Precision targeting of specific white matter bundles that traverse the subcallosal cingulate has been linked to efficacy of deep brain stimulation for treatment resistant depression. Methods to confirm optimal target engagement in this heterogenous region are now critical to establish an objective treatment protocol. As yet unexamined are the time-frequency features of the SCC evoked potential, including spectral power and phase-clustering. We examined these spectral features—evoked power and phase clustering—in a sample of TRD patients with implanted SCC stimulators. Electroencephalogram was (...) recorded during wakeful rest. Location of electrical stimulation in the SCC target region was the experimental manipulation. EEG was analyzed at the surface level with an average reference for a cluster of frontal sensors and at a time window identified by prior study. Morlet wavelets generated indices of evoked power and inter-trial phase clustering. Enhanced phase clustering at theta frequency was observed in every subject and was significantly correlated with SCC-EP magnitude, but only during left SCC stimulation. Stimulation to dorsal SCC evinced stronger phase clustering than ventral SCC. There was a weak correlation between phase clustering and white matter density. An increase in evoked delta power was also coincident with SCC-EP, but was less consistent across participants. DBS evoked time-frequency features index mm-scale changes to the location of stimulation in the SCC target region and correlate with structural characteristics implicated in treatment optimization. Results also imply a shared generative mechanism between evoked potentials evinced by electrical stimulation and evoked potentials evinced by auditory/visual stimuli and behavioral tasks. Understanding how current injection impacts downstream cortical activity is essential to building new technologies that adapt treatment parameters to individual differences in neurophysiology. (shrink)

La relación entre lengua y sexualidad recién ha comenzado a cobrar importancia dentro de los estudios socioculturales. Este trabajo explora las distintas pistas lingüísticas encriptadas en el cuento La búsqueda de Elizabeth, de Marta Pessarrodona, para desenmascarar la velada identidad sexual del personaje central. Un análisis referente al proceso de reconocimiento, búsqueda y aceptación de una identidad sexual no canónica de la protagonista validará los cuatro principios propuestos por Bucholtz y Hall : afloramiento, indexicalidad, relacionalidad y parcialidad.

El principal objetivo de este estudio consiste en dar cuenta de cómo se enmarca la forma de tratamiento nominal marico en el habla de jóvenes universitarios de Caracas, Venezuela, dentro de la Teoría de la cortesía, según la perspectiva ofrecida por los hablantes. Igualmente, se busca documentar qué cambios está presentando en los contextos de uso así como en sus funciones pragmáticas. Los participantes fueron 60 estudiantes universitarios, 30 mujeres y 30 hombres, de 17 a 21 años. Tradicionalmente, la palabra (...) marico se ha usado como agresión verbal vulgar y ha sido, generalmente, considerada un insulto. Luego del análisis cualitativo de los datos, se plantea que esta FTN se halla en una fase de transición de insulto a marcador pragmático anticortés que indica solidaridad dentro de un grupo etario específico y está perdiendo su carácter agraviador. En la actualidad, la juventud caraqueña emplea esta FTN no solo para implicar lazos de amistad, sino para expresar emociones como sorpresa y enojo, crear efectos de intriga, hacer bromas, abrir y cerrar oraciones e, incluso, sustituir otras FTN que nunca han sido consideradas insultos en el español de Venezuela. La metodología empleada fue el cuestionario y el análisis cualitativo de reportes en primera persona. Las variables de edad y sexo son factores determinantes, puesto que parece haber tendencia entre los jóvenes entrevistados a no emplear esta forma nominal con hablantes que están fuera de su grupo etario y las mujeres siguen siendo conservadoras al restringir, más que los hombres, el uso de este vocablo. (shrink)

BackgroundEthics review is the process of assessing the ethics of research involving humans. The Ethics Review Committee (ERC) is the key oversight mechanism designated to ensure ethics review. Whether or not this governance mechanism is still fit for purpose in the data-driven research context remains a debated issue among research ethics experts.Main textIn this article, we seek to address this issue in a twofold manner. First, we review the strengths and weaknesses of ERCs in ensuring ethical oversight. Second, we map (...) these strengths and weaknesses onto specific challenges raised by big data research. We distinguish two categories of potential weakness. The first category concerns persistent weaknesses, i.e., those which are not specific to big data research, but may be exacerbated by it. The second category concerns novel weaknesses, i.e., those which are created by and inherent to big data projects. Within this second category, we further distinguish between purview weaknesses related to the ERC’s scope (e.g., how big data projects may evade ERC review) and functional weaknesses, related to the ERC’s way of operating. Based on this analysis, we propose reforms aimed at improving the oversight capacity of ERCs in the era of big data science.ConclusionsWe believe the oversight mechanism could benefit from these reforms because they will help to overcome data-intensive research challenges and consequently benefit research at large. (shrink)

