The problem of the time of a killing is often cited as providing grounds for rejecting the action identification thesis favoured by Anscombe and Davidson. In this paper I make three claims. First, I claim that this problem is a threat to the action identification thesis because of two assumptions the thesis makes: since the thesis takes actions to be a kind of doings, it has to assume that agents’ doings last as long as their actions and vice versa. Second, (...) I claim that not making both of these assumptions necessarily leads to another problem, the problem of the acting dead. This means that any theory of action has to choose its poison and face either one of these unresolved problems. Third, I claim that the solution to the problem of the time of a killing can be found by heeding linguistic arguments that ‘kill’ cannot mean ‘cause to die,’ as is commonly assumed, but instead has to have a more complex meaning. I discuss an alternative, more complex proposal and show how it allows us to keep the action identification thesis, fits colloquial usage of ‘kill’ and deals with the problem of the time of a killing. (shrink)

Stakeholder involvement in design is desirable from both a practical and an ethical point of view. It is difficult to do well, however, and some problems recur again and again, both of a practical nature, e.g. stakeholders acting strategically rather than openly, and of an ethical nature, e.g. power imbalances unduly affecting the outcome of the process. Hidden Design has been proposed as a method to deal with the practical problems of stakeholder involvement. It aims to do so by taking (...) the observation of stakeholder actions, rather than the outcomes of a deliberative process, as its input. Furthermore, it hides from stakeholders the fact that a design process is taking place so that they will not behave differently than they otherwise would. Both aspects of Hidden Design have raised ethical worries. In this paper I make an ethical analysis of what it means for a design process to leave participants uninformed or deceived rather than acquiring their informed consent beforehand, and to use observation of actions rather than deliberation as input for design, using Hidden Design as a case study. This analysis is based on two sets of normative guidelines: the ethical guidelines for psychological research involving deception or uninformed participants from two professional psychological organisations, and Habermasian norms for a fair and just process. It supports the conclusion that stakeholder involvement in design organised in this way can be ethically acceptable, though under a number of conditions and constraints. (shrink)

Dialogic Teaching is effective in fostering student learning; yet, it is hard to implement. Little research focused on secondary teachers’ learning of DT and on the link between teachers’ understanding and practices, although these two are usually strongly intertwined. Using a wide range of evidence, this case study systematically investigated and compared two secondary teachers’ understanding and practice of DT during their participation in a continuing professional development programme. The CPDP appeared effective to some extent. The History teacher’s understanding of (...) DT, i.e. being a co-learner, appeared highly effective in implementing DT, whereas the Mathematics teacher’s understanding of DT, i.e. creating a democratic learning environment, seemed only effective to some extent. Focusing on both teachers’ understanding and practice when developing DT seemed fruitful in explaining differences in practice. Future research could further explore to what extent understanding DT as being a co-learner facilitates professional development. (shrink)

Developmental dyslexia is considered to be most effectively addressed with preventive phonics-based interventions, including grapheme-phoneme coupling and blending exercises. These intervention types require intact speech perception abilities, given their large focus on exercises with auditorily presented phonemes. Yet some children with dyslexia experience problems in this domain due to a poorer sensitivity to rise times, i.e., rhythmic acoustic cues present in the speech envelope. As a result, the often subtle speech perception problems could potentially constrain an optimal response to phonics-based (...) interventions in at-risk children. The current study therefore aimed to extend existing research by examining the presence of potential speech perception deficits in pre-readers at cognitive risk for dyslexia when compared to typically developing peers and to explore the added value of a preventive auditory intervention for at-risk pre-readers, targeting rise time sensitivity, on speech perception and other reading-related skills. To obtain the first research objective, we longitudinally compared speech-in-noise perception between 28 5-year-old pre-readers with and 30 peers without a cognitive risk for dyslexia during the second half of the third year of kindergarten. The second research objective was addressed by exploring growth in speech perception and other reading-related skills in an independent sample of 62 at-risk 5-year-old pre-readers who all combined a 12-week preventive phonics-based intervention with an auditory story listening intervention. In half of the sample, story recordings contained artificially enhanced rise times, while in the other half, stories remained unprocessed. Results revealed a slower speech-in-noise perception growth in the at-risk compared to the non-at-risk group, due to an emerged deficit at the end of kindergarten. Concerning the auditory intervention effects, both intervention groups showed equal growth in speech-in-noise perception and other reading-related skills, suggesting no boost of envelope-enhanced story listening on top of the effect of combining GraphoGame-Flemish with listening to unprocessed stories. These findings thus provide evidence for a link between speech perception problems and dyslexia, yet do not support the potential of the auditory intervention in its current form. (shrink)

