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  1.  19
    Early-Emerging Cognitive Vulnerability to Depression and the Serotonin Transporter Promoter Region Polymorphism.E. P. Hayden, L. R. Dougherty, B. Maloney, T. M. Olino, H. Sheikh, C. E. Durbin, J. I. Nurnberger Jr, D. K. Lahiri & D. N. Klein - 2008 - J Affect Disord 107:227-30.
    BACKGROUND: Serotonin transporter promoter genotype appears to increase risk for depression in the context of stressful life events. However, the effects of this genotype on measures of stress sensitivity are poorly understood. Therefore, this study examined whether 5-HTTLPR genotype was associated with negative information processing biases in early childhood. METHOD: Thirty-nine unselected seven-year-old children completed a negative mood induction procedure and a Self-Referent Encoding Task designed to measure positive and negative schematic processing. Children were also genotyped for the 5-HTTLPR gene. (...)
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  2.  12
    Temperamental Fearfulness in Childhood and the Serotonin Transporter Promoter Region Polymorphism: A Multimethod Association Study.E. P. Hayden, L. R. Dougherty, B. Maloney, C. Emily Durbin, T. M. Olino, J. I. Nurnberger Jr, D. K. Lahiri & D. N. Klein - 2007 - Psychiatr Genet 17:135-42.
    OBJECTIVES: Early-emerging, temperamental differences in fear-related traits may be a heritable vulnerability factor for anxiety disorders. Previous research indicates that the serotonin transporter promoter region polymorphism is a candidate gene for such traits. METHODS: Associations between 5-HTTLPR genotype and indices of fearful child temperament, derived from maternal report and standardized laboratory observations, were examined in a community sample of 95 preschool-aged children. RESULTS: Children with one or more long alleles of the 5-HTTLPR gene were rated as significantly more nervous during (...)
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