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Emily A. Largent [28]Emily Largent [11]
  1.  22
    When Is It Ethical for Physician-Investigators to Seek Consent From Their Own Patients?Stephanie R. Morain, Steven Joffe & Emily A. Largent - 2019 - American Journal of Bioethics 19 (4):11-18.
    Classic statements of research ethics advise against permitting physician-investigators to obtain consent for research participation from patients with whom they have preexisting treatment relationships. Reluctance about “dual-role” consent reflects the view that distinct normative commitments govern physician–patient and investigator–participant relationships, and that blurring the research–care boundary could lead to ethical transgressions. However, several features of contemporary research demand reconsideration of the ethics of dual-role consent. Here, we examine three arguments advanced against dual-role consent: that it creates role conflict for the (...)
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  2. Misconceptions About Coercion and Undue Influence: Reflections on the Views of Irb Members.Emily Largent, Christine Grady, Franklin G. Miller & Alan Wertheimer - 2013 - Bioethics 27 (9):500-507.
    Payment to recruit research subjects is a common practice but raises ethical concerns relating to the potential for coercion or undue influence. We conducted the first national study of IRB members and human subjects protection professionals to explore attitudes as to whether and why payment of research participants constitutes coercion or undue influence. Upon critical evaluation of the cogency of ethical concerns regarding payment, as reflected in our survey results, we found expansive or inconsistent views about coercion and undue influence (...)
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  3.  9
    Supported Decision Making With People at the Margins of Autonomy.Andrew Peterson, Jason Karlawish & Emily Largent - 2020 - American Journal of Bioethics 21 (11):4-18.
    This article argues that supported decision making is ideal for people with dynamic cognitive and functional impairments that place them at the margins of autonomy. First, we argue that guardianship and similar surrogate decision-making frameworks may be inappropriate for people with dynamic impairments. Second, we provide a conceptual foundation for supported decision making for individuals with dynamic impairments, which integrates the social model of disability with relational accounts of autonomy. Third, we propose a three-step model that specifies the necessary conditions (...)
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  4.  29
    Can RESEARCH and CARE Be Ethically Integrated?Emily A. Largent, Steven Joffe & Franklin G. Miller - 2011 - Hastings Center Report 41 (4):37-46.
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  5.  6
    Promoting Ethical Payment in Human Infection Challenge Studies.Holly Fernandez Lynch, Thomas C. Darton, Jae Levy, Frank McCormick, Ubaka Ogbogu, Ruth O. Payne, Alvin E. Roth, Akilah Jefferson Shah, Thomas Smiley & Emily A. Largent - 2021 - American Journal of Bioethics 21 (3):11-31.
    To prepare for potential human infection challenge studies involving SARS-CoV-2, we convened a multidisciplinary working group to address ethical questions regarding whether and how much SAR...
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  6.  9
    Compensating for Research Risk: Permissible but Not Obligatory.Holly Fernandez Lynch & Emily A. Largent - 2020 - Journal of Medical Ethics 46 (12):827-828.
    When payment is offered for controlled human infection model research, ethical concerns may be heightened due to unfamiliarity with this study design as well as perceptions—and misperceptions—regarding risk. Against this backdrop, we commend Grimwade et al 1 for their careful handling of the relevant issues, coupling empirical and conceptual approaches. We agree with foundational elements of the authors’ analysis, including the acceptability of payment for research risk.1 However, in our view, it is preferable to treat payment for risk as a (...)
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  7.  10
    Differential Payment to Research Participants in the Same Study: An Ethical Analysis.Govind Persad, Holly Fernandez Lynch & Emily Largent - 2019 - Journal of Medical Ethics 45 (5):318-322.
    Recognising that offers of payment to research participants can serve various purposes—reimbursement, compensation and incentive—helps uncover differences between participants, which can justify differential payment of participants within the same study. Participants with different study-related expenses will need different amounts of reimbursement to be restored to their preparticipation financial baseline. Differential compensation can be acceptable when some research participants commit more time or assume greater burdens than others, or if inter-site differences affect the value of compensation. Finally, it may be permissible (...)
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  8.  20
    Differential Payments to Research Participants in the Same Study: An Ethical Analysis.Govind Persad, Holly Fernandez Lynch & Emily Largent - 2019 - Journal of Medical Ethics 1:10.1136/medethics-2018-105140.
    Recognizing that offers of payment to research participants can serve various purposes—reimbursement, compensation, and incentive—helps uncover differences between participants that can justify differential payment of participants within the same study. Participants with different study-related expenses will need different amounts of reimbursement to be restored to their pre-participation financial baseline. Differential compensation can be acceptable when some research participants commit more time or assume greater burdens than others, or if inter-site differences affect the value of compensation. Finally, it may be permissible (...)
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  9.  7
    From Preferences to Policies? Considerations When Incorporating Empirical Ethics Findings Into Research Policymaking.Emily A. Largent & Stephanie R. Morain - 2020 - Journal of Medical Ethics 46 (6):378-379.
