that this new definition is far too broad by discussing an activity that is not an instance of playing a game but is wrongfully ruled as one on this new definition.

Extensive empirical work has shown that species richness decreases roughly exponentially or quadratically with latitude. What appears to be a latitudinal gradient in fact may simply be a negative correlation of latitude with area at that latitude, due to convergence of lines of meridian at the poles. There is simply less area at high latitudes, which means fewer niches and fewer opportunities for speciation, hence diminished biodiversity at high latitudes. Similarly, analytic geometry of a cone shows that species number should (...) decrease linearly with altitude on a conical mountain. Here, I provide an explicit mathematical model of the area hypothesis of species richness along latitude and altitude gradients. I re-analyze a previously published latitudinal gradient dataset and show that species number is a linear function of the predicted area and that species number is more fully explained by predicted area than by a quadratic function of latitude. However, analytic geometry is not needed if precise measures of area are known. (shrink)

Nelson Goodman claims to have given us a criterion for likeness of meaning that is more stringent than simple coextensiveness and yet that avoids the familiar extentionalist objections. The notion of a nominal compound plays a key role in his account. I show that Goodman's comments concerning this notion are inadequate, that his comments concerning expressions like unicorn-picture are subject to two serious objections: they don't support his claims about likeness of meaning and they make English an unlearnable language.

Virtual reality (VR) offers a simulated environment where users can interact directly with their surroundings and provokes questions about embodiment and disconnection. This article will demonstrate how VR’s unique embodiment features differentiate it from the experience of non-VR online and video games and allow the transfer of movement and first-person perspective into the ‘gamespace.’ Drawing upon Merleau-Ponty’s concept of embodiment, I will argue that 1) VR is a coping experience, and 2) the VR environment becomes the world of our engagement. (...) This understanding of the VR experience allows us to reassess this technology, showing how it uses bodily action and perception to open up new digitally-mediated possibilities for connection. (shrink)

Many aspects of biology, such as population genetics and senescence, are predicated on identifying individuals and generations. Conventional demarcations of individuals and generations, such as physiological autonomy, unicellular bottlenecks, and alternation of generation, are rife with problems. Do physically separated cuttings or plant ramets constitute separate individuals or generations? Are chimaeras one or more individuals? To resolve these problems, Clarke : 321–361, 2012) proposed that individuals are circumscribed by mechanisms that constrain heritable variance in fitness. Simultaneously, Gorelick and Heng : (...) 1088–1098 2011) showed that sex constrains heritable variance Therefore, for eukaryotes, meiosis and karyogamy provide a consistent way to demarcate individuals and generations. Epigenetic reset associated with meiosis and karyogamy rejuvenates the next generation, but not the parent that engaged in the sex act. Wholesale epigenetic resets that probably only occur with meiosis and karyogamy imply that monozygotic twins are two different individuals, but apomictic progeny are diffuse parts of one disaggregated individual. Mitotic heritability circumscribes an individual, whereas meiotic heritability demarcates new individuals and generations. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Tolle, LegeCommencement Address at the Dominican House of Studies, May 13, 2022Michael RootTolle, lege. Tolle, lege. "Take up, read." Few such simple words have had such a crucial impact on the history of Christian theology. In the summer of 386, Augustine of Hippo was a torn man. He had come to believe the Gospel, but he could not bring himself to break with sinful habits, habits so ingrained he (...) called them "necessities." His soul was torn between two wills within him, he said, each pointing in a different direction. Nothing seemed able to be able to break the interior logjam. He says that he willed that he would will the good, but not with a complete will, and so he remained paralyzed. After hearing a friend and mentor describe the conversion of Victorinus, a famous Roman teacher of rhetoric, and another friend speak of the monastic retreat of St. Anthony, the spiritual conflict within Augustine reached a fever pitch and he retreated to a corner of the garden in the house he was staying at. Suddenly, from over the wall, he heard a child chanting the words tolle, lege: "take up, read." He could not think of any childhood rhyme or chant that involved those words—they must be a sign from God. So, he rushed over to where a copy of St. Paul's letters was lying, opened it, and read at random. His eye fell on Romans 13:13: "Let us conduct ourselves becomingly as in the day, not in reveling and drunkenness, not in debauchery and licentiousness, not in quarreling and jealousy." As he himself puts in his Confessions: "No further wished I to read, nor was there need to do so. Instantly, in truth, at the end of this sentence, as if before a peaceful light streaming into my heart, all the dark shadows of doubt fled away" (8.12.29). [End Page 9]You who are graduating are now coming to the end of a process that has involved a great deal of taking up and reading. I trust that the taking up and reading has not been to cure you of reveling and drunkenness, not to mention the rest of St. Paul's list, but rather to form you, most immediately within the discipline of theology and for many of you, within the vocation of the priesthood and the Dominican Order. Some of what you have taken up and read has, I hope, been inspiring. I hope that at least on occasion you felt as if a peaceful light was streaming into your hearts. Some of what you read, I would guess, you found mind-numbingly boring. But it is all part of the process.Of course you did more than just take up and read. You thought about what you were reading. You compared it with other things you had read. You related it to your own experience. You discussed it with other students. You wrote about it in papers and on exams. The medieval university master had three tasks: legere, disputare, praedicare—read, dispute, and (in this context) present. You have done much the same thing—reading, arguing, presenting.Reading with this kind of attention does not leave us unaffected. We do not just learn new information; we come to inhabit a different world, with a different landscape and a different population. It makes a difference whether one's effective world includes only places like Washington, New York, and Elizabeth, New Jersey, or also Jerusalem, the old Jerusalem and the new Jerusalem, the North Africa of Augustine, and the Paris of Thomas Aquinas. The person whose imaginative world is mostly populated by characters from Friends and Game of Thrones will be a different sort of person from the one whose imaginative world includes Abraham, David, St. Paul, Dominic, and Alyosha Karamazov. It is as much an exaggeration to say you are what you read as to say you are what you eat. But at least for some of us (and if you are graduating from Pontifical Faculty of the Immaculate Conception, you are probably in this group), at least some of what we read changes not only what we... (shrink)

Race is a prominent category in medicine. Epidemiologists describe how rates of morbidity and mortality vary with race, and doctors consider the race of their patients when deciding whether to test them for sickle cell anemia or what drug to use to treat their hypertension. At the same time, critics of racial classification say that race is not real but only an illusion or that race is scientifically meaningless. In this paper, I explain how race is used in medicine as (...) a proxy for genes that encode drug metabolizing enzymes and how a proper understanding of race calls into doubt the practice of treating race as a marker of any medically relevant genetic trait. (shrink)

Lactantius' treatise the de opificio dei has received little attention from classical scholars in modern times. There are two main reasons for this. First, Lactantius is regarded essentially as a Christian apologist and therefore of interest primarily to theologians and students of Christian history. Second, that work which has been done on the treatise has tended to the view that the opif.'s interest for scholars lies largely in the question of its written sources, its main such source, according to several (...) commentators, being the Hermetic body of writings. Both of these reasons need re-examining. With regard to the first, it is unfortunate that the only surviving works of Lactantius are his specifically Christian treatises, written after the outbreak of persecution in A.D. 303. As such they represent only a portion of his work, being composed in the last two decades of a long life. The basis of his reputation as a rhetorician, a reputation which secured him his appointment as professor of Latin rhetoric at Nicomedia under Diocletian, must have been his earlier works, which pre-date his conversion in c. 300. (shrink)