Obedience: a simple term. Stanley Milgram, the famous experimental social psychologist, shocked the world with theory about it. Another man, Pol Pot, the infamous leader of the Khmer Rouge, showed how far the desire for obedience could go in human societies. Milgram conducted his experiments in the controlled environment of the US psychology laboratory of the 1960s. Pol Pot experimented with Utopia in the totalitarian Kampuchea of the 1970s. In this article, we discuss the process through which the Khmer Rouge (...) regime created an army of unquestioningly obedient soldiers – including child soldiers. Based on these two cases, we advance a framework on how obedience can be grown or countered. (shrink)

The eukaryotic helicase is an 11-subunit machine containing an Mcm2-7 motor ring that encircles DNA, Cdc45 and the GINS tetramer, referred to as CMG. CMG is “built” on DNA at origins in two steps. First, two Mcm2-7 rings are assembled around duplex DNA at origins in G1 phase, forming the Mcm2-7 “double hexamer.” In a second step, in S phase Cdc45 and GINS are assembled onto each Mcm2-7 ring, hence producing two CMGs that ultimately form two replication forks that travel (...) in opposite directions. Here, we review recent findings about CMG structure and function. The CMG unwinds the parental duplex and is also the organizing center of the replisome: it binds DNA polymerases and other factors. EM studies reveal a 20-subunit core replisome with the leading Pol ϵ and lagging Pol α-primase on opposite faces of CMG, forming a fundamentally asymmetric architecture. Structural studies of CMG at a replication fork reveal unexpected details of how CMG engages the DNA fork. The structures of CMG and the Mcm2-7 double hexamer on DNA suggest a completely unanticipated process for formation of bidirectional replication forks at origins. Here, we review the structure and function of CMG, the 11 subunit helicase for eukaryotic DNA replication. Two CMGs are assembled at origins starting from two Mcm2-7 hexamers oriented N-to-N. The orientation of CMG at a forked DNA implies that the two CMGs at an origin pass one another. (shrink)

Obedience: a simple term. Stanley Milgram, the famous experimental social psychologist, shocked the world with theory about it. Another man, Pol Pot, the infamous leader of the Khmer Rouge, showed how far the desire for obedience could go in human societies. Milgram conducted his experiments in the controlled environment of the US psychology laboratory of the 1960s. Pol Pot experimented with Utopia in the totalitarian Kampuchea of the 1970s. In this article, we discuss the process through which the Khmer Rouge (...) regime created an army of unquestioningly obedient soldiers – including child soldiers. Based on these two cases, we advance a framework on how obedience can be grown or countered. (shrink)

Recueil de textes écrits par des intimes du philosophe, à l'occasion du dixième anniversaire de sa mort : Jeannette Colombel, Jean-Pierre Faye, Jean-Luc Nancy ou encore Jacques Derrida, Roger-Pol Droit, Fanny Deleuze...

Nosso artigo visa um estudo sobre os cadernos intitulados como “Manuscritos econômico-filosóficos” de Karl Marx, do ano de 1844, tendo em vista a posição privilegiada que o texto ocupa no desenvolvimento do pensamento do autor. Do mesmo modo, os manuscritos guardam os primeiros estudos teóricos da economia política de um jovem Marx e seu pensamento precoce – anterior àquele de “O capital” –, ao mesmo tempo que também representou o aprimoramento das “armas da crítica” pela “crítica das armas” contra os (...) jovens hegelianos do grupo de Berlim (principalmente Bauer e Stirner) e o pensamento e herança deixada por Hegel. Tais estudos possivelmente também foram importantes para a edificação da amizade que ele também começaria poucos meses após os manuscritos serem “concluídos” – conclusão que só seria realizada com a publicação mas que nunca ocorreu durante a vida de Karl Marx, senão, ocorreria apenas em 1932 (integralmente) com a redescoberta dos mesmos alguns anos antes com o impulso da revolução bolchevique na Rússia. Por fim, buscaremos apontar em que medida as concepções e o pensamento do jovem autor se conservam ou se transformam – parcial ou completamente – nos anos imediatamente posteriores. (shrink)

