In this paper, rather than focusing on genes as an organising concept around which historical considerations of theory and practice in genetics are elucidated, we place genetic markers at the heart of our analysis. This reflects their central role in the subject of our account, livestock genetics concerning the domesticated pig, Sus scrofa. We define a genetic marker as a element existing in different forms in the genome, that can be identified and mapped using a variety of quantitative, classical and (...) molecular genetic techniques. The conjugation of pig genome researchers around the common object of the marker from the early-1990s allowed the distinctive theories and approaches of quantitative and molecular genetics concerning the size and distribution of gene effects to align in projects to populate genome maps. Critical to this was the nature of markers as ontologically inert, internally heterogeneous and relational. Though genes as an organising and categorising principle remained important, the particular concatenation of limitations, opportunities, and intended research goals of the pig genetics community, meant that a progressively stronger focus on the identification and mapping of markers rather than genes per se became a hallmark of the community. We therefore detail a different way of doing genetics to more gene-centred accounts. By doing so, we reveal the presence of practices, concepts and communities that would otherwise be hidden. (shrink)

In this paper, rather than focusing on genes as an organising concept around which historical considerations of theory and practice in genetics are elucidated, we place genetic markers at the heart of our analysis. This reflects their central role in the subject of our account, livestock genetics concerning the domesticated pig, Sus scrofa. We define a genetic marker as a element existing in different forms in the genome, that can be identified and mapped using a variety of quantitative, classical and (...) molecular genetic techniques. The conjugation of pig genome researchers around the common object of the marker from the early-1990s allowed the distinctive theories and approaches of quantitative and molecular genetics concerning the size and distribution of gene effects to align in projects to populate genome maps. Critical to this was the nature of markers as ontologically inert, internally heterogeneous and relational. Though genes as an organising and categorising principle remained important, the particular concatenation of limitations, opportunities, and intended research goals of the pig genetics community, meant that a progressively stronger focus on the identification and mapping of markers rather than genes per se became a hallmark of the community. We therefore detail a different way of doing genetics to more gene-centred accounts. By doing so, we reveal the presence of practices, concepts and communities that would otherwise be hidden. (shrink)

Metaphysical realism is the view that most of the objects that populate the world exist independently of our thought and have their natures independently of how, if at all, we conceive of them. It is committed, in my opinion, to a robust form of essentialism. Many modern forms of anti-realism have their roots in a form of conceptualism, according to which all truths about essence knowable by us are ultimately grounded in our concepts, rather than in things 'in themselves'. My (...) aim is to show that conceptualist anti-realism is an incoherent doctrine and how we can support metaphysical realism and robust essentialism, while still properly acknowledging the cognitive role of concepts in mediating our grasp of the nature of mind-independent reality.RésuméLe réalisme métaphysique est la conception suivant laquelle la plupart des objets qui peuplent le monde existent indépendamment de notre pensée et possèdent une nature indépendante de la manière dont nous pouvons éventuellement la concevoir. A mon sens cette position engage à admettre une forme robuste d'essentialisme. Beaucoup des formes modernes de l'anti-réalisme tirent leurs origines d'une forme de conceptualisme, suivant laquelle toutes les vérités que nous puissions connaître au sujet des essences sont en dernière analyse fondées sur nos concepts, plutôt que dans les choses « en elles-mêmes ». Mon but est de montrer que l'anti-réalisme conceptualiste est une doctrine incohérente, et comment nous pouvons soutenir le réalisme métaphysique et l'essentialisme robuste, tout en reconnaissant clairement le rôle cognitif des concepts en tant qu'intermédiaires dans notre appréhension de la nature de la réalité indépendante de l'esprit. (shrink)

Ted Honderich's 'Radical Externalism' concerning the nature of consciousness is a refreshing, and in many ways very appealing, approach to a long- standing and seemingly intractable philosophical conundrum. Although I sympathize with many of his motivations in advancing the theory and share his hostility for certain alternative approaches that are currently popular, I will serve him better by playing devil's advocate than by simply recording my points of agreement with him. If his theory is a good one, it should be (...) able to stand up to the strongest criticisms that we can muster against it. I shall do my best to articulate some of those criticisms as forcefully as I can. (shrink)

A self or person does not appear to be identifiable with his or her organic body, nor with any part of it, such as the brain; and yet selves seem to be agents, capable of bringing about physical events as causal consequences of certain of their conscious mental states. How is this possible in a universe in which, it appears, every physical event has a sufficient cause which is wholly physical? The answer is that this is possible if a certain (...) kind of naturalistic dualism is true, according to which the conscious mental states of selves, although not identifiable with physical states of their brains, are emergent effects of prior physical causes. Moreover, mental causation on this model promises to explain certain aspects of physical behaviour which may appear arbitrary and coincidental from a purely physical point of view. (shrink)

This paper challenges David Chalmers' proposed division of the problems of consciousness into the `easy' ones and the `hard' one, the former allegedly being susceptible to explanation in terms of computational or neural mechanisms and the latter supposedly turning on the fact that experiential `qualia' resist any sort of functional definition. Such a division, it is argued, rests upon a misrepresention of the nature of human cognition and experience and their intimate interrelationship, thereby neglecting a vitally important insight of Kant. (...) From a Kantian perspective, our capacity for conceptual thought is so inextricably bound up with our capacity for phenomenal consciousness that it is an illusion to imagine that there are any `easy' problems of consciousness, resolvable within the computational or neural paradigms. (shrink)