According to the biopsychosocial model, developed by the late Dr. George Engel, how physicians approach patients and the problems they present is very much ...

Most metazoan organisms have evolved a mildly acidified and calcium diminished sorting hub in the early secretory pathway commonly referred to as the Endoplasmic Reticulum‐Golgi intermediate compartment (ERGIC). These membranous vesicular‐tubular clusters are found tightly juxtaposed to ER subdomains that are competent for the production of COPII‐coated transport carriers. In contrast to many unicellular systems, metazoan COPII carriers largely transit just a few hundred nanometers to the ERGIC, prior to COPI‐dependent transport on to the cis‐Golgi. The mechanisms underlying formation and (...) maintenance of ERGIC membranes are poorly defined. However, recent evidence suggests an important role for Trk‐fused gene (TFG) in regulating the integrity of the ER/ERGIC interface. Moreover, in the absence of cytoskeletal elements to scaffold tracks on which COPII carriers might move, TFG appears to promote anterograde cargo transport by locally tethering COPII carriers adjacent to ERGIC membranes. This action, regulated in part by the intrinsically disordered domain of TFG, provides sufficient time for COPII coat disassembly prior to heterotypic membrane fusion and cargo delivery to the ERGIC. -/- . (shrink)

Editors’ Note: A major goal of Science and Engineering Ethics is to promote discussion of the ethical issues raised by various aspects of science and engineering, both within the pages of this journal and beyond. We are beginning a series of case presentations and discussions in the Educational Forum. We invite readers to respond to the case and accompanying commentaries, and to submit other cases and commentaries for future publication. We look forward to hearing from you. — S. J. Bird, (...) R. E. Spier. (shrink)

It is sometimes suggested that Berkeley adheres to an empirical criterion of meaning, on which a term is meaningful just in case it signifies an idea (i.e., an immediate object of perceptual experience). This criterion is thought to underlie his rejection of the term ‘matter’ as meaningless. As is well known, Berkeley thinks that it is impossible to perceive matter. If one cannot perceive matter, then, per Berkeley, one can have no idea of it; if one can have no idea (...) of it, then one cannot speak meaningfully of it. But if this is Berkeley’s position, then there is a puzzle, because Berkeley also explicitly claims that it is impossible to perceive/have ideas of minds. So if he is relying on a criterion on which terms get their meaning by referring to ideas, then, just as Berkeley rejects talk of material substance, so, too, must he reject talk of mental substance. Famously, however, Berkeley insists that there is no parity between the cases of material and mental substance. It is typically suggested that the disparity between matter and minds rests on the fact that although one cannot strictly speaking perceive minds, nonetheless Berkeley thinks that one can have experiential access to minds via reflection, and that this access allows for meaningful talk of minds. Of course, one can only have reflective experience of one’s own mind. But what of other minds, which one cannot reflectively experience? Here the usual tactic is to suppose that, although one cannot have direct reflective experience of other minds, nonetheless one can indirectly experience such minds via analogy to our own minds, and that this indirect experience grounds the meaningfulness of talk of other minds. In this paper, I argue that the reasoning behind Berkeley’s ‘likeness principle,’ that an idea can only be like another idea, can be generalized to argue against this experience-based account of our access to other minds. I claim instead that Berkeley allows for the meaningfulness of talk of other minds by expanding the criterion of meaning in a different way. I argue that Berkeley holds a criterion of meaning on which a term is meaningful just in case it signifies either an object of experience or an object that one has reason to posit on the basis of experience, i.e., an object that is necessary to explain our experiences. When an object is neither experienced nor explains our experiences, then and only then is Berkeley willing to reject it as meaningless. Thus he writes of “the word matter,” that “it is no matter whether there is such a thing or no, since it no way concerns us: and I do not see the advantage there is in disputing about we know not what, and we know not why” (Principles, §77.) The word is not meaningless merely because we do not know what matter might be; it is meaningless because we also do not know why it should be. Correspondingly, I argue that the term ‘mind’ is meaningful because although we have no experience of minds, nonetheless they play an important role in explaining our experiences. (shrink)

The shift to a market economy in post-communist Eastern Europe has had a profound impact on science and scientists across the region, leading to reforms in research management practices and to drastic cuts in funding levels everywhere. Many countries are moving to a system of competitive research grants awarded on the basis of peer review. The introduction of peer review is not simply a technical matter. It signifies a fundamental change in the social structure of science, enhancing profession-al autonomy and (...) giving working scientists a voice in the allocation of resources. This book combines first-hand accounts of the reform process with analyses of the strengths and weaknesses of both peer review and quantitative indicators. (shrink)

This chapter begins with a brief examination of the life of Damaris Cudworth Masham. Section II focuses on her philosophical writing including her correspondence, her ideas on the relationship of faith and reason, her views on reason and women’s education and possible feminist aspects of her views on morality and epistemology.