    Interest in the use of medical data for health research is increasing. Yet, as Elizabeth Ford and colleagues rightly note, there are open questions about the suitability of existing ethical and regulatory oversight frameworks for these research approaches. In their feature article, ‘Should free text data in electronic medical records be shared for research? A citizen’s jury study in the United Kingdom’, Ford et al report the results of a deliberative engagement study in which 18 members of the public were (...)
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  10.  17
    Patient‐Engaged Research: Choosing the “Right” Patients to Avoid Pitfalls.Emily A. Largent, Holly Fernandez Lynch & Matthew S. McCoy - 2018 - Hastings Center Report 48 (5):26-34.
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  11.  37
    Which Orphans Will Find a Home? The Rule of Rescue in Resource Allocation for Rare Diseases.Emily A. Largent & Steven D. Pearson - 2012 - Hastings Center Report 42 (1):27-34.
    The rule of rescue describes the moral impulse to save identifiable lives in immediate danger at any expense. Think of the extremes taken to rescue a small child who has fallen down a well, a woman pinned beneath the rubble of an earthquake, or a submarine crew trapped on the ocean floor. No effort is deemed too great. Yet should this same moral instinct to rescue, regardless of cost, be applied in the emergency room, the hospital, or the community clinic? (...)
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  12.  16
    For Love and Money: The Need to Rethink Benefits in HIV Cure Studies.Emily Largent - 2017 - Journal of Medical Ethics 43 (2):96-99.
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  13.  4
    Patient-Centered Outcomes Research: Stakeholder Perspectives and Ethical and Regulatory Oversight Issues.Emily A. Largent, Joel S. Weissman, Avni Gupta, Melissa Abraham, Ronen Rozenblum, Holly Fernandez Lynch & I. Glenn Cohen - 2018 - IRB: Ethics & Human Research 40 (1):7-17.
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  14.  16
    What's Trust Got to Do With It? Trust and the Importance of the Research–Care Distinction.Emily A. Largent - 2015 - American Journal of Bioethics 15 (9):22-24.
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  15.  7
    Public Attitudes Toward Consent When Research Is Integrated Into Care—Any “Ought” From All the “Is”?Stephanie R. Morain & Emily A. Largent - 2021 - Hastings Center Report 51 (2):22-32.
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  16.  13
    Filthy Lucre or Fitting Offer? Understanding Worries About Payments to Research Participants.Holly Fernandez Lynch, Ezekiel J. Emanuel & Emily A. Largent - 2019 - American Journal of Bioethics 19 (9):1-4.
    Volume 19, Issue 9, September 2019, Page 1-4.
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  17.  11
    Response to Open Peer Commentaries: When Is It Ethical for Physician-Investigators to Seek Consent From Their Own Patients?Stephanie R. Morain, Steven Joffe & Emily A. Largent - 2019 - American Journal of Bioethics 19 (5):W3-W4.
    Volume 19, Issue 5, May 2019, Page W3-W4.
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  18.  19
    A Prescription for Ethical Learning.Emily A. Largent, Franklin G. Miller & Steven Joffe - 2013 - Hastings Center Report 43 (s1):28-29.
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  19.  19
    A Prescription for Ethical Learning.Emily A. Largent, Franklin G. Miller & Steven Joffe - 2013 - Hastings Center Report 43 (s1):S28-S29.
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  20.  59
    COVID-19 Vaccine Refusal and Fair Allocation of Scarce Medical Resources.Govind Persad & Emily A. Largent - 2022 - JAMA Health Forum 3 (4):e220356.
    When hospitals face surges of patients with COVID-19, fair allocation of scarce medical resources remains a challenge. Scarcity has at times encompassed not only hospital and intensive care unit beds—often reflecting staffing shortages—but also therapies and intensive treatments. Safe, highly effective COVID-19 vaccines have been free and widely available since mid-2021, yet many Americans remain unvaccinated by choice. Should their decision to forgo vaccination be considered when allocating scarce resources? Some have suggested it should, while others disagree. We offer a (...)
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  21.  4
    Precision Medicine Research: An Exception or An Exemplar?Emily A. Largent - 2019 - Journal of Law, Medicine and Ethics 47 (1):149-151.
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  22.  29
    Of Drowning Children and Doubtful Analogies.Emily A. Largent - 2019 - Hastings Center Report 49 (4):26-28.
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  23.  6
    Getting Into Their Heads: When the Investigator is Also the Treating Physician.Stephanie R. Morain, Emily A. Largent & Anna Wexler - 2021 - American Journal of Bioethics Neuroscience 12 (1):68-70.
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  24.  20
    Issues With Tissues.Emily Largent - 2016 - American Journal of Bioethics 16 (11):37-39.
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  25.  14
    Health Care Organizations and the Power of Procedure.Emily A. Largent - 2016 - American Journal of Bioethics 16 (1):51-53.
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  26.  14
    The Legality and Ethics of Mandating COVID-19 Vaccination.Emily A. Largent & Franklin G. Miller - 2021 - Perspectives in Biology and Medicine 64 (4):479-493.
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  27.  20
    Public Perspectives on COVID-19 Vaccine Prioritization.Govind Persad, Ezekiel J. Emanuel, Samantha Sangenito, Aaron Glickman, Steven Phillips & Emily A. Largent - 2021 - JAMA Network Open 4 (4):e217943.
