Newborn screening (NBS) began in the 1960s by testing all newborns for a single condition—phenylketonuria, or PKU—which, when identified and treated early, significantly reduces morbidity. Over the...

Over the past decade, there has been an extensive debate about whether researchers have an obligation to disclose genetic research findings, including primary and secondary findings. There appears to be an emerging (but disputed) view that researchers have some obligation to disclose some genetic findings to some research participants. The contours of this obligation, however, remain unclear. -/- As this paper will explore, much of this confusion is definitional or conceptual in nature. The extent of a researcher’s obligation to return (...) secondary and other research findings is often limited by reference to terms and concepts like “incidental,” “analytic validity,” “clinical validity,” “clinical relevance,” “clinical utility,” “clinical significance,” “actionability,” and “desirability.” These terms are used in different ways by different writers to describe obligations in different sorts of cases. -/- Underneath this definitional confusion is a general notion, supported by much of the literature, that findings only need to be disclosed when they surpass certain presumably objective or measureable thresholds, such as medical importance or scientific reproducibility. The problem is that there is significant variability in the way that these terms and concepts are used in the literature and, as such, in defining the scope of an obligation to return findings that surpasses the relevant thresholds. -/- The goal of this paper is to analyze the definitional muddle underlying the debate about returning genetic research findings, with the hope of answering a few questions. First, what is the range of definitions being used in this debate? Based on an extensive literature review, Part 1 will lay out a range of articulated definitions for each relevant term, with the goal of categorizing them into a handful of distinct types. Part 2 explains the definitional redundancy and confusion in the current literature, and, drawing from the terminological patterns identified in Part 1, outlines more cohesive building blocks to inform the development of future disclosure frameworks.Our minimum goal in articulating these conceptual building blocks is to promote clearer articulations of, and distinctions between, future disclosure frameworks. More ambitiously, we suggest which definitions and conceptualizations we consider most appropriate to use in future disclosure frameworks. Here, we seek to balance benefits to participants through the disclosure of important information with the minimization of undue burdens on individual researchers and the research enterprise more generally. -/- Our analysis builds upon the central philosophical distinction between concepts and conceptions. The basic idea is that the “concept” of X refers to the general (and relatively uncontroversial) structure/shape of X, while various “conceptions” of X are more particular, filled out, and controversial elaborations of the concept. In other words, “concepts” of X will be formal representations of X, while “conceptions” of X will be substantive interpretations of the key elements and relationships operating within that formal framework. (Implicit in this distinction is an important point about the nature of disagreement – namely, that in order for two or more parties to “disagree” about X as opposed to simply talk past one another, there must be at least enough shared agreement about X to know that the parties are referring to the same thing. A concept of X provides this point of common agreement, while competing conceptions of X mark the areas where disagreement arises.) In this paper, we will employ this distinction in a fundamental way to clarify exactly where the primary disagreements arise in the debate over disclosing genetic research findings. -/- We propose that, underlying all the seeming confusion and disagreement, there are three central and widely agreed upon concepts at work in this debate—validity, value, and volition. The first two concepts concern the nature of the information itself. An obligation to disclose only exists when findings are valid and have value but there are competing conceptions of how to determine or define validity and valuableness. The third concept—volition—pertains not to the information but rather to the person to whom it will be disclosed. Does that person want or not want the information, and what is the best way of determining this? Here, too, competing conceptions arise. Our key point, though, is that almost all of the ethical disagreement arises because of competing conceptions of these three concepts. Understanding and appreciating this key point can help to refocus the substantive debate by providing some common ground to start from in determining how best to interpret these shared concepts. This refocusing can, ideally, produce more productive debate and facilitate some progress in resolving it. (shrink)

When corporations are accused of unethical behaviour by external actors, executives from those organizations are usually compelled to offer communicative responses to defend their corporate image. To demonstrate the effect that corporate executives'' communicative responses have on third parties'' perception of corporate image, we present the Corporate Communicative Response Model in this paper. Of the five potential communicative responses contained in this model (no response, denial, excuse, justification, and concession), results from our empirical test demonstrate that a concession is the (...) most effective and robust communicative option. (shrink)

Recent advances in philosophical thinking about consciousness, such as cognitive phenomenology and mereological analysis, provide a framework that facilitates using computational models to explore issues surrounding the nature of consciousness. Here we suggest that, in particular, studying the computational mechanisms of working memory and its cognitive control is highly likely to identify computational correlates of consciousness and thereby lead to a deeper understanding of the nature of consciousness. We describe our recent computational models of human working memory and propose that (...) three computational correlates of consciousness follow from the results of this work: itinerant attractor sequences, top-down gating, and very fast weight changes. Our current investigation is focused on evaluating whether these three correlates are sufficient to create more complex working memory models that encompass compositionality and basic causal inference. We conclude that computational models of working memory are likely to be a fruitful approach to advancing our understanding of consciousness in general and in determining the long-term potential for development of an artificial consciousness specifically. (shrink)

