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Eline M. Bunnik [28]Eline Maria Bunnik [1]
  1.  14
    Should Pregnant Women Be Charged for Non-Invasive Prenatal Screening? Implications for Reproductive Autonomy and Equal Access.Eline M. Bunnik, Adriana Kater-Kuipers, Robert-Jan H. Galjaard & Inez D. de Beaufort - 2020 - Journal of Medical Ethics 46 (3):194-198.
    The introduction of non-invasive prenatal testing in healthcare systems around the world offers an opportunity to reconsider funding policies for prenatal screening. In some countries with universal access healthcare systems, pregnant women and their partners are asked to pay for NIPT. In this paper, we discuss two important rationales for charging women for NIPT: to prevent increased uptake of NIPT and to promote informed choice. First, given the aim of prenatal screening, high or low uptake rates are not intrinsically desirable (...)
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  2.  17
    Ethics of Routine: A Critical Analysis of the Concept of ‘Routinisation’ in Prenatal Screening.Adriana Kater-Kuipers, Inez D. de Beaufort, Robert-Jan H. Galjaard & Eline M. Bunnik - 2018 - Journal of Medical Ethics 44 (9):626-631.
    In the debate surrounding the introduction of non-invasive prenatal testing in prenatal screening programmes, the concept of routinisation is often used to refer to concerns and potential negative consequences of the test. A literature analysis shows that routinisation has many different meanings, which can be distinguished in three major versions of the concept. Each of these versions comprises several inter-related fears and concerns regarding prenatal screening and particularly regarding NIPT in three areas: informed choice, freedom to choose and consequences for (...)
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  3.  17
    Personal Utility in Genomic Testing: Is There Such a Thing?Eline M. Bunnik, A. Cecile J. W. Janssens & Maartje H. N. Schermer - 2015 - Journal of Medical Ethics 41 (4):322-326.
  4.  6
    Toward a Framework for Assessing Privacy Risks in Multi-Omic Research and Databases.Charles Dupras & Eline M. Bunnik - 2021 - American Journal of Bioethics 21 (12):46-64.
    While the accumulation and increased circulation of genomic data have captured much attention over the past decade, privacy risks raised by the diversification and integration of omics have been la...
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  5.  30
    Ethical Framework for the Detection, Management and Communication of Incidental Findings in Imaging Studies, Building on an Interview Study of Researchers’ Practices and Perspectives.Eline M. Bunnik, Lisa van Bodegom, Wim Pinxten, Inez D. de Beaufort & Meike W. Vernooij - 2017 - BMC Medical Ethics 18 (1):10.
    As thousands of healthy research participants are being included in small and large imaging studies, it is essential that dilemmas raised by the detection of incidental findings are adequately handled. Current ethical guidance indicates that pathways for dealing with incidental findings should be in place, but does not specify what such pathways should look like. Building on an interview study of researchers’ practices and perspectives, we identified key considerations for the set-up of pathways for the detection, management and communication of (...)
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  6.  54
    The New Genetics and Informed Consent: Differentiating Choice to Preserve Autonomy.Eline M. Bunnik, Antina Jong, Niels Nijsingh & Guido M. W. R. Wert - 2013 - Bioethics 27 (6):348-355.
    The advent of new genetic and genomic technologies may cause friction with the principle of respect for autonomy and demands a rethinking of traditional interpretations of the concept of informed consent. Technologies such as whole-genome sequencing and micro-array based analysis enable genome-wide testing for many heterogeneous abnormalities and predispositions simultaneously. This may challenge the feasibility of providing adequate pre-test information and achieving autonomous decision-making. At a symposium held at the 11th World Congress of Bioethics in June 2012 (Rotterdam), organized by (...)
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  7.  57
    Informed Consent in Direct-to-Consumer Personal Genome Testing: The Outline of A Model Between Specific and Generic Consent.Eline M. Bunnik, A. Cecile J. W. Janssens & Maartje H. N. Schermer - 2013 - Bioethics 27 (3):343-351.
    Broad genome-wide testing is increasingly finding its way to the public through the online direct-to-consumer marketing of so-called personal genome tests. Personal genome tests estimate genetic susceptibilities to multiple diseases and other phenotypic traits simultaneously. Providers commonly make use of Terms of Service agreements rather than informed consent procedures. However, to protect consumers from the potential physical, psychological and social harms associated with personal genome testing and to promote autonomous decision-making with regard to the testing offer, we argue that current (...)
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  8.  2
    The New Genetics and Informed Consent: Differentiating Choice to Preserve Autonomy.Eline M. Bunnik, Antina de Jong, Niels Nijsingh & Guido M. W. R. de Wert - 2013 - Bioethics 27 (6):348-355.
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  9.  10
    Rethinking Counselling in Prenatal Screening: An Ethical Analysis of Informed Consent in the Context of Non‐Invasive Prenatal Testing.Adriana Kater‐Kuipers, Inez D. Beaufort, Robert‐Jan H. Galjaard & Eline M. Bunnik - 2020 - Bioethics 34 (7):671-678.