Pursuing the Forms: Equality and Excellence in Plato's Republic and Symposium -- Equality and Excellence in the Education of Cyrus -- Splendid Equality in the Nicomachean Ethics: Munificence -- How Excellence Bows to Equality in Aristotle's Politics -- First Among Equals: Philosophers, Statesmen, and Citizens in Spinoza's Democracy -- Excellence and Equality in Fénelon's Telemachus -- The Seductive Danger of Equality and Excellence: The Moderating Wisdom of Montesquieu's Science of Ovidian Metamorphosis -- Equality and Excellence in Rousseau's Emile, Book III (...) -- Hegel's Evaluation of Liberalism: Equality of Rights without Human Excellence -- Democracy, Nobility, and Freedom: The Political and Moral Aesthetics of Tocqueville -- Does Kierkegaard Have a Concept of Excellence? -- Nietzsche: The Indignity of Equality -- The Good and the Excellent: John Rawls's Egalitarian Liberalism. (shrink)

A collection of essays on civil religion in modern political philosophy, exploring the engagement between modern thought and the Christian tradition.

This book investigates how constructed representations of the child have and continue to restrict children’s opportunities to engage in moral discourses, and the implications this has on children’s everyday experiences. By considering a moral dimension to both structure and agency, the author focuses on the nature of the images that are used to represent the child and how these sit in contrast to the active and meaning-driven way in which children negotiate their everyday lives. The book therefore argues that ‘morality’ (...) provides a filter to understand the backdrop for interaction, as well as offering a focus for engaging with the individual as a social agent, acting and reacting in the world around them. Negotiating Childhoods will be of interest to students and scholars of sociology, childhood studies, criminology, social work, culture and media studies and philosophy. (shrink)

This volume represents a contribution to the investigation of these issues of perennial interest and import, featuring essays whose authors hope to extend, deepen, and, in some cases, move in new directions, the current state of discussion.

This book explores the extent to which children engage with morality within their everyday lives.

Scientific societies can play an important role in promoting ethical research practices among their members, and over the past two decades several studies have addressed how societies perform this role. This survey continues this research by examining current efforts by scientific societies to promote research integrity among their members. The data indicate that although many of the societies are working to promote research integrity through ethics codes and activities, they lack rigorous assessment methods to determine the effectiveness of their efforts.

The problem is a simple one. A placebo is “a substance provided to a patient that the physician believes has no specific pharmacological effect upon the condition being treated” (AMA 2007). 1 But i...

The essence of a mental event such as self-deception lies in its function – its place in the life of an animal. But the function of self-deception corresponds to that of interpersonal deception. Therefore self-deception, contrary to Mele's thesis, is essentially isomorphic with interpersonal deception.

The relation between leibniz's logical and his metaphysical views is the subject of much modern scholarship. Some commentators have argued that his metaphysics is based on his logic; others have taken the opposite position. However, Both sides pose the question in terms of 'priority'. On the contrary, I argue that it is likely that leibniz means the psr to play "both" a logical and a metaphysical role. The ambiguity of leibniz's psr indicates that he equates the metaphysical notion of causation (...) with the logical notion of deduction. The psr's ambiguity results less from any confusion on leibniz's part between the notions of cause and reason, Than from his desire to identify logic and metaphysics. That identity is achieved not by reducing one to the other, But by incorporating them on an equal basis into a single discipline. (shrink)

In a familiar limerick attributed to Ronald Knox, the narrator asks how a “tree/should continue to be/when there’s no one about in the Quad,” and is subsequently reassured that its continuous existence is guaranteed by God’s being “always about in the Quad” observing it. This is meant to capture Berkeley’s so‐called ‘continuity argument’ for the existence of God, on which the claim that objects exist continuously over time is supposed to entail the existence of a Divine Mind that continuously perceives (...) the ideas that constitute those objects. But the continuity argument is not an uncontroversial one. For one thing, we might ask what divine perception is supposed to be like – does God perceive all of the ideas that we do, and in the same way that we do? And if so, does this mean that God perceives pain – that God suffers? For another thing, we might ask whether Berkeley is entitled to the claim that objects exist continuously to begin with. In this paper, I look at some of the problems associated with the continuity argument, and then present a reading of divine perception that attempts to prevent these problems from arising at the outset. (shrink)

Berkeley writes in his ThreeDialogues Between Hylas and Philonous that he “acknowledge[s] a twofold state of things, the one ectypal or natural, the other archetypal and eternal[.] The former was created in time; the latter existed from everlasting in the mind of God”. On a straightforward reading of this passage, it looks as though Berkeley is an indirect perception theorist, who thinks that our sensory ideas are copies or resemblances of archetypal divine ideas. But this is problematic because Berkeley’s rejection (...) of scepticism seems partly to rest on a rejection of indirect perception. In this paper, I consider, and reject, three different approaches to solving this problem: that Berkeley’s remarks on archetypes are unrepresentative; that Berkeley is indeed committed to divine archetypal ideas ; and that Berkeley thinks divine archetypal ideas are identical to human ideas. I finally settle on a fourth strategy, which involves reading Berkeley’s archetypes as divine powers to produce ideas. I claim that this reading is consistent with the texts, that it has an etymological basis and philosophical precedent, and that it resolves the problems associated with the other three approaches to archetypes. (shrink)