    In this survey study of 4735 US adults, respondents of all demographic and political affiliations agreed with prioritizing COVID-19 vaccine access for health care workers, adults of any age with serious comorbid conditions, frontline workers (eg, teachers and grocery workers), and Black, Hispanic, Native American, and other communities that have been disproportionately affected by COVID-19. Older adult respondents were less likely than younger respondents to list healthy people older than 65 years as 1 of their top 4 priority groups. These (...)
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  28.  4
    A Case of Patient Abandonment, or an Abandonment of Patients?Jason Karlawish, Andrew Peterson, Justin T. Clapp & Emily A. Largent - 2022 - American Journal of Bioethics 22 (7):86-87.
    First—before you define the dilemma, parse out principles, or vocalize about virtues—consider what caused this case.The COVID-19 pandemic has challenged us all, but particularly caregivers and the...
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  29.  12
    Incorporating Health Equity Into COVID-19 Reopening Plans: Policy Experimentation in California.Emily A. Largent, Govind Persad, Michelle M. Mello, Danielle M. Wenner, Daniel B. Kramer, Brownsyne Tucker Edmonds & Monica Peek - 2021 - American Journal of Public Health 1 (1):e1-e8.
    California has focused on health equity in the state’s COVID-19 reopening plan. The Blueprint for a Safer Economy assigns each of California’s 58 counties into 1 of 4 tiers based on 2 metrics: test positivity rate and adjusted case rate. To advance to the next less-restrictive tier, counties must meet that tier’s test positivity and adjusted case rate thresholds. In addition, counties must have a plan for targeted investments within disadvantaged communities, and counties with more than 106 000 residents must (...)
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  30.  2
    Diversity in IRB Membership: Views of IRB Chairpersons at U.S. Universities and Academic Medical Centers.Sydney Churchill, Emily A. Largent, Elizabeth Taggert & Holly Fernandez Lynch - 2022 - AJOB Empirical Bioethics 13 (4):237-250.
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  31.  6
    Supported Decision Making with People at the Margins of Autonomy: Response to Commentaries.Emily A. Largent, Jason Karlawish & Andrew Peterson - 2021 - American Journal of Bioethics 22 (1):W1-W4.
    Supported decision making is a model of decision making in which an adult with impaired capacity enters freely into an agreement with a closely trusted person or persons (the “s...
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  32.  25
    Mountains and Molehills When Using Social Media as a Research Support Tool.Holly Fernandez Lynch & Emily A. Largent - 2019 - American Journal of Bioethics 19 (6):64-66.
    Volume 19, Issue 6, June 2019, Page 64-66.
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  33. Losing Our Minds? Direct-to-Consumer Genetic Testing and Alzheimer's Disease.Emily Largent - 2021 - In I. Glenn Cohen, Nita A. Farahany, Henry T. Greely & Carmel Shachar (eds.), Consumer genetic technologies: ethical and legal considerations. Cambridge University Press.
     
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  34. The Many Vs. The Few Reply.Emily Largent & Norman Daniels - 2012 - Hastings Center Report 42 (5):8-9.
     
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  35. US Public Attitudes Toward COVID-19 Vaccine Mandates.Emily Largent, Persad A., Sangenito Govind, Glickman Samantha, Boyle Aaron, Emanuel Connor & J. Ezekiel - 2020 - JAMA Netw. Open 3 (12):e2033324.
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  36.  3
    Think Pragmatically: Investigators’ Obligations to Patient-Subjects When Research is Embedded in Care.Stephanie Morain & Emily Largent - forthcoming - American Journal of Bioethics:1-12.
    Growing interest in embedded research approaches—where research is incorporated into clinical care—has spurred numerous studies to generate knowledge relevant to the real-world needs of patients and other stakeholders. However, it also has presented ethical challenges. An emerging challenge is how to understand the nature and extent of investigators’ obligations to patient-subjects. Prior scholarship on investigator duties has generally been grounded upon the premise that research and clinical care are distinct activities, bearing distinct duties. Yet this premise—and its corresponding implications—are challenged (...)
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  37.  18
    Functionalism, Formalism, and Undue Influence.Emily Largent - 2017 - American Journal of Bioethics 17 (12):23-25.
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  38.  16
    Mutual Obligations in Research and Withholding Payment From Deceptive Participants.Holly Fernandez Lynch, Luke Gelinas & Emily A. Largent - 2018 - American Journal of Bioethics 18 (4):85-87.
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  39.  4
    Plumbing the Depths of Ethical Payment for Research Participation.Holly Fernandez Lynch, Thomas C. Darton, Jae Levy, Frank McCormick, Ubaka Ogbogu, Ruth O. Payne, Alvin E. Roth, Akilah Jefferson Shah, Thomas Smiley & Emily A. Largent - 2021 - American Journal of Bioethics 21 (5):W8-W11.
    The peer commentaries on our Target Article, “Promoting Ethical Payment in Human Infection Challenge Studies,” offer a number of insights that will help advance the co...
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