According to previous research, threatening people’s belief in free will may undermine moral judgments and behavior. Four studies tested this claim. Study 1 used a Velten technique to threaten people’s belief in free will and found no effects on moral behavior, judgments of blame, and punishment decisions. Study 2 used six different threats to free will and failed to find effects on judgments of blame and wrongness. Study 3 found no effects on moral judgment when manipulating general free will beliefs (...) but found strong effects when manipulating the perceived choice capacity of the judged agent. Study 4 used pretested narratives that varied agents’ apparent free will and found that perceived choice capacity mediated the relationship between free will and blame. These results suggest that people’s general beliefs about whether free will exists have no impact on moral judgments but specific judgments about the agent’s choice capacity do. (shrink)

Thomas Jefferson and Philosophy: Essays on the Philosophical Cast of Jefferson’s Writings is a collection of essays on topics that relate to philosophical aspects of Jefferson’s thinking over the years. Much historical insight is given to ground the various philosophical strands in Jefferson’s thought and writing on topics such as political philosophy, moral philosophy, slavery, republicanism, wall of separation, liberty, educational philosophy, and architecture.

Paternalism in the medical care of children is appropriate and ethically justifiable. However, dilemmatic disagreement by paternalistic agents as to which clinical choice is in the child's best interest may occur because of the underlying conflict between two rival standards for the moral value of life: longevity versus quality. Neither standard is unreasonable. Either could be the basis for choice of medical care by the parents or by the pediatrician. Having the child choose between options disputed by his parents and (...) the pediatrician is unlikely to resolve their conflict. Exercise of informed consent by the adolescent requires agreement by his parents to relinquish their paternalistic veto. The probable best-interest choice by the child when he has matured could be reasonably made from either standard. Therefore, the longevity/quality of life question ought not ordinarily to be foreclosed by paternalistic authority which opts for one standard to the exclusion of the other. Medical interventions, paternalistically determined, are justified in the face of deteriorating quality, but only as long as the interventions themselves do not cause deterioration. Application of this limitation of paternalism to the zone of agreement between the rival life standards is made to clinical case examples. Multiple extrinsic criteria may measure the quality of life. Three quality factors, sensation of pain, capacity to communicate and physical functioning are considered. The extent of the zone of agreement between the two life standards varies because quality of life is a relative good, contingent both upon which extrinsic criteria are selected to assess it and upon the priorities which are set among these criteria. (shrink)

Background: Ethics support services are growing in Europe to help doctors in dealing with ethical difficulties. Currently, insufficient attention has been focused on the experiences of doctors who have faced ethical difficulties in these countries to provide an evidence base for the development of these services.Methods: A survey instrument was adapted to explore the types of ethical dilemma faced by European doctors, how they ranked the difficulty of these dilemmas, their satisfaction with the resolution of a recent ethically difficult case (...) and the types of help they would consider useful. The questionnaire was translated and given to general internists in Norway, Switzerland, Italy and the UK.Results: Survey respondents ranged in age from 28 to 82 years, and averaged 25 years in practice. Only a minority reported having access to ethics consultation in individual cases. The ethical difficulties most often reported as being encountered were uncertain or impaired decision-making capacity , disagreement among caregivers and limitation of treatment at the end of life . The frequency of most ethical difficulties varied among countries, as did the type of issue considered most difficult. The types of help most often identified as potentially useful were professional reassurance about the decision being correct , someone capable of providing specific advice , help in weighing outcomes and clarification of the issues . Few of the types of help expected to be useful varied among countries.Conclusion: Cultural differences may indeed influence how doctors perceive ethical difficulties. The type of help needed, however, did not vary markedly. The general structure of ethics support services would not have to be radically altered to suit cultural variations among the surveyed countries. (shrink)

When external groups accuse a business organization of unethical practices, managers of the accused organization usually offer a communicative response to attempt to protect their organization's public image. Even though many researchers readily concur that analysis of these communicative responses is important to our understanding of business and society conflict, few investigations have focused on developing a theoretical framework for analyzing these communicative strategies used by managers. In addition, research in this area has suffered from a lack of empirical investigation. (...) In this paper we address both of these weaknesses in the existing literature. First, we explicate Impression Management Theory as an appropriate framework for studying organizational communicative responses, paying particular attention to the concept of accounts. Second, we critique previous investigations of organizational accounts and discuss the major contributions of our study. Third, we propose a coding system and content analyze the accounts offered by managers from 21 organizations that were recently the targets of consumer boycotts. Finally, we report the results of our empirical investigation and discuss ethical issues related to organizational accounts. (shrink)