Background: Electroconvulsive therapy is one of the most effective treatments for major depressive disorder. Recently, there has been increasing attention to evaluate the effect of ECT on resting-state functional magnetic resonance imaging. This study aims to compare rs-fMRI of depressive disorder patients with healthy participants, investigate whether pre-ECT dynamic functional network connectivity network estimated from patients rs-fMRI is associated with an eventual ECT outcome, and explore the effect of ECT on brain network states.Method: Resting-state functional magnetic resonance imaging data were (...) collected from 119 patients with depression or depressive disorder, and 61 healthy participants, with an age mean of 52.25 years old. The pre-ECT and post-ECT Hamilton Depression Rating Scale were 25.59 ± 6.14 and 11.48 ± 9.07, respectively. Twenty-four independent components from default mode and cognitive control network were extracted, using group-independent component analysis from pre-ECT and post-ECT rs-fMRI. Then, the sliding window approach was used to estimate the pre-and post-ECT dFNC of each subject. Next, k-means clustering was separately applied to pre-ECT dFNC and post-ECT dFNC to assess three distinct states from each participant. We calculated the amount of time each subject spends in each state, which is called “occupancy rate” or OCR. Next, we compared OCR values between HC and DEP participants. We also calculated the partial correlation between pre-ECT OCRs and HDRS change while controlling for age, gender, and site. Finally, we evaluated the effectiveness of ECT by comparing pre- and post-ECT OCR of DEP and HC participants.Results: The main findings include depressive disorder patients had significantly lower OCR values than the HC group in state 2, where connectivity between cognitive control network and default mode network was relatively higher than other states, Pre-ECT OCR of state, with more negative connectivity between CCN and DMN components, is linked with the HDRS changes. This means that those DEP patients who spent less time in this state showed more HDRS change, and The post-ECT OCR analysis suggested that ECT increased the amount of time DEP patients spent in state 2.Conclusion: Our finding suggests that dynamic functional network connectivity features, estimated from CCN and DMN, show promise as a predictive biomarker of the ECT outcome of DEP patients. Also, this study identifies a possible underlying mechanism associated with the ECT effect on DEP patients. (shrink)

Dutch investigators continue to play a key role in animal behavior studies today . The present collection of current Dutch writings on animal consciousness ...

El importante papel que el perdón juega en el ámbito de la justicia transicional hace necesario verificar cómo se justifica en el imaginario de nuestra sociedad contemporánea. Puesto que parece tratarse de una realidad que pertenece más bien al campo de lo religioso, resulta más relevante aún considerar la discusión sobre su posible fundamento moral. Para ello, hay que partir de la distinción entre perdón incondicional y perdón condicionado, y plantear la posibilidad e incluso la obligatoriedad de cada uno. Pues (...) bien, la contradicción inherente a la defensa del carácter obligatorio del perdón concluye en la naturaleza supererogatoria del mismo. Este carácter supererogatorio muestra todo perdón como inmerecido. Así, el principal problema que queda sin resolver es la ausencia de puntos de partida para una argumentación sobre el perdón. De ahí, las dificultades de nuestras comunidades políticas contemporáneas para gestionar las situaciones de justicia transicional. (shrink)

Este Dicionario Enciclopedia do Pensamento Galego, coordinado por Andrés Torres Queiruga e Manuel Rivas García e redactado por corenta e seis persoas, trata de conxuntar un dicionario de pensadores galegos e unha visión temática que permita encadrar o labor máis directamente filosófico no campo xeral da nosa cultura. De aí a súa división en dúas partes: a primeira, un dicionario de autores, e a segunda, unha enciclopedia que complementa temas, ideas e persoeiros que propiamente non caben na primeira. Deste (...) xeito, o Dicionario, en orde alfabética, permite un percorrido polo enteiro transcurso da nosa historia intelectual e da achega realizada por cento dez autores, mentres que a Enciclopedia propicia un amplo encadramento nos diversos campos da cultura: antropoloxía, pensamento científico, dereito, economía, estética, exilio, feminismo, literatura, matemática, medicina, nacionalismo, pedagoxía, política, prensa e relixión. Por último os índices onomástico e temático permiten diversos percorridos, que, conxuntando sincronía e diacronía, poden axudar a unha visión máis integral e realista da nosa cultura. A nómina de pensadores da primeira parte chega aos nosos días, ocupándose con maior profundidade dos autores fenecidos e delimitando a extension das entradas consonte á importancia do seu pensamento. Para os autores vivos acudiuse, cando foi posible, á información dos propios interesados, adoptándose un criterio de estrita austeridade informativa, cinxíndoa a datos biográficos básicos e referencia á obra publicada no eido filosófico. Para a redacción da parte enciclopédica escolléronse estudosos cualificados, cuxa asinatura consta ao final dos mesmos. Ordenados, tamén, alfabeticamente estes traballos de maior extensión intentan ofrecer unha visión mais global e panorámica, recollendo problemas, preocupacións ou iniciativas que están presentes na cultura actual, procurando sinalar as directrices históricas que seguirn ao longo do tempo. (shrink)