In Aristotle’s Politics viii 7, 1341b 38–40, there is a reference to some books peri poietikes in which katharsis will be explained more clearly. The future tense of the verb is important and may be the sign of the aristotelian origin of the reference; it would prove in an indisputable way that, when writing Pol. vii–viii, Aristotle thought of a Poetics as the obvious sequel for the discussion about educational problems. So, the logical connection of the argument in Politics and (...) Poetics is in agreement with (and is confirmed by) the famous definition of tragedy in Poet. 6, 1449b 24–28: here Aristotle says that the various items of the definition must be obtained from “the things already said”, but the reference is not fully satisfied by Poetics 1–5: in these chapters no mention is made of katharsis, pity and fear. For these items the reference is satisfied only by the text of Politics viii 7, and the two references, Pol. viii 7 to a Poetics, Poet.6 (by implication) to Pol. viii 7, agree about the sequel of the books and strengthen each other. But the topics of katharsis and education never are fully clarified, neither in the Politics, nor in the Poetics. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:The Female in Aristotle’s Biology: Reason or RationalizationTony PreusRobert Mayhew. The Female in Aristotle’s Biology: Reason or Rationalization. Chicago: University of Chicago Press, 2004. Pp. xi +136. Cloth, $28.00.Aristotle's views on the ethical, social, and political roles of women have repeatedly drawn the attention of scholars. Often, the central focus of the discussion is Politics I.13, 1260 a13, where Aristotle says that although women have a deliberative faculty, (...) it is akuron, "without authority." A charitable (from our point of view) interpretation of that word would have him mean that women are capable of ethical and political decision-making, but fourth-century BCE Athenian social arrangements prevent their exercising that capacity outside the home. However, many readers of Aristotle suppose that he means to indicate a natural difference between men and women, some mental or moral inferiority of women. A few passages in the Politics support that interpretation (e.g., Pol. I.2, 1254 b13, 12.1259 a40), but those do not provide a "scientific" or "biological" grounding of female inferiority. That sort of thing one would expect to find in the biological works. Mayhew's monograph is an exposition of the errors and exaggerations of some of those writers, from the usually careful Martha Nussbaum to the usually unreliable Luce Iragaray.The least cautious critics of Aristotle's views on women typically fasten on his views on sexual generation; as Mayhew shows (ch. 3), such critics either claim that Aristotle believed that women contribute only a place for generation to occur, or that women contribute totally passive matter. Mayhew is able to demonstrate, rather easily, that either claim depends on total ignorance or total misunderstanding of the actual contents of the Generation of Animals. In Aristotle's opinion, the female provides proximate matter for the offspring, something that is almost able to develop into a new individual and needing only the impetus and form provided by the male contribution. Having started with the "form/matter" distinction, it is pretty obvious that the female provides the matter (a bird egg is all of the matter that goes to make the chick), and the male is necessary for reproduction to [End Page 109] occur, so it must be a source of movement (at least) and some element of form (since the offspring partially resembles its male parent) that comes from that source. (For older discussions of this issue, see my Science and Philosophy in Aristotle's Biological Works [Hildesheim, 1975], ch. 2, and J. Morsink, "Was Aristotle's Biology Sexist?" J. Hist. Biol.12 [1979]:83-112, neither noted by Mayhew). But what would be the ethical or political implications of that distinction? Aristotle says that it is "better" to provide form, but there's no straightforward way to conclude from that difference that a woman's deliberative faculty is less authoritative than a man's, any more than there is any straightforward way to argue from the fact that a woman might spend some time pregnant that a permanent pay differential is justified. And Aristotle does not try to make that sort of argument, as a matter of fact.Mayhew deals with most of the other arguments that some have derived from the biological works to support their view that Aristotle's "science" is the foundation of his (supposed) sexism. For example, he points out that although Aristotle does call "kings" the bees that we call "queens," he also calls the analogue among wasps the "mothers" or "wombs"; Mayhew says that Aristotle seems to have thought that the king/queen bee was hermaphroditic and parthenogenetic. Mayhew also has an original and interesting chapter on Aristotle's comparisons between women and eunuchs; although he notes that Aristotle was friendly with at least one eunuch, Hermeias, the uncle of Aristotle's young wife, he leaves out Aristotle's poetic praise of Hermeias (see R. Renehan, in Greek, Roman, and Byz. Stud.23 [1982]: 251-74). Suppose women were "eunuchoid" according to Aristotle, it couldn't mean that they were consequently intellectually inferior, since at least one eunuch was, in Aristotle's opinion, intellectually superior.Mayhew also discusses, adequately enough, the issues of brain... (shrink)