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  10.  7
    The Impact of Incidental Findings Detected During Brain Imaging on Research Participants of the Rotterdam Study: An Interview Study.Charlotte H. C. Bomhof, Lisa van Bodegom, Meike W. Vernooij, Wim Pinxten, Inez D. de Beaufort & Eline M. Bunnik - 2020 - Cambridge Quarterly of Healthcare Ethics 29 (4):542-556.
    This interview study investigates the short- and long-term implications of incidental findings detected through brain imaging on research participants’ lives and their surroundings. For this study, nine participants of the Rotterdam Scan Study with an incidental finding were approached and interviewed. When examining research participants’ narratives on the impact of the disclosure of incidental findings, the authors identified five sets of tensions with regard to motivations for and expectations of research participation, preferences regarding disclosure, short- and long-term impacts and impacts (...)
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  11.  14
    On the Personal Utility of Alzheimer’s Disease-Related Biomarker Testing in the Research Context.Eline M. Bunnik, Edo Richard, Richard Milne & Maartje H. N. Schermer - 2018 - Journal of Medical Ethics 44 (12):830-834.
    Many healthy volunteers choose to take part in Alzheimer’s disease prevention studies because they want to know whether they will develop dementia—and what they can do to reduce their risk—and are therefore interested in learning the results of AD biomarker tests. Proponents of AD biomarker disclosure often refer to the personal utility of AD biomarkers, claiming that research participants will be able to use AD biomarker information for personal purposes, such as planning ahead or making important life decisions. In this (...)
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  12.  6
    Rethinking Counselling in Prenatal Screening: An Ethical Analysis of Informed Consent in the Context of Non‐Invasive Prenatal Testing.Adriana Kater‐Kuipers, Inez D. De Beaufort, Robert‐Jan H. Galjaard & Eline M. Bunnik - 2020 - Bioethics 34 (7):671-678.
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  13.  6
    The Role of Physicians in Expanded Access to Investigational Drugs: A Mixed-Methods Study of Physicians’ Views and Experiences in The Netherlands.Eline M. Bunnik & Nikkie Aarts - 2021 - Journal of Bioethical Inquiry 18 (2):319-334.
    Treating physicians have key roles to play in expanded access to investigational drugs, by identifying investigational treatment options, assessing the balance of risks and potential benefits, informing their patients, and applying to the regulatory authorities. This study is the first to explore physicians’ experiences and moral views, with the aim of understanding the conditions under which doctors decide to pursue expanded access for their patients and the obstacles and facilitators they encounter in the Netherlands. In this mixed-methods study, semi-structured interviews (...)
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  14.  2
    Delineating the Scope of NIPT: Ethics Meets Practice.Eline M. Bunnik - 2022 - American Journal of Bioethics 22 (2):34-36.
    As noninvasive prenatal testing is being implemented as a first-trimester prenatal screening modality in healthcare systems around the world, it raises ethical concerns. In theory, NIPT allo...
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  15.  13
    Let Us Not Take the Ethics Out of Innovative Practice: A Case Against Institutional Review.Eline M. Bunnik - 2019 - American Journal of Bioethics 19 (6):36-38.
    Volume 19, Issue 6, June 2019, Page 36-38.
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  16.  3
    Informed Consent in Direct-to-Consumer Personal Genome Testing: The Outline of A Model Between Specific and Generic Consent.Eline M. Bunnik, A. Cecile J. W. Janssens & Maartje H. N. Schermer - 2014 - Bioethics 28 (7):343-351.
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  17.  1
    Should Doctors Offer Biomarker Testing to Those Afraid to Develop Alzheimer’s Dementia?: Applying the Method of Reflective Equilibrium for a Clinical Dilemma.Marthe Smedinga, Eline M. Bunnik, Edo Richard & Maartje H. N. Schermer - 2022 - Journal of Bioethical Inquiry 19 (2):287-297.
    An increasing number of people seek medical attention for mild cognitive symptoms at older age, worried that they might develop Alzheimer’s disease. Some clinical practice guidelines suggest offering biomarker testing in such cases, using a brain scan or a lumbar puncture, to improve diagnostic certainty about Alzheimer’s disease and enable an earlier diagnosis. Critics, on the other hand, point out that there is no effective Alzheimer treatment available and argue that biomarker tests lack clinical validity. The debate on the ethical (...)
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  18.  3
    What Do Patients with Unmet Medical Needs Want? A Qualitative Study of Patients’ Views and Experiences with Expanded Access to Unapproved, Investigational Treatments in the Netherlands.Eline M. Bunnik & Nikkie Aarts - 2019 - BMC Medical Ethics 20 (1):1-17.
    Background Patients with unmet medical needs sometimes resort to non-standard treatment options, including the use of unapproved, investigational drugs in the context of clinical trials, compassionate use or named-patient programs. The views and experiences of patients with unmet medical needs regarding unapproved, investigational drugs have not yet been examined empirically. Methods In this qualitative study, exploratory interviews and focus groups were held with patients with chronic or life-threatening diseases, about topics related to non-standard treatment options, such as the search for (...)