As a first step in involving user emotion in human‐computer interaction, a memory‐based expert system (JANUS; Kearney, 1991) was designed to interpret facial expression in terms of the signaled emotion. Anticipating that a VDU‐mounted camera will eventually supply face parameters automatically, JANUS now accepts manually made measurements on a digitized full‐face photograph and returns emotion labels used by college students. An intermediate representation in terms of face actions (e.g., mouth open) is also used. Production rules convert the geometry into these. (...) A dynamic memory (Kolodner, 1984; Schank, 1982) interprets the face actions in terms of emotion labels. The memory is dynamic in the sense that new emotion labels can be learned with experience. A prototype system has been implemented on a Sun 2/120 system using POPLOG. Validation studies on the prototype suggest that the interpretations achieved are generally consistent with those of college students without formal instruction in emotion signals. (shrink)

After an intensive 4-year process, the World Medical Association (WMA) has revised its International Code of Medical Ethics (ICoME). In their report outlining this process, Parsa-Parsi et al not only describe how the WMA sought to ‘cultivat[e] international agreement’ on a ‘global medical ethos’, but also outline the philosophical framework of the ICoME: how the WMA, as the ‘global representation of the medical profession’, created and revised the ICoME through the process of international professional self-regulation.1 However, there is a significant (...) tension to be found in this framework—one which contrasts the international scope of the ICoME with the supposed source of its legitimacy. Here, we seek to characterise this tension and the doubt which it casts on the legitimacy of the ICoME. (shrink)

The Ockhamist claims that our ability to do otherwise is not endangered by God’s foreknowledge because facts about God’s past beliefs regarding future contingents are soft facts about the past—i.e., temporally relational facts that depend in some sense on what happens in the future. But if our freedom, given God’s foreknowledge, requires altering some fact about the past that is clearly a hard fact, then Ockhamism fails even if facts about God’s past beliefs are soft. Recent opponents of Ockhamism, including (...) David Widerker and Peter van Inwagen, have argued along precisely these lines. Their arguments, if successful, would undermine Ockhamism while avoiding the controversy over the alleged softness of facts about God’s past beliefs. But these arguments do not succeed. The past facts they rely on must be clear and uncontroversial examples of hard facts about the past, and these facts must be such that an ability to refrain from the relevant future action implies an ability to alter the relevant hard fact. We demonstrate the flaw in these arguments by showing how they rely on past facts that do not satisfy these criteria. The Ockhamist may have troubles, but this type of argument is not one of them. (shrink)

The emergence of the “4th Industrial Revolution,” i.e. the convergence of artificial intelligence, the Internet of Things, advanced materials, and bioengineering technologies, could accelerate socioeconomic insecurities and anxieties or provide beneficial alternatives to the status quo. In the post-Covid-19 era, the entities that are best positioned to capitalize on these innovations are large firms, which use digital platforms and big data to orchestrate vast ecosystems of users and extract market share across industry sectors. Nonetheless, these technologies also have the potential (...) to democratize ownership, broaden political-economic participation, and reduce environmental harms. We articulate the potential sociotechnical pathways in this high-stakes crossroads by analyzing cellular agriculture, an exemplary 4th Industrial Revolution technology that synergizes computer science, biopharma, tissue engineering, and food science to grow cultured meat, dairy, and egg products from cultured cells and/or genetically modified yeast. Our exploration of this space involved multi-sited ethnographic research in both the cellular agriculture community and alternative economic organizations devoted to open source licensing, member-owned cooperatives, social financing, and platform business models. Upon discussing how these latter approaches could potentially facilitate alternative sociotechnical pathways in cellular agriculture, we reflect upon the broader implications of this work with respect to the 4th Industrial Revolution and the enduring need for public policy reform. (shrink)