In anticipation of updating annotated bibliographies on Aristotle’s Ethics and Politics for Oxford Bibliography Online, I have sought to keep a running tabulation of all books, edited collections, translations, and journal articles which are primarily devoted to Aristotle’s ethical and political writings (including their historical reception but excluding neo–Aristotelian virtue ethics). In general, criteria for inclusion in this bibliography are that the work be: (1) publication in a peer–reviewed or academic/university press between 2011–2020; (2) “substantially” devoted to one of Aristotle’s (...) ethical or political works (e.g., Pol, EN, EE, MM, Athenian Constitution, Protrepticus); and/or (3) devoted to ethical or political concepts examined elsewhere in Aristotle’s corpus (e.g., Rhetoric, Poetics, zoological treatises, etc.). I encourage scholars to alert me about published works that I have omitted or listed incorrectly. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:The Female in Aristotle’s Biology: Reason or RationalizationTony PreusRobert Mayhew. The Female in Aristotle’s Biology: Reason or Rationalization. Chicago: University of Chicago Press, 2004. Pp. xi +136. Cloth, $28.00.Aristotle's views on the ethical, social, and political roles of women have repeatedly drawn the attention of scholars. Often, the central focus of the discussion is Politics I.13, 1260 a13, where Aristotle says that although women have a deliberative faculty, (...) it is akuron, "without authority." A charitable (from our point of view) interpretation of that word would have him mean that women are capable of ethical and political decision-making, but fourth-century BCE Athenian social arrangements prevent their exercising that capacity outside the home. However, many readers of Aristotle suppose that he means to indicate a natural difference between men and women, some mental or moral inferiority of women. A few passages in the Politics support that interpretation (e.g., Pol. I.2, 1254 b13, 12.1259 a40), but those do not provide a "scientific" or "biological" grounding of female inferiority. That sort of thing one would expect to find in the biological works. Mayhew's monograph is an exposition of the errors and exaggerations of some of those writers, from the usually careful Martha Nussbaum to the usually unreliable Luce Iragaray.The least cautious critics of Aristotle's views on women typically fasten on his views on sexual generation; as Mayhew shows (ch. 3), such critics either claim that Aristotle believed that women contribute only a place for generation to occur, or that women contribute totally passive matter. Mayhew is able to demonstrate, rather easily, that either claim depends on total ignorance or total misunderstanding of the actual contents of the Generation of Animals. In Aristotle's opinion, the female provides proximate matter for the offspring, something that is almost able to develop into a new individual and needing only the impetus and form provided by the male contribution. Having started with the "form/matter" distinction, it is pretty obvious that the female provides the matter (a bird egg is all of the matter that goes to make the chick), and the male is necessary for reproduction to [End Page 109] occur, so it must be a source of movement (at least) and some element of form (since the offspring partially resembles its male parent) that comes from that source. (For older discussions of this issue, see my Science and Philosophy in Aristotle's Biological Works [Hildesheim, 1975], ch. 2, and J. Morsink, "Was Aristotle's Biology Sexist?" J. Hist. Biol.12 [1979]:83-112, neither noted by Mayhew). But what would be the ethical or political implications of that distinction? Aristotle says that it is "better" to provide form, but there's no straightforward way to conclude from that difference that a woman's deliberative faculty is less authoritative than a man's, any more than there is any straightforward way to argue from the fact that a woman might spend some time pregnant that a permanent pay differential is justified. And Aristotle does not try to make that sort of argument, as a matter of fact.Mayhew deals with most of the other arguments that some have derived from the biological works to support their view that Aristotle's "science" is the foundation of his (supposed) sexism. For example, he points out that although Aristotle does call "kings" the bees that we call "queens," he also calls the analogue among wasps the "mothers" or "wombs"; Mayhew says that Aristotle seems to have thought that the king/queen bee was hermaphroditic and parthenogenetic. Mayhew also has an original and interesting chapter on Aristotle's comparisons between women and eunuchs; although he notes that Aristotle was friendly with at least one eunuch, Hermeias, the uncle of Aristotle's young wife, he leaves out Aristotle's poetic praise of Hermeias (see R. Renehan, in Greek, Roman, and Byz. Stud.23 [1982]: 251-74). Suppose women were "eunuchoid" according to Aristotle, it couldn't mean that they were consequently intellectually inferior, since at least one eunuch was, in Aristotle's opinion, intellectually superior.Mayhew also discusses, adequately enough, the issues of brain... (shrink)

Edward Pols is no stranger to these pages; indeed, his three most recent articles in The Review of Metaphysics are all versions of chapters in this, his fourth book. Those of us who have followed his philosophical development closely will recognize that The Acts of our Being elaborates and clarifies--but does not presuppose knowledge of--Meditation on a Prisoner. His general aim with regard to human agency and human action is to show that, yes, things really are as they seem, i.e., (...) that our common sense view that we ourselves originate our actions and are responsible for them, a view which more often than not is found to be contrary to scientific dogma, is in fact the correct view. His general strategy is to blaze a via media between the immediate prejudice which favors prima facie rational agency and the authoritative physiology which pretends to dispense with the concept of "agent." Realizing his task to be a tough one, Pols shrewdly substitutes the term "ontic responsibility," i.e., the state of being of such an ontological nature that accountability is appropriate and seemly, for the old bugaboo of a term "free will," thus perhaps facilitating a serious encounter with his more scientifically inclined readers. While acknowledging that reductionist science has been largely successful in shifting the everyday perception of human nature away from the ancient common sense view toward physicalist explanations and toward a broad faith in the eventual accomplishment of an exhaustive "perfected physiology," he takes great pains to demonstrate that it is not this newly popular scientific view, but the prima facie view, which is the philosophical ground of the entire legal structure, and hence, by extension, of social organization and civilization in general. Addressing the intelligent layperson rather than his professional colleague, Pols claims fundamentally that science's current project is to prove to us that we are actually something other than what we seem to ourselves to be. But science ought, instead of cancelling our prima facie knowledge of ourselves, to contribute to a fuller understanding of this prima facie knowledge. (shrink)