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  19.  12
    Do Genomic Tests Enhance Autonomy?Eline M. Bunnik - 2015 - Journal of Medical Ethics 41 (4):315-316.
  20.  10
    A Model for Communication About Longshot Treatments in the Context of Early Access to Unapproved, Investigational Drugs.Eline M. Bunnik & Nikkie Aarts - 2018 - American Journal of Bioethics 18 (1):34-36.
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  21.  29
    Personal Genome Testing: Test Characteristics to Clarify the Discourse on Ethical, Legal and Societal Issues.Eline M. Bunnik, Maartje H. N. Schermer & A. Cecile J. W. Janssens - 2011 - BMC Medical Ethics 12 (1):11.
    Background: As genetics technology proceeds, practices of genetic testing have become more heterogeneous: many different types of tests are finding their way to the public in different settings and for a variety of purposes. This diversification is relevant to the discourse on ethical, legal and societal issues (ELSI) surrounding genetic testing, which must evolve to encompass these differences. One important development is the rise of personal genome testing on the basis of genetic profiling: the testing of multiple genetic variants simultaneously (...)
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  22.  5
    Physicians Must Discuss Potential Long-Term Risks of Fecal Microbiota Transplantation to Ensure Informed Consent.Eline M. Bunnik, Nikkie Aarts & Lea Ann Chen - 2017 - American Journal of Bioethics 17 (5):61-63.
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  23.  23
    Ethical Issues in the Beauty Salon: The Development of National Ethics Guidelines for Aestheticians in the Netherlands.Eline M. Bunnik, Frans Meulenberg & Inez D. de Beaufort - forthcoming - Narrative Inquiry in Bioethics.
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  24. Why Exceptional Public Investment in the Development of Vaccines Is Justified for COVID-19, But Not for Other Unmet Medical Needs.Eline M. Bunnik & Jilles Smids - 2021 - American Journal of Bioethics 21 (12):22-25.
    In response to the COVID-19 pandemic, states have funneled exceptional amounts of public funding into research and development of diagnostics, treatments and vaccines to help fight the virus. In th...
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  25.  19
    Scanning the Body, Sequencing the Genome: Dealing with Unsolicited Findings.Roel H. P. Wouters, Candice Cornelis, Ainsley J. Newson, Eline M. Bunnik & Annelien L. Bredenoord - 2017 - Bioethics 31 (9):648-656.
    The introduction of novel diagnostic techniques in clinical domains such as genomics and radiology has led to a rich ethical debate on how to handle unsolicited findings that result from these innovations. Yet while unsolicited findings arise in both genomics and radiology, most of the relevant literature to date has tended to focus on only one of these domains. In this article, we synthesize and critically assess similarities and differences between “scanning the body” and “sequencing the genome” from an ethical (...)
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  26.  9
    Why NIPT Should Be Publicly Funded.Eline Maria Bunnik, Adriana Kater-Kuipers, Robert-Jan H. Galjaard & Inez de Beaufort - 2020 - Journal of Medical Ethics 46 (11):783-784.
    Asking pregnant women to pay for non-invasive prenatal testing out of pocket leads to unequal access across socioeconomic strata. To avoid these social justice issues, first-trimester prenatal screening should be publicly funded in countries such as the Netherlands, with universal coverage healthcare systems that offer all other antenatal care services and screening programmes free of charge. In this reply, we offer three additional reasons for public funding of NIPT. First, NIPT may not primarily have medical utility for women and children, (...)
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  27.  6
    Ethical Issues in the Beauty Salon: The Development of National Ethics Guidelines for Aestheticians in the Netherlands.Eline M. Bunnik, Frans Meulenberg & Inez D. de Beaufort - 2018 - Narrative Inquiry in Bioethics 8 (3):247-260.
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  28.  1
    Correction to: Should Doctors Offer Biomarker Testing to Those Afraid to Develop Alzheimer’s Dementia?Marthe Smedinga, Eline M. Bunnik, Edo Richard & Maartje H. N. Schermer - 2022 - Journal of Bioethical Inquiry 19 (2):299-299.
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  29.  4
    Prevention in the Age of Personal Responsibility: Epigenetic Risk-Predictive Screening for Female Cancers as a Case Study.Ineke Bolt, Eline M. Bunnik, Krista Tromp, Nora Pashayan, Martin Widschwendter & Inez de Beaufort - 2021 - Journal of Medical Ethics 47 (12):46-46.
    Epigenetic markers could potentially be used for risk assessment in risk-stratified population-based cancer screening programmes. Whereas current screening programmes generally aim to detect existing cancer, epigenetic markers could be used to provide risk estimates for not-yet-existing cancers. Epigenetic risk-predictive tests may thus allow for new opportunities for risk assessment for developing cancer in the future. Since epigenetic changes are presumed to be modifiable, preventive measures, such as lifestyle modification, could be used to reduce the risk of cancer. Moreover, epigenetic markers (...)
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