The thesis that there can be vague objects is the thesis that there can be identity statements which are indeterminate in truth-value (i.e., neither true nor false) as a result of vagueness (as opposed, e.g., to reference-failure), "the singular terms of which do not have their references fixed by vague descriptive means". (if this is "not" what is meant by the thesis that there can be vague objects, it is not clear what "is" meant by it.) the possibility of vague (...) objects should not be taken, in itself, to imply the more radical thesis that the identity relation can be one of "degree". one can hold that the concept of degrees of identity is absurd (how can one thing be more or less identical to another?) "and" that indeterminacy in identity is possible; hence, any incoherence in the idea of degrees of identity does not thereby undermine the idea of indeterminate identity. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Hume Studies Volume XXVI, Number 1, April 2000, pp. 171-177 Hume's Revised Racism Revisited AARON GARRETT John Immerwahr's brief note "Hume's Revised Racism" is doubtless one of the most intriguing recent discussions of Hume and racism.1 Immerwahr presents a thesis as to why Hume revised a footnote originally added to his essay "Of National Characters" (hereafter "ONC") in 1753. In this note I will examine and dispute Immerwahr's (...) thesis, which I believe can be shown to be seriously flawed. It is important to do so, as Immerwahr's note has been quoted a number of times in books and articles on Hume, and his thesis has been taken as gospel without sufficient examination of the grounds for his claims.2 As a consequence, Immerwahr's thesis is in danger of becoming a stubborn belief, even if not properly supportable. The controversy about Hume's racism centers on one infamous footnote added to the essay "Of National Characters" in the 1753-1754 edition of Essays and Treatises on Several Subjects. Why should we care about one footnote? We should care because the footnote seems to go against the image of a philosopher we thought we knew, and whom we likely esteem. In addition, it is shockingly bigoted. It reads in its entirety: I am apt to suspect the negroes, and in general all the other species of men (for there are four or five different kinds) to be naturally inferior to the whites. There never was a civilized nation of any other complexion than white, nor even any individual eminent either in action or speculation. No ingenious manufactures amongst them, no arts, no Aaron Garrett is at the Department of Philosophy, Boston University, 745 Commonwealth Avenue, Boston, MA 02215, USA. e-mail: garrett@bu.edu 172 Aaron Ganett sciences. On the other hand, the most rude and barbarous of the whites, such as the ancient Germans, the present Tartars, have still something eminent about them, in their valour, form of government, or some other particular. Such a uniform and constant difference could not happen, in so many countries and ages, if nature had not made an original distinction betwixt these breeds of men. Not to mention our colonies, there are Negroe slaves dispersed all over Europe, of which none ever discovered any symptom of ingenuity; tho' low people, without education, will start up amongst us, and distinguish themselves in every profession. In Jamaica, indeed, they talk of one negroe as a man of parts and learning; but 'tis likely he is admired for very slender accomplishments, like a parrot, who speaks a few words plainly.3 The footnote was not present in the 1748 edition of the Essays, Moral and Political, or Three Essays, Moral and Political, where ONC first saw light. In the 1768 edition there is one very minor alteration (from "tho' low people" to "though low people"). In the 1770 edition the footnote becomes an endnote, M,4 and there are again a few minor changes (from "betwixt these breeds of men" to "between these breeds of men"; from "of which never discovered" to "of whom never discovered"; for "'tis likely he is admired," read "it is likely he is admired") and one interesting substantive change (for "admired for very slender accomplishments," read "admired for slender accomplishments"). The most important change from the 1753 version of the note is in the 1777 posthumous edition, which Hume had corrected before he died. Hume rewrote the first two lines of 177OM, to read in 1777M: I am apt to suspect the negroes to be naturally inferior to the whites. There scarcely ever was a civilized nation of that complexion, nor even any individual eminent either in action or speculation.5 In "Hume's Revised Racism," Immerwahr argues that it is likely that Hume, after reading James Beattie's "Essay On Truth" and in light of his criticisms, revised the footnote in the 1777 edition of ONC. Immerwahr cites two pieces of evidence, a letter from Hume to Strahan to which he refers but does not quote, and Beattie's criticisms of Hume, which Hume may have read (although how much of it he read... (shrink)

As its title suggests, Mondin’s book is encyclopedic. It treats of theological language from the Greeks—in fact, Plato and Aristotle with very brief mention of others—to the present time. The entries are necessarily short but Karl Barth, Paul Tillich and Rudolf Bultmann among the moderns and Augustine and Aquinas among the classics get complete chapters to themselves. Heidegger does not, perhaps surprisingly, receive separate treatment although he is referred to as the source of both Gadamer and Ricoeur and specifically as (...) the source of the overcoming of the subject-object schema and so of the new hermeneutics. One might have expected more discussion of Bultmann’s relation to Heidegger. The section on linguistic analysis in general and Wittgenstein in particular is quite short but, granted that the book is taken as an encyclopedic reference work, is quite useful for anyone unfamiliar with analysis who wanted to begin a study of the theory of theological language within this school. Indeed, the usefulness of the book as a reference work on the problem is its major merit. The essays or entries do not pretend to achieve more than a swift survey of the author or school treated. As an aid to work the book is worth having. No price is given; there is an index of authors mentioned which in most cases is accurate; the entry on Freud is wrongly noted at 435 instead of 434. The bibliographies are restricted to the footnotes which is perhaps slightly awkward and sometimes only the Italian translation of a book is given e.g. on page 460 footnote 66 there is a reference to MacQuarrie, Ha senso parlare di Dio? which, I presume, is a translation of God-Talk. The book would be a better instrument if the original titles were given as well. (shrink)