R??SUM???? travers l?????tude de la correspondance philosophique entre Descartes et Henry More, je souhaiterais montrer que les th??mes centraux en sont la consid??ration de la nature de l???espace et le statut de l???infini, bien que la pol??mique aborde??galement le probl??me ontologique de la distinction entre l?????tendue et la pens??e, et les questions physiques de la n??gation du vide et de l???atomisme. More rejette l???hypoth??se cart??sienne d???un univers ind??fini, qu???il consid??re??tre une mani??re d??tourn??e de postuler le caract??re infini de l???univers, ce (...) qui revient?? attribuer tout autant l???infinit???? la mati??re qu????? Dieu, d???o?? le fait que Descartes soit un mat??rialiste selon Henry More. ABSTRACT The correspondence between Descartes and More covers a diversity of each author???s fundamental philosophical views. Their polemics range over not only general aspects of physics, but also extend to cosmology and theology. On the one hand, we have God as infinite and His creation as indefinite for Descartes; on the other hand, God as extant, ubiquitous and omnipresent, and His creation as limited for Henry More. It is this last problem that constitutes the focus of my essay, strictly speaking??? the problem of the universe as infinite. (shrink)

Estudio y an lisis del pensamiento e influencia de Thomas Hobbes en la pol tica contempor nea, consider ndolo el creador de la primera teor a del estado moderno. el reconocimiento de Hobbes son sus teor as sobre el materialismo en filosof a, el utilitarismo en moral y el despotismo en pol tica. Textos y ensayos referentes al iusnaturalismo, las sociedades parciales y la ley natural y civil en la filosof a de Hobbes.

Pese a la estricta contextualización de lomágico como demoníaco en el tejido dela narrativa de El asno dorado de Apuleyo,una corriente que se ha descuidado enla academia moderna explora su legadopagano –r et i ene el al cance par a unahi pót esi s fact i bl e en l a forma de unacoalición paradigmática entre su progeniei nevi tabl e, l as bruj as desesperadas aligual que una comunidad distinguida detaumaturgos, los teúrgos, cuya identidaden el discurso intelectual proporciona elejemplo (...) más fino de las formas politeistasde adivinación. En Sobre los misterios deJamblico, se clarifica la representación deotra tipología de magia, la natural, queavala un notable paralelo en una premisacompartida –los niveles de motivación.Deseo proponer, que en tanto arroja luzsobre una clasificación dual de la magiac omo demoní ac a y nat ur al , t ambi énrefleja de manera fascinante los grados deunidad entre las brujas desesperadas ylos teúrgos en cuestión –las operacionesde l os pri meros a menudo sust ent ans us pl a n t e a mi e n t o s pa r a o c ul t a r e lconocimiento y su potencial no es inferiora l as preocupaci ones el evadas de l ossegundos.Despite the strict contextualization ofmagic as demonic within the fabric ofnar r at i ve i n Aput ei us ’ Go l de n As s , aneglected current in modern academia itspagan legacy - retains scope for a feasiblehypothesis in the form of a paradigmaticcoalition between its inevitable progeny,desperate witches as well as a distinguishedc o mmu n i t y o f t h a u ma t a u r g o i , t h etheurgist, whose identity in intellectualdi scour se, chi ef l y t he f i nest possi bl ee x e mpl um of pol yt he i s t i c f or ms ofdi vi nat i on I ambl i chus’ De Myst eri es,clarify their representation of anothertypology of magic, natural, endorsinga striking parallel in a shared premise -levels of motivation. I wish to propose,that in as much as it throws light on twofold classification of magic as demonic andnatural it also fascinatingly reflects degreesof unity, though not without reserve insome areas, between the desperate witchesand theurgists in question - the formerwhose operations often underpin theirclaims to occult knowledge and whosepotential is no less inferior to the elevatedconcerns of the latter. (shrink)

In this in ter view, the pres ti gious an thro - pol o gist, his to rian and T.V. anaouncer, Alan Macfarlane com ments on some of the is sues that have been ad dressed in his writ ings. His main the o ret i cal con cern has been to study the pe cu - liar con di tions that gave rise to the mod e..

In lieu of an abstract, here is a brief excerpt of the content:THREE NOTIONS OF RESOLUTIO AND THE STRUCTURE OF REASONING IN AQUINAS 1 EILEEN c. SWEENEY Boston College Chestnut Hill, Massachusetts RESOLUTIO, better known by the English transliteration of its Greek counterpart, "analysis," has been touted as " the conceptual model for some of the most important ideas in the history of philosophy, including the history of the methodology and philosophy of science." 2 But while resolution /analysis may be (...) important in the histories of philosophy and science, its own history is, to say the least, confused. A Renaissance commentator, Jeremias Triverius gives some sense of this when, after giving a list of four methods of dialectic (division, definition, demonstration, and resolution),3 he writes, 1 I have used the following abbreviations for works by Thomas Aquinas. All translations of Aquinas are my own. Commentum in Quatuor Libros Sententiarum (ed. Busa): In Sent; Compendium Theologiae (ed. Busa): Comp Theo!; E:rpositio Super Librum Boethii De Trinitate (ed. Decker): Exp de Trin; In Aristotelis Libros Posterium Analyticorum (ed. Marietti) : In Anal Post; In Duodecem Libros Metaphysicorum Aristotelis E:rpositio (ed. Marietti): In Meta; In Librum Beati Dionysii De Divinis Nominibus E:rpositio (ed. Marietti): In Div Nom; Sententia Libri Ethicorum Aristotelis ad Nichomachum: In Ethic; Sententia Libri Politicormn Aristotelis (ed. Leonine): In Pol; De Substantiis Separatis (ed. Busa): De Sub Sep; Summa Contra Gentiles (ed. Leonine): SCG; Summa Theologiae (ed. Leonine): ST; Questiones Disputatae de Veritate: QDV. 2 Jaakko Hintikka and Unto Remes, The Method of Analysis (Boston: D. Reidel, 1974), p. 1. s These four methods of dialectic are also given by a number of ancient commentators, for example, Ammonius (In Porphyrii Isagogen, in Commentaria in Aristotelem Graeca [hereafter, CAG], ed. Maximilian Wallies [Berlin, 1891], vol. IV, pt. 6, p. 34, 11. 19-20) and a later commentator, David (Davidis Prolegomena et in Porphyrii Isagogen Commentarium, CAG, ed. Adolf Busse [Berlin, 1904], vol. 18, p. 88, 11. 6-10). 197 198 EILEEN C. SWEENEY Now anyone who has some knowledge of dialectical matters knows what Definition, Division, and Demonstration are. There is no general agreement, however, so far as I can see, on Resolution. Some identify it with Division. Others regard it as contrary [to Divi- • ] 4 S!On, ••• Triverius, like many modern commentators, adds to, rather than sorts out, the confusion, continuing, " And since each one is entitled to his opinion, I am now maintaining that Resolution is contrary to Demonstration...." 5 Many centuries before Triverius we find a similar ambiguity in Greek commentators on Aristotle, who outline several types of analysis. Unlike Triverius, however, most seem untroubled by the multiple types; Ammonius and David, without puzzlement, explain carefully that analysis is the opposite of each of the other three methods.6 The lack of 4 Jeremias Triverius, In texnhn [sic] Galeni clarissimi commentarii (Lyon, 1547), p. 14; cited and translated in Nea! Gilbert, Renaissance Concepts of Method (New York: Columbia University Press, 1960), p. 106. Galen's opening remarks of the Ars medica, giving three methods of teaching (analysis, synthesis, and definition) is a common locus for the discussion of resolution/ analysis in the Middle Ages and Renaissance. Galen's contribution, at least for Aquinas, seems to have been completely mediated by Medieval Arabic commentators. Galen's own discussions are either incomplete, as in the opening passage to the Ars medica (in Claudii Galeni Opera Omnia, ed. C. G. Kiihn, [Repr. Hildesheim: Georg Olms, 1965], vol. I, pp. 305-306), which merely mentions the word, or are unclear accounts of analysis (Cf. Galen's discussion of analysis in De Peccatorum, in Opera Omnia, vol. 5, ch. 5, pp. 80-81). On two of the Arabic commentaries' descriptions of analysis to accompany medieval translations of Galen, see below, nn. 80 & 83. On Galen's supposed contribution to the notion of resolution and method in the development of experimental science, see A. C. Crombie, Robert Grosseteste and the Origins of Experimental Science (Oxford: Clarendon Press, 1953), especially pp. 7680, and Gilbert, Renaissance Method, pp, 13-27, 44-46. 5 Triverius, In texnhn, p. 14; Gilbert, p. 106. 6 For analysis as the opposite of division, definition, and demonstration, see Ammonius, In Aristotelis Analyticorum Priorum Librum I Commentarium, CAG, ed. Maximilian Wallies, (Berlin, 1891... (shrink)

Causal closure arguments against interactionist dualism are currently popular amongst physicalists. Such an argument appeals to some principles of the causal closure of the physical, together with certain other premises, to conclude that at least some mental events are identical with physical events. However, it is crucial to the success of any such argument that the physical causal closure principle to which it appeals is neither too strong nor too weak by certain standards. In this paper, it is argued that (...) various forms of naturalistic dualism, of an emergentist character, are consistent with the strongest physical causal closure principles that can plausibly be advocated. (shrink)

Non-Cartesian substance dualism maintains that persons or selves are distinct from their organic physical bodies and any parts of those bodies. It regards persons as ‘substances’ in their own right, but does not maintain that persons are necessarily separable from their bodies, in the sense of being capable of disembodied existence. In this paper, it is urged that NCSD is better equipped than either Cartesian dualism or standard forms of physicalism to explain the possibility of mental causation. A model of (...) mental causation adopting the NCSD perspective is proposed which, it is argued, is consistent with all that is currently known about the operations of the human central nervous system, including the brain. Physicalism, by contrast, seems ill-equipped to explain the distinctively intentional or teleological character of mental causation, because it effectively reduces all such causation to ‘blind’ physical causation at a neurological level. (shrink)

Unlike the most well‐characterized prokaryotic polymerase, E. Coli DNA pol I, none of the eukaryotic polymerases have their own 5′ to 3′ exonuclease domain for nick translation and Okazaki fragment processing. In eukaryotes, FEN‐1 is an endo‐and exonuclease that carries out this function independently of the polymerase molecules. Only seven nucleases have been cloned from multicellular eukaryotic cells. Among these, FEN‐1 is intriguing because it has complex structural preferences; specifically, it cleaves at branched DNA structures. The cloning of FEN‐1 permitted (...) establishment of the first eukaryotic nuclease family, predicting that S. cerevisiae RAD2 (S. pombe Rad13) and its mammalian homolog, XPG, would have similar structural specficity. The FEN‐1 nuclease family includes several similar enzymes encoded by bacteriophages. The crystal structures of two enzymes in the FEN‐1 nuclease family have been solved and they provide a structural basis for the interesting steric requirements of FEN‐1 substrates. Because of their unique structural specificities, FEN‐1 and its family members have important roles in DNA replication, repair and, potentially, recombination. Recently, FEN‐1 was found to specifically associate with PCNA, explaining some aspects of FEN‐1 function during DNA replication and potentially in DNA repair. (shrink)

Misunderstanding of the dynamical behavior of the ventilatory system, especially under assisted ventilation, may explain the problems encountered in ventilatory support monitoring. Proportional assist ventilation (PAV) that theoretically gives a breath by breath assistance presents instability with high levels of assistance. We have constructed a mathematical model of interactions between three objects: the central respiratory pattern generator modelled by a modified Van der Pol oscillator, the mechanical respiratory system which is the passive part of the system and a controlled ventilator (...) that follows its own law. The dynamical study of our model shows the existence of two crucial behaviors, i.e. oscillations and damping, depending on only two parameters, namely the time constant of the mechanical respiratory system and a cumulative interaction index. The same result is observed in simulations of spontaneous breathing as well as of PAV. In this last case, increasing assistance leads first to an increase of the tidal volume (VT), a further increase in assistance inducing a decrease in VT, ending in damping of the whole system to an attractive fixed point. We conclude that instabilities observed in PAV may be explained by the different possible dynamical behaviors of the system rather than changes in mechanical characteristics of the respiratory system. (shrink)

The symbolism introduced earlier provides a convenient vehicle for examining the status and consistency of Aristotle's three diverse justifications and for explaining how he means to avoid Protagorean relativism without embracing Platonic absolutism. When the variables ‘ x ’ and ‘ y ’ are allowed to range over the groups of free men in a given polis as well as over individual free men, the formula for the Aristotelian conception of justice expresses the major premiss of Aristotle's three justifications: (1) (...) (∀ x )(∀ y ) (P(x)·W(x)/P(y)·W(y)=V(T(x))/V(T(y)))Democracy is justified by adding a minor premiss to the effect that as a group the many ( m ) are superior (>) in virtue and wealth to the few best men ( f ): 85 (2 d ) (P(m) · W(m)) > (P(f) · W(f)) (3 d ) V(T(m))>V(T(f))Absolute kingship is justified when a godlike man ( g ) appears in a polis who is incommensurably superior (≫) in virtue and wealth to all the remaining free men ( r ): (2 k ) (P(g) · W(g)) ≫ (P(r) · W(r)) (3 k ) V(T(g)) ≫ V(T(r))True aristocracy requires a more complex justification, which was symbolized in Section 4. These justifications are compatible with each other since they apply to different situations. The polises where democracy and true aristocracy are justified contain no godlike men, and the polis in which democracy is justified differs from that in which true aristocracy is justified in containing a large group of free men who individually have little virtue ( Pol. III.11.1281b23-25, 1282a25-26). Each of the justifications is a valid deductive argument. Aristotle affirms the major premiss they share on the basis of a twofold appeal to nature. The principle of distributive justice, the concept as distinguished from the various conceptions of distributive justice, is itself according to nature ( Pol. VII.3.1325b7-10) and so too is one particular standard of worth, the standard of the best polis. Consequently, the question of the status of these three justifications, whether they are purely hypothetical or not, is a question about the minor premiss or premisses of each. In the case of the democratic premiss Aristotle's answer is straightforward: it is sometimes but not always true ( Pol. III.11.1281bl5-21). Hence the justification of democracy is not purely hypothetical. Nor is the justification of absolute kingship. The man who is “like a god among men” ( Pol. III.13.1284a10-11) would be a man of heroic virtue (see VII.14.1332bl6-27); and such a man, Aristotle says, is “rare” ( σπávιoη ) (not nonexistent) ( E.N. VII.1.1145a27-28). The minor premisses of the aristocratic argument describe a situation where all of the free men in a given polis have sufficient wealth for the exercise of the moral and intellectual virtues and where all of the older free men of the polis are men of practical wisdom. In the Politics Aristotle makes only the modest claim that such a situation is possible: It is not possible for the best constitution to come into being without appropriate equipment [that is, the appropriate quality and quantity of territory and of citizens and noncitizens]. Hence one must presuppose many things as one would wish them to be, though none of them must be impossible ( Pol. VII.4.1325b37-38; see also II.6.1265al7-18). But Aristotle appears to subscribe to the principle that every possibility is realized at some moment of time ( Top. 11.11.115bl7-18, Met. Θ.4.1047b3-6, N.2.1088b23-25). This principle together with the claim that the situation described is possible entails that the situation sometimes occurs. Thus even Aristotle's justification of true aristocracy is not purely hypothetical. The final question is Aristotle's way of avoiding Protagorean relativism without embracing Platonic absolutism. The relativist, along with everyone else ( E.N. V.3.1131a13-14, Pol. III.12.1282bl8), can accept the principle of distributive justice: Q(x)/Q(y) = V(T(x))/V(T(y)) And he can concede that particular instances of this principle, particular conceptions of justice, accurately describe the modes of distributing political authority that appear just to particular polises and to particular philosophers. What he denies is that there is any basis for ranking these various conceptions of justice or for singling one out as the best (Plato, Theaet. 172A-B). Aristotle, following in Plato's track ( Laws X.888D7-890D8), maintains against the relativist that nature provides such a basis. But he departs from Plato in his conception of nature. For Plato “the just by nature” ( τó ρυσει δίκ↑oν }) ( Rep. VI.501B2) is the Form of justice, an incorporeal entity ( Phdo. 65D4-5, Soph. 246B8) that exists beyond time and space ( Tim. 37C6-38C3, 51E6-52B2), whereas for Aristotle the sensible world is the realm of nature ( Met. A.1.1069a30-b2). Thus in appealing to nature Aristotle does not appeal to a transcendent standard. Nor does he appeal to his main criterion of the natural, namely, happening always or for the most part. Aristotle's theory of justice is anchored to nature by means of the polis described in Politics VII and VIII, and he regards this polis as natural because it fosters the true end of human life and because its social and political structure reflects the natural hierarchy of human beings and the natural stages of life. Thus the nature that Aristotle's theory of justice is ultimately founded on is human nature. (shrink)

Limit cycles, because they are constituted of a periodic succession of states (discrete or continuous) constitute a good manner to store information. From any points of the state space reached after a perturbation or stimulation of the cognitive system storing this information, one can aim to join through a more or less long return trajectory a precise neighbourhood of the asymptotic trajectory at a specific moment (or a specific place) on the limit cycle, i.e. where the information of interest stands. (...) We propose that the isochronal fibration, initially imagined and described by A. T. Winfree may be an excellent way to connect directly those two locations. Each isochron is indeed the set of points in temporal phase with one single point of the attractor. The characterisation of the isochronal fibration of various dynamical systems is not easy and until now has principally only been done numerically but not analytically. By integrating the homogeneous solutions of the dynamical system we can solve this fibration in the case of the well known anharmonic pendulum. Other isochronal fibration on classical examples such as the van der Pol system and the non-symmetrical PFK limit cycle are obtained numerically and we also provide the first numerical study on 3-dimentional systems like the anharmonic pendulum with a linear relaxation on its third variable and the Lorenz attractor. The empirical approach seems us useful for dealing with the isochronal fibration which could constitute a powerful tool for understanding and controlling the dynamics of biological or biological-inspired systems. (shrink)

During the past few years significant progress has been made in our understanding of the structure and function of the proteins involved in eukaryotic DNA replication. Data from several laboratories suggest that, in contrast to prokaryotic DNA replication, two distinct DNA polymerases are required for eukaryotic DNA replication, i.e. DNA polymerase delta for the synthesis of the leading strand and DNA polymerase alpha for the lagging strand. Several accessory proteins analogous to prokaryotic replication factors have been identified and some of (...) these are specific for pol delta whereas others affect both DNA replicases. The replicases and their accessory proteins appear to be highly conserved in eukaryotes, as homologous proteins have been found in species ranging from humans to yeast. (shrink)

The 'developmental systems' perspective in biology is intended to replace the idea of a genetic program. This new perspective is strongly convergent with recent work in psychology on situated/embodied cognition and on the role of external 'scaffolding' in cognitive development. Cognitive processes, including those which can be explained in evolutionary terms, are not 'inherited' or produced in accordance with an inherited program. Instead, they are constructed in each generation through the interaction of a range of developmental resources. The attractors which (...) emerge during development and explain robust and/or widespread outcomes are themselves constructed during the process. At no stage is there an explanatory stopping point where some resources control or program the rest of the developmental cascade. 'Human nature' is a description of how things generally turn out, not an explanation of why they turn out that way. Finally, we suggest that what is distinctive about human development is its degree of reliance on external scaffolding. (shrink)