Este trabajo analiza las implicancias de la relación comprensión lectora y resolución de problemas en matemática por medio de un análisis detallado de la formulación lingüística de problemas matemáticos y su resolución en un manual de apoyo docente elaborado para este propósito. De esta forma, se detallan diferentes enunciados de problemas en matemáticas para analizar desde su estructura verbal -conforme a una complejidad creciente e integrada- a fin de exponer su impacto enlas posibilidades de resolución por parte de los estudiantes (...) universitarios de primeraño en la Facultad de Ingeniería de la UC Temuco. (shrink)

Ethical Aspects Related to Nursing Care for Persons with Disabilities: A Qualitative Analysis Aspectos éticos relacionados com a atenção de enfermagem em pessoas com deficiência: uma análise qualitativa The purpose of the study is to describe ethical aspects related to nursing care for persons with disabilities; a population considered socially vulnerable and in conditions of inequality. It corresponds to the first phase of a primary study conducted in Atacama, Chile using a qualitative methodology and content analysis. Nursing graduates are interviewed (...) respecting Ezekiel Emanuel’s ethical criteria. The main findings account for ontological categories such as moral reasoning, value system, nurse-patient relationship model, consequences of the ethical nursing action, strategies to overcome moral conflicts, and barriers in care. It is concluded that caring for people with disabilities is a source of dilemma and moral anguish for nurses, especially when it comes to individuals with sensitive or cognitive disabilities. The paternalistic medical model predominates in the clinical context, limiting the right to autonomy of persons with disabilities. Instrumental values such as efficiency are added to traditional moral values promoted by nurses. Civic values considered fundamental to the challenge of human diversity and life in a democracy are not mentioned. Para citar este artículo / To reference this article / Para citar este artigo Campillay-Campillay M, Rivas-Rivero E, Dubó-Araya P, Calle-Carrasco A. Aspectos éticos relacionados con la atención de enfermería en personas en situación de discapacidad: un análisis cualitativo. Pers Bioet. 2020;24:43-56. DOI: https://doi.org/10.5294/pebi.2020.24.1.4 Recibido: 19/07/2019 Aceptado: 12/11/2019 Publicado: 07/05/2020. (shrink)

Fin troppo abituati a leggere il 1927 di Heidegger (Sein und Zeit) e di Marcel (JournalMéthaphysique) con gli occhi del dopo e delle filosofie dell’esistenza, non ci si accorgesempre di una lettura diversa già in corso con gli occhi del prima e di Io e Tu (1923) diBuber. Il comune racconto polemico e antisartriano rivendica l’Essere più che l’esistere,ma rischia di fermarsi alla vicinanza, dentro cui si prepara invece un racconto alternativoche imparenta Marcel più con il principio dialogico (Buber, 1954) (...) e il pensiero dell’altro(Lévinas,1975). «Accordo fondamentale» con Heidegger per lo Zuspruch des Seins e laVerità come apertura, «prossimità metafisica», sensibilità comune, influenze. Fanno peròda netto contrasto l’«accordo disaccordo» e le «differenze essenziali» di Marcel per leaperture bloccate, il filosofare astratto, il «disconoscimento dell’altro» (Ma relation avecHeidegger, 1957, 1979). E quel «credere di stare davanti al mistero» di Heidegger (Letterasull’umanismo, 1947) sembra una svista. (shrink)

Tanto en el ámbito académico como en el de las instituciones profesionales de la psicología se suele reconocer el aporte de la reflexión ética. Sin embargo, la forma como los mismos profesionales enfrentan los dilemas éticos evidencia un apego a valores personales antes que a principios deontológicos. Es posible que esto pueda entenderse a partir de la posmodernidad, pero es claro que para ahondar en el tema es necesario hacer un análisis que parta desde el carácter moral de la psicología, (...) examine el rol de los códigos de ética e indague sobre el rol de la formación ética. (shrink)

El propósito es abordar, a partir de una perspectiva doblemente crítica, el actual “giro hacia la felicidad”, vale decir, la elevación del imperativo de la felicidad a la categoría de horizonte político y ético incuestionable que ha protagonizado el surgimiento de la psicología positiva a comienzos del siglo XXI y que hoy desborda la literatura académica e invade un número creciente de prácticas de la vida cotidiana. Ello supondrá, por un lado, entender esta versión actual del llamado “pensamiento positivo” como (...) una narrativa sancionadora del orden económico neoliberal, fundamentalmente a través de la promoción de un nuevo “éthos psicoterapéutico”. Y, por otro, desde la corriente anglosajona del “giro afectivo”, implicará analizar en qué medida los discursos sobre la felicidad en general, y en particular la “nueva ciencia de la felicidad”, legitiman una serie de modos de vida por encima de otros y refrendan estructuras de poder preexistentes. (shrink)

In his earlier work on the System of Transcendental Idealism, which combined Naturphilosophie and transcendental philosophy, Schelling argued that it is only by becoming-art that philosophy can complete itself as a discipline. He proposed this formulation in response to Kant’s critical inventory of reason offering to reclaim philosophy from its entanglement in pre-critical or dogmatic traditions. But Kant avoided to ground reason in the notion of externality, the in-itself, which, owing to its pre-critical derivation, must give way to the a (...) prioris and categories of the understanding. Meanwhile, by renewing the problem of the in-itself via the self-positing ego, Fichte was the first to challenge the Kantian legacy. But the emphasis on subjectivity through its power of self-positing gave way to what in principle negates nature as the true ground of the initself; in Schelling’s description, the equivalent of the annihilation of nature. Comparatively, Schelling proposed to demonstrate the reverse, which is the extinction of the subject that has continued to nourish the reflexive standpoint of reason. To accomplish this end, Schelling invoked in his Philosophy of Art, one of the places in which he extended his discussion of the so-called identity-system, the concept of the ideal type, or rather, the destroyer of known world established by critical reason. (shrink)

According to a growing body of studies, people’s ability to forecast future emotional experiences is generally biased. Nonetheless, the existing literature has mainly explored affective forecasting in relation to specific events, whereas little is still known about the ability to make general estimations of future emotional states. Based on existing evidence suggesting future-oriented disposition as a key factor for mental health, the aims of the current study were (1) to investigate the relationship between negative (NA) and positive (PA) affective forecasting (...) biases and perceived psychological well-being, and (2) to explore whether positively biased predictions are associated with resilience and foster one’s skills to cope with stressful events. To do so, we asked 85 undergraduate students to forecast PA and NA over two weeks, as well as to report their daily affect through a web-based Ecological Momentary Assessment. According to the results, positively biased PA forecasting (i.e., overestimating positive emotional states) was associated with greater perceived psychological well-being and higher resilience. When high levels of stress were experienced, participants holding an optimistic, yet biased, estimation of future PA were more likely to successfully manage stressors, thus maintaining lower levels of NA and higher levels of positive emotions. We suggest that positively biased PA forecasting is an adaptive cognitive distortion that boosts people’s resilience and mental health, thus opening new avenues for the promotion of psychological well-being. (shrink)

Apoptosis is now widely recognized as a common form of cell death and represents a mechanism of cell clearance in many physiological situations where deletion of cells is required. Peptide growth factors, initially characterised as stimulators of cell proliferation, have now been shown to inhibit death in many cell types. Deprivation of growth factors leads to the induction of apoptosis, i.e. condensation of chromatin and degradation in oligonucleosomesized fragments, formation of plasma and nuclear membrane blebs and cell fragmentation into apoptotic (...) bodies which can be taken up by neighbouring cells. Here we discuss the mechanism(;s) by which growth factors may inhibit apoptosis. (shrink)

El presente artículo tiene por intención principal dilucidar las distinciones y relaciones conceptuales que existen entre labor, trabajo y ocio, en el pensamiento de Hannah Arendt y Walter Benjamin, a modo de esclarecer cómo los posicionamientos de ambos autores contribuyen a la crítica de la concepción del trabajo moderno. Para ello, será necesario exponer los matices conceptuales de la obra de Arendt, a saber, la distinción entre trabajo y labor, con el fin de trazar las diferencias y puntos de encuentro (...) con las reflexiones de Benjamin en torno a los cambios traídos como consecuencia del auge del capitalismo industrial y en la experiencia del ocio. Entre estos matices, esclarecimientos y contrastes, es preciso no solo destacar la importancia de la relación e influencia de ambos autores, sino su vigencia en las problemáticas sociales contemporáneas al respecto. (shrink)