The unity of this study rests on the notion that both statistics and emergence are intimately connected with randomness. A statistical law discovers an ideal frequency from which the actual frequency diverges only randomly i.e. the divergence is not contained in a law. Statistics and randomness, thus, mutually define each other. Emergence is related on the one hand, to regularly recurring events and, on the other hand, to the non-ordered events on one level which may be contained in a higher (...) order law. A discussion of the three linked notions naturally turns to the relations between the sciences and to the relations between the events which are their objects; thus the apparent oddness of a considered subtitle—‘Towards an adequate Weltanschauung’ —is eliminated, for an adequate Weltanschauung for the contemporary philosopher will have to include a position on the interconnexions between sciences. Perhaps the philosopher of science will readily grant this but recent thrusts in the philosophy of art, as well as the clear tendencies of the human sciences indicate that an understanding of these questions is increasingly important. It must be clear, for instance, that no serious comprehensive study of artistic meaning after Langer can afford to neglect utterly the nature of the shift from biological regularity to artistic pattern. I have passed from the unity on the side of the object to a corresponding unity on the side of the subject. For how is one to go about the discovery of the relevant interconnexions. So an earlier title refers to the concrete logic of discovery which itself is discovered not merely—perhaps not at all—by the verbal objectification of a theory but by the actual operations of the discoverer who is reflecting critically on himself. This view on the nature of philosophic enquiry, from which belief as present within the scientific community and essential to the proper development of science, is excluded, guides the form of the expression which continually points away from itself to the crucial experiments which the reader must himself perform. Indicative of this elusiveness is a reference to Goedel which is little more than an indication that at this point in the argument it would be valuable to do some work on the theorem. One may be inclined to cavil at this mode of expression; nevertheless it may be suggested that if philosophy does differ significantly from science it is possible that its proper mode of expression will likewise differ from that of science, and that this mode requires more investigation than it has yet received. Perhaps Wittgenstein is not aphorism at all. (shrink)

Expression is at once content and structure. Of late attention has shifted from the meaning of expression as content to its meaning as structure. This shift has occurred in various fields: in philosophy notably with the Heidegger of Holzwege and with the later Wittgenstein; in linguistics there is the well known work of Sapir and men like Bernstein who acknowledge a debt to Sapir; in social anthropology the investigations of Lévi-Strauss are associated with this movement; and the French structuralist school (...) in literary criticism also approaches some problems from this angle. It is not a wholly new approach and doubtless historians will reveal its antecedents; what is new, perhaps, is the shift in emphasis. Marshall McLuhan has brought this shift in emphasis to the public notice in works that are both lively and at times provocative. But McLuhan is suggestive above all and he rarely carries his suggestions through. One would hope that those following him might take up some of the suggestions and work them out more fully. The telephone, for instance, has connected distant parts of the world so that decisions made in one hemisphere can be, in a few moments, communicated to another. Conversely, since the decision of the man on the spot can be communicated to the remote chief at once, the practice of delegation of authority changes. But how much, how often, to what extent does the technology run before its reasonable implementation? Such are the precise questions that now emerge. Unfortunately, The Presence of The Word does not take us much farther towards an answer. However, besides these investigations, there is another aspect to the whole field: the very notion of content and structure. In much of the writing in this area there seems to be some confusion, and some authors, when professedly talking of structure, allow content in by the back door. This criticism has been made by Durand of Lévi-Strauss. The confusion stems from a prior failure to distinguish between expression and meaning and a consequent failure to differentiate modalities of meaning. Prior to a discussion of a distinction between structure and content on the level of expression, there is needed a clarification of the structure of meaning. No matter what science one may be referring to, one will discover that it is theory verified in instances. When this has been clarified one can go on to discuss the relation of expression to theory e.g. the structure of scientific expression. Besides scientific meaning, there is aesthetic, symbolic and interpersonal meaning and here again their structure must be analysed. One question in the analysis will be, as before, the relation of expression to meaning. The relation of expression to meaning will differ in the several modalities and the significance of a shift in the way of expression will likewise differ from mode to mode. Fr Ong does not very clearly advert to this aspect of the problem and nowhere does he treat it adequately